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Immune regulation and immunotherapy in autoimmune disease
Assembles the insights and experience of over twenty experts and thought leaders in the field of autoimmune disease and immunotherapy. These discussions represent some of the newest concepts in autoimmune mechanisms and an array of new treatments that would have been considered science fiction only two decades ago. This book provides a wide-ranging review of two main arenas of current research: that of autoimmune mechanisms of disease and that of the latest developments in immunotherapy, with an emphasis upon multiple sclerosis.
Imaging Technologies and Transdermal Delivery in Skin Disorders
This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work.
Imaging in Drug Discovery and Early Clinical Trials
Efficient tools for the selection and validation of drug targets both at the preclinical and clinical level are required. Non-invasive imaging and in particular molecular imaging methods are becoming essential technologies to support drug discovery and dvelopment. Imaging provides structural, functional, metabolic and molecular readouts that are being applied to characterize a disease phenotype (diagnosis), to elucidate molecular mechanisms involved, to evaluate drug efficacy and safety, and to identify potential biomarkers of the drug's mechanism-of-action, efficacy and safety. Non-invasive imaging techniques constitute a bridge between preclinical and clinical drug evaluation. In this monograph the contribution of imaging modalities to the various stages of drug discovery and development, from early target validation to their use in clinical development programs, is described. Chapters are devoted to the description of the drug discovery process as such, to the various imaging modalities being used both preclinically and clinically, to applications of imaging during the optimization of a lead compound (addressing issues such as bioavailability and efficacy) and during the drug safety evaluation.
Imaging Cellular and Molecular Biological Functions
Imaging cellular and molecular biological function’ provides a unique selection of essays by leading experts, aiming at scientist and student alike who are interested in all aspects of modern imaging, from its application and up-scaling to its development. Indeed the philosophy of this volume is to provide student, researcher, PI, professional or provost the means to enter this applications field with confidence, and to construct the means to answer their own specific questions.
Imaging Beyond the Pinhole Camera
The world's first photograph was taken in 1826 using a pinhole camera called camera obscura. Cameras used since then are basically following the pinhole camera principle. This book looks at the development as well as the applications of alternative camera architectures.
Image-Guided IMRT
Intensity-modulated radiation therapy (IMRT), one of the most important developments in radiation oncology in the past 25 years, involves technology to deliver radiation to tumors in the right location, quantity and time. Unavoidable irradiation of surrounding normal tissues is distributed so as to preserve their function. The achievements and future directions in the field are grouped in the three sections of the book, each suitable for supporting a teaching course.
Image recognition : progress, trends and challenges
Focuses on research trends in image processing and recognition and corresponding developments. Among them, the book focuses on recent research, especially in the field of advanced human-computer interaction and intelligent computing. Given the existing interaction and recognition of the station, some novel topics are proposed, including how to establish a cognitive model in human-computer interaction and how to express and transfer human knowledge into human-machine image recognition. In an interactive implementation, how to implement user experience through image recognition during machine interaction
Image Processing : Dealing with Texture ; 2nd ed.
Updates the classic work on texture analysis theory and methods without abandoning the foundational essentials of this landmark work. Like the first, the new edition offers an analysis of texture in digital images that are essential to a diverse range of applications such as: robotics, defense, medicine and the geo-sciences. Designed to easily locate information on specific problems, the text is structured around a series of helpful questions and answers. Updated to include the most recent developments in the field, many chapters have been completely revised including: Fractals and Multifractals, Image Statistics, Texture Repair, Local Phase Features, Dual Tree Complex Wavelet Transform, Ridgelets and Curvelets and Deep Texture Features. The book takes a two-level mathematical approach: light math is covered in the main level of the book, with harder math identified in separate boxes.
Illustrated Pollen Terminology
Offers a fully illustrated compendium of glossary terms and basic principles in the field of palynology, making it an indispensable tool for all palynologists. It is a revised and extended edition of “Pollen Terminology. An illustrated handbook,” published in 2009. This second edition, titled “Illustrated Pollen Terminology” shares additional insights into new and stunning aspects of palynology. The chapter “Illustrated Pollen Terms” is the main part of this book and comprises more than 300 widely used terms illustrated with over 1,000 high-quality images. It provides a detailed survey of the manifold ornamentation and structures of pollen, and offers essential insights into their stunning beauty.
Illustrated Dental Embryology, Histology, and Anatomy
A full-color review of dental structures, Illustrated Dental Embryology, Histology, and Anatomy, 4th Edition provides a complete look at the development, cellular makeup, and morphology of the teeth and associated structures. A clear, reader-friendly writing style makes it easy to understand both basic science and clinical applications, putting the material into the context of everyday dental practice. New to this edition are updates on caries risk, safe levels of fluoride use, and prevention of periodontal disease.
Illustrated C# 2008
The unique, visual format of Illustrated C# 2008 has been specially created by author and teacher of development methods, Daniel Solis. The concise text, use of tables to clarify language features, frequent figures and diagrams, as well as focused code samples all combine to create a unique approach that will help you understand and get to work with C# fast. It was while teaching numerous seminars on various programming languages that the author realized the immense power that diagrams have in explaining programming language concepts. Most people learn quicker and retain information better when the material is presented in a clean, simple, visual format. To achieve this result in his book, Solis uses concise text and bulleted lists, tables to clarify and summarize language features, as well as his renowned and ubiquitous figures and diagrams.
