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Lung biology and pathophysiology
The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas exchange. In addition to lung structural cells, immune cells, including alveolar macrophages and lymphocytes play critical roles in the maintenance of lung function. This book contributes to the understanding homeostasis of lung cells in the physiological and pathological conditions critical to the development of novel therapeutics.
Les souffrances psychologiques des malades du cancer : Comment les reconnaître, comment les traiter? = The psychological suffering of cancer patients : How to recognize them, how to treat them?
This book thus proposes, reconnecting with the most clinical and frankly psychodynamic vein, to bear witness to the encounter with the reality of cancerous disease and with all the imagination that it arouses. It is also a tribute to the sick - but just as much to their loved ones and their caregivers - who then engage in these territories of the crash, the unpredictable, where everything leads to think and do.
Cardiac Mechanotransduction
For about hundred years the investigation of heart physiology has had one central guiding principle, the "law" of Frank and Starling. This connects the return of blood into the heart and the blood pressure with cardiac con traction force. The "law" does it in a way that enables the cardiovascular system to react to perturbations without major malfunctions. This book is a compilation of reviews of prominent scientists on this subject. The differ ence of the original formulation of the Frank-Starling principle is that mechanotransduction is the central theme that leads the reader through the book. Since the discovery of the "law" the scope of topics related to this subject has broadened enormously, as can be seen easily by glancing at the contents of this book. Mechanotransduction in the heart has many faces that range from molecules to humans and their diseases.
Axonal branching and recovery of coordinated muscle activity after transsection of the facial nerve in adult rats
Facial nerve surgery inevitably leads to partial pareses, abnormally associated movements and pathologically altered reflexes. The reason for this "post-paralytic syndrome" is the misdirected reinnervation of targets
Au-delà de linformation, la prévention : Par l’équipe du département de prévention Épidaure = Prevention goes beyond information : By the Epidaure Prevention department team
The prevention of the most frequent and deadly pathologies (cancers, cardiovascular diseases, accidents) essentially involves modifying risky behavior, a challenge which cannot be resolved by the simple dissemination of information. To be able to modify behavior, it is necessary to take into account, on the one hand, the individuals themselves and what leads them to change their ways of living and, on the other hand, the cultural, social, physical and economic environment. who shapes people and whose modifications are necessary for individual changes. Thus, preventive health actions are effective as long as they strengthen the ability to exercise control over individual and collective health determinants.
Antimalarial natural products
Begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type.
Algal Toxins : Nature, Occurrence, Effect and Detection
This volume contains the lectures and seminars given at the NATO Advanced Study Institute on “Sensor Systems for Biological Threads: The Algal Toxins Case”, held in Pisa, Italy in October, 2007. Algae can form heavy growths in ponds, lakes, reservoirs and sl- moving rivers throughout the world; algae can house toxins which are - ually released into water when the cells rupture or die. Hundreds of toxins have been identified so far. Detection methods, including rapid screening, have been developed to help us learning more about them, especially to find out which toxins are a real threat for people and what conditions encourage their production and accumulation. Early detection of algal toxins is an - portant aspect for public safety and natural environment, and significant efforts are underway to develop effective and reliable tools that can be used for this purpose.
Algal Toxins : Nature, Occurrence, Effect and Detection
This volume contains the lectures and seminars given at the NATO Advanced Study Institute on “Sensor Systems for Biological Threads: The Algal Toxins Case”, held in Pisa, Italy in October, 2007. Algae can form heavy growths in ponds, lakes, reservoirs and sl- moving rivers throughout the world; algae can house toxins which are - ually released into water when the cells rupture or die. Hundreds of toxins have been identified so far. Detection methods, including rapid screening, have been developed to help us learning more about them, especially to find out which toxins are a real threat for people and what conditions encourage their production and accumulation. Early detection of algal toxins is an - portant aspect for public safety and natural environment, and significant efforts are underway to develop effective and reliable tools that can be used for this purpose.
Advanced structural chemistry : Tailoring properties of inorganic materials and their applications ; 3 Vols.
Advanced Structural Chemistry clarifies the relationships between synthesis and structure, as well as structure and property, both of which are central to the creation of new materials with unique functions. In addition to subjects like the syntheses of metal-oxide clusters, metal-organic cages, and metal-organic frameworks with tailored optical, electric, ferroelectric, magnetic, adsorption, separation, and catalytic properties, the accomplished editor Rong Cao provides readers with information on a wide variety of topics
Abiotic Stress Tolerance in Plants : Toward the Improvement of Global Environment and Food
Stresses in plants caused by salt, drought, temperature, oxygen, and toxic compounds are the principal reason for reduction in crop yield. For example, high salinity in soils accounts for large decline in the yield of a wide variety of crops world over; ~1000 million ha of land is affected by soil salinity. Increased sunlight leads to the generation of reactive oxygen species, which damage the plant cells. The threat of global environment change makes it increasingly demanding to generate crop plants that could withstand such harsh conditions. Much progress has been made in the identification and characterization of the mechanisms that allow plants to tolerate abiotic stresses.
Liberal Democracy : Prosperity through Freedom
Aims to show which factors have been decisive in the rise of successful countries. Never before have so many people been so well off. However, prosperity is not a law of nature; it has to be worked for. A liberal economy stands at the forefront of this success – not as a political system, but as a set of economic rules promoting competition, which in turn leads to innovation, research and enormous productivity.
