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Cancer drug resistance : methods and protocols
Discusses the latest techniques used to identify cancer drug resistance determinants at the molecular, cellular, and functional levels. Chapters in this book cover up-to-date topics including tumor-microenvironment cell co-culture methods and microfluidics systems; workflows for functional assessment of drug resistance in vitro and in vivo; quantitative techniques for identifying quiescent blood-flow circulating cells; and single-cell characterization methods, such as mass cytometry.
Bioimage Data Analysis Workflows
This book provides students and researchers in the life sciences with essential practical information on how to quantitatively analyze data images. It refrains from focusing on theory, and instead uses practical examples and step-by step protocols to familiarize readers with the most commonly used image processing and analysis platforms such as ImageJ, MatLab and Python.
Big Data and Global Trade Law
Explores the relevance of global trade law for data, big data and cross-border data flows. Contributing authors from different disciplines including law, economics and political science analyze developments at the World Trade Organization and in preferential trade venues by asking what future-oriented models for data governance are available and viable in the area of trade law and policy. The collection paints the broad picture of the interaction between digital technologies and trade regulation as well as provides in-depth analyses of critical to the data-driven economy issues, such as privacy and AI, and different countries' perspectives.
Macroscopic Transport Equations for Rarefied Gas Flows : Approximation Methods in Kinetic Theory
This book discusses classical and modern methods to derive macroscopic transport equations for rarefied gases from the Boltzmann equation, for small and moderate Knudsen numbers, i.e.as well as the new order of magnitude method, which avoids the short-comings of the classical methods, but retains their benefits.
Machine learning and its application to reacting flows: ml and combustion
These two fields, ML and turbulent combustion, have large body of work and knowledge on their own, and this book brings them together and explain the complexities and challenges involved in applying ML techniques to simulate and study reacting flows. This is important as to the world’s total primary energy supply (TPES), since more than 90% of this supply is through combustion technologies and the non-negligible effects of combustion on environment. Although alternative technologies based on renewable energies are coming up, their shares for the TPES is are less than 5% currently and one needs a complete paradigm shift to replace combustion sources. The book covers the current state of the art in these two topics and outlines the challenges involved, merits and drawbacks of using ML for turbulent combustion simulations including avenues which can be explored to overcome the challenges.
Automated machine learning : Methods, systems, challenges
This book presents the first comprehensive overview of general methods in Automated Machine Learning (AutoML), collects descriptions of existing systems based on these methods, and discusses the first series of international challenges of AutoML systems. The recent success of commercial ML applications and the rapid growth of the field has created a high demand for off-the-shelf ML methods that can be used easily and without expert knowledge. However, many of the recent machine learning successes crucially rely on human experts, who manually select appropriate ML architectures (deep learning architectures or more traditional ML workflows) and their hyperparameters. To overcome this problem, the field of AutoML targets a progressive automation of machine learning, based on principles from optimization and machine learning itself.
Algorithms on Trees and Graphs : With Python Code
Introduces graph algorithms on an intuitive basis followed by a detailed exposition using structured pseudocode, with correctness proofs as well as worst-case analyses. Centered around the fundamental issue of graph isomorphism, the content goes beyond classical graph problems of shortest paths, spanning trees, flows in networks, and matchings in bipartite graphs. Advanced algorithmic results and techniques of practical relevance are presented in a coherent and consolidated way. Numerous illustrations, examples, problems, exercises, and a comprehensive bibliography support students and professionals in using the book as a text and source of reference. Furthermore, Python code for all algorithms presented is given in an appendix. Topics and features: Algorithms are first presented on an intuitive basis, followed by a detailed exposition using structured pseudocode / Correctness proofs are given, together with a worst-case analysis of the algorithms / Full implementation of all the algorithms in Python / An extensive chapter is devoted to the algorithmic techniques used in the book / Solutions to all the problems
A Modern Course in Aeroelasticity
In this new edition, the fundamental material on classical linear aeroelasticity has been revised. Also new material has been added describing recent results on the research frontiers dealing with nonlinear aeroelasticity as well as major advances in the modelling of unsteady aerodynamic flows using the methods of computational fluid dynamics and reduced order modeling techniques.
Material Flow Management : Improving Cost Efficiency and Environmental Performance
The implementation of material flow management offers enterprises a high potential for realizing new economic competitive advantages. The eco-efficient optimization of material flows aims at reducing costs while simultaneously achieving long-term sustainability with regard to ecological and societal aspects. Knowledge of existing methods and the latest trends is a key prerequisite for successfully implementing, refining and disseminating material flow management approaches.
Managing Elevated Risk : Global Liquidity, Capital Flows, and Macroprudential Policy—An Asian Perspective
Discusses the risks and opportunities that arise in Emerging Asia given the context of a new environment in global liquidity and capital flows. It elaborates on the need to ensure financial and overall economic stability in the region through improved financial regulation and other policy measures to minimize the emergent risks. "Managing Elevated Risk: Global Liquidity, Capital Flows, and Macroprudential Policy—An Asian Perspective" also explores the range of policy options that may be deployed to address the impact of global liquidity on domestic financial and socio-economic conditions including income inequality. The book is primarily aimed at policy makers, financial market regulators and supervisory agencies to help them improve national regulatory systems and to promote harmonization of national regulations and practices in line with global standards.
