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Fungi as an Alternative Source of Anticancer and Antioxidant
Fungi are an " excellent but underexplored source " for new therapeutic compounds. The limited availability of bioactive principles in plant sources could be surpassed by exploiting the chemical entities in the endophytes fungi . fungi represent a rich source of bioactive metabolite that can manipulated to produce desirable novel analogs. In addition to the active substances that can be extracted from the fungi, so that they are useful in several mechanisms. Exploring and exploiting of metabolites from endophytic in terrestrial, mangrove and marine habitats may provide an avenue for discovery of drug candidates against deadly human disease. This review focuses on the production of antioxidant and anticancer from severa fungi habitats.
Fundamentals of Artificial Intelligence
Fundamentals of Artificial Intelligence introduces the foundations of present day AI and provides coverage to recent developments in AI such as Constraint Satisfaction Problems, Adversarial Search and Game Theory, Statistical Learning Theory, Automated Planning, Intelligent Agents, Information Retrieval, Natural Language & Speech Processing, and Machine Vision. The book features a wealth of examples and illustrations, and practical approaches along with the theoretical concepts. It covers all major areas of AI in the domain of recent developments. The book is intended primarily for students who major in computer science at undergraduate and graduate level but will also be of interest as a foundation to researchers in the area of AI.
Frontiers in Anti-Infective Drug Discovery ; Vol.9
Covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The ninth volume of this series features 5 reviews that cover some aspects of clinical and pre-clinical antimicrobial drug development, with 2 chapters focusing on drugs to treat leishmaniasis and dengue fever, respectively. - Use of preclinical and early clinical data for accelerating antimicrobial drug development - Post-translational modifications: host defence mechanism, pathogenic weapon, and emerged target of anti-infective drugs - Scope and limitations on the potent antimicrobial activities of hydrazone derivatives - Current scenario of anti-leishmanial drugs and treatment - Dengue hemorrhagic fever: the potential repurposing drugs
From brows to trust : Evaluating embodied conversational agents
This book will help experts and designers in the specification and development of applications incorporating ECAs. Part 1 provides guidelines for evaluation methodologies and the identification of design and evaluation parameters. Part 2 demonstrates the importance of considering the user's perspective and interaction experience. Part 3 addresses issues in fine-tuning design parameters of ECAs and verifying the perceived effect. Finally, in Part 4 lessons learned from a number of application case studies are presented. The book is intended for both ECA researchers in academia and industry, and developers and designers interested in applying the technology.
From Animals to Animats 9 ; 9th International Conference on Simulation of Adaptive Behavior, SAB 2006, Rome, Italy, September 25-29, 2006, Proceedings
This book constitutes the refereed proceedings of the 9th International Conference on Simulation of Adaptive Behavior, SAB 2006. The 35 revised full papers and 35 revised poster papers presented are organized in topical sections on the animat approach to adaptive behaviour, perception and motor control, action selection and behavioral sequences, navigation and internal world models, learning and adaptation, evolution, collective and social behaviours, applied adaptive behavior and more.
From Animals to Animats 10 ; 10th International Conference on Simulation of Adaptive Behavior, SAB 2008, Osaka, Japan, July 7-12, 2008. Proceedings
This book constitutes the refereed proceedings of the 10th International Conference on Simulation of Adaptive Behavior, SAB 2008, held in Osaka, Japan in July 2008.The 30 revised full papers and 21 revised poster papers presented were carefully reviewed and selected from 110 submissions. The papers are organized in topical sections on the animat approach to adaptive behaviour, evolution, navigation and internal world models, perception and control, learning and adaptation, cognition, emotion and behaviour, collective and social behaviours, adaptive behaviour in language and communication, and applied adaptive behaviour.
Foundations of fuzzy logic and soft computing ; 12th International Fuzzy Systems Association World Congress, IFSA 2007, Cancun, Mexico, Junw 18-21, 2007, Proceedings
This book comprises a selection of papers from IFSA 2007 on new methods and theories that contribute to the foundations of fuzzy logic and soft computing. methodologies. Soft computing consists of several computing paradigms which can be used to produce powerful intelligent systems for solving real-world problems.
