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Adult stem cells : Methods and protocols
Expands on the previous edition with updated chapters covering a broader range of tissues and techniques pertaining to stem cell technologies. The chapters also cover topics such as the generation of iPSC-derived cells unique to the individual human genome addressing the possibility of more personalized clinical applications to an individual with a specific degenerative disease; and the use of nanoparticles such as 3D scaffolds and biomaterials as a means of improving stem cell viability after transplantation in the host tissue. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Adult Orthodontics
An authoritative resource on the subject of adult orthodontics, marrying together clinical guidance with a thorough evaluation of the evidence base. Sample topics discussed within the book include: Context for adult orthodontics, including patient demographics and aetiologyTreatment planning considerations, including patient case profiles, initial outcomes and longer-term expectationsInterdisciplinary and multidisciplinary approaches, including the links between adult orthodontics and periodontics, prosthetics, and temporomandibular disorders
Adrenomedullin in Cardiovascular Disease
Adrenomedullin in Cardiovascular Disease is an up-to-date review of the most relevant aspects of adrenomedullin. It encompasses a broad range of fields including biochemistry, molecular biology, physiology, pharmacology, pathophysiology of cardiovascular disease and clinical applications of adrenomedullin to cardiovascular disease.
Adrenal Glands : Diagnostic Aspects and Surgical Therapy
Surgery of the Adrenal Glands is a comprehensive medical textbook that includes everything that a surgeon, but for all purposes any physicain or medical student, may want to find on adrenal surgery in a friendly, up to date, evidence based manner. 30 of the most renowned names in the field of adrenal surgery from the US and Europe draw on their experience in exploring diagnosis, indications for surgery, choice of operation and operative techniques, and surgical outcomes for every major adrenal condition. Over 200 exquisite illustrations, ranging from intraoperative photographs, line drawings, diagnostic images, pathology slides, tables and graphs are available to make each case discussed comprehensible and easy to follow. Traditional and novel therapeutic recommendations are introduced and the latest developments in minimal-access operative techniques are discussed and reviewed. Finally, the best approaches in dealing with challenging conditions such as adrenal incidentaloma, subclinical Cushing's syndrom, Congenital Adrenal Hyperplasia, Mineralcorticoid Express Syndrome, Extraadrenal and Malignant Pheochromocytoma are discussed.
Adipose Tissue and Adipokines in Health and Disease
The aim of Adipose Tissue and Adipokines in Health and Disease is to provide comprehensive information regarding adipose tissue, its physiological functions and its role in disease. This volume contains a collection of information spanning the entire range of adipose tissue studies, from basic anatomical and physiological research to epidemiology and clinical aspects, in one place. This book is indispensable for basic researchers and clinicians interested in the fields of obesity, metabolic diseases, inflammation and immunity, and specialists in each of the pathologies associated with obesity.
Adhesion Molecules : Function and Inhibition
Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.
Addressing the Climate Crisis : Local action in theory and practice
This book brings together a collection of cutting-edge insights into how action can and is already being taken against climate change at multiple levels of our societies, amidst growing calls for transformative and inclusive climate action. In an era of increasing recognition regarding climate and ecological breakdown, this book offers hope, inspiration and analyses for multi-level climate action, spanning varied communities, places, spaces, agents and disciplines, demonstrating how the energy and dynamism of local scales are a powerful resource in turning the tide.
Adaptive Mesh Refinement - Theory and Applications; Proceedings of the Chicago Workshop on Adaptive Mesh Refinement Methods, Sept. 3-5, 2003
Advanced numerical simulations that use adaptive mesh refinement (AMR) methods have now become routine in engineering and science. Originally developed for computational fluid dynamics applications these methods have propagated to fields as diverse as astrophysics, climate modeling, combustion, biophysics and many others. The underlying physical models and equations used in these disciplines are rather different, yet algorithmic and implementation issues facing practitioners are often remarkably similar. Unfortunately, there has been little effort to review the advances and outstanding issues of adaptive mesh refinement methods across such a variety of fields. This book attempts to bridge this gap. The book presents a collection of papers by experts in the field of AMR who analyze past advances in the field and evaluate the current state of adaptive mesh refinement methods in scientific computing.
Adaptive dynamic programming for chemotherapy drug delivery
Focuses on the practical application of Adaptive Dynamic Programming (ADP) in chemotherapy drug delivery, taking into account clinical variables and real-time data. ADP's ability to adapt to changing conditions and make optimal decisions in complex and uncertain situations makes it a valuable tool in addressing pressing challenges in healthcare and other fields. As optimization technology evolves, we can expect to see even more sophisticated and powerful solutions emerge.
Adaptive and Personalized Semantic Web
Web Personalization can be defined as any set of actions that can tailor the Web experience to a particular user or set of users. To achieve effective personalization, organizations must rely on all available data, including the usage and click-stream data (reflecting user behaviour), the site content, the site structure, domain knowledge, as well as user demographics and profiles. In addition, efficient and intelligent techniques are needed to mine this data for actionable knowledge, and to effectively use the discovered knowledge to enhance the users' Web experience.
