Bioactive Confirmation II
- Author
- Thomas Peters
- Publication Year
- 2008
- Publisher
- Springer
- Language
- English
- Document Type
- Book
- Faculty / Subject Heading
- Chemistry and Materials Science
- Download Book Read book
Specific binding of a ligand to a receptor is a key step in a variety of biol- ical processes, such as immune reactions, enzyme cascades, or intracellular transport processes. The ligand-receptor terminology implies that the rec- tor molecule is signi?cantly larger than the ligand, and the term "bioactive conformation" usually characterizes the conformation of a ligand when it is bound to a receptor. In a more general sense, bioactive conformation applies toanymoleculeinabiologicallyrelevantboundstateregardlessofsizecons- erations. Mostofthecontributions tothisbookaddressligandsthat aremuch smaller than their receptors. X-ray crystallography and high resolution NMR spectroscopy are the two main experimental techniques used to study bioactive conformations. The- fore, the twovolumes ofthisbookcover approachesthat use either ofthetwo techniques, or a combination thereof.
Keywords: Chemistry and Materials Science / Lipid / RNA / Analytical chemistry / Biochemistry / Chemistry / Conformation / Medicinal chemistry / Organic chemistry / Self-assembly
