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Lymphocyte Trafficking in Health and Disease
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
KRAS : Methods and protocols
Details protocols ranging from high yield production metabolically labeled KRAS for NMR studies to approaches that quantify engagement of novel molecules that bind KRAS in live cells. Chapters focus on protein production and characterization, biochemical assays, cell-based assays, KRAS-membrane interactions, targeting KRAS, and cell models.
Checkpoint Responses in Cancer Therapy
This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.
Cancer du sein avancé : 29es Journées de la Société Française de Sénologie et Pathologie Mammaire (SFSPM) Avignon, 14–16 novembre 2007 = Advanced breast cancer : 29th Days of the French Society of Senology and Breast Pathology (SFSPM) Avignon, November 14–16, 2007
These days are an opportunity to remind and persuade those less convinced that the treatment of this very particular phase of the disease is not limited to a score played by a few speakers or even by medical oncologists alone; but on the contrary, we must bring into play a truly philharmonic polyphonic ensemble, united around the patient and comprising all the players in multidisciplinary care: general practitioner, surgeon, radiotherapist, imaging specialist, gynecologist, general practitioner, psychologist, algologist, supportive care workers ...
Bio-Applications of Nanoparticles
In this edited book, we highlight the central players in the Bionanotechnology field, which are the nanostructures and biomolecules. The book starts by describing how nanostructures are synthesized and by describing the wide variety of nanostructures available for biological research and applications. Also shown are the techniques used to synthesize a wide variety of biological molecules. Next, there is a focus on the assembly of nanostructures with biological molecules, which could lead to the design of multi-functional nanosystems. In the following chapters, examples of the unique properties of nanostructures are provided along with the current applications of these nanostructures in biology and medicine. Some applications include the use of gold nanoparticles in diagnostic applications, quantum dots and silica nanoparticles for imaging, and liposomes for drug delivery. In the final chapters of the book, the toxicity of nanostructures are described. This book provides broad examples of current developments in Bionanotechnology research and would be an excellent introduction to the field.
Basic methods for the biochemical lab
Covers : quantitative methods (proteins, nucleic acids, phospholipids and carbohydrates), electrophoresis (several polyacrylamide and agarose systems, 2D-PAGE, detection methods and affinity electrophoresis), chromatographic protocols (thin-layer chromatography, GPC, IEC, affinity chromatography, HPLC), immunochemical protocols (hapten-carrier and enzyme conjugation, immunization and antibody purification, immune affinity chromatography, ELISA), centrifugation (differential and density gradient centrifugation for cells and cellular fractions), radioactivity (labeling and counting), buffers (buffer properties and compositions).
Macroscopic Transport Equations for Rarefied Gas Flows : Approximation Methods in Kinetic Theory
This book discusses classical and modern methods to derive macroscopic transport equations for rarefied gases from the Boltzmann equation, for small and moderate Knudsen numbers, i.e.as well as the new order of magnitude method, which avoids the short-comings of the classical methods, but retains their benefits.
Beginning Java Objects : From concepts to code
Learning to design objects effectively with Java is the goal of Beginning Java Objects: From Concepts to Code, Second Edition. Plenty of titles dig into the Java language in massive detail, but this one takes the unique approach of stepping back and looking at fundamental object concepts first. Mastery of Java—from understanding the basic language features to building complete industrial-strength Java applications—emerges only after a thorough tour of thinking in objects. The first edition of Beginning Java Objects has been a bestseller; this second edition includes material on the key features of J2SE 5, conceptual introductions to JDBC and J2EE, and an in-depth treatment of the critical design principles of model-data layer separation and model-view separation.
Beginning GIMP : From novice to professional
Beginning GIMP: From Novice to Professional explains how to use the open source image manipulation program, GIMP version 2.4. You'll learn how to install GIMP on Windows, Linux, and MacOS X platforms. Once you've installed the application, you'll learn about the interface and configuration options, and then jump into a quick–and–simple project to familiarize yourself even further. With four–color graphics and screenshots throughout, you'll learn how to prepare camera images for display on web pagesincluding functions like rescaling, cropping, and balancing color. The book also explains with great detail how to utilize layers, paths, and masks. You'll also learn how to draw lines and shapes, use patterns and gradients, and even create your own brushes, patterns, and gradients.
Beginning Database-Driven Application Development in Java EE : Using GlassFish™
The book explains in detail how you can organize your Java EE solution into a multilayer architecture, placing most emphasis on how to implement the persistence and database tiers of an application. Through many examples, this book shows how you can efficiently use the Java Persistence features available in the Java EE platform. Find out how you can greatly simplify the task of building the persistence layer of your Java EE application by moving some application logic into the underlying database, utilizing database views, stored programs, and triggers. The book also explains how to deploy Java EE applications to GlassFish, a free, open source Java EE 5–compliant application server.
AutoCAD 2006 VBA : A programmer's reference
This book will help you take full advantage of the Visual Basic for Applications programming environment within AutoCAD 2006. Whether you want to automate routine tasks, or create sophisticated applications or design that can be generated programmatically, this book will empower you to make AutoCAD work for you. This book is also suitable if you're a power user who wants to make use of the advanced features of AutoCAD 2006 VBA, and you need a fast reference for the full AutoCAD object model. You'll learn to run Autodesk design tasks in the embedded VBA environment. This book is loaded with source code examples, and gives you no matter your skill level the necessary tools to accomplish your AutoCAD 2006 automation tasks.
Access Control Models and Architectures For IoT and Cyber Physical Systems
Presents cybersecurity aspects of ubiquitous and growing IoT and Cyber Physical Systems. It also introduces a range of conceptual, theoretical, and foundational access control solutions. This was developed by the authors to provide an overall broader perspective and grounded approach to solve access control problems in IoT and CPS.
