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Bioactive Confirmation II
Specific binding of a ligand to a receptor is a key step in a variety of biol- ical processes, such as immune reactions, enzyme cascades, or intracellular transport processes. The ligand-receptor terminology implies that the rec- tor molecule is signi?cantly larger than the ligand, and the term "bioactive conformation" usually characterizes the conformation of a ligand when it is bound to a receptor. In a more general sense, bioactive conformation applies toanymoleculeinabiologicallyrelevantboundstateregardlessofsizecons- erations. Mostofthecontributions tothisbookaddressligandsthat aremuch smaller than their receptors. X-ray crystallography and high resolution NMR spectroscopy are the two main experimental techniques used to study bioactive conformations. The- fore, the twovolumes ofthisbookcover approachesthat use either ofthetwo techniques, or a combination thereof.
Bifurcations, Instabilities, Degradation in Geomechanics
Leading international researchers and practitioners of bifurcations and instabilities in geomechanics debate the developments and applications which have occurred over the last few decades. The topics covered include modeling of bifurcation, structural failure of geomaterials and geostructures, advanced analytical, numerical and experimental techniques, and application and development of generalised continuum models etc. In addition analytical solutions, numerical methods, experimental techniques, and case histories are presented. Beside fundamental research findings, applications in geotechnical, petroleum, mining, and bulk materials engineering are emphasised.
Beyond Kyoto : A new global climate certificate system : Continuing Kyoto commitsments or a global ´Cap and Trade´ scheme for a sustainable climate policy?
This book shows how humankind can ‘prevent dangerous interference with the c- mate system’ without dangerous interference with the global economic system. In the two underlying studies on behalf of the Ministry of Environment and Transport of i the German federal state of Baden-Württemberg, the results have been elaborated through scientific evaluation of different climate protection systems and intensive developmental work on an efficient climate protection system. The results will be presented in nine chapters according to the following nine basic R&D steps: 1. Quantifying the ‘ultimate climate objective’ of the world community in order ‘to prevent dangerous interference with the climate system,’ thus achieving climate sustainability; 2. Development of a comprehensive standard system for evaluating the prospect of success for different climate protection systems; 3. Based on this scientific standard system, evaluation of the current Kyoto system and of the most important proposals for ‘incremental regime evolution’ of the Kyoto system. Unfortunately, it must be noted that these systems are incapable of achi- ing climate sustainability; 4. Evaluating three proposals for ‘structural regime change’ of the Kyoto system. Following this objective evaluation process and numeric comparison of the diff- ent proposals, 5. Description of the eight basic elements of GCCS and its in-depth ‘critical asse- ment;’ 6.
Beauty’s Appeal : Measure and Excess
Beauty fulfils human existence. As it registers in our aesthetic experience, beauty enhances nature’s enchantment around us and our inward experience lifting our soul toward moral elevation. Carried by creative imagination (Imaginatio Creatrix), beauty participates in the moulding of the forms of the intellective constitution of the mind in tandem with praxis and seeks deeper enigmas of the real in the labyrinth of the cosmos. Yet with the evolution of human development and in technological inventions, beauty, while suffusing all modalities of experience, seems to undergo transformations and expansion. Are there perduring norms and modalities of beauty or are we carried along blindly by human development? Is there a measure intrinsic to our human ontopoietic unfolding and the growth of human life that we may follow instead of the whim of fancy and excess? The present collection of art-explorations seeks the elemental ties of Human Condition. Together, the authors aim to answer the questions posed above.
Barriers and Biases in Computer-Mediated Knowledge Communication : And How They May Be Overcome
This books deals with computer-mediated cooperation and communication scenarios in teaching and learning situations, leisure activities (e.g. laypersons looking for expert information on the internet), and net-based communication at work. Such scenarios will become increasingly important. But the successful use of such computer-mediated settings is not trivial. Cooperative learning and work itself requires special skills and strategies. And the technical settings with sometimes restricted, sometimes new possibilities for communication add problems on top of the cooperation itself. What are the barriers in computer-mediated communication for cooperative learning and work? Which are the most relevant biases in computer-mediated information processing? Based on empirical research the contributors from psychology, education and computer sciences offer different perspectives on the nature and causes of such barriers.