Foodborne Microbial Pathogens : Mechanisms and Pathogenesis
The author presents up-to-date information on molecular and cellular mechanism of several major foodborne microbial pathogens, including select agents for bioterrorism, virulence genes and their regulation in the host or the food environment, pathogenicity testing models, clinical symptoms, and prevention and control strategies. In order to understand the disease process, one must have certain understanding about the role of the immune system. Thus this book also covers the host parasite interaction to a level where the readers will have a better appreciation for the disease mechanism.
Foodborne bacterial pathogens : Methods and protocols
This updated volume presents a compilation of various representative techniques and approaches currently used to study bacterial foodborne pathogens. Chapters guide the reader through bacterial pathogen detection and quantification in food, molecular, phenotypic, metabolic characterization of food pathogens, and ecology of foodborne bacterial pathogens. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Focus on bacterial biofilms
Bacterial biofilms are colonies of bacterial cells embedded in their self-produced matrix composed of polysaccharides, DNA, and proteins. They protect bacterial cells against antibiotics, antibacterial agents, soaps and detergents, and shear stress. Some of the most common biofilm-associated infections in humans include urinary tract infections, infection of wounds and surgical sites, diabetic foot ulcers, dental caries (tooth decay) and gingivitis (gum inflammation), ventilator-associated infections, sinusitis, microbial keratitis, secondary infection related to Covid-19 and other viral infections, and so on. Bacterial resistance to common antibiotics (e.g., penicillin, gentamycin, erythromycin, ciprofloxacin, etc.) is driving us to a catastrophic failure of our health systems. Strategies to develop novel antibacterial agents and technology must be prioritized to combat and eradicate biofilms and their associated challenges. This book provides a comprehensive overview of biofilms with chapters on bacterial virulence factors, quorum sensing in bacteria, antimicrobial resistance in bacteria, strategies to develop new antibacterial agents, and much more.
Focal liver lesions : Detection, characterization, ablation
Few fields of medicine have witnessed such impressive progress as the diagnosis and treatment of liver tumors. Advances in imaging technology, the development of novel contrast agents, and the introduction of optimized scanning protocols have greatly facilitated the non-invasive detection and characterization of focal liver lesions. Furthermore, image-guided techniques for percutaneous tumor ablation have become an accepted alternative treatment for patients with inoperable liver cancer. This book provides a comprehensive and up-to-date overview of the role of diagnostic and interventional radiology in respect of liver tumors. The volume moves from background sections on methodology and segmental liver anatomy to the main sections on the diagnosis of benign and malignant liver lesions. An integrated approach, focused on the correlation of ultrasound, CT, and MR imaging findings, is presented. Finally, a full section describes the principles, methods, and results of percutaneous tumor ablation techniques.
Fluconazole : Pharmacology, clinical uses and health effects
Fluconazole is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. In this book, the authors present current research in the study of the pharmacology, clinical uses and health effects of fluconazole. Topics discussed include the utilization of fluconazole in adult intensive care units; the use of fluconazole in veterinary species and a description of variances from the human experience as well as findings in veterinary species which may have applicability in human medicine; common clinical uses and in vitro activity features on fluconazole; and the discovery and development of medically-important antifungal agents, particularly the azole derivatives and the development of fluconazole and its clinical applications.
Flavonoids as nutraceuticals
Flavonoids are well-known plant metabolites that have extraordinary properties that can be used for treating health issues. The pharmaceutical importance of flavonoids is due to their anti-depressant, anti-viral, anti-inflammatory, and antioxidant capacities. They are also of great importance when it comes to neuroprotection, cardiovascular disorders, and many types of cancer. Flavonoids are also easily available and produce less harmful side effects than some conventional therapeutics. This new volume examines the growing use of flavonoids for prevention and treatment of diseases and discusses their beneficial mechanisms. Chapters in the volume address diverse uses as anti-aging tools, as anti-inflammatory agents, for treating pregnancy-induced disorders, as a promising tool to combat infection of Covid-19, etc. The book explores their specific therapeutic antiviral potentials, the gene expression by flavonoids, and the role of flavonoids in agriculture.
