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Molecular Biology of Human Cancers: An Advanced Student's Textbook
Presents many of the molecules and mechanisms generally important in human cancers. Following an overview on the cancer problem, individual chapters deal with cancer genetics and epigenetics, DNA damage and repair, oncogenes, tumor suppressors, regulatory pathways in cancer, apoptosis, cellular senescence, tumor invasion, and metastasis. A consensus is emerging that while these common mechanisms and molecules are all relevant to human cancers, in each cancer type (or even subtype) a selection of them are extremely important. For selected cancers, the route from genetic and epigenetic changes to their biological and clinical behavior can already be traced. Part II of the book presents a broad, but exemplary selection of cancers that serve as paradigms to illustrate this point. In fact, cancer research has now reached a critical stage, in which the accumulated knowledge on molecular mechanisms is gradually translated into improved prevention, diagnosis, and treatment. The state, pitfalls, and potential of these efforts are summarized in Part III. More than ever, cancer research is now an interdisciplinary effort which requires a basic knowledge of commonly used terms, facts, issues, and concepts. The aim of this book is to provide advanced students and practitioners of different disciplines with this basis, bridging the gap between standard textbooks of molecular biology, pathology, and oncology on the one hand and the specialized cancer literature on the other.
Modern Sliding Mode Control Theory : New Perspectives and Applications
This book is a collection of invited chapters covering several areas of modern sliding mode control theory. The authors identify key contributions defining the theoretical and applicative state of the art of the sliding mode control theory and the most promising trends of the ongoing research activities. The contributions is divided in four main parts: Part I: Basic Theory. Part II: Design Methods. Part III: Observers and Fault Detection. Part IV: Applications.
Modern pharmaceutics
Covers the curriculum and syllabus developed by the Pharmacy Council of India, providing students with the necessary knowledge and skills required in the field of pharmaceutical services
Modern Morphometrics in Physical Anthropology
Morphometrics has undergone a revolutionary transformation in the past two decades as new methods have been developed to address shortcomings in the traditional multivirate analysis of linear distances, angles, and indices. While there is much active research in the field, the new approaches to shape analysis are already making significant and ever-increasing contributions to biological research, including physical anthropology. Modern Morphometrics in Physical Anthropology highlights the basic machinery of the most important methods, while introducing novel extensions to these methods and illustrating how they provide enhanced results compared to more traditional approaches. Modern Morphometrics in Physical Anthropology provides a comprehensive sampling of the applications of modern, sophisticated methods of shape analysis in anthropology, and serves as a starting point for the exploration of these practices by students and researchers who might otherwise lack the local expertise or training to get started. This text is an important resource for the general morphometric community that includes ecologists, evolutionary biologists, systematists, and medical researchers.
Modern industrial services : A cookbook for design, delivery, and management
This book is an outcome of several years of research, practice, and teaching experience of the authors on the challenges that underpin the successful switch to services for manufacturing firms. Ideal for a student as well as a practitioner, the book describes the industrial services ecosystem, the barriers and challenges, and a roadmap for building service excellence. Curated cases are used to describe the current approaches in practice to overcome the barriers. The book also provides several tools, each with a short introduction, that the authors have used successfully in projects to help overcome the servitization barriers. Many of these tools are from management, design thinking, or service design.
Modern Hematology : Biology and Clinical Management
The first chapters of this book contain a self-contained introduction to path integrals in Euclidean quantum mechanics and statistical mechanics. The resulting high-dimensional integrals can be estimated with the help of Monte Carlo simulations based on Markov processes. The most commonly used algorithms are presented in detail so as to prepare the reader for the use of high-performance computers as an “experimental” tool for this burgeoning field of theoretical physics. Several chapters are then devoted to an introduction to simple lattice field theories and a variety of spin systems with discrete and continuous spins, where the ubiquitous Ising model serves as an ideal guide for introducing the fascinating area of phase transitions. As an alternative to the lattice formulation of quantum field theories, variants of the flexible renormalization group methods are discussed in detail. Since, according to our present-day knowledge, all fundamental interactions in nature are described by gauge theories, the remaining chapters of the book deal with gauge theories without and with matter.
