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Computational biology in drug discovery and repurposing
Takes an in-depth look at the emerging and prospective field of computational biology and bioinformatics, which possesses the ability to analyze large accumulated biological data collected from sequence analysis of proteins and genes and cell population with an aim to make new predictions pertaining to drug discovery and new biology. The book explains the basic methodology associated with a bioinformatics and computational approach in drug designing. It then goes on to cover the implementation of computational programming, bioinformatics, pharmacophore modeling, biotechnological techniques, and pharmaceutical chemistry in designing drugs. The major advantage of intervention of computer language or programming is to cut down the number of steps and costs in the field of drug designing, reducing the repeating steps and saving time in screening the potent component for drug or vaccine designin
Competence and Vulnerability in Biomedical Research
In this book, the author develops a novel justificatory framework for making judgments of decisional competence to consent to biomedical research with reference to five groups of cognitively vulnerable individuals - older children and adolescents, adults with intellectual disabilities, adults with depression, adults with schizophrenia and adults with dementia, including Alzheimer’s disease.
Clinical nuclear medicine
Clinical Nuclear Medicine … focuses on the universal state of the art in both diagnostic and therapeutic radionuclide methodology. … This book is easily readable, with presentation of essential points and plentiful references, and the quality of the figures and tables is excellent. … is a useful guide to students, technologists, and practitioners in nuclear medicine and radiology, as well as to general physicians who request nuclear diagnosis or treatment. … will be a welcome contribution to the bookshelf of nuclear medicine or radiology clinics.
Chromosomal alterations : Methods, results and importance in human health
Cytogenetics is a very important research tool in basic and applied research. The uses of cytogenetics in human-population monitoring, in biological dosimetry in radiation accidents and in astronauts and as a predictive measure of cancer are topics discussed in this book. The book will help the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and therefore will be of interest to all who are interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields.
Care-Related Quality of Life in Old Age : Concepts, Models and Empirical Findings
Care-Related Quality of Life in Old Age explains the theory behind Care Keys, its methodology, empirical findings, and practical considerations in promoting effective, efficient elder care aimed at social and emotional well-being and including disabled and cognitively impaired patients.
Cancer Informatics in the Post Genomic Era : Toward Information-Based Medicine
Medical information science requires analytic tools. This is achieved by developing and assessing methods and systems for the acquisition, processing, and interpretation of patient data, aided by scientific discovery. Cancer Informatics in Post-Genomic Era provides both the necessary methodology and practical information tools.Key challenges include integrating research and clinical care, sharing data, and establishing partnerships within and across sectors of patient diagnosis and treatment.Addressing important clinical questions in cancer research will benefit from expanding computational biology.
Biomolecular and bioanalytical techniques : Theory, methodology and applications
Offers an introduction to, and a basic understanding of, a wide range of biophysical techniques. The text takes an interdisciplinary approach with contributions from a panel of distinguished experts. With a focus on research, the text comprehensively covers a broad selection of topics drawn from contemporary research in the fields of chemistry and biology. Each of the internationally reputed authors has contributed a single chapter on a specific technique. The chapters cover the specific technique’s background, theory, principles, technique, methodology, protocol and applications.
Biomedical EPR ; Part B : Methodology, Instrumentation, and Dynamics
Biomedical EPR – Part B focuses on applications of EPR techniques and instrumentation, with applications to dynamics. The book celebrates the 70th birthday of Prof. James S. Hyde, Medical College of Wisconsin, and his contributions to this field. Chapters are written to provide introductory material for new-comers to the field that lead into up-to-date reviews that provide perspective on the wide range of questions that can be addressed by EPR.
Bacterial secretion systems : Methods and protocols
Cover techniques used to study secretion systems. Chapters focus on identifying and localizing the different subunits, defining interactions within subunits, monitoring conformational changes, purifying and imaging of large complexes, defining the assembly pathway by fluorescence microscopy and the role of energy during assembly and/or secretion, identifying secreted effectors as well as using reporters to follow effector transport. Written in the highly
Analisi di Rasch e questionari di misura : Applicazioni in medicina e scienze sociali = Rasch analysis and measurement questionnaires: Applications in medicine and social sciences
Evaluation questionnaires are the most used tools nowadays in the field of medicine and the human sciences to evaluate variables such as disability, altruism or pain. However, clinicians are often unfamiliar with these tools. What do they really measure? How are the results to be interpreted? This book tries to answer these questions.
Allelopathy in Sustainable Agriculture and Forestry
This book reports on the latest advances in allelopathy through the contributions of leading scientists in the field. The book addresses the history of allelopathy, the science of allelochemicals, and the application of allelopathy in agriculture and forestry. An emphasis on both methodology and application makes Allelopathy a truly practical reference for scientists, researchers and students of plant science, agriculture, forestry, terrestrial ecology and environmental science.
Legal Programming : Designing Legally Compliant RFID and Software Agent Architectures for Retail Processes and Beyond
LEGAL PROGRAMMING: Designing Legally Compliant RFID and Software Agent Architectures for Retail Processes and Beyond provides a process-oriented discussion of the legal concerns presented by agent-based technologies, processes and programming. It offers a general outline of the potential legal difficulties that could arise in relation to them, focusing on the programming of negotiation and contracting processes in a privacy, consumer and commercial context. The authors will elucidate how it is possible to create form of legal framework and design methodology for transaction agents, applicable in any environment and not just in a specific proprietary framework, that provides the right level of compliance and trust. Key elements considered include the design and programming of legally compliant methods, the determination of rights in respect of objects and variables, and ontologies and programming frameworks for agent interactions. Examples are used to illustrate the points made and provide a practical perspective.