Finite Mixture and Markov Switching Models
The prominence of finite mixture modelling is greater than ever. Many important statistical topics like clustering data, outlier treatment, or dealing with unobserved heterogeneity involve finite mixture models in some way or other. The area of potential applications goes beyond simple data analysis and extends to regression analysis and to non-linear time series analysis using Markov switching models.It is the first time that the Bayesian perspective of finite mixture modelling is systematically presented in book form. It is argued that the Bayesian approach provides much insight in this context and is easily implemented in practice. Although the main focus is on Bayesian inference, the author reviews several frequentist techniques, especially selecting the number of components of a finite mixture model, and discusses some of their shortcomings compared to the Bayesian approach. The aim of this book is to impart the finite mixture and Markov switching approach to statistical modelling to a wide-ranging community. This includes not only statisticians, but also biologists, economists, engineers, financial agents, market researcher, medical researchers or any other frequent user of statistical models. This book should help newcomers to the field to understand how finite mixture and Markov switching models are formulated, what structures they imply on the data, what they could be used for, and how they are estimated.
Financial risk management with bayesian estimation of GARCH models : Theory and applications
This book presents methodologies for the Bayesian estimation of GARCH models and their application to financial risk management. The study of these models from a Bayesian viewpoint is relatively recent and can be considered very promising due to the advantages of the Bayesian approach, in particular the possibility of obtaining small-sample results and integrating these results in a formal decision model. The first two chapters introduce the work and give an overview of the Bayesian paradigm for inference. The next three chapters describe the estimation of the GARCH model with Normal innovations and the linear regression models with conditionally Normal and Student-t-GJR errors. The sixth chapter shows how agents facing different risk perspectives can select their optimal Value at Risk Bayesian point estimate and documents that the differences between individuals can be substantial in terms of regulatory capital.
Field-Based Coordination for Pervasive Multiagent Systems
Software systems involve autonomous and distributed software components that have to execute and interact in open and dynamic environments, such as in pervasive, autonomous, and mobile applications. The requirements with respect to dynamics, openness, scalability, and decentralization call for new approaches to software design and development, capable of supporting spontaneous configuration, tolerating partial failures, or arranging adaptive reorganization of the whole system.
Ferroptosis : Methods and protocols
A comprehensive collection of experimental protocols for investigating ferroptosis in different systems, including cultured cells, animal models, and human tissues. The techniques covered in this book look at various aspects of ferroptosis ranging from the detection of lipid peroxidation to the measurement of glutathione peroxidase activity and the evaluation of mitochondrial morphology. Chapters also discuss basic molecular biology methods such as quantitative PCR and immunoblotting, and advanced imaging techniques such as transmission electron microscopy and confocal fluorescence microscopy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Exploring the Vertebrate Central Cholinergic Nervous System
The volume’s eleven chapters cover a wide variety of topics including the complexity of synthesis of acetylcholine, cholinesterases, cholinergic teratology, anticholinesterase agents, clinical use of cholinergic drugs, central cholinergic pathways and behaviors with cholinergic correlates. The figures and diagrams help illustrate various subjects and its photographs of "cholinergikes" of the past and present bring a personal note to the book. The book illustrates the peaks that have been reached in the course of the history of cholinergic research and challenges the perennial frontier of human science: the understanding of ourselves.
Experimental Glycoscience : Glycobiology
The aim of this book is to provide experimental protocols covering many aspects of glycobiology, glycotechnology, and chemistry: biochemistry, molecular and cellular biology, genetics, physiology, and medicine. The protocols are all self-contained descriptions of the equipment and reagents needed, followed by details of the experimental procedure.
Experimental Glycoscience : Glycobiology
The aim of this book is to provide experimental protocols covering many aspects of glycobiology, glycotechnology, and chemistry: biochemistry, molecular and cellular biology, genetics, physiology, and medicine. The protocols are all self-contained descriptions of the equipment and reagents needed, followed by details of the experimental procedure.
