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Breast cancer chemosensitivity
In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem Breast Cancer Chemosensitivity moves on to focus on the latest findings of molecular mechanisms of drug resistance. These include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents. Breast Cancer Chemosensitivity provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment.
Breast cancer ; 2nd ed.
This book highlights M. D. Anderson Cancer Center’s multidisciplinary approach and reviews the entire spectrum of patient care, from prevention and screening through diagnosis and treatment through posttreatment follow-up and survivorship issues.
Breast cancer : Nuclear medicine in diagnosis and therapeutic options
This book provides general information on breast cancer management and considers all new methods of diagnosis and therapy. It focuses on nuclear medicine modalities by comparing their results with other diagnostic and therapeutic approaches.
Brain Metastases
Brain metastases are the most dreaded complication of systemic cancer, affecting approximately 170,000 people a year, a far greater incidence than primary brain tumors. Advances in modern chemotherapy have led to an improved control of system cancers, often with agents that poorly penetrate the central nervous system, resulting in an increasing incidence of brain metastases. Traditional chemotherapy has had little impact on brain metastases. The main therapeutic option is radiation therapy, and in a small number of patients - surgery. However, refinements in all of these treatments offer some positive outcomes and an increased ability to stratify patients based on certain criteria.
Botulinum toxin
Offering a step-by-step, practical approach to this commonly performed cosmetic procedure, Procedures in Cosmetic Dermatology: Botulinum Toxin, 5th Edition, enables you to master the up-to-date cosmetic techniques that produce the superior results your patients expect. It covers the science behind these neuromodulators and their usage areas in cosmetic dermatology, as well as the latest treatment options—all abundantly illustrated and evidence based. A substantial video library demonstrating injection techniques helps you successfully incorporate the latest procedures into your practice.
Bone densitometry for technologists
Radiologic technologists, nurse practitioners, physician assistants, and dedicated densitometry technologists can find new guidelines for bone density testing, new therapies for osteoporosis, and new treatment guidelines for osteoporosis, as well as new chapters on pediatric densitometry body composition assessments, and the use of skeletal morphometry in diagnosis and fracture risk prediction. The twelve appendices have also been updated to reflect the most current information available, including contacts for densitometry equipment manufacturers and organizations, guidelines for bone density testing and CPT codes, definitions of terms, and new conversion equations.
Bisphosphonates in medical practice : Actions - side effects - indications - strategies
Clinical osteology is now an independent specialty which nevertheless encompasses all branches of medicine and effects each and every one of us: Bone is Every Body´s Business: This book has been designed as an up to date manual to deal with the currently recognized indications for bisphosphonates, to outline situations and conditions for prevention of skeletal disorders, and to provide practical guidelines for treatment. It is intended for doctors who seek precise information on bisphosphonates in medical practice to enable them to treat patients with disorders of bone or better still to avoid their occurrence .
Biomarkers as targeted herbal drug discovery : A pharmacological approach to nanomedicines
Looks at the applications of biomarkers as important tools for herbal drug discovery, presenting research on phytoconstituents with advanced nanotechnological applications for healthcare benefits. Herbal drug discovery based on biomarkers is an emerging area in complementary and alternative medicine that has tremendous potential in healthcare. Conventional medications have limited efficacy and high toxicity, whereas herbal drugs are said to provide wide structural diversity that is not usually seen with conventional/synthetic drug molecules. Recognition of various herbal constituents, such as terpenoids, fatty acids, flavonoids and steroids, are well explored in the management and treatment of various disorders in this volume. These agents target various biomarkers such as nitric oxide (NO), cytokines, chemokines, adhesion molecules, NF- kβ, lipoxygenase (LOX), and arachidonic acid. Reviews the literature on inflammatory biomarkers in the treatment of diseases Looks at the development of herbal drug discovery based on biomarkers Explores emerging concepts of nanomedicines for herbal drug delivery Takes an interdisciplinary approach, with application to disciplines related to medical, pharmaceutical, biotechnological, Ayurvedic, Unani and biomedical engineering fields
Biological Basis of Geriatric Oncology
Biological Basis of Geriatric Oncology highlights research issues that are specific to geriatric oncology in the field of carcinogenesis and cancer prevention and treatment, based on the biologic interactions of cancer and age. It illustrates the benefit of the principles of geriatrics in the management of cancer in the older individual.
