Applied biophysics for drug discovery
- Author
- Donald Preston Huddler, Edward Zartler
- Publication Year
- 2017
- Publisher
- Wiley
- Language
- English
- Document Type
- Book
- Faculty / Subject Heading
- Medical Science
- Download Book Read book
It is a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery. Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns.
Keywords: Drug Discovery / Thermodynamics of Biomolecular Interactions / Isothermal Titration Calorimetry / Thermodynamic Rules of Thumb / Fragment‐Based Drug Design / Enthalpic Screening / Protein–Protein Interactions / Microscale Thermophoresis in Drug Discovery / Weak Affinity Chromatography / NMR Methods /