Abstraction, refinement and proof for probabilistic systems
Probabilistic techniques are increasingly being employed in computer programs and systems because they can increase efficiency in sequential algorithms, enable otherwise nonfunctional distribution applications, and allow quantification of risk and safety in general. This makes operational models of how they work, and logics for reasoning about them, extremely important. Abstraction, Refinement and Proof for Probabilistic Systems presents a rigorous approach to modeling and reasoning about computer systems that incorporate probability. Its foundations lie in traditional Boolean sequential-program logic—but its extension to numeric rather than merely true-or-false judgments takes it much further, into areas such as randomized algorithms, fault tolerance, and, in distributed systems, almost-certain symmetry breaking. The presentation begins with the familiar "assertional" style of program development and continues with increasing specialization: Part I treats probabilistic program logic, including many examples and case studies; Part II sets out the detailed semantics; and Part III applies the approach to advanced material on temporal calculi and two-player games.
6G Mobile Wireless Networks
Specifically, this book covers the following topics: 6G Use Cases, Requirements, Metrics and Enabling Technologies, PHY Technologies for 6G Wireless, Reconfigurable Intelligent Surface for 6G Wireless Networks, Millimeter-wave and Terahertz Spectrum for 6G Wireless, Challenges in Transport Layer for Tbit/s Communications, High-capacity Backhaul Connectivity for 6G Wireless, Cloud Native Approach for 6G Wireless Networks, Machine Type Communications in 6G, Edge Intelligence and Pervasive AI in 6G, Blockchain: Foundations and Role in 6G, Role of Open-source Platforms in 6G, and Quantum Computing and 6G Wireless.
Anatomy of the forehead, face, and neck: a dissection manual
Provides a detailed step-by-step approach to the dissection of the forehead, face, and neck, in a structural, layered approach. This dissection manual follows an atlas format, with color photographs from past professional lectures and classroom courses, as well as line drawings, enhancing descriptions. Clinical correlations are also interjected throughout to highlight the importance of individual anatomic structures. Chapters describe the preparation and storage of specimens and the dissection of the forehead and eyebrows, the midface, nose, ear, and lower face, and the neck.
Adobe Illustrator Classroom in a Book
Adobe Illustrator Classroom in a Book (2023 release) uses real-world, project-based learning to cover the basics and beyond, providing countless tips and techniques to help you become more productive with the program. For beginners and experienced users alike, you can follow the book from start to finish or choose only those lessons that interest you. Learn to create artwork, from precise drawings to stylistic paintings. Make logos, illustrations, posters, podcast covers, flyers, and more. Explore selections, shapes, and color, progress to freeform gradients and layers. Work with dynamic symbols, artistic brushes, and creative effects.
Barcelona : urban architecture and community since 2010
Highlights some of the most exciting structures built in Barcelona since 2010, bringing readers on a guided tour of surprising residential buildings, intriguing museums and extraordinary community spaces. The projects, including many additions to existing buildings, are documented with photos, floor plans and texts. Supplementary interviews introduce readers to key players in Barcelona’s architectural scene, while essays shed light on little-known aspects of the city’s urban development and transport planning.
Mathematical Modelling for Sustainable Development
Mathematics needs Sustainable Development. When science was gradually reinvented in European medieval societies, it was legitimised as contributing to the disclosure of God’s divine creation. The conflicts that emerged became well known as a result of the clash between Galileo and the Church. Science found a new legitimacy through recognition that it was a powerful force against superstition. In the Enlightenment the argument was pushed forward by attributing Progress to the advancement of science: science could produce a better world by promoting rationality. In our modern society, science has become intimately linked to technology. Science for its own sake unfortunately rarely has positive outcomes in terms of research grant applications. Meanwhile, science and technology, and the progress they are supposed to produce, meet with wide scale scepticism. We all know of the current global problems: climate change, resource depletion, a thinning ozone layer, space debris, declining biodiversity, malnutrition, dying ecosystems, global inequity, and the risk of unprecedented nuclear wars
Magnetic Heterostructures : Advances and Perspectives in Spinstructures and Spintransport
Magnetic heterostructures constitute an important field in magnetism and nanotechnology, which has developed over the past fifteen years due to important advances in epitaxial- growth techniques and lithographic processes. Magnetic heterostructures combine different physical properties which do not exist in nature. Examples are semiconductors/ferromagnets, superconductors/ferromagnets, and ferromagnets/antiferromagnets. These combinations display rich and novel physical properties different from those that exit in any single one of them. Interlayer exchange coupling, exchange bias, proximity effects, giant magneto-resistance, tunneling magneto-resistance, spininjection and spintransport are examples of new physical phenomena that rely on the combination of different materials layers
Life - As a Matter of Fat : The Emerging Science of Lipidomics
Lipids are as important for life as proteins, sugars, and genes. The present book gives a multi-disciplinary perspective on the physics of life and the particular role played by lipids and the lipid-bilayer component of cell membranes. The book is aimed at undergraduate students and young research workers within physics, chemistry, biochemistry, molecular biology, nutrition, as well as pharmaceutical and biomedical sciences. The emphasis is on the physical properties of lipid membranes seen as soft and molecularly structured interfaces. By combining and synthesizing insights obtained from a variety of recent studies, an attempt is made to clarify what membrane structure is and how it can be quantitatively described. Furthermore, it is shown how biological function mediated by membranes is controlled by lipid membrane structure and organization on length scales ranging from the size of the individual molecule, across molecular assemblies of proteins and lipid domains in the range of nanometers, to the size of whole cells. Applications of lipids in nano-technology and biomedicine are also described.