Beginning relational data modeling
Data storage design, and awareness of how data needs to be utilized within an organization, is of prime importance in ensuring that company data systems work efficiently. 'Beginning Data Modeling' leads readers you step by step through the process of developing an effective logical data model for a relational database model.
Autonomes fahren : Technische, rechtliche und gesellschaftliche aspekte = Autonomous driving : Technical, legal and social aspects
This book provides answers to a wide range of these and other questions. Experts from Germany and the USA describe central topics related to the automation of vehicles on public roads from an engineering and social science perspective. They show which "decisions" are required of an autonomous vehicle or which "ethics" must be programmed. The authors discuss expectations and concerns that characterize the individual and societal acceptance of autonomous driving. An increased safety potential through autonomous vehicles is compared to the challenges and solution approaches that play a role in securing the safety concept. In addition, they explain what possibilities for change and opportunities arise for our mobility and the reorganization of traffic, not least for freight traffic. The book thus offers an up-to-date, comprehensive and scientifically sound examination of the topic of "autonomous driving".
Artificial intelligence for multisource geospatial information
Collects 10 original research contributions published in the Special Issue entitled “Artificial Intelligence for Multisource Geospatial Information” of the ISPRS International Journal of Geo-Information. The focus is on different methods of Geospatial Artificial Intelligence (GeoAI) based on deep learning using different network architectures, clustering, soft computing, and semantic approaches. They are proposed to deal with a variety of Geospatial Big Data (GBD), such as georeferenced texts and photos in social networks, remote sensing images, cartographic maps, multidimensional geo databases, metadata in spatial data infrastructures, and for different tasks, such as for multisource georeferenced text integration and geodata flexible querying, for social sensing by applying sentiment analysis, clustering and geo analysis, for segmentation of roads, clouds and snow, and for detection of small targets and people on the streets.
Applied Parallel Computing ; State of the Art in Scientific Computing
Introduction The PARA workshops in the past were devoted to parallel computing methods in science and technology. There have been seven PARA meetings to date: PARA’94, PARA’95 and PARA’96 in Lyngby, Denmark, PARA’98 in Umea, ? Sweden, PARA 2000 in Bergen, N- way, PARA 2002 in Espoo, Finland, and PARA 2004 again in Lyngby, Denmark. The ?rst six meetings featured lectures in modern numerical algorithms, computer science, en- neering, and industrial applications, all in the context of scienti?c parallel computing. This meeting in the series, the PARA 2004 Workshop with the title “State of the Art in Scienti?c Computing.
Agent Intelligence Through Data Mining
AGENT INTELLIGENCE THROUGH DATA MINING offers a self-contained overview of a relatively young but important area of research: the intersection of agent technology and data mining. This intersection leads to considerable advancements in the area of information technologies, drawing the increasing attention of both research and industrial communities. It can take two forms: a) the more mundane use of intelligent agents for improved data mining and; b) the use of data mining for smarter, more efficient agents. The second approach is the main focus of this volume. this book presents a methodology for developing multi-agent systems, describes available open-source tools to support this process, and demonstrates the application of the methodology on three different cases. AGENT INTELLIGENCE THROUGH DATA MINING is designed for a professional audience composed of researchers and practitioners in industry.
Abstract Computing Machines : A Lambda Calculus Perspective
The book addresses ways and means of organizing computations, highlighting the relationship between algorithms and the basic mechanisms and runtime structures necessary to execute them using machines. It completely abstracts from concrete programming languages and machine architectures, taking instead the lambda calculus as the basic programming and program execution model to design various abstract machines for its correct implementation. The emphasis is on fully normalizing machines based on full-fledged beta-reductions as essential prerequisites for symbolic computations that treat functions and variables truly as first-class objects. Their weakly normalizing counterparts are shown to be functional abstract machines that sacrifice the flavors of full beta-reductions for decidedly simpler runtime structures and improved runtime efficiency. Further downgrading of the lambda calculus leads to classical imperative machines that permit side-effecting operations on the runtime environment.
Clinical insertion techniques of orthodontic temporary anchorage devices
Clinical Insertion Techniques of Orthodontic Temporary Anchorage Devices is the first comprehensive guide to the clinical insertion techniques for temporary anchorage devices (TADs) and the clinical applications of TADs according to different anatomic regions. It provides detailed clinical insertion instructions and applications, as well as guidance on choosing an optimal insertion site, detailed insertion techniques, and potential complications and their solutions.
Burnt human remains : Recovery, analysis, and interpretation
Presents an in-depth multidisciplinary approach to the detection, recovery, analysis, and identification of thermally altered remains. Bridging the gap between research and practice, this invaluable one-stop reference provides detailed coverage of analytical techniques in forensic medicine and pathology, forensic anthropology, forensic odontology, and forensic chemistry and forensic biology.
LRFD Bridge Design : Fundamentals and Applications
Examines and explains material from the 9th edition of the AASHTO LRFD Bridge Design Specifications, including deck and parapet design, load calculations, limit states and load combinations, concrete and steel I-girder design, bearing design, and more. With increased focus on earthquake resiliency, two separate chapters– one on conventional seismic design and the other on seismic isolation applied to bridges– will fully address this vital topic. The primary focus is on steel and concrete I-girder bridges, with regard to both superstructure and substructure design. / Includes several worked examples for a project bridge as well as actual bridges designed by the author / Examines seismic design concepts and design details for bridges / Presents the latest material based on the 9th edition of the LRFD Bridge Design Specifications / Covers fatigue, strength, service, and extreme event limit states / Includes numerous solved problems and exercises at the end of each chapter to illustrate the concepts presented