Adaptive and Integrated Water Management : Coping with Complexity and Uncertainty
Includes selected contributions on conceptual and methodological innovations and empirical insights from case studies on important themes such as multi-level governance, change management, vulnerability assessment, environmental flows, uncertainty analysis and the impacts of climate change. The book addresses a wide interdisciplinary audience of scientists and professionals from academia, industry, and involved in policy making.
Adapting the built environment for climate change : Design principles for climate emergencies
Adapting the Built Environment for Climate Change: Design Principles for Climate Emergencies analyzes several scenarios and proposes various adaptation strategies for climate emergencies (heat waves, wildfires, floods, and storms). Divided into three themes, the book offers an organized vision of a complex and multi-factor challenge. It covers climatic resilience and building refurbishment, implications for service life prediction and maintainability, and climate adaptation in the maintenance and management of buildings. Sections cover infrastructure materials, climate emergency adaptation and building adaptation to heat waves, wildfires, floods and storms.
Adapting dermal fillers in clinical practice
There have been many different brands of dermal fillers approved for use for soft tissue augmentation in the US market alone, comprising four different types of temporary fillers and one permanent type, with several other brands and types also available elsewhere in the world. Against such a potentially bewildering variety and range of choices, this new text offers a scientific and an anatomic rationale for why a particular filler should be selected as optimal for each individual location and indication and how it should best be used in treatments. International experts share their clinical knowledge and expertise to guide all levels of aesthetic practitioners toward the best results for each individual patient.
Acute Promyelocytic Leukemia : Molecular Genetics, Mouse Models and Targeted Therapy
Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy.
Acute Myelogenous Leukemia
The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. Bringing together new concepts and findings in the basic and clinical science of AML, the book emphasizes the molecular basis for new therapies that stand to have the greatest potential impact on the clinical face of these diseases. The text provides insights into selected novel strategies currently and prospectively being developed, including interruption of specific signal transduction pathways, modulation of gene expression, attempts to reinstate differentiation, and immunomodulation.
Acute Endocrinology : From Cause to Consequence
The integration of endocrinology in critical care medicine has led to new experimental and clinical data on the complex endocrine and metabolic derangements accompanying non-endocrine severe illnesses. The joining of these two disciplines has generated important novel insights with significant clinical implications. Acute Endocrinology: From Cause to Consequence compiles these new findings into an important and highly relevant new resource.
Active Processes and Otoacoustic Emissions in Hearing
Sounds that are actually produced by healthy ears allow researchers and clinicians to study hearing and cochlear function noninvasively in both animals and humans. Active Processes and Otoacoustic Emissions in Hearing presents the first serious review of the biological basis of these otoacoustic emissions. Active processes, such as those in hair cells that produce emissions, represent a burgeoning and important area of sensory research. By providing a basis for understanding how and why otoacoustic emissions testing works through a basic understanding of general hearing processes, this volume will also interest clinicians, particularly otolaryngologists and audiologists.
Actin-Binding Proteins and Disease
This volume, written by experts in the field, is the first to deal with the relationship between human disease and the actin cytoskeleton. It provides overviews of actin and selected actin-binding proteins, and then focuses on diseases that involve these proteins. Specific chapters deal with actin, cofilin, profilin, gelsolin and thymosin ¾4. Other chapters discuss the roles of multiple actin-binding proteins in cancer and metastasis, leukocyte disorders, and heart failure, and there is a chapter that describes how intracellular pathogens use the host actin cytoskeleton. This seminal volume is intended for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
Acquired Brain Injury : An Integrative Neuro-Rehabilitation Approach
Regardless of etiology, such as accident, tumor, stroke or assault, acquired brain injury presents numerous challenges for survivors, caregivers and treating professionals. Interdisciplinary and integrated evaluations, treatment, and management can mean the difference between successful recovery and unfortunate outcomes. The first book to present a comprehensive team approach to rehabilitation of ABI survivors, Acquired Brain Injury gives medical and clinical specialists a deeper understanding of not only each others' roles, but also their complementary functions.
Acid Rain - Deposition to Recovery
Acid rain is still with us. Although it is a problem that people have worked diligently to solve, there are still many problem areas throughout the world. In reality the focus of acid rain research has shifted, and this book adds new vision to the topic. It contains papers, selected from Acid Rain 2005, the 7th International Conference on Acid Deposition, that take a broad perspective of the issues, emphasizing a number of themes: - the emission, concentration and deposition of pollutants / - nitrogen and trace elements in ecosystems and their effects on forests, water and soil / - studies of material damage and recovery - critical loads / The book is aimed at scientists and researchers who are working in the area of acid rain and its effects, and on nutrient cycling. This latest research will be of value to those concerned with the mitigation of acid rain effects.
