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Acute Promyelocytic Leukemia : Molecular Genetics, Mouse Models and Targeted Therapy
Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy.
Actin-Binding Proteins and Disease
This volume, written by experts in the field, is the first to deal with the relationship between human disease and the actin cytoskeleton. It provides overviews of actin and selected actin-binding proteins, and then focuses on diseases that involve these proteins. Specific chapters deal with actin, cofilin, profilin, gelsolin and thymosin ¾4. Other chapters discuss the roles of multiple actin-binding proteins in cancer and metastasis, leukocyte disorders, and heart failure, and there is a chapter that describes how intracellular pathogens use the host actin cytoskeleton. This seminal volume is intended for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
A Closer Look at Antibiotic Resistance
Bacterial infections have become more difficult, and sometimes impossible, to treat due to antibiotic resistance, which occurs when bacteria develop the ability to defeat the available drugs designed to kill them. According to the Centers for Disease Control and Prevention, each year, 2 million Americans become sick with antibiotic-resistant infections, and of that, about 23,000 die. This book examines the challenges related to antibiotic resistance, the development and use of diagnostic testing to identify antibiotic resistance, the development of treatments for resistant infections, and appropriate antibiotic use.
3D cell culture : Methods and protocols
Expands on the previous edition with discussions about the latest organoid models developed for many more organs; new hydrogels and devices for 3D culture; and the organoid systems that have been improved by incorporating more components of tissue microenvironments in the in vitro culture. The chapters in this book are organized into five parts and cover topics such as biofabrication, organoids, microfluidic systems, bioprinting, and image analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Matching Properties of Deep Sub-Micron MOS Transistors
Matching Properties of Deep Sub-Micron MOS Transistors examines this interesting phenomenon. Microscopic fluctuations cause stochastic parameter fluctuations that affect the accuracy of the MOSFET. For analog circuits this determines the trade-off between speed, power, accuracy and yield.
Macroscopic Transport Equations for Rarefied Gas Flows : Approximation Methods in Kinetic Theory
This book discusses classical and modern methods to derive macroscopic transport equations for rarefied gases from the Boltzmann equation, for small and moderate Knudsen numbers, i.e.as well as the new order of magnitude method, which avoids the short-comings of the classical methods, but retains their benefits.
Machine Learning and Probabilistic Graphical Models for Decision Support Systems
Presents recent advancements in research, a review of new methods and techniques, and applications in decision support systems (DSS) with Machine Learning and Probabilistic Graphical Models, which are very effective techniques in gaining knowledge from Big Data and in interpreting decisions. It explores Bayesian network learning, Control Chart, Reinforcement Learning for multicriteria DSS, Anomaly Detection in Smart Manufacturing with Federated Learning, DSS in healthcare, DSS for supply chain management, etc. Researchers and practitioners alike will benefit from this book to enhance the understanding of machine learning, Probabilistic Graphical Models, and their uses in DSS in the context of decision making with uncertainty. The real-world case studies in various fields with guidance and recommendations for the practical applications of these studies are introduced in each chapter.
LINQ for Visual C# 2008
Every C# programmer needs to learn about LINQ (Language–Integrated Query), Microsoft's breakthrough technology for simplifying and unifying data access from any data source. With LINQ, you can write more elegant and flexible code—not just to access databases and files, but to manipulate data structures and XML. This book is a short, yet comprehensive guide to the major features of LINQ and the significant enhancements introduced with .NET 3.5. There is no better source for getting a head–start on the future of these technologies than this book.
Laser additive manufacturing: design, materials, processes and applications
Laser-based additive manufacturing (LAM) is a revolutionary advanced digital manufacturing technology developed in recent decades, which is also a key strategic technology for technological innovation and industrial sustainability. This technology unlocks the design and constraints of traditional manufacturing and meets the needs of complex geometry fabrication and high-performance part fabrication. A deeper understanding of the design, materials, processes, structures, properties and applications is desired to produce novel functional devices, as well as defect-free structurally sound and reliable LAM parts.The topics in this Special Issue reprint include macro- and micro-scale additive manufacturing with lasers, such as structure/material design, fabrication, modeling and simulation, in situ characterization of additive manufacturing processes and ex situ materials characterization and performance, with an overview that covers various applications in aerospace, biomedicine, optics and energy.
Component-Based Software Development for Embedded Systems : An Overview of Current Research Trends
Embedded systems are ubiquitous. They appear in cell phones, microwave ovens, refrigerators, consumer electronics, cars, and jets. Some of these embedded s- tems are safety- or security-critical such as in medical equipment, nuclear plants, and X-by-wire control systems in naval, ground and aerospace transportation - hicles. With the continuing shift from hardware to software, embedded systems are increasingly dominated by embedded software. Embedded software is complex. Its engineering inherently involves a mul- disciplinary interplay with the physics of the embedding system or environment. Embedded software also comes in ever larger quantity and diversity. The next generation of premium automobiles will carry around one gigabyte of binary code. The proposed US DDX submarine is e?ectively a ?oating embedded so- ware system, comprising 30 billion lines of code written in over 100 programming languages. Embedded software is expensive. Cost estimates are quoted at around US$15– 30 per line (from commencement to shipping). In the defense realm, costs can range up to $100, while for highly critical applications, such as the Space Shuttle, the cost per line approximates $1,000. In view of the exponential increase in complexity, the projected costs of future embedded software are staggering.
