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Open IT-Based Innovation : Moving Towards Cooperative IT Transfer and Knowledge Diffusion ; IFIP TC8 WG 8.6 International Working Conference October 22–24, 2008, Madrid, Spain

The IFIP series publishes state-of-the-art results in the sciences and technologies of information and communication. The scope of the series includes: foundations of computer science; software theory and practice; education; computer applications in technology; communication systems; systems modeling and optimization; information systems; computers and society; computer systems technology; security and protection in information processing systems; artificial intelligence; and human-computer interaction. Proceedings and post-proceedings of refereed international conferences in computer science and interdisciplinary fields are featured.

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Open and Closed Innovation : Different Cultures for Different Strategies

Open Innovation is a phenomenon in both research and management practice. Since radical innovation or new business development often require external technologies or ways of commercialization, many firms have shifted from a Closed to an Open Innovation model. However, firms often face difficulties during the implementation. While the implementation effort usually focuses on external ideas and technologies as well as the processes to identify them, cultural challenges are neglected. Philipp Herzog develops a theoretical framework arguing that Open Innovation and Closed Innovation cultures need to be different (e.g. regarding the not-invented-here (NIH) syndrome). Based on a multi-respondent survey among 120 R&D employees from three business units of a leading chemical firm, he provides empirical evidence for many of the hypothesized differences in innovation culture.

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Open access databases and datasets for drug discovery

With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.

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Ontology Matching

Euzenat and Shvaiko’s book is devoted to ontology matching as a solution to the semantic heterogeneity problem faced by computer systems. Ontology matching aims at finding correspondences between semantically related entities of different ontologies. These correspondences may stand for equivalence as well as other relations, such as consequence, subsumption, or disjointness, between ontology entities.

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Ontology Management : Semantic Web, Semantic Web Services, and Business Applications

This volume describes relevant tasks, practical and theoretical challenges, limitations and methodologies, plus available software tools. The editors discuss integrating the conceptual and technical dimensions with a business view on using ontologies, by stressing the cost dimension of ontology engineering and by providing guidance on how up-to-date tooling helps to build, maintain, and use ontologies.  Also included is a one-stop reference on all aspects of managing ontological data and best practices on ontology management for a number of application domains.

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Ontologies-Based Databases and Information Systems ; 1st and Second VLDB Workshops, ODBIS 2005/2006 Trondheim, Norway, September 2-3, 2005 Seoul, Korea, September 11, 2006 Revised Papers

This book constitutes the refereed post-proceedings of the First and Second VLDB Workshop Ontologies-based techniques for DataBases and Information Systems, held in Trondheim, Norway, September 2005 and Seoul, Korea, September 2006.

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Ontologies-Based Business Integration

E-business integration is a vision we have developed over a long period of time. As we have worked in business practice for many years prior to and in parallel with our academic research, we have always thought of such - tegration not only as an intellectual challenge but also as a real business tool. Consequently, when we started our project on Ontologies-based R- onciliation for Business Integration (ORBI) in 2004, not only pure science but also business objectives were at the center of our research. We were very happy to be able to form a project consortium that consisted not only of renowned researchers but also of experienced business practitioners from a range of companies. Each played a specific role – as user, provider or co-developer of the application components that are based on the me- ods we have developed. So may this book find its way not only to the desks of researchers and students, but also into the offices and minds of business practitioners worldwide who are dealing with the challenge of integrating their business processes, applications and information.

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Ontologies for Urban Development

Action C21 of the European programme for Cooperation in the field of Scientific and Technical Research (COST—http://www.cost.esf.org/) is dedicated to investigating urban ontologies for an improved communication in urban civil engineering projects. The Action, known informally as "Towntology", brings together a large and heterogeneous grouping from across Europe, whose interests range from construction to urban tourism and from transport infrastructure to resource visualisation. On 6-7 November 2006, in Geneva, the Action convened a successful workshop to address emerging issues in the field. This volume presents the contributions to that workshop, in many cases revised afterwards to capture some of the outcomes of discussion.

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Ontologies for Agents : Theory and Experiences

On the other hand, ontologies have established themselves as a powerful tool to enable kno- edge sharing, and a growing number of applications have bene?ted from the use of ontologies as a means to achieve semantic interoperability among heterogeneous, distributed systems. In principle ontologies and agents are a match made in heaven, that has failed to happen. What makes a simple piece of software an agent is its ability to communicate in a ”social” environment, to make autonomous decisions, and to be proactive on behalf of its user. Communication ultimately depends on und- standing the goals, preferences, and constraints posed by the user. Autonomy is theabilitytoperformataskwithlittleornouserintervention,whileproactiveness involves acting autonomously with no need for user prompting. Communication, but also autonomy and proactiveness, depend on knowledge. The ability to c- municate depends on understanding the syntax (terms and structure) and the semantics of a language. Ontologies provide the terms used to describe a domain and the semantics associated with them. In addition, ontologies are often comp- mented by some logical rules that constrain the meaning assigned to the terms. These constraints are represented by inference rules that can be used by agents to perform the reasoning on which autonomy and proactiveness are based.

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Ontologies : A Handbook of Principles, Concepts and Applications in Information Systems

The primary objective of ONTOLOGIES: A Handbook of Principles, Concepts and Applications in Information Systems is to mobilize a collective awareness in the research community to the leading and emerging developments in ODIS, and consequently, highlight the enormous potential of ODIS research to both fundamentally transform and create innovative solutions to several problems in various domains. This book is a compilation of 32 leading-edge chapter contributions from some of the top researchers in the community working in various fundamental and applied disciplines related to ODIS. These chapters are organized into four broad themes: Foundations of ODIS, Ontological Engineering, ODIS Architectures, and ODIS Applications.