Il solito Albert e la piccola Dolly : La scienza dei bambini e dei ragazzi = The usual Albert and little Dolly : The science of children and young people
After hundreds of years, science has come out of the ivory tower and entered society. Today science is not done with laboratory research alone but by involving different social actors. There are scientists, but also politicians, administrators, entrepreneurs and ordinary people, young and old. Their fears, real or perceived, can put a stop to its development. Their trust and their hopes nourish it and create a climate of expectations that are not always met. In the great narrative of science, the first actors, the scientists, are from time to time destroyers and benefactors, saints or monsters, fathers of the Golem with feet of clay or of Frankestein who turns and destroys. Not infrequently then there are many Sisyphus who continually restart their business - and it is not excluded that in the eyes of some they share with Penelope the habit of undoing at night what they do during the day.
Il Parlagioco : Uno strumento per comunicare attraverso il gioco = he Parlagioco: A tool for communicating through play
Il Parlagioco nasce da un'esperienza riabilitativa con un bambino autistico, il cui linguaggio aveva bisogno di regole comunicative. Per questo è stato creato un gioco di carte per realizzare uno scambio interattivo attraverso il desiderio di comunicare giocando. Il Parlagioco è servito anche a ridurre l'iperselettività tipica dell'autismo, orientando l'attenzione del bambino verso gli elementi esaustivi, ignorando i dettagli insignificanti allo scopo di cogliere i nessi di un insieme necessari a una comprensione globale. Da questa esperienza il Parlagioco è stato ulteriormente sviluppato per promuovere la pragmatica della comunicazione e le regole del linguaggio in ambito clinico. La sua applicazione nei disturbi specifici del linguaggio permette di ampliare il lessico, la comprensione di nuovi vocaboli e la produzione di richieste. Quando il disturbo del linguaggio è invece associato a ritardo mentale nelle malattie genetiche o neurologiche, esso consente delle facilitazioni nel proporre compiti specifici di riabilitazione linguistica. La presentazione grafica allettante e la proposta ludica fannno si' che esso sia facilmente applicabile anche in ambito scolastico e familiare.
III European Conference on computational mechanics : Solids, structures and coupled problems in engineering : Book of abstracts
Computational Mechanics in Solid, Structures and Coupled Problems in Engineering is today a mature science with applications to major industrial projects. This book contains the edited version of the Abstracts of Plenary and Keynote Lectures and Papers, and a companion CD-ROM with the full-length papers, presented at the III European Conference on Computational Mechanics: Solids, Structures and Coupled Problems in Engineering (ECCM-2006), The book reflects the state-of-art of Computation Mechanics in Solids, Structures and Coupled Problems in Engineering and it includes contributions by the world most active researchers in this field.
Identifying, Assessing, and Treating Conduct Disorder at School
Identifying, Assessing, and Treating Conduct Disorder at School bridges the gap between science and practice, providing school professionals with the information they need to coordinate efforts and enhance communication between parents, other educators, administrators, and social services providers. In addition, it offers guidance on the interventions that are likely to be most effective in meeting the unique needs of youths with conduct disorder.
Identifying, Assessing, and Treating Autism at School
As the rate of autism diagnosis continues to escalate, awareness and recognition of this developmental brain disorder - as well as a demand for services - are also mushrooming. School districts, already struggling under the weight of withering budgets and increasing enrollments, are now scrambling to strike a balance between the types of services and treatments parents want for their children and what the school system can afford to provide. Consequently, a broad cross-section of professionals and parents are searching for the means and methods by which to identify and address the wide-ranging.
Ibuprofen : Discovery, development and therapeutics
Ibuprofen has become one of the foremost pain-relieving medications world-wide with its proven safety and efficacy in a wide variety of painful and inflammatory conditions. It has also been widely investigated for application in a variety of painful and non-pain inflammatory states including cancer and neurodegenerative conditions, reflecting the unique and novel properties of the drug that would never have been foreseen from knowledge of the properties when it was initially discovered.
Iberian World Empires and the Globalization of Europe 1415–1668
This book analyses Iberian expansion by using knowledge accumulated in recent years to test some of the most important theories regarding Europe’s economic development. Adopting a comparative perspective, it considers the impact of early globalization on Iberian and Western European institutions, social development and political economies. This book finds its impact decisive for institutional development, political economies, and processes of state-building in Iberia and Europe. The book engages current historiographies and revindicates the need to take the concept of composite monarchies as a point of departure in order to understand the period’s economic and social developments, analysing the institutions and societies resulting from contact with Iberian peoples in America and Asia. The outcome is a study that nuances and contests an excessively-negative yet prevalent image of the Iberian societies, explores the difficult relationship between empires and globalization and opens paths for comparisons to other imperial formations.
IAEA Atlas of Cardiac PET/CT : A Case-Study Approach
This book presents a wide portfolio of examples of positron emission tomography coupled with computer tomography (PET/CT) studies in various cardiac conditions in order to provide a rationale for the implementation of this technology in an array of clinical conditions. Cardiovascular diseases are a major contributor to premature morbidity and mortality worldwide. Low- and middle-income countries (LMICs) are particularly affected by cardiovascular diseases (CVDs), with more than 75% of all CVDs deaths occurring in these countries. For this reason, target 3.4 of the United Nations (UN) Sustainable Development Goals (SDGs) agenda aims at a 30% reduction in premature mortality due to non-communicable diseases (NCDs), which include CVDs, by 2030.
Hypomelanosis Vitiligo & Albinism
• In General, understanding the disease is the best way to reach a perfect treatment. • This study aims to discuss the Hypomelanosis: • Vitiligo and Albinism and understanding the pathophysiology and present a types, symptoms and diagnosis of it. • Treatment ways and it's development, Nano-Drug and role of PRP in the treatments also had been presented. • The effect of Vitiligo on family members and living with it also had been discussed. • Finally, we have searched in managements and recommendations of Vitiligo patients during COVID-19 pandemic.
