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Le dépistage du cancer bronchique : De l'espoir à la réalité = Lung cancer screening : From hope to reality
An ambitious program has been launched in terms of research, diagnosis, prevention, and screening. Among cancers, the leading cause of cancer death is lung cancer. This disease, so closely linked to behavioral habits, both focuses and encapsulates the problem. Despite constant progress in treatment, the prognosis remains bleak, explaining the fatalistic impression left by the last decade. While significant efforts were being made in screening for other cancer sites, lung cancer remained in the shadows, with studies showing limited effectiveness in this approach. The advent of spiral CT scanning has revolutionized the field, giving rise to new hope alongside anti-smoking campaigns. Autofluorescence endoscopy, by enabling the diagnosis of pre-neoplastic lesions, completes an arsenal that finally allows us to envision an effective, combined strategy. This book brings together all the elements relating to screening and early diagnosis. The road from hope to reality is long, but we must acknowledge that, for the first time, we know it exists.
Chromosomal alterations : Methods, results and importance in human health
Cytogenetics is a very important research tool in basic and applied research. The uses of cytogenetics in human-population monitoring, in biological dosimetry in radiation accidents and in astronauts and as a predictive measure of cancer are topics discussed in this book. The book will help the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and therefore will be of interest to all who are interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields.
Chlorophylls and Bacteriochlorophylls : Biochemistry, Biophysics, Functions and Applications
This book summarizes the chemical, physical, biological and medical aspects of chlorophyll (and bacteriochlorophyll) research and development, with a focus on the tremendous progress achieved over the past 15 years. Each section has an up-to-date introductory overview which is followed by a series of concise well-focused and fully-referenced chapters written by experts in (bio)chemistry, (bio)physics, photobiology and photomedicine.
Cancer cell biology : methods and protocols
Provides detailed methods on the mechanisms of underlying cancer cell biology. Chapters guide readers through techniques for culturing cancer cell lines, xenografts, cryopreservation of tumor cells, analyzing the co-culture of breast cancer cells, protein secretion by ELISA, flow cytometry-based, multi-parametric immunofluorescence analysis, protein expression by western blot, analysis of surface protein levels, protein recycling by biotinylation assay, and proteomics analysis by liquid chromatography-mass spectrometry.
Bacterial secretion systems : Methods and protocols
Cover techniques used to study secretion systems. Chapters focus on identifying and localizing the different subunits, defining interactions within subunits, monitoring conformational changes, purifying and imaging of large complexes, defining the assembly pathway by fluorescence microscopy and the role of energy during assembly and/or secretion, identifying secreted effectors as well as using reporters to follow effector transport. Written in the highly
Bacterial regulatory RNA : Methods and protocols
Details new and updated methods used for studying prokaryotic non-coding RNAs and their protein accomplices. Chapters detail discovery of ncRNAs, characterization of their structure, functions, and their interactomes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Laser Spectroscopy : Vol.2 Experimental Techniques
Keeping abreast of the latest techniques and applications, this new edition of the standard reference and graduate text on laser spectroscopy has been completely revised and expanded. While the general concept is unchanged, the new edition features a broad array of new material, e.g. frequency doubling in external cavities, reliable cw-parametric oscillators, tunable narrow-band UV sources, more sensitive detection techniques, tunable femtosecond and sub-femtosecond lasers (X-ray region and the attosecond range), control of atomic and molecular excitations, frequency combs able to synchronize independent femtosecond lasers, coherent matter waves, and still more applications in chemical analysis, medical diagnostics, and engineering.
Biophysical Aspects of Transmembrane Signaling
Transmembrane signaling is one of the most significant cell biological events in the life and death of cells in general and lymphocytes in particular. Until recently biochemists and biophysicists were not accustomed to thinking of these processes from the side of a high number of complex biochemical events and an equally high number of physical changes at molecular and cellular levels at the same time. Both types of researchers were convinced that their findings are the most decisive, having higher importance than the findings of the other scientist population. Both casts were wrong. Life, even at cellular level, has a number of interacting physical and biochemical mechanisms, which finally build up the creation of an "excited" cell that will respond to particular signals from the outer or inner world.
