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Magnetic Resonance of Myelination and Myelin Disorders
The book has been extensively revised and expanded to do justice to the rapid advances in MR technology, molecular biochemistry, and genetics and the discovery of new disease entities with prominent white matter involvement. Forty chapters have been added, and the number of illustrations has risen considerably. The ability to confirm the presence of genetic alterations in a number of disorders allows more advantageous presentation of the phenotypic variation as expressed in differ.
Clinical metabolomics applications in genetic diseases
Helps readers discover the forefront of personalized medicine on clinical metabolomics and its applications in genetic diseases. This comprehensive guide offers a functional relationship map between cell components and genetic variations in various diseases, providing insights that can be applied to personalized medicine. Covers the latest developments in metabolomics for health, with practical guidance for clinical experts looking to advance their laboratory techniques and career. The metabolomics profile is a powerful tool that has revolutionized our understanding of the relationship between genetics, clinical readouts, and disease outcomes. By integrating metabolomics with genomics and clinical phenotypes, the authors have developed diagnostic and prediction models that have vastly improved patient outcomes and deepened the understanding of disease mechanisms.
25 Years of P53 Research
Communication, awareness and access to information: Given the complexity of the field and the fact that data pertaining to each particular aspects of p53 biology or deregulation are scattered in many different publications, it is extremely difficult to access the full scale of relevant information of any specific p53-related topic. This book may help in this task by putting into perspective both general considerations on the p53 pathway and more specific information on various aspects of p53. In the longer term, however, open access to p53 complexity will require the development of knowledge bases accessible through the web and using simple navigation tools to guide users towards the specific information they need. Several efforts are currently being developed in that direction. They need to be strenghtened and better integrated within the rapidly growing galaxy of web-based information sources on molecular and individual variations in cancer. 2. Reference functional assays and structural analysis: Given the huge diversity of cellular and animal models for wild-type or mutant p53 functions, it will be important to set up standard, universally accepted assays to measure critical p53 protein functions.
Machine Learning in Computer Vision
The goal of this book is to address the use of several important machine learning techniques into computer vision applications. An innovative combination of computer vision and machine learning techniques has the promise of advancing the field of computer vision, which contributes to better understanding of complex real-world applications. The effective usage of machine learning technology in real-world computer vision problems requires understanding the domain of application, abstraction of a learning problem from a given computer vision task, and the selection of appropriate representations for the learnable (input) and learned (internal) entities of the system. In this book, we address all these important aspects from a new perspective: that the key element in the current computer revolution is the use of machine learning to capture the variations in visual appearance, rather than having the designer of the model accomplish this. As a bonus, models learned from large datasets are likely to be more robust and more realistic than the brittle all-design models.
Linear Genetic Programming
Linear Genetic Programming examines the evolution of imperative computer programs written as linear sequences of instructions. In contrast to functional expressions or syntax trees used in traditional Genetic Programming (GP), Linear Genetic Programming (LGP) employs a linear program structure as genetic material whose primary characteristics are exploited to achieve acceleration of both execution time and evolutionary progress.
An Invitation to Statistics in Wasserstein Space
This book presents the key aspects of statistics in Wasserstein spaces, i.e. statistics in the space of probability measures when endowed with the geometry of optimal transportation.
Anatomical Variations in Clinical Dentistry
This excellently illustrated book aims to equip dentists, oral surgeons, and trainees with the detailed knowledge of anatomical variations in the oral region that is now required for optimal daily clinical practice.
Managing Measurement Risk in Building and Civil Engineering
Managing Measurement Risk in Building and Civil Engineering will help all those who use measurement in their work or deal with the output from the measurement process, to understand not only the ‘ins and outs’ of measuring construction work but also the relationship that measurement has with contracts, procurement, claims and post-contract control in construction. The book is for quantity surveyors, engineers and building surveyors but also for site engineers required to record and measure events on site with a view to establishing entitlement to variations, extras and contractual claims.