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Online Storage Systems and Transportation Problems with Applications : Optimization Models and Mathematical Solutions

This books covers the analysis and development of online algorithms involving exact optimization and heuristic techniques, and their application to solve two real life problems. The first problem is concerned with a complex technical system: a special carousel based high-speed storage system - Rotastore. It is shown that this logistic problem leads to an NP-hard Batch PreSorting problem which is not easy to solve optimally in offline situations. The second problem originates in the health sector and leads to a vehicle routing problem. Reasonable solutions for the offline case covering a whole day with a few hundred orders are constructed with a heuristic approach, as well as by simulated annealing. Optimal solutions for typical online instances are computed by an efficient column enumeration approach leading to a set partitioning problem and a set of routing-scheduling subproblems. The latter are solved exactly with a branch-and-bound method which prunes nodes if they are value-dominated by previous found solutions or if they are infeasible with respect to the capacity or temporal constraints.

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Online Marketing

Provides a clear and practice-oriented overview of the basics of online marketing. Short learning units, clear didactic modules and the accompanying learning control ensure a sustainable transfer of knowledge. It is thus aimed at all those who deal with questions of online marketing in the context of their education and training (also as a minor subject) as well as their professional practice.

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Online hate speech in the European Union : A discourse-analytic perspective

open access under a CC BY 4.0 license and reports on research carried out as part of the European Union co-funded C.O.N.T.A.C.T. project which targeted hate speech and hate crime across a number of EU member states. It showcases the bearing that discourse analytic research can have on our understanding of this phenomenon that is a growing global cause for concern.

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Online Communities and Social Computing ; 2nd International Conference, OCSC 2007, Held as Part of HCI International 2007, Beijing, China, July 22-27, 2007, Proceedings

The 12th International Conference on Human-Computer Interaction, HCI Inter- tional 2007, was held in Beijing, P.R. China, 22-27 July 2007. This volume, edited by Douglas Schuler, contains papers in the thematic area of Online Communities and Social Computing, addressing the following major topics: • Designing and Developing On-line Communities • Knowledge, Collaboration, Learning and Local On-line Communities

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Online Business Security Systems

On-Line Business Security Systems, a professional book, applies the concept of synchronization to security of global heterogeneous and hetero-standard systems by modeling the relationship of risk access spots (RAS) between advanced and developing economy's network platforms. The proposed model is more effective at securing the electronic security gap between these economies in real life applications.

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One hundred years of social protection : The changing social question in Brazil, India, China, and South Africa

As the first in-depth study of the ideational foundations of social protection policies and programmes in these four countries, the contributions demonstrate that the social question was articulated in an increasingly inclusive way.

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Ondansetron Patches

The objective of this study was to develop the matrix of transdermal drug delivery system (TDDS) of ondansetron hydrochloride (ODH), in which ondansetron is the first serotonin subtype 3 receptor antagonist indicated for the treatment and/or prophylaxis of postoperative, chemotherapy or radiotherapy induced emesis. It has been proven efficient and safe to treat such symptoms, by using in vitro drug release study and evaluate the effect of eucalyptus oil and different percentage of carbopol 940. The result of drug release decreased by increasing the percentage of carbopol 940 which achieved the purpose of the study by prolonging the release of the ondansetron . The patch provides a means to reduce the side effects associated with its oral therapy, avoidence of the first-pass metabolism and minimize inconsistency in absorption across GIT. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin.

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Oncology : An Evidence-Based Approach

Reflect the principles and current practice of oncology with contributors from the fields of medical, surgical, and radiation oncology. The textbook will incorporate an evidence-based approach, enabling the reader to make decisions on the basis of concrete data. Sections on solid tumors, hematologic malignancies and the practice of oncology address the natural history and therapy for the full spectrum of neoplastic diseases in the adult. Further sections present fundamentals of supportive care of the cancer patient, the management of oncologic emergencies and acute toxicities of therapy, as well as care of metastatic disease and the terminally-ill patient. Breaking new ground, the textbook features thoughtful, in-depth sections on cancer prevention and control, cancer surviorship, the economics of cancer care, and cancer informatics. Cancer imaging is covered with an organ system-based approach, with an additional chapter on the especially intriguing potential of PET. Furthermore, a comprehensive section on translational basic science reviews the fundamentals of molecular biology, the cell cycle and signal transduction, carcinogenesis, cancer genetics, the biology of invations and metastasis, and tumor immunology.

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On the Way to the Web : The Secret History of the Internet and its Founders

On the Way to the Web: The Secret History of the Internet and Its Founders is an absorbing chronicle of the inventive, individualistic, and often cantankerous individuals who set the Internet free. Michael A. Banks describes how the online population created a new culture and turned a new frontier into their vision of the future. This book will introduce you to the innovators who laid the foundation for the Internet and the World Wide Web, the man who invented online chat, and the people who invented the products all of us use online every day. Learn where, when, how and why the Internet came into being, and exactly what hundreds of thousands of people were doing online before the Web. See who was behind it all, and what inspired them.

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On the Uniqueness of Humankind

Europäische Akademie organized the conference "The Uniqueness of Humankind – Über die Sonderstellung des Menschen". The proceedings of the conference documented in this volume approached the theoretical and practical concept of the "Sonderstellung" against the background of present day knowledge in biosciences.

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