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25 Years of P53 Research
Communication, awareness and access to information: Given the complexity of the field and the fact that data pertaining to each particular aspects of p53 biology or deregulation are scattered in many different publications, it is extremely difficult to access the full scale of relevant information of any specific p53-related topic. This book may help in this task by putting into perspective both general considerations on the p53 pathway and more specific information on various aspects of p53. In the longer term, however, open access to p53 complexity will require the development of knowledge bases accessible through the web and using simple navigation tools to guide users towards the specific information they need. Several efforts are currently being developed in that direction. They need to be strenghtened and better integrated within the rapidly growing galaxy of web-based information sources on molecular and individual variations in cancer. 2. Reference functional assays and structural analysis: Given the huge diversity of cellular and animal models for wild-type or mutant p53 functions, it will be important to set up standard, universally accepted assays to measure critical p53 protein functions.
Machine learning and deep learning in medical data analytics and healthcare applications
Introduces and explores a variety of schemes designed to empower, enhance, and represent multi-institutional and multi-disciplinary machine learning (ML) and deep learning (DL) research in healthcare paradigms. Serving as a unique compendium of existing and emerging ML/DL paradigms for the healthcare sector, this book demonstrates the depth, breadth, complexity, and diversity of this multi-disciplinary area. It provides a comprehensive overview of ML/DL algorithms and explores the related use cases in enterprises such as computer-aided medical diagnostics, drug discovery and development, medical imaging, automation, robotic surgery, electronic smart records creation, outbreak prediction, medical image analysis, and radiation treatments.
Linear Genetic Programming
Linear Genetic Programming examines the evolution of imperative computer programs written as linear sequences of instructions. In contrast to functional expressions or syntax trees used in traditional Genetic Programming (GP), Linear Genetic Programming (LGP) employs a linear program structure as genetic material whose primary characteristics are exploited to achieve acceleration of both execution time and evolutionary progress.
Component-Based Software Development for Embedded Systems : An Overview of Current Research Trends
Embedded systems are ubiquitous. They appear in cell phones, microwave ovens, refrigerators, consumer electronics, cars, and jets. Some of these embedded s- tems are safety- or security-critical such as in medical equipment, nuclear plants, and X-by-wire control systems in naval, ground and aerospace transportation - hicles. With the continuing shift from hardware to software, embedded systems are increasingly dominated by embedded software. Embedded software is complex. Its engineering inherently involves a mul- disciplinary interplay with the physics of the embedding system or environment. Embedded software also comes in ever larger quantity and diversity. The next generation of premium automobiles will carry around one gigabyte of binary code. The proposed US DDX submarine is e?ectively a ?oating embedded so- ware system, comprising 30 billion lines of code written in over 100 programming languages. Embedded software is expensive. Cost estimates are quoted at around US$15– 30 per line (from commencement to shipping). In the defense realm, costs can range up to $100, while for highly critical applications, such as the Space Shuttle, the cost per line approximates $1,000. In view of the exponential increase in complexity, the projected costs of future embedded software are staggering.
Communication research into the digital society : Fundamental insights from the Amsterdam School of Communication Research
Media and communication have become ubiquitous in today’s societies andaffect all aspects of life. On an individual level, they impact how we learnabout the world, how we entertain ourselves, and how we interact withothers. On an organisational level, the interactions between media andorganisations, such as political parties, NGOs, businesses and brands, shapeorganisations’ reputation, legitimacy, trust and (financial) performance, aswell as individuals’ consumer, political, social and health behaviours. Atthe societal level, media and communication are crucial for shaping publicopinion on current issues such as climate change, sustainability, diversity,and well-being.
Artificial intelligence techniques in hydrology and water resources management
The sustainable management of water cycles is crucial in the context of climate change and global warming. It involves managing global, regional, and local water cycles, as well as urban, agricultural, and industrial water cycles, to conserve water resources and their relationships with energy, food, microclimates, biodiversity, ecosystem functioning, and anthropogenic activities. Hydrological modeling is indispensable for achieving this goal, as it is essential for water resources management and the mitigation of natural disasters. In recent decades, the application of artificial intelligence (AI) techniques in hydrology and water resources management has led to notable advances. In the face of hydro-geo-meteorological uncertainty, AI approaches have proven to be powerful tools for accurately modeling complex, nonlinear hydrological processes and effectively utilizing various digital and imaging data sources, such as ground gauges, remote sensing tools, and in situ Internet of Things (IoT) devices.