(R)Evolution : Organizations and the Dynamics of the Environment
Investigates the possible changes needed for industrial organizations to adapt to and remain competitive in their ever evolving environment. (R)Evolution’s main area of contribution to these very complex issues is embedded in the work’s ambitious attempt to borrow from evolutionary biology and genetics not only metaphors but also concepts and models to be adapted to the management of business organizations. The work provides us with a comprehensive vision of adaptation and variation in the business community, integrating various intellectual inputs which are based on an evolutionary vision of economic behavior. Using an extensive study of the literature in management science, and applying new models and methodologies in numerous case studies, Dekkers draws many insightful conclusions including the claim that companies often evolve slower than generally expected. Furthermore the research calls into question the effectiveness of the common practice of corporate reorganization. Embracing and merging most major contemporary developments in the theories of change into a comprehensive integrated approach, (R)Evolution is an invaluable resource for researchers specializing in the management of technological change.
Basics design and living
Residential Buildings are normally the first design projects encountered by the student in his or her training. The focus at this point is on the different conceptual possibilities that allow one to take the first step toward an actual idea. Themes: concepts and kinds of cohabitation and dwelling residential functions the creation of living space design in housing construction This book is intended to help readers to find an easy way into the complex subject of housing design, explaining fundamental concepts, the way the individual living areas can cohere, and building form variations.
Mathematical Models for Registration and Applications to Medical Imaging
Image registration is an emerging topic in image processing with many applications in medical imaging, picture and movie processing. The classical problem of image registration is concerned with ?nding an appropriate transformation between two data sets. This fuzzy de?nition of registration requires a mathematical modeling and in particular a mathematical speci?cation of the terms appropriate transformations and correlation between data sets. Depending on the type of application, typically Euler, rigid, plastic, elastic deformations are considered. The variety of similarity p measures ranges from a simpleL distance between the pixel values of the data to mutual information or entropy distances. This goal of this book is to highlight by some experts in industry and medicine relevant and emerging image registration applications and to show new emerging mathematical technologies in these areas. Currently, many registration application are solved based on variational prin- ple requiring sophisticated analysis, such as calculus of variations and the theory of partial differential equations, to name but a few. Due to the numerical compl- ity of registration problems ef?cient numerical realization are required. Concepts like multi-level solver for partial differential equations, non-convex optimization, and so on play an important role. Mathematical and numerical issues in the area of registration are discussed by some of the experts in this volume.
Mathematical Aspects of Classical and Celestial Mechanics
In this book we describe the basic principles, problems, and methods of clssical mechanics. Our main attention is devoted to the mathematical side of the subject. Although the physical background of the models considered here and the applied aspects of the phenomena studied in this book are explored to a considerably lesser extent, we have tried to set forth first and foremost the “working” apparatus of classical mechanics. This apparatus is contained mainly in Chapters 1, 3, 5, 6, and 8. Chapter 1 is devoted to the basic mathematical models of classical - chanics that are usually used for describing the motion of real mechanical systems. Special attention is given to the study of motion with constraints and to the problems of realization of constraints in dynamics. In Chapter 3 we discuss symmetry groups of mechanical systems and the corresponding conservation laws. We also expound various aspects of ord- reduction theory for systems with symmetries, which is often used in appli- tions. Chapter 4 is devoted to variational principles and methods of classical mechanics. They allow one, in particular, to obtain non-trivial results on the existence of periodic trajectories. Special attention is given to the case where the region of possible motion has a non-empty boundary. Applications of the variational methods to the theory of stability of motion are indicated.
Mathematical and Computational Models for Congestion Charging
This book presents rigorous treatments of issues related to congestion pricing. The chapters describe recent advances in areas such as mathematical and computational models for predicting traffic congestion, determining when, where, and how much to levy tolls, and analyzing the impact of tolls on transporation systems. The analyses and methodologies developed in this book provide Mechanisms that aid in determining and comparing congestion pricing schemes; Methodologies for evaluating the efficiency of existing and proposed congestion pricing schemes; A means to predict the impact of pricing on urban transporation systems; and Information essential to the financial and political success of congestion pricing programs.
