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Immunology of Pregnancy
Reproductive Immunology is a growing area in both immunology and reproductive sciences and is helping us to better understand several complications of pregnancy. Immunology of Pregnancy is the first book to give a complete and up to date review of our knowledge related to the role of the immune system during pregnancy and the interactions between the placenta and the maternal immune system. This new title covers in detail all the different hypotheses and studies related to the immunology of implantation and provide a practical approach for the application of basic reproductive immunology research to pregnancy complications such as preeclampsia, pre-term labor and IUGR.
Immunoinformatics
Immunoinformatics is an emerging subdiscipline of bioinformatics. It utilizes mathematics, information science, computer engineering, genomics, proteomics and immunological methods to bridge immunology and informatics. Similar to bioionformatics which became a driving force in genome research, immunoinformatics enables data-driven research strategies and systems approaches that aim at understanding the networks regulating the immune system. Considering the breath of topic, Immunoinformatics was composed to provide a cross-section of research ranging from data integration, epitope predictions to systems level applications. In ten chapters experts in the field introduce and discuss research strategies for immunologists and bioinformaticians who wish to endeavour existing and new approaches to gain insight into the workings of the immune system.
Immunogenetics: Methods and Protocols
Explores techniques for working in the field of immunogenetics, i.e. fundamental and translational research into the adaptive immune receptor repertoire. Many chapters are dedicated to lab protocols, bioinformatics, and immunoinformatics analysis of high-resolution immunome analysis, exemplified by numerous applications. Additionally, the newest technological variations on these protocols are discussed, including non-amplicon, single-cell, and cell-free strategies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Immunogenetics of Autoimmune Disease
Utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches
Immobilisation of DNA on Chips II
DNA chips are gaining increasing importance in different fields ranging from medicine to analytical chemistry with applications in the latter in food safety and food quality issues as well as in environmental protection. In the medical field, DNA chips are frequently used in arrays for gene expression studies to identify diseased cells due to over- or under-expression of certain genes, to follow the response of drug treatments, or to grade cancers), for genotyping of individuals, for the detection of single nucleotide polymorphisms, point mutations, and short tandem reports, or moreover for genome and transcriptome analyses in the quasi post-genomic sequencing era. Furthermore, due to some unique properties of DNA molecules, self-assembled layers of DNA are promising candidates in the field of molecular electronics.the main focus of these two volumes is on the immobilization chemistry, considering the various aspects of the immobilization process itself, since different types of nucleic acids, support materials, surface activation chemistries and patterning tools are of key concern.
Immersive Audio Signal Processing
This text introduces graduate students and researchers to the basics of digital signal processing relevant to audio/acoustics and psychoacoustics and a variety of topics and latest results in immersive audio processing research.It Covers relevant background material adequately .Topics include immersive audio synthesis and rendering, multichannel room equalization, audio selective signal cancellation, signal processing for audio applications, surround sound processing, psychoacoustics and its incorporation in audio signal processing algorithms for solving various problems Real-world measurements depicted in the book demonstrate efficiency and power of the various solutions presented
Imaging Technologies and Transdermal Delivery in Skin Disorders
This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work.
Imaging planetario : Guida all’uso della webcam = Planetary Imaging : Guide to using the webcam
In this book, Martin Mobberley introduces the amateur to the use of webcams and digital image processing, while providing detailed tips for shooting the Sun, Moon and planets. Each object, with its specific shooting and processing techniques, is treated in a separate chapter. Through the images in this book, the amateur will be able to realize what can be done by applying a webcam to your telescope!
Imaging Pelvic Floor Disorders
This volume builds on the success of the first edition of Imaging Pelvic Floor Disorders and is aimed at those practitioners with an interest in the imaging, diagnosis and treatment of pelvic floor dysfunction. Concise textual information from acknowledged experts is complemented by high-quality diagrams and images to provide a thorough update of this rapidly evolving field. Introductory chapters fully elucidate the anatomical basis underlying disorders of the pelvic floor. State of the art imaging techniques and their application in pelvic floor dysfunction are then discussed in detail. Additions since the first edition include consideration of the effect of aging and new chapters on perineal ultrasound, functional MRI and MRI of the levator muscles.
Imaging of the Shoulder : Techniques and Applications
This volume covers the broad spectrum of imaging methods and abnormalities of relevance in the diagnostic workup of the shoulder. In the first part of the book, individual chapters are devoted to radiography, arthrography, computed tomography and CT arthrography, magnetic resonance imaging and MR arthrography, ultrasound and interventional procedures. The second part of the book then documents the application of these techniques to each of the clinical problems and diseases encountered in the shoulder. The authors are all experts in their field and include rising stars of musculoskeletal radiology.