Biophotonics ; Optical science and engineering for the 21st century
Biophotonics: Optical Science and Engineering in the 21st Century serves as an ideal aid to the research and development of these areas integrating light, photonics, and biological systems.Key topics include: Fluctuation Correlation Spectroscopy in Cells: Determination of Molecular Aggregation ,Using GFP and FRET Technologies for Studying Signaling Mechanisms of Apoptosis in a Single Living Cell, Study on Protein-Protein Interaction in Single Living Cells, Functional Optical Coherence Tomography: Simultaneous In Vivo Imaging of Tissue Structure and Physiology, Imaging –Photo- and Sonodynamic Diagnosis of Cancer Mediated by Chemiluminescence Probes, Biophotonic Analysis of Spontaneous Self-Organizing Oxidative Processes in Aqueous Systems, Biophoton Emission and Defense Systems in Plants
Atomic and Nuclear Analytical Methods : XRF, Mössbauer, XPS, NAA and Ion-Beam Spectroscopic Techniques
This book is a blend of analytical methods based on the phenomenon of atomic and nuclear physics. It comprises comprehensive presentations about X-ray Fluorescence (XRF), Mössbauer Spectroscopy (MS), X-ray Photoelectron Spectroscopy (XPS), Neutron- Activation Analysis (NAA), Particle Induced X-ray Emission Analysis (PIXE), Rutherford Backscattering Analysis (RBS), Elastic Recoil Detection (ERD), Nuclear Reaction Analysis (NRA), Particle Induced Gamma-ray Emission Analysis (PIGE), and Accelerator Mass Spectrometry (AMS). These techniques are commonly applied in the fields of medicine, biology, environmental studies, archaeology or geology et al. and pursued in major international research laboratories.
Applications of Synchrotron Radiation : Micro Beams in Cell Micro Biology and Medicine
This book demonstrates the applications of synchrotron radiation in certain aspects of cell microbiology, specifically non-destructive elemental analyses, chemical-state analyses and imaging (distribution) of the elements within a cell. The basics for understanding and applications of synchrotron radiation are also described to make the contents easier to be understood for a wide group of researchers in medical and biological sciences who might not be familiar with the physics of synchrotron radiation. The two main techniques that are discussed in this book are the x-ray fluorescence spectroscopy (XRF) and the x-ray fine structure analysis (XAFS).
Advanced Time-Correlated Single Photon Counting Techniques
Time-correlated single photon counting (TCSPC) is a remarkable technique for recording low-level light signals with extremely high precision and picosecond-time resolution. TCSPC has developed from an intrinsically time-consuming and one-dimensional technique into a fast, multi-dimensional technique to record light signals. So this reference and text describes how advanced TCSPC techniques work and demonstrates their application to time-resolved laser scanning microscopy, single molecule spectroscopy, photon correlation experiments, and diffuse optical tomography of biological tissue. It gives practical hints about constructing suitable optical systems, choosing and using detectors, detector safety, preamplifiers, and using the control features and optimising the operating conditions of TCSPC devices. Advanced TCSPC Techniques is an indispensable tool for everyone in research and development who is confronted with the task of recording low-intensity light signals in the picosecond and nanosecond range.
Advanced Techniques in Biophysics
Technical advancements are basic elements in our life. In biophysical studies, new applications and improvements in well-established techniques are being implemented every day. This book deals with advancements produced not only from a technical point of view, but also from new approaches that are being taken in the study of biophysical samples, such as nanotechniques or single-cell measurements. This book constitutes a privileged observatory for reviewing novel applications of biophysical techniques that can help the reader enter an area where the technology is progressing quickly and where a comprehensive explanation is not always to be found.
Advanced concepts in fluorescence sensing ; Part A : Small molecule sensing
"This volume incorporates authoritative small molecule analytical fluorescence sensing reviews specialized enough to be attractive to professional researchers, yet also appealing to the wider audience of scientists in related disciplines of fluorescence. Advanced Concepts in Fluorescence Sensing Part A: Small Molecule Sensing is an essential reference for any lab working in the analytical fluorescence sensing field. All academics, bench scientists, and industry professionals wishing to take advantage of the latest and greatest in the continuously emerging field of fluorescence sensing will find it an invaluable resource. Advanced Concepts in Fluorescence Sensing Part A: Small Molecule Sensing topics include: Probes for Anion and Cation Sensing / Fluorescent Carbon Dioxide Indicators / Fluorescent Redox-Switchable Devices / PET based Fluorescence Sensors / Oxygen Sensing / Fluorescence Sensing using Charge Transfer Probes / Fluorescence-based Nitric Oxide Detection "