Anti-fragile ICT Systems
Introduces a novel approach to the design and operation of large ICT systems. It views the technical solutions and their stakeholders as complex adaptive systems and argues that traditional risk analyses cannot predict all future incidents with major impacts. To avoid unacceptable events, it is necessary to establish and operate anti-fragile ICT systems that limit the impact of all incidents, and which learn from small-impact incidents how to function increasingly well in changing environments. The book applies four design principles and one operational principle to achieve anti-fragility for different classes of incidents. It discusses how systems can achieve high availability, prevent malware epidemics, and detect anomalies. Analyses of Netflix’s media streaming solution, Norwegian telecom infrastructures, e-government platforms, and Numenta’s anomaly detection software show that cloud computing is essential to achieving anti-fragility for classes of events with negative impacts.
Analysis and Development of Sustainable Urban Production Systems
Manufacturing of products in urban production sites is connected to unique potentials, yet also to specific challenges. Urban factories can provide functional diversity and contribute positive impacts to a city. The concept of urban production receives rising attention in research and industry and it is recognized in its interdisciplinary nature. With a holistic approach from both the urban perspective and the factory perspective, negative impacts can be minimized, positive effects enabled and mutually beneficial, symbiotic combinations created. The presented framework and methods for the evaluation and implementation of sustainable urban production systems allow the assessment of impacts and provide the means to control and utilize the unique strengths of urban factories for cities and industry. This will allow a structured derivation of methods and measures from the concept of urban production for producing enterprises and the urban stakeholders.
Community Oral Health Practice for the Dental Hygienist
Describes the role of the public health professional in improving the oral health care of people throughout the community. It discusses key topics such as access to care, the assessment needed for program planning, social responsibility and government policy, cultural diversity, and career options in public health. Written by respected dental educator Christine French Beatty, this book helps you prepare for the National Board Dental Hygiene Examination (NBDHE) and to develop the core competencies needed in the practice setting.
Knowing the Salween River : Resource Politics of a Contested Transboundary River
Focuses on the Salween River, shared by China, Myanmar, and Thailand, that is increasingly at the heart of pressing regional development debates. The basin supports the livelihoods of over 10 million people, and within it there is great socio-economic, cultural and political diversity. The basin is witnessing intensifying dynamics of resource extraction, alongside large dam construction, conservation and development intervention, that is unfolding within a complex terrain of local, national and transnational governance. With a focus on the contested politics of water and associated resources in the Salween basin, this book offers a collection of empirical case studies that highlights local knowledge and perspectives. Given the paucity of grounded social science studies in this contested basin, this book provides conceptual insights at the intersection of resource governance, development, and politics of knowledge relevant to researchers, policy-makers and practitioners at a time when rapid change is underway.
Biodiversity and health in the face of climate change
This book identifies and discusses biodiversity’s contribution to physical, mental and spiritual health and wellbeing. Furthermore, the book identifies the implications of this relationship for nature conservation, public health, landscape architecture and urban planning – and considers the opportunities of nature-based solutions for climate change adaptation. This transdisciplinary book will attract a wide audience interested in biodiversity, ecology, resource management, public health, psychology, urban planning, and landscape architecture. The emphasis is on multiple human health benefits from biodiversity - in particular with respect to the increasing challenge of climate change.
Marketing ; 16th ed.
Expanded coverage on social responsibility and sustainability topics such as privacy, social entrepreneurship, diversity, equity, inclusion, and environmental impact. The 16e continues its real-world focus with “Marketing Matters,” “Making Responsible Decisions,” “Insights about me,” “Applying Marketing Metrics,” “Integration of the Customer Journey” and “Building your Marketing Plan” features throughout. Key marketplace changes related to the pandemic such as curbside pick-up, touchless payment, and delivery have been incorporated.
Competition in Marketing : Two Essays on the Impact of Information on Managerial Decisions and on Spatial Product Differentiation
In her first essay Vera Magin uses primary experimental data to explore the effects of information on marketing decisions, performance, and competition. In her second essay the author discusses several approaches to measure product differentiation in spatial contexts. In doing so, she refers to the measurement of diversity and also applies methods from disciplines like spatial statistics, forestry, and geography.