Bioimaging in Neurodegeneration
offers both the physician and researcher a critical survey of the best new technologies for studying neurodegeneration, as well as describing their optimal use in the diagnosis and treatment of specific neurodegenerative diseases
Benign anorectal diseases : Diagnosis with endoanal and endorectal ultrasound and new treatment options
New three-dimensional endoanal and endorectal ultrasonographic and magnetic resonance imaging techniques have given better insight into the complex anatomy of the pelvic floor and its pathologic modification in benign anorectal diseases. Obstetrical events leading to fecal incontinence in females, the relationship between fistulous tracks and the sphincter complex, and mechanisms of obstructed defecation syndrome can now be accurately evaluated, which is of fundamental importance for decision making.
Behavioral pharmacology of the cholinergic system
The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.
Behavioral interventions for prevention and control of sexually transmitted diseases
Before AIDS, the role of behavioral interventions in preventing transmission of sexually transmitted diseases was acknowledged in text books and journals but rarely promoted effectively in public health practice. Informed by a comprehensive knowledge of behavioral theory, intervention methods, and affected populations, the authors of this important book examine the central role of behavioral interventions in combating STDs. The book addresses the complexities and social contexts of human behaviors which spread STDs, the cultural barriers to STD education (ranging from conservative mores to "stay out of my bedroom" libertarianism), and the sociopolitical nuances surrounding treatment.
Basis and Treatment of Cardiac Arrhythmias
Incorporating the information related to mechanisms and treatment of cardiac arrhythmia, this book discusses genetics of arrhythmias, cell signalling molecules as potential therapeutic targets and trafficking to the membrane. These approaches and implementations of anti-arrhythmic therapy derive from many decades of research.
Barile's clinical toxicology : Principles and mechanisms ; 3rd ed.
Examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. Special emphasis is placed on signs and symptoms of diseases and pathology caused by toxins and clinical drugs. Includes the source, pharmacological and toxicological mechanism of action, detection and identification in body fluids, and treatment of exposure. An overview of protocols for managing various toxic ingestions, and the antidotes and treatments associated with their pathology, are discussed. In addition, effect of toxins on a limited number of body systems and drug-induced adverse drug reactions are also covered
Balloon Kyphoplasty
This book focuses on balloon kyphoplasty and alter- tive minimally invasive treatments for stabilization of osteoporotic vertebral fractures. The optimal treatment of a patient with osteoporotic vertebral fractures requires an interdisciplinary - proach, and therefore our book draws on the expertise of orthopedic surgeons, traumatologists and neu- surgeons, and also includes a chapter on medical treatment.
Atherosclerosis : Diet and Drugs
Divided into four parts and intends to give an overview on the pathogenesis of atherosclerosis, established treatment and prevention regimen, and of perspectives for the development of new treatment modalities.
Artrite reumatoide e spondiloentesoartriti : Diagnostica per immagini e imaging follow-up = Rheumatoid Arthritis and Spondyloentesoarthritis : Follow-up imaging and imaging
Recent technological evolutions in diagnostic imaging have allowed him to grasp the anatomical and functional alterations that characterize the onset phase of degenerative and inflammatory arthropathies. In the context of the latter, in particular, imaging is not only fundamental in the diagnosis of the early stage of arthritis but also in defining their evolution and response to modern therapeutic treatment. The evaluation of a new imaging semeiology, which makes considerable use of the use of contrast medium in relation to both power Doppler and magnetic resonance imaging, has made it possible to narrow the gap between histology and imaging in rheumatological diagnostics.
Artificial intelligence based cancer nanomedicine : Diagnostics, therapeutics and bioethics
Nanomedicine is evolving with novel drug formulations devised for multifunctional approaches towards diagnostics ad therapeutics. Nanomedicine-based drug therapy is normally explored at a fixed dose. The drug action is time-dependent, dose-dependent and patient-specific. To overcome challenges of nanomedicine testing, artificial intelligence (AI) serves as a helping tool for optimizing the drug and dose parameters. Real time conversions between these two features enables upgradation of patient data acquisition and improved design of nanomaterials. In this scenario, AI-based pattern analysis and algorithms models can greatly improve accuracy of diagnostics and therapeutics.
Aromatase Inhibitors
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.
