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Mass Vaccination : Global Aspects - Progress and Obstacles
Mass immunization is the blitzkrieg of vaccination practice. It serves to rapidly protect populations, both because of the high coverage achieved and because of the herd immunity thereby induced. However, as in war, mass immunization campaigns must be conducted intelligently, with careful strategy and strong attention to logistics of supply and deployment. If conducted badly, mass immunization may fail or even be counter-productive. In this volume, some of the most successful practitioners of mass im- nization tell us about its art and science. David Heymann and Bruce Aylward of WHO begin the book with a theoretical and practical overview of mass immunization. Michael Lane, who participated in the successful effort to eradicate smallpox relates how this was done using mass vaccination and other strategies. Application of mass immunization by the US military is c- ered by John Grabenstein and Remington Nevin, who have a large experience in these matters. Karen Noakes and David Salisbury recount the striking s- cesses of mass immunization in the United Kingdom. The global control of the clostridia that produce diphtheria toxin is described by Charles Vitek. Hepa- tis A is decreasing dramatically under the impact of large-scale vaccination, as Francis André illustrates. The French experience with Hepatitis B vac- nation has been mixed, and François Denis and Daniel Levy-Bruhl explain the circumstances. In?uenza vaccination is an annual example of large-scale campaigns, the complexity of which is recounted by Benjamin Schwartz and Pascale Wortley.
Manual of intracytoplasmic sperm injection in human assisted reproduction
For around half of the couples who have trouble conceiving the cause of infertility is sperm-related. Intracytoplasmic sperm injection (ICSI) is the most common and successful treatment for male infertility. Here, the pioneers for the technique, along with authorities in the field, describe the underlying science of ICSI and other micromanipulation techniques. Practical advice for performing the techniques is covered in depth, including sperm selection, laser-assisted ICSI, and the use of piezo in ICSI. Examining the safety of ICSI in animal models as well as the impact of ICSI on the health and well-being of the children conceived through the procedure is discussed. This manual is an essential resource for clinical embryologists and laboratory personnel wishing to refine or develop techniques and improve outcomes.
Manifestations dermatologiques des maladies du système hématopoïétique et oncologie dermatologique : Dermatologie et médecine ; Vol.3 = Dermatological manifestations of diseases of the hematopoietic system anddermatological oncology : Dermatology and medicine ; Vol.3
Provides an update on all the disorders of the hematopoietic system with dermatological expression or with a cutaneous origin. Myeloproliferative and myelodysplastic syndromes, leukemias, lymphomas and cutaneous histiocytoses are thus widely described in the light of the latest clinical (classification, new entities) and therapeutic advances.
Manifestations dermatologiques des connectivites vascularites et affections systémiques apparentées : Dermatologie et médecine = Dermatological manifestations of connectivitis, vasculitis and related systemic conditions: Dermatology and medicine
Deals with all the skin and mucous membrane manifestations observed during the various so-called systemic, common or rare diseases. Each chapter covers in an exhaustive and original way the clinical, anatomopathological and therapeutic knowledge essential to the practice of dermatology and internal medicine. The work is abundantly illustrated with color clinical iconography, carefully selected for its clinical representativeness. The didactic anatomopathological figures have been enriched with explanatory diagrams facilitating their reading by the practitioner unfamiliar with dermatological histology. Produced by a group of leading authors in their field, this book is intended for dermatologists, rheumatologists and internists as well as all professionals concerned with systemic diseases and internal medicine.
Liver MRI : Correlation with other Imaging Modalities and Histopathology
In this seminal manuscript the - thor described a new imaging technique which moved the single dimension of NMR spectroscopy to the dual dimension of spatial orientation, thereby resulting in the foundation of modern magnetic re- nance (MR) imaging. Over the ensuing years, MR imaging has assumed an increasingly important role in clinical imaging. It distinguishes itself from other imaging modalities, such as ultrasound (US) or computed tomography (CT), by the unique ability to visualize specific tissue components in a non-- vasive manner. In the earlier days, diagnostic MR imaging was limited to cerebral and musculoskeletal diseases. - aging of other areas which are more prone to movement through breathing (abdominal) or pulsation motions (cardiac) became available more recently, with the introduction of faster sequences and the - velopment of more dedicated MR imaging coils.