Modern Food Microbiology
With 30 revised and updated chapters, the new edition of this classic text brings benefits to professors and students alike who will find new sections on proteobacteria, bottled water, food sanitizers (eletrolyzed oxidating water, ozone, chlorine, activin, chitosans, endolysins, etc.), bicontrol, biosensors quorum sensing, molecular genetic methods of analysis, food safety objectives, noroviruses, and prions. The book builds on the trusted and established sections on food preservation by modified atmosphere, high pressure and pulsed electric field processing, food-borne pathogens, food regulations, fresh-cut produce, new food products, and risk assessment and analysis. In-depth references, appendixes, illustrations, index and thorough updating of taxonomies make this an essential for every food scientist.
Modern Construction Handbook
Tried and tested component details, examples focusing on sustainability and energy consumption, and an update on finite element analysis (FEA) and computational fluid dynamics (CFD) introduced in the last edition set new standards for this handbook which serves as a foundational textbook in many architecture courses
Modern clinic design : strategies for an era of change
A comprehensive guide to optimizing patient experience through the design of the built environment. Written by a team of veteran healthcare interior designers, architects, and engineers, this book addresses the impacts of evolving legislation, changing technologies, and emerging nontraditional clinic models on clinic design, and illustrates effective design strategies for any type of clinic. Readers will find innovative ideas about lean design, design for flexibility Understand how recent industry developments impact facility design Learn how design strategies can help create a positive patient experience Examine emerging clinic models that are becoming increasingly prevalent Analyze the impact of technology on clinic design
Modern aspects of pharmaceutical quality assurance : developing and proposing application models, SOPs, practical audit systems for pharma industry
Aims to develop a tool that will substantially decrease the number of Inspectional Observations and Warning letters, thus eliminating Import Alerts and Consent Decree. This book targets the Pharmaceutical Industry and students of Pharmaceutical Quality Assurance so they can get in hand-ready consolidated information on Pharmaceutical Quality guidelines, Quality metrics, and implementation of simplified SOP guidelines, plant layouts to implement Quality metrics for Pharmaceutical Manufacturing systems in tablets, capsules, liquid orals, and semi-solid dosage forms.
Modern Aryne Chemistry
The book reveiws the recent use of aryne chemistry for the development of new multicomponent reactions. New advances in this area has shown rapid emergence of a new class of reactions classified under rearrangement reactions. The author also includes information on aryne methods that have been employed for the synthesis of several natural products. The simplicity and sophistication of the synthetic strategy using arynes can serve as a springboard for organic chemists to explore new possibilities and imagine applications of the concept of arynes.
Models, Methods and Tools for Product Service Design : The Manutelligence Project
This book summarizes research being pursued within the Manutelligence project, the goal of which is to help enterprises develop smart, social and flexible products with high value added services. Manutelligence has improved Product and Service Design by developing suitable models and methods, and connecting them through a modular, collaborative and secure ICT Platform. The use of real data collected in real time by Internet of Things (IoT) technologies underpins the design of product-service systems and makes it possible to monitor them throughout their life cycle. Available data allows costs and sustainability issues to be more accurately measured and simulated in the form of Life Cycle Cost (LCC) and Life Cycle Assessment (LCA). Analysing data from IoT systems and sharing LCC and LCA information via the ICT Platform can help to accelerate the design of product-service systems, reduce costs and better understand customer needs. Industrial partners involved in Manutelligence provide a clear overview of the project's outcomes, and demonstrate how its technological solutions can be used to improve the design of product-service systems and the management of product-service life cycles.
Modellistica numerica per problemi differenziali = Numerical modeling for differential problems
This text introduces the basic concepts for the numerical modeling of partial differential problems. We consider the classic elliptic, parabolic and hyperbolic linear equations, but also other equations, such as those of diffusion and transport, of Navier-Stokes, and the conservation laws, and we provide numerous physical examples underlying these equations. Then we analyze numerical resolution methods based on finite elements, finite differences, finite volumes, spectral methods and domain decomposition methods. In particular, the algorithmic and computer implementation aspects are discussed and various easy-to-use programs are provided.