Mathematica for Theoretical Physics : Classical Mechanics and Nonlinear Dynamics
Mathematica for Theoretical Physics: Classical Mechanics and Nonlinear Dynamics This second edition of Baumann's Mathematica® in Theoretical Physics shows readers how to solve physical problems and deal with their underlying theoretical concepts while using Mathematica® to derive numeric and symbolic solutions. Each example and calculation can be evaluated by the reader, and the reader can change the example calculations and adopt the given code to related or similar problems. The second edition has been completely revised and expanded into two volumes: The first volume covers classical mechanics and nonlinear dynamics. Both topics are the basis of a regular mechanics course. The second volume covers electrodynamics, quantum mechanics, relativity, and fractals and fractional calculus. New examples have been added and the representation has been reworked to provide a more interactive problem-solving presentation. This book can be used as a textbook or as a reference work, by students and researchers alike. A brief glossary of terms and functions is contained in the appendices.
Low-Power High-Level Synthesis for Nanoscale CMOS Circuits
Low-Power High-Level Synthesis for Nanoscale CMOS Circuits addresses the need for analysis, characterization, estimation, and optimization of the various forms of power dissipation in the presence of process variations of nano-CMOS technologies. The authors show very large-scale integration (VLSI) researchers and engineers how to minimize the different types of power consumption of digital circuits.
Lifting Modules : Supplements and Projectivity in Module Theory
Extending modules are generalizations of injective modules and, dually, lifting modules generalize projective supplemented modules. There is a certain asymmetry in this duality. While the theory of extending modules is well documented in monographs and text books, the purpose of our monograph is to provide a thorough study of supplements and projectivity conditions needed to investigate classes of modules related to lifting modules. The text begins with an introduction to small submodules, the radical, variations on projectivity, and hollow dimension. The subsequent chapters consider preradicals and torsion theories (in particular related to small modules), decompositions of modules (including the exchange property and local semi-T-nilpotency), supplements in modules (with specific emphasis on semilocal endomorphism rings), finishing with a long chapter on lifting modules, leading up their use in the theory of perfect rings, Harada rings, and quasi-Frobenius rings.
Leray–Schauder Type Alternatives, Complementarity Problems and Variational Inequalities
Complementarity theory, a relatively new domain in applied mathematics, has deep connections with several aspects of fundamental mathematics and also has many applications in optimization, economics and engineering. The study of variational inequalities is another domain of applied mathematics with many applications to the study of certain problems with unilateral conditions. This book is the first to discuss complementarity theory and variational inequalities using Leray–Schauder type alternatives.
Language Learning Motivation and L2 Pragmatic Competence
It presents an original study that not only enriches our knowledge of the feasibility of modern technology in collecting large-scale data related to pragmatic competence but also eminently connects L2 pragmatics more closely with mainstream second language acquisition research by focusing on the role of motivation in pragmatic learning.
Comparative Environmental Politics
The book explores five major topics: state-society relations; environmental non-governmental organizations (ENGOs); Green parties and environmental movements; institutions of government and policy-making; variations in the capacities of states to protect the environment; and national responses to global problems. It compares and contrasts rich and poor nations, large and small countries, liberal democracies and authoritarian states.
Compact Riemann Surfaces : An Introduction to Contemporary Mathematics
Although Riemann surfaces are a time-honoured field, this book is novel in its broad perspective that systematically explores the connection with other fields of mathematics. It can serve as an introduction to contemporary mathematics as a whole as it develops background material from algebraic topology, differential geometry, the calculus of variations, elliptic PDE, and algebraic geometry. It is unique among textbooks on Riemann surfaces in including an introduction to Teichmüller theory.