Le dépistage du cancer du col de lutérus = Cervical cancer screening
Each year, cervical cancer kills approximately 1,000 people in France, making it the fifth leading cause of cancer death and the eighth most common cancer among women. While eradicating cervical cancer is not possible, a national screening campaign should significantly reduce its incidence. This campaign should be based, in particular, on the systematic use of Pap smears. Conventional Pap smears have already reduced the number of invasive cancers by more than 50%. Improving them requires optimizing their sensitivity. This book details the natural history of cervical cancer, its incidence and mortality, and the various aspects of screening: general principles, the French screening program, the different types of Pap smears, the role and contribution of the HPV test, the management of abnormal Pap smears, the role of colposcopy, and the follow-up of treated women. It is intended for all those involved in this screening : specialist interns and gynecologists, pathologists and biologists, public health physicians, but also general practitioners whose role in screening is privileged since they are at the forefront of medical demand.
Le dépistage du cancer bronchique : De l'espoir à la réalité = Lung cancer screening : From hope to reality
An ambitious program has been launched in terms of research, diagnosis, prevention, and screening. Among cancers, the leading cause of cancer death is lung cancer. This disease, so closely linked to behavioral habits, both focuses and encapsulates the problem. Despite constant progress in treatment, the prognosis remains bleak, explaining the fatalistic impression left by the last decade. While significant efforts were being made in screening for other cancer sites, lung cancer remained in the shadows, with studies showing limited effectiveness in this approach. The advent of spiral CT scanning has revolutionized the field, giving rise to new hope alongside anti-smoking campaigns. Autofluorescence endoscopy, by enabling the diagnosis of pre-neoplastic lesions, completes an arsenal that finally allows us to envision an effective, combined strategy. This book brings together all the elements relating to screening and early diagnosis. The road from hope to reality is long, but we must acknowledge that, for the first time, we know it exists.
Complementary and Alternative Medicine : Ethics, the Patient, and the Physician
Complementary and Alternative Medicine examines the real-life implications of patient issues and the healthcare system in which care is delivered. Because complementary and alternative medicine (CAM) are not presently considered to be a part of conventional medicine, this book discusses the effect that CAM has on patients, physicians, healthcare, and policymakers. Also included are the implications that CAM has on traditional patient-physician relationships as well as the physician's ethical obligations on this subject.
Common Chinese materia medica ; Vol.6
Describes 226 species of 32 families of medicinal plants, which are commonly used in Chinese medicine. The most important species are Aquilaria sinensis and Daphne genkwa of Thymelaeaceae; Benincasa hispida, Siraitia grosvenorii, Trichosanthes kirilowii and Trichosanthes rosthornii of Cucurbitaceae; Camellia sinensis of Theaceae; Cleistocalyx operculatus, Eugenia caryophyllata and Rhodomyrtus tomentosa of Myrtaceae; Osbeckia chinensis of Melastomataceae; Quisqualis indica and Terminalia chebula of Combretaceae; Hypericum japonicum of Hypericaceae; Microcos paniculata of Tiliaceae; Hibiscus mutabilis of Malvaceae; Croton crassifolius, C. lachnocarpus, C. tiglium, Euphorbia humifusa, E. lathyris, E. pekinensis, Phyllanthus emblica and Sauropus spatulifolius of Euphorbiaceae. In each specie, it introduces the scientific names, medicinal names, morphologies, habitats, distributions, acquisition and processing methods of these medicinal plants, the content of medicinal properties, therapeutic effects, usage and dosage of these medicinal plants, and attaches unedited color pictures and pictures of part herbal medicines of each species.
Common Chinese materia medica ; Vol.10
Records 5 species of resin, 74 species of animals, 41 species of minerals and fossils. There are resins such as Liquidambar orientalis, Commiphore myrrha, Boswellia carterii, Garcinia hanburyi; animals such as Solenognathus hardwickii, , Cervus nippon, Scolopendra subspinipes, Cryptotympana pustulata, Agkistrodon acutus, Bombyx mori, Collocalia esculenta, Moschus moschiferus, Hippocampus kelloggi, Gekko gekko; minerals and fossils such as mercury, gypsum, alum, mirabilite, cinnabar, actinolite, calomel, keel, dens draconis, lithodes, fossilia spiriferis.
Cereal genomics
Through these basic studies, it also became fairly apparent that the genomes of all cereals are related and were derived from the same lineage, million of years ago.
Cephalopods Present and Past : New Insights and Fresh Perspectives
Cephalopods are diverse, highly developed molluscs capable of swimming and jet propulsion. These animals are an important component of present-day marine ecos- tems throughout the world and comprise approximately 900 species. They also have an extraordinary fossil record, extending back to the Cambrian Period, with as many as 10,000 extinct species. Throughout their long history, they have experienced sp- tacular radiations and near-total extinctions. Because of their superb fossil record, they also serve as ideal index fossils to subdivide geologic time. This book touches on many of these themes, and it treats both fossil and present-day cephalopods.