Applied Research in Environmental Economics
Sustainable development, climate policy, and biodiversity conservation are examples of issues on the current political agenda in many countries. These themes are also subject to economic research, and economic insights are increasingly finding their way into the design of environmental policy. Still, the reception of academic findings by policy makers as well as the timely identification of policy-relevant questions by economic researchers often seem to be problematic. This volume attempts to vitalise the exchange between policy makers and academics. It offers a snapshot of environmental economic research on a range of policy-relevant problems.
Agricultural biodiversity and biotechnology in economic development
The topics addressed in this book are of vital importance to the survival of humankind. Agricultural biodiversity, encompassing genetic diversity as well as human knowledge, is the base upon which agricultural production has been built, and protecting this resource is critical to ensuring the capacity of current and future generations to adapt to unforeseen challenges. Agricultural biodiversity underpins the productivity of all agricultural systems and is particularly important for poor and food-insecure farmers, who maintain highly diverse production systems in response to the marginal and risky production conditions they operate under. Understanding the importance of agricultural biodiversity in the livelihoods of the food insecure and enhancing its performance through the use of a variety of tools, including biotechnology, is a critically important issue in the world today
Kuwabara Payne McKenna Blumberg Architects
Kuwabara Payne McKenna Blumberg Architects, founded in 1987 in Toronto, is one of most innovative architectural offi ces in North America today. They have made a name for themselves both for their integrated design process embodying collaboration with experts, clients and future users as well as the diversity of their aesthetically refined and finely detailed designs. The work ranges from cultural institutions such as the Toronto International Film Festival and Orchestra Hall in Minneapolis to ecologically innovative concepts such as Manitoba Hydro Place in Winnipeg, developed with leading climate engineers Transsolar of Stuttgart.
Cities and Affordable Housing : Planning, Design and Policy Nexus
Provides a comparative perspective on housing and planning policies affecting the future of cities, focusing on people- and place-based outcomes using the nexus of planning, design and policy. A rich mosaic of case studies features good practices of city-led strategies for affordable housing provision, as well as individual projects capitalising on partnerships to build mixed-income housing and revitalise neighbourhoods. Twenty chapters provide unique perspectives on diversity of approaches in eight countries and 12 cities in Europe, Canada and the USA.
Mathematical Modelling for Sustainable Development
Mathematics needs Sustainable Development. When science was gradually reinvented in European medieval societies, it was legitimised as contributing to the disclosure of God’s divine creation. The conflicts that emerged became well known as a result of the clash between Galileo and the Church. Science found a new legitimacy through recognition that it was a powerful force against superstition. In the Enlightenment the argument was pushed forward by attributing Progress to the advancement of science: science could produce a better world by promoting rationality. In our modern society, science has become intimately linked to technology. Science for its own sake unfortunately rarely has positive outcomes in terms of research grant applications. Meanwhile, science and technology, and the progress they are supposed to produce, meet with wide scale scepticism. We all know of the current global problems: climate change, resource depletion, a thinning ozone layer, space debris, declining biodiversity, malnutrition, dying ecosystems, global inequity, and the risk of unprecedented nuclear wars
Mathematical Control Theory and Finance
This book highlights recent developments in mathematical control theory and its applications to finance. It presents a collection of original contributions by distinguished scholars, addressing a large spectrum of problems and techniques. Control theory provides a large set of theoretical and computational tools with applications in a wide range of fields, ranging from "pure" areas of mathematics up to applied sciences like finance. Stochastic optimal control is a well established and important tool of mathematical finance. Other branches of control theory have found comparatively less applications to financial problems, but the exchange of ideas and methods has intensified in recent years. This volume should contribute to establish bridges between these separate fields. The diversity of topics covered as well as the large array of techniques and ideas brought in to obtain the results make this volume a valuable resource for advanced students and researchers.
Maritime Archaeology and Social Relations : British Action in the Southern Hemisphere
This book goes beyond a descriptive analysis of wrecks by exploring them and their cargoes as embodiments of 18th century social relations. Maritime Archaeology and Social Relations challenges traditional maritime approaches providing a different perspective that emphasises the richness, diversity and complexity of British action.By applying the concept of praxis, British action is integrated in both land and maritime spaces. A closer look into the associated experienced landscapes enhances our understanding of how social identities were projected at local and global levels.
