Acute Promyelocytic Leukemia : Molecular Genetics, Mouse Models and Targeted Therapy
- Author
- Pier Paolo Pandolfi, Peter K. Vogt
- Publication Year
- 2007
- Publisher
- Springer
- Language
- English
- Document Type
- Book
- Faculty / Subject Heading
- Medical Science
- Download Book Read book
Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy.
Keywords: Biomedical and life sciences / All-trans retinoic acid (ATRA) / Chromosom / Small ubiquitin-like modifier (SUMO) / Clinical trial / Genes / Genetics / Leukemia / MicroRNA / Molecular genetics / Peptides / Protein / Proteins / Targeted therapy / Transcription / Translation