Campbell biology; 12th ed.
Delivers a trusted, accurate, current, and pedagogically innovative experience that guides students to a true understanding of biology. The author team advances Neil Campbell's vision of meeting and equipping students at their individual skill levels by developing tools, visuals, resources, and activities that encourage participation and engage students in their learning. Known for strategically integrating text and artwork, this trusted course solution works hand in hand with Mastering Biology to reinforce key concepts, build scientific skills, and promote active learning.
CADD and informatics in drug discovery
Updates knowledge on recent advances in computational and bioinformatics tools/techniques and their practical applications in modern drug design and discovery programme. Also it encompasses fundamental principles, advanced methodologies and applications of various CADD approaches including several cutting-edge areas / presenting recent developments covering ongoing trends in the field of computer-aided drug discovery. Having contributions by a global team of experts, the book is expected to be an ideal resource for drug discovery scientists, medicinal chemists, pharmacologists, toxicologists, phytochemists, biochemists, biologists, RandD personnel, researchers, students, teachers and those working in the field of drug discovery. It will fill the knowledge gaps that exist in the current CADD approaches and methodologies/ protocols being widely used in both academic and research practices. Further, a special focus on current status of various computational drug design approaches (SBDD, LBDD, De-novo drug design, Pharmacophore-based search), bioinformatics tools and databases, computational screening and modeling of phytochemicals/natural products, artificial intelligence and machine learning, and network pharmacology and system biology would certainly guide researchers, students or readers to conduct their research in the emerging area(s) of interest. It is also expected to be highly beneficial to different stakeholders working in the pharmaceutical and biotechnology industries (RandD), the academic as well as research sectors. .
Brain tumor pathology : Current diagnostic hotspots and pitfalls
Since Bailey and Cushing (1926), all brain tumor classifications have been called histogenetic. The nosographic position that the tumor types progressively acquired in the classification systems derived from the resemblance of tumor cells to those of the cytogenesis, modified whenever new information became available from different biological research fields and especially from molecular genetics. Classically, on the basis of the rough correspondence between the mature/immature aspect of tumor cells and the benign/malignant biological behavior of the tumors, the histological labels contained a prognostic significance. The supposed origin of the tumors was thus a factor for prognosis. Later on, with the concept of anaplasia (Cox, 1933; Kernohan et al., 1949) new criteria were introduced for establishing the malignancy grades of tumors. Immunohistochemistry and later molecular genetics further refined the prognostic diagnoses, substantially increasing the opportunities to recognize the cell origin of tumors, beside revealing the pathogenetic mechanisms. Prognoses became more accurate, as required by the greater and more targeted possibilities of therapy.
Biologics in General Medicine
The idea for this book was born during the symposium on biologics organized by ZAFES (Center for Drug Research, Development and Safety at the University of Frankfurt am Main) in September 2005. Highly distinguished researchers special- ing in the field of biologics had gathered together to exchange information on this relatively new subject. Realizing that this symposium was one of the few sources of condensed information on biologics, it became obvious that we had to create a means of informing an interested wider circle of scientists and especially general c- nicians. Therefore, the editors of this book suggested to the researchers at the symposium andalsotoprominent scientists andcliniciansinvolvedinthe developmentand application of biologics as their major field of interest the idea of assembling this compendium. We received an overwhelmingly positive response – thankfully also from the publisher – most being more than willing to support this innovative project with highly relevant chapters on the latest state of the art.
Bioinformatics tools for pharmaceutical drug product development
Presents the latest information on bioinformatics tools, artificial intelligence, machine learning, computational methods, protein interactions, peptide-based drug design, and omics technologies. And include bioinformatics tools for the pharmaceutical sector and the healthcare sector. Bioinformatics brings a new era in research to accelerate drug target and vaccine design development, improving validation approaches as well as facilitating and identifying side effects and predicting drug resistance. As such, this will aid in more successful drug candidates from discovery to clinical trials to the market, and most importantly make it a more cost-effective process overall.
Asymmetric synthesis of drugs and natural products
Focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations
Applied biophysics for drug discovery
It is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns.
Applications of nanotechnology in drug discovery and delivery
Presents complete coverage of the application of nanotechnology in the discovery of new drugs and efficient target delivery of drugs. The book highlights recent advances of nanotechnology applications in the biomedical sciences, starting with chapters that provide the basics of nanotechnology, nanoparticles and nanocarriers. Part II deals with the application of nanotechnology in drug discovery, with an emphasis on enhanced delivery of pharmaceutical products, with Part III discussing toxicological and safety issues arising from the use of nanomaterials