Modellistica Numerica per Problemi Differenziali = Numerical Modeling for Differential Problems
This text introduces the fundamental concepts for the numerical modeling of partial differential problems. We consider the classic linear elliptic, parabolic and hyperbolic equations, but also other equations, such as those of diffusion and transport, of Navier-Stokes, and the conservation laws. Numerous physical examples underlying these equations are provided, their main mathematical properties are studied, then numerical resolution methods based on finite elements, finite differences, finite volumes and spectral methods are proposed and analyzed. In particular, the algorithmic and computer implementation aspects are discussed and some easy-to-use programs in C ++ language are provided. The text does not presuppose an advanced mathematical knowledge of partial differential equations: the strictly indispensable concepts in this regard are reported in the Appendix. The volume is therefore suitable for students of scientific degree courses (Engineering, Mathematics, Physics, Chemistry, Information Sciences) and recommended for researchers from the academic and extra-academic world who want to approach this interesting branch of applied mathematics.
Modelling, State Observation and Diagnosis of Quantised Systems
The book concerns quantised systems which emerge from continuous-variable systems by quantising the values of all signals. It is shown how this leads to an abstract system description by means of a stochastic automaton. Based on stochastic automata, new methods for the solution to state observation and fault diagnostic problems are derived. The methods are extended to networks of stochastic automata, allowing component-oriented modelling and, thus, to deal with complex systems. The practical applicability and usefulness of the approach is shown at several examples.
Modelling the dispersion of radionuclides in the marine environment : An introduction
This book is a practical guide to the subject of numerical modelling of radioactivity dispersion in the marine environment. Thus, the techniques and numerical procedures required are explained in detail, with the aim of enabling the reader to build a real mathematical model. The book covers basic concepts and techniques, such as solving the advection-diffusion equation in a simple 1D form, as well as the most recent developments (full 3D models for non-conservative radionuclides including chemical reactions and speciation). A chapter is dedicated to the basic hydrodynamic modelling that is always required to simulate the dispersion of tracers in the sea; Eulerian and Lagrangian modelling techniques are also described. A chapter describes sensitivity and uncertainty analysis, the final stage in modelling works. A review on some published radionuclide dispersion models is also included.
Modelling Autonomic Communications Environments ; 3rd IEEE International Workshop, MACE 2008, Samos Island, Greece, September 22-26, 2008. Proceedings
Research and development of autonomics have come a long way, and we are delighted to present the proceedings of the 3rd IEEE International Workshop on Modelling Autonomic Communications Environments (MACE 2008).Asin the last two years, this workshopwasheld aspart of Manweek, the International Week on Management of Networks and Services, which took place on the lovely Island of Samos in Greece .MACE started as anexperimentin2006,andcreatedasmallcommunitythat nowfnds it self attracted backeachyearby afeeling ofexcitement-thatthere is something new going on. Certainly, MACE is not as shiny or practiced as other well-known conferences and workshops, but we consider this a feature of the workshopitself.
Modelling and Estimation Strategies for Fault Diagnosis of Non-Linear Systems : From Analytical to Soft Computing Approaches
This monograph presents a variety of techniques that can be used for designing robust fault diagnosis schemes for non-linear systems. The introductory part of the book is of a tutorial value and can be perceived as a good starting point for the new-comers to this field. Subsequently, advanced robust observer structures are presented. Parameter estimation based techniques are discussed as well. A particular attention is drawn to experimental design for fault diagnosis. The book also presents a number of robust soft computing approaches utilizing evolutionary algorithms and neural networks. All approaches described in this book are illustrated by practical applications.
Modélisation et statistique spatiales = Spatial modeling and statistics
Spatial statistics are undergoing significant development due to their use in many fields: earth sciences, environment and climatology, epidemiology, econometrics, image analysis, etc. This book presents the main spatial models used as well as their statistics for the three types of data: geostatistics (observation on a continuous domain), data on a discrete network, point data. The objective is to present in a concise but mathematically complete way the most classical models (second order and variogram; software model and Gibbs-Markov field; point processes) as well as their simulation by MCMC algorithm. Then comes the presentation of statistical tools useful for their study.
Modeling Theory in Science Education
The book focuses as much on course content as on instruction and learning methodology, and presents practical aspects that have repeatedly demonstrated their value in fostering meaningful and equitable learning of physics and other science courses at the secondary school and college levels.The author shows how a scientific theory that is the object of a given science course can be organized around a limited set of basic models. Special tools are introduced, including modeling schemata, for students to meaningfully construct models and required conceptions, and for teachers to efficiently plan instruction and assess and regulate student learning and teaching practice. A scientific model is conceived to represent a particular pattern in the structure or behavior of physical realities and to explore and reify the pattern in specific ways. The author further shows how to engage students in modeling activities through structured learning cycles.