Component-Based Software Testing with UML
Component-based software development regards software construction in terms of conventional engineering disciplines where the assembly of systems from readily-available prefabricated parts is the norm. Because both component-based systems themselves and the stakeholders in component-based development projects are different from traditional software systems, component-based testing also needs to deviate from traditional software testing approaches. Gross first describes the specific challenges related to component-based testing like the lack of internal knowledge of a component or the usage of a component in diverse contexts. He argues that only built-in contract testing, a test organization for component-based applications founded on building test artifacts directly into components, can prevent catastrophic failures like the one that caused the now famous ARIANE 5 crash in 1996. This book is the first comprehensive treatment of the intricacies of testing component-based software systems. With its strong modeling background, it appeals to researchers and graduate students specializing in component-based software engineering. Professionals architecting and developing component-based systems will profit from the UML-based methodology and the implementation hints based on the XUnit and JUnit frameworks.
Case-Based Approximate Reasoning
Case-based reasoning (CBR) has received a great deal of attention in recent years and has established itself as a core methodology in the field of artificial intelligence. The key idea of CBR is to tackle new problems by referring to similar problems that have already been solved in the past. More precisely, CBR proceeds from individual experiences in the form of cases. The generalization beyond these experiences typically relies on a kind of regularity assumption demanding that 'similar problems have similar solutions'. Making use of different frameworks of approximate reasoning and reasoning under uncertainty, notably probabilistic and fuzzy set-based techniques, this book develops formal models of the above inference principle, which is fundamental to CBR. The case-based approximate reasoning methods thus obtained especially emphasize the heuristic nature of case-based inference and aspects of uncertainty in CBR. This way, the book contributes to a solid foundation of CBR which is grounded on formal concepts and techniques from the aforementioned fields. Besides, it establishes interesting relationships between CBR and approximate reasoning, which not only cast new light on existing methods but also enhance the development of novel approaches and hybrid systems.
Building a Data Warehouse : With Examples in SQL Server
The book is organized as follows. In the beginning of this book (chapters 1 through 6), you learn how to build a data warehouse, for example, defining the architecture, understanding the methodology, gathering the requirements, designing the data models, and creating the databases. Then in chapters 7 through 10, you learn how to populate the data warehouse, for example, extracting from source systems, loading the data stores, maintaining data quality, and utilizing the metadata. After you populate the data warehouse, in chapters 11 through 15, you explore how to present data to users using reports and multidimensional databases and how to use the data in the data warehouse for business intelligence, customer relationship management, and other purposes. Chapters 16 and 17 wrap up the book: After you have built your data warehouse, before it can be released to production, you need to test it thoroughly. After your application is in production, you need to understand how to administer data warehouse operation.
Balanced Website Design : Optimising Aesthetics, Usability and Purpose
Balanced Website Design (BWD) is a new methodology that fuses the strengths of traditional structured, stepped, and iterative approaches with a sharp focus on defining and achieving the desired characteristics of purpose, usability and aesthetics – absolutely essential requirements for any website. The book includes discussions of new perspectives on usability and aesthetics in the special context of website design. BWD is suitable for all types of websites, for individual and/or team projects, and should prove to be of significant value for even the most experienced of website designers. BWD provides guidance, structure and detailed documentation/process support for the activity of designing and implementing your next website – helping you to maximise its effectiveness and relevance.
Algebraic Methodology and Software Technology ; 12th International Conference, AMAST 2008 Urbana, IL, USA, July 28-31, 2008 Proceedings
This book constitutes the refereed proceedings of the 12th International Conference on Algebraic Methodology and Software Technology, AMAST 2008, held in Urbana, IL, USA, in July 2008.
Agent Intelligence Through Data Mining
AGENT INTELLIGENCE THROUGH DATA MINING offers a self-contained overview of a relatively young but important area of research: the intersection of agent technology and data mining. This intersection leads to considerable advancements in the area of information technologies, drawing the increasing attention of both research and industrial communities. It can take two forms: a) the more mundane use of intelligent agents for improved data mining and; b) the use of data mining for smarter, more efficient agents. The second approach is the main focus of this volume. this book presents a methodology for developing multi-agent systems, describes available open-source tools to support this process, and demonstrates the application of the methodology on three different cases. AGENT INTELLIGENCE THROUGH DATA MINING is designed for a professional audience composed of researchers and practitioners in industry.
Adaptive Learning of Polynomial Networks : Genetic Programming, Backpropagation and Bayesian Methods
This book provides theoretical and practical knowledge for develop ment of algorithms that infer linear and nonlinear models. It offers a methodology for inductive learning of polynomial neural network mod els from data. The design of such tools contributes to better statistical data modelling when addressing tasks from various areas like system identification, chaotic time-series prediction, financial forecasting and data mining. The main claim is that the model identification process involves several equally important steps: finding the model structure, estimating the model weight parameters, and tuning these weights with respect to the adopted assumptions about the underlying data distrib ution. When the learning process is organized according to these steps, performed together one after the other or separately, one may expect to discover models that generalize well.
A Platform-Centric Approach to System-on-Chip (SOC) Design
The book proposes a new methodology for realizing platform-centric design of complex systems, and presents a detailed plan for its implementation. The proposed plan allows component vendors, system integrators and product developers to collaborate effectively and efficiently to create complex products within budget and schedule constraints.