Azaheterocycles Based on -, ß-Unsaturated Carbonyls
Devoted to heterocyclizations of aliphatic and aromatic, -unsaturated carbonyls with various binucleophiles leading to three-, five-, six and seven-membered partially hydrogenated nitrogen-containing heterocycles. During the last decade interest in these classes of organic c- pounds has been experiencing a scientific renaissance owing to their significant role in biological processes in living cells and diverse effects on physiological activities. In addition, such compounds are also more prevalent from the vi- point of ''classical'' problems of organic chemistry, among them reactivity, chemo- and regioselectivity, tautomerism, conformational analysis and features of their electronic structure. The character of these problems in the case of partially hydrogenated heterocycles differs sufficiently from that for hetero- omatized and perhydrogenated heterocyclic compounds and investigations in this field very often lead to interesting and unusual results. Extensively characterized cyclocondensations of, -unsaturated carbonyls, their synthetic equivalents and their precursors are the most widespread, facile and generally valid pathway to dihydroazaheterocycles.
Axions : Theory, Cosmology, and Experimental Searches
Axions are peculiar hypothetical particles that could both solve the CP problem of quantum chromodynamics and at the same time account for the dark matter of the universe. Based on a series of lectures by world experts in this field held at CERN (Geneva), this volume provides a pedagogical introduction to the theory, cosmology and astrophysics of these fascinating particles and gives an up-to-date account of the status and prospect of ongoing and planned experimental searches. Learners and practitioners of astroparticle physics will find in this book both a concise introduction and a current reference work to a showcase topic that connects the "inner space" of the elementary particle world with the "outer space" of the universe at large.
AVENUE21. Connected and Automated Driving : Prospects for Urban Europe
This publication examines the impact of connected and automated vehicles on the European city and the conditions that can enable this technology to make a positive contribution to urban development. The authors argue for two theses that have thus far received little attention in scientific discourse: as connected and automated vehicles will not be ready for use in all parts of the city for a long time, previously assumed effects – from traffic safety to traffic performance as well as spatial effects – will need to be re-evaluated.
Atomistic approaches in modern biology : From quantum chemistry to molecular simulations
This volume of Topics in Current Chemistry presents an overview of atomistic theoreticalmethodsapplied tomolecular biologicalsystems. Itthus repesents abottom-upview of chemistryonbiologyfroma theoreticalperspective. The chapters arearrangedsuchthat important issuesareconsidered startingfrom a quantum mechanical perspective and proceeding to a molecular mechanics and molecular dynamics descriptiono fthemotionoftheelementaryparticles involved.which are responsible for the properties and function of biomolecules. Depending on the length and time scales relevant for a given phenomenon to be investigated, tailored theoretical methods are required to account for these. If one is interested in large scale motions of molecules, a molecul- mechnanics-based description willbeappropriate.
Asymptotic Theory of Statistics and Probability
An encyclopedic treatment of classic as well as contemporary large sample theory, dealing with both statistical problems and probabilistic issues and tools. It is written in an extremely lucid style, with an emphasis on the conceptual discussion of the importance of a problem and the impact and relevance of the theorems. The book has 34 chapters over a wide range of topics, nearly 600 exercises for practice and instruction, and another 300 worked out examples. It also includes a large compendium of 300 useful inequalities on probability, linear algebra, and analysis that are collected together from numerous sources, as an invaluable reference for researchers in statistics, probability, and mathematics.
Astroparticle physics
The book describes the branch of astrophysics in which processes in the universe are investigated with experimental methods known from particle physics experiments. After a historical introduction to the basics of elementary particles, their interactions and the relevant detection techniques are described. The main body of the book concerns cosmic rays. The modern aspects of astroparticle physics are described in a chapter on cosmology. The book provides an orientation in the field of astroparticle physics that many beginners might look for. The physics issues are presented with little mathematics, and the results are illustrated by many diagrams. The reader has a chance to enter this field of astrophysics with a book that closes the gap between expert and popular level.
Astronomical image and data analysis
With information and scale as central themes, this comprehensive survey explains how to handle real problems in astronomical data analysis using a modern arsenal of powerful techniques. It treats those innovative methods of image, signal, and data processing that are proving to be both effective and widely relevant. The coverage includes chapters or appendices on: detection and filtering; image compression; multichannel, multiscale, and catalog data analytical methods; wavelets transforms, Picard iteration, and software tools. This second edition of Starck and Murtagh's highly appreciated reference again deals with topics that are at or beyond the state of the art. It presents material which is more algorithmically oriented than most alternatives and broaches new areas like ridgelet and curvelet transforms. Throughout the book various additions and updates have been made.