Imaging of the hip & bony pelvis : Techniques and applications
This is a comprehensive textbook on imaging of the bony pelvis and hip joint that provides a detailed description of the techniques and imaging findings relevant to this complex anatomical region. In the first part of the book, the various techniques and procedures employed for imaging the pelvis and hip are discussed in detail. The second part of the book documents the application of these techniques to the diverse clinical problems and diseases encountered.
Imaging in Pediatric Skeletal Trauma : Techniques and Applications
This is a comprehensive textbook on imaging of pediatric skeletal trauma. It provides a detailed description of the techniques used and the imaging findings, detailing their clinical relevance. Emphasis is placed on those injuries and their radiological features which are important to the orthopedic surgeon and the successful management of the child.
Imaging in Drug Discovery and Early Clinical Trials
Efficient tools for the selection and validation of drug targets both at the preclinical and clinical level are required. Non-invasive imaging and in particular molecular imaging methods are becoming essential technologies to support drug discovery and dvelopment. Imaging provides structural, functional, metabolic and molecular readouts that are being applied to characterize a disease phenotype (diagnosis), to elucidate molecular mechanisms involved, to evaluate drug efficacy and safety, and to identify potential biomarkers of the drug's mechanism-of-action, efficacy and safety. Non-invasive imaging techniques constitute a bridge between preclinical and clinical drug evaluation. In this monograph the contribution of imaging modalities to the various stages of drug discovery and development, from early target validation to their use in clinical development programs, is described. Chapters are devoted to the description of the drug discovery process as such, to the various imaging modalities being used both preclinically and clinically, to applications of imaging during the optimization of a lead compound (addressing issues such as bioavailability and efficacy) and during the drug safety evaluation.
Imaging for Detection and Identification
The dynamic interaction between world-renowned scientists from the usually disparate communities of pure mathematicians and applied sci- tists which occurred at our seven previous ASI’s continued at this meeting. The fusion of basic ideas in mathematics, radar, sonar, biology, and ch- istry with ongoing improvements in hardware and computation offers the promise of much more sophisticated and accurate detection and identi?cation capabilities than currently exist. Coupled with the dramatic rise in the need for surveillance in innumerable aspects of our daily lives, brought about by hostile acts deemed unimaginable only a few short years ago, the time is ripe for image processing scientists in these usually diverse ?elds to join together in a concerted effort to combat the new brands of terrorism. This ASI was one important initial step.
Imaging Cellular and Molecular Biological Functions
Imaging cellular and molecular biological function’ provides a unique selection of essays by leading experts, aiming at scientist and student alike who are interested in all aspects of modern imaging, from its application and up-scaling to its development. Indeed the philosophy of this volume is to provide student, researcher, PI, professional or provost the means to enter this applications field with confidence, and to construct the means to answer their own specific questions.
Imaging Beyond the Pinhole Camera
The world's first photograph was taken in 1826 using a pinhole camera called camera obscura. Cameras used since then are basically following the pinhole camera principle. This book looks at the development as well as the applications of alternative camera architectures.
Image-Guided Interventions : Technology and Applications
Responding to the growing demand for minimally invasive procedures, Image-Guided Interventions: Technology and Applications provides a cohesive overview of the current technological advances in image-guided surgery, and their applications in the clinical environment.
Image-Based Rendering
Image-based rendering (IBR) refers to a collection of techniques and representations that allows 3D scenes and objects to be visualized in a realistic way without full 3D model reconstruction. The potential for photorealistic visualization has tremendous appeal, especially for applications such as video games, virtual travel, and E-commerce, which stand to greatly benefit from this technology.
Image Processing Using Pulse-Coupled Neural Networks
This is the first book to explain and demonstrate the tremendous ability of Pulse-Coupled Neural Networks (PCNNs) when applied to the field of image processing. PCNNs and their derivatives are biologically inspired models that are powerful tools for extracting texture, segments, and edges from images.
Image Processing in Radiology : Current Applications
Few fields have witnessed such impressive advances as image processing in radiology. The progress achieved has revolutionized diagnosis and greatly facilitated treatment selection and accurate planning of procedures. This book provides a comprehensive and up-to-date description of how to use 2D and 3D processing tools in clinical radiology.