Building supply chain excellence in emerging economies
How can we manage supply chains well in emerging economies, coordinate information flows with multiple partners, tackle challenges such as unexpected disruptions, diversify the risks and increase flexibilities, are the topics and issues of the book.
Asset Sales : Their Role in Restructuring and Financing Firms
Examines the corporate asset market and the mechanisms of asset sale transactions. The book then focuses on the theory of finance in asset sales (the efficiency and financing theory) and the extensive empirical literature now available. In light of recent and rapid technological and digital advances, the last section presents new perspectives on analyzing asset sales transactions. Chiefly intended as a primer for PhD students and academics, the book offers a road map of the empirical research landscape and suggests future research directions.
Approaching consumer culture : Global flows and local contexts
This collection analyzes the impact of Western consumer culture on local cultures and consumption in Southeast Europe and East Asia. Cultural, historical, economic and sociopolitical contexts are examined regarding buying behaviors, usage and customization practices and consumer activism, specifically in Bulgaria, Serbia, and Romania as cultures continue to evolve in the post-socialist era, and in China and Japan as a continuation of movements toward modernity and progress. Surprising and thought-provoking contrasts stand out as consumers balance the global with the local in terms of clothing, technology, luxury items, and food.
Ambiguities in Decision-oriented Life Cycle Inventories: The Role of Mental Models and Values
Shows for the first time how mental models and values influence this attribution in the life cycle inventory step of LCA. One of the key findings is that the different management rules for a sustainable use of materials must be taken into account for the attribution of material and energy flows to a product. Otherwise, improvement options recommended by an LCA might turn out to even worsen the environmental situation if reassessed from a meta-perspective. As a consequence of this book, the claim of unambiguitiy (‘objectivity’) of the life cycle inventory must be abandoned. A group-model building process for LCA is developed that allows one to grasp the decision makers' mental models and values in the inventory analysis on a case- and situation-specific basis. Only by this, LCA results will become relevant in a decision-making process. Two case studies on the modelling of recycling and other end-of-life options of aluminium windows and beech wood railway sleepers in LCA complement the methodological part.
Linear Programming : Foundations and Extensions
Linear Programming: Foundations and Extensions is an introduction to the field of optimization. The book emphasizes constrained optimization, beginning with a substantial treatment of linear programming, and proceeding to convex analysis, network flows, integer programming, quadratic programming, and convex optimization. The book is carefully written. Specific examples and concrete algorithms precede more abstract topics. Topics are clearly developed with a large number of numerical examples worked out in detail.
Lattice Boltzmann Modeling : An Introduction for Geoscientists and Engineers
Lattice Boltzmann models have a remarkable ability to simulate single- and multi-phase fluids and transport processes within them. A rich variety of behaviors, including higher Reynolds numbers flows, phase separation, evaporation, condensation, cavitation, buoyancy, and interactions with surfaces can readily be simulated. This book provides a basic introduction that emphasizes intuition and simplistic conceptualization of processes. It avoids the more difficult mathematics that underlies LB models. The model is viewed from a particle perspective where collisions, streaming, and particle-particle/particle-surface interactions constitute the entire conceptual framework. Beginners and those with more interest in model application than detailed mathematical foundations will find this a powerful "quick start" guide. Example simulations, exercises, and computer codes are included. Working code is provided on the Internet.
Large Eddy Simulation for Incompressible Flows : An Introduction
First concise textbook on Large-Eddy Simulation, a very important method in scientific computing and engineeringFrom the foreword to the third edition written by Charles Meneveau: ".
Lagrangian Transport in Geophysical Jets and Waves : The Dynamical Systems Approach
This book provides an accessible introduction to a new set of methods for the analysis of Lagrangian motion in geophysical flows. These methods were originally developed in the abstract mathematical setting of dynamical systems theory, through a geometric approach to differential equations. Despite the recent developments in this field and the existence of a substantial body of work on geophysical fluid problems in the dynamical systems and geophysical literature, this is the first introductory text that presents these methods in the context of geophysical fluid flow. The book is organized into seven chapters; the first introduces the geophysical context and the mathematical models of geophysical fluid flow that are explored in subsequent chapters. The second and third cover the simplest case of steady flow, develop basic mathematical concepts and definitions, and touch on some important topics from the classical theory of Hamiltonian systems. The fundamental elements and methods of Lagrangian transport analysis in time-dependent flows that are the main subject of the book are described in the fourth, fifth, and sixth chapters. The seventh chapter gives a brief survey of some of the rapidly evolving research in geophysical fluid dynamics that makes use of this new approach. Related supplementary material, including a glossary and an introduction to numerical methods, is given in the appendices.
Complex Effects in Large Eddy Simulations
This volume contains a collection of expert views on the state of the art in Large Eddy Simulation (LES) and its application to complex ?ows. Much of the material in this volume was inspired by contributions that were originally presented at the symposium on Complex E?ects in Large Eddy Simulation held in Lemesos (Limassol), Cyprus, between September 21st and 24th, 2005.
Chemical Reactor Modeling : Multiphase Reactive Flows
Chemical Reactor Modeling closes the gap between Chemical Reaction Engineering and Fluid Mechanics. It presents the fundamentals of the single-fluid and multi-fluid models for the analysis of single- and multiphase reactive flows in chemical reactors with a chemical reactor engineering rather than mathematical bias.