Astrobiology : Future perspectives
Astrobiology, a new exciting interdisciplinary research field, seeks to unravel the origin and evolution of life wherever it might exist in the Universe. The current view of the origin of life on Earth is that it is strongly connected to the origin and evolution of our planet and, indeed, of the Universe as a whole. We are fortunate to be living in an era where centuries of speculation about the two ancient and fundamental problems: the origin of life and its prevalence in the Universe are being replaced by experimental science. The subject of Astrobiology can be approached from many different perspectives. This book is focused on abiogenic organic matter from the viewpoint of astronomy and planetary science and considers its potential relevance to the origins of life on Earth and elsewhere. Guided by the review papers in this book, the concluding chapter aims to identify key questions to motivate future research and stimulate astrobiological applications of current and future research facilities and space missions. Today’s rich array of new spacecraft, telescopes and dedicated scientists promises a steady flow of discoveries and insights that will ultimately lead us to the answers we seek.
Assessment in mathematics education : Large-scale assessment and classroom assessment
Provides an overview of current research on a variety of topics related to both large-scale and classroom assessment. First, the purposes, traditions and principles of assessment are considered, with particular attention to those common to all levels of assessment and those more connected with either classroom or large-scale assessment. Assessment design based on sound assessment principles is discussed, differentiating between large-scale and classroom assessment, but also examining how the design principles overlap. The focus then shifts to classroom assessment and provides specific examples of assessment strategies, before examining the impact of large-scale assessment on curriculum, policy, instruction, and classroom assessment.
Assessing Quality in European Higher Education Institutions : Dissemination, Methods and Procedures
This book collects the evaluation and accreditation experiences gathered by higher education institutions in Finland, France, Germany, Italy, the Netherlands, Portugal, the United Kingdom and Sweden.
Assessing and Managing Earthquake Risk : Geo-scientific and Engineering Knowledge for Earthquake Risk Mitigation: developments, tools, techniques
This book points out the need of a multidisciplinary approach in the field of risk assessment and management. It provides an overview of the problems, approaches and common practices directly related to earthquake risk mitigation and, in particular, to the preparation of earthquake emergency plans. Written by a team of specialists from different disciplines, the authors worked together extensively in order to create unity and continuity in the text as a whole. Each topic is illustrated with examples of actual applications taken from the bibliography – including websites with available relevant information. Case studies and information on some relevant international projects are given.
Argumentative Indicators in Discourse : A Pragma-Dialectical Study
Argumentative Indicators: A Pragma-Dialectical Study identifies and analyses English words and expressions that are crucial for an adequate reconstruction of argumentative discourse. It provides the analyst of argumentative discussions and texts with a systematic set of instruments for giving a well-founded analysis which results in an analytic overview of the elements that are relevant for the evaluation of the argumentation. In the book a systematic connection is made between linguistic insights into the characteristics of argumentative discourse and insights from argumentation theory into the resolution of differences of opinion by means of argumentation.
Argumentation in Science Education : Perspectives from Classroom-Based Research
This book brings together the work of leading experts in argumentation in science education. It presents research combining theoretical and empirical perspectives relevant for secondary science classrooms. Since the 1990s, argumentation studies have increased at a rapid pace, from stray papers to a wealth of research exploring ever more sophisticated issues. This volume constitutes a unique collection and covers fundamental issues in argumentation such as cognitive, methodological and epistemological aspects; classroom-based research in teaching and learning of argumentation in science classrooms; and argumentation in context such as in socio-scientific and moral contexts. The book’s underlying premise is that argumentation is a significant aspect of scientific inquiry and plays an important role in teaching and learning of science.
Arguing on the Toulmin model : New essays in argument analysis and evaluation
In The Uses of Argument Stephen Toulmin proposed a new model for the layout of arguments, with six components: claim, data, warrant, qualifier, rebuttal, backing. Toulmin’s model has been appropriated, adapted and extended by researchers in the fields of speech communications, philosophy and artificial intelligence. The volume aims to bring together the best contemporary reflection in these fields on the Toulmin model and its current appropriation.
Arabic Computational Morphology : Knowledge-based and Empirical Methods
The morphology of Arabic poses special challenges to computational natural language processing systems. The exceptional degree of ambiguity in the writing system, the rich morphology, and the highly complex word formation process of roots and patterns all contribute to making computational approaches to Arabic very challenging. Indeed many computational linguists across the world have taken up this challenge over time, and many of the researchers with a track record in this research area have contributed to this book.