C++ mit Visual Studio 2019 : C++17 für Studierende und erfahrene Programmierer
C++ hat sich in den letzten Jahren rasant entwickelt: C++11, C++14, C++17 und C++20 haben viele Verbesserungen und neue Möglichkeiten gebracht. Vieles, was vor 10 Jahren noch gut und empfehlenswert war, kann heute besser und sicherer gemacht werden. Dieses Buch stellt C++ mit Visual Studio 2019 auf dem Stand von Mai 2020 umfassend dar. Das ist nicht nur der Umfang von C++17, sondern auch schon ein Teil von C++20.
C++ /CLI : The Visual C++ Language for .NET
C++/CLI: The Visual C++ Language for .NET introduces Microsoft's extensions to the C++ syntax that allow you to target the common language runtime the key to the heart of the .NET 3.0 platform. In 12 no-fluff chapters, Microsoft insider Gordon Hogenson takes you into the core of the C++/CLI language and explains both how the language elements work and how Microsoft intends them to be used.
Building a Data Warehouse : With Examples in SQL Server
The book is organized as follows. In the beginning of this book (chapters 1 through 6), you learn how to build a data warehouse, for example, defining the architecture, understanding the methodology, gathering the requirements, designing the data models, and creating the databases. Then in chapters 7 through 10, you learn how to populate the data warehouse, for example, extracting from source systems, loading the data stores, maintaining data quality, and utilizing the metadata. After you populate the data warehouse, in chapters 11 through 15, you explore how to present data to users using reports and multidimensional databases and how to use the data in the data warehouse for business intelligence, customer relationship management, and other purposes. Chapters 16 and 17 wrap up the book: After you have built your data warehouse, before it can be released to production, you need to test it thoroughly. After your application is in production, you need to understand how to administer data warehouse operation.
Brain and Human Body Modeling : Computational Human Modeling at EMBC 2018
This book describes modern applications of computational human modeling with specific emphasis in the areas of neurology and neuroelectromagnetics, depression and cancer treatments, radio-frequency studies and wireless communications. Special consideration is also given to the use of human modeling to the computational assessment of relevant regulatory and safety requirements. Readers working on applications that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest developments in computational modelling and human phantom development to assess a given technology’s safety and efficacy in a timely manner.
Biological and medical data analysis ; Vol. 3745 ; 6th International symposium, ISBMDA 2005, Aveiro, Portugal, November 10-11, 2005, Proceedings
The 6th International Symposium on Biological and Medical Data Analysisaimed to become a place where researchersinvolved in these diverse but increas-ingly complementary areas could meet topresent and discuss their scientificresults.The papers in this volume discuss issues from statistical models to archi-tectures and applications to bioinformatics and biomedicine. They cover bothpractical experience and novel research ideas and concepts.
Bioinformatics technologies
Solving modern biological problems requires advanced computational methods. Bioinformatics evolved from the active interaction of two fast-developing disciplines, biology and information technology. The central issue of this emerging field is the transformation of often distributed and unstructured biological data into meaningful information. This book describes the application of well-established concepts and techniques from areas like data mining, machine learning, database technologies, and visualization techniques to problems like protein data analysis, genome analysis and sequence databases. Chen has collected contributions from leading researchers in each area. The chapters can be read independently, as each offers a complete overview of its specific area, or, combined, this monograph is a comprehensive treatment that will appeal to students, researchers, and R&D professionals in industry who need a state-of-the-art introduction into this challenging and exciting young field.
Bioinformatics research and development ; 2nd International Conference, BIRD 2008 Vienna, Austria, July 7-9, 2008 Proceedings
This book constitutes the refereed proceedings of the Second International Bioinformatics Research and Development Conference, BIRD 2008, held in Vienna, Austria in July 2008.
Bioinformatics
In this textbook present mathematical models in bioinformatics and they describe the biological problems that inspire the computer science tools used to handle the enormous data sets involved. The first part of the book covers the mathematical and computational methods, while the practical applications are presented in the second part. The mathematical presentation is descriptive and avoids unnecessary formalism, and yet remains clear and precise. Emphasis is laid on motivation through biological problems and cross applications. Each of the four chapters in the first part is accompanied by exercises and problems to support an understanding of the techniques presented. Each of the six chapters of the second part is devoted to some specific application domain: sequence alignment, molecular phylogenetics and coalescence theory, genomics, proteomics, RNA, and DNA microarrays. Each chapter concludes with a problems and projects section, to deepen the reader's understanding and to allow for the design of derived methods. Many of the projects involve publicly available software and/or Web-based bioinformatics depositories. Finally, the book closes with a thorough bibliography, reaching from classic research results to very recent findings, providing many pointers for future research.Overall, this volume is ideally suited for a senior undergraduate or graduate course on bioinformatics, with a strong focus on its mathematical and computer science background.
Beginning Web Development, Silverlight, and ASP.NET AJAX : From novice to professional
Beginning Web Development, Silverlight, and ASP.NET AJAX: From Novice to Professional aims to give you the skills you need to start building web applications with Microsoft's next–generation technology as quickly as possible. Whether you're interested in ASP.NET AJAX, Silverlight, or the technologies that support them (WPF, WCF, WF, etc.), this book is the starting point that you need. It adopts a “zero to hero” approach that concentrates on achieving practical results you can use in real projects rather than presenting a deep academic treatment that can't be immediately applied.
Beginning VB 2008 : From novice to professional
This book is for anyone who wants to write good Visual Basic 2008 code, even if you have never programmed before. Writing good code can be a challenge, there are so many options, especially in a language like Visual Basic. If you want to really get the best from a programming language you need to know which features work best in which situations and understand their strengths and weaknesses. It is this understanding that makes the difference between coding and coding well.
