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Mechanisms of mineralization of vertebrate skeletal and dental tissues
Presents a multi-disciplinary approach to understanding mechanisms regulating the formation of mineral in vertebrate skeletal and dental tissues. The focus of the book is directed toward the mineralization process, an evolutionarily conserved system in which cells synthesize a complex and unique extracellular matrix into which mineral is deposited. Regulatory control is viewed though lenses that emphasize the genetic, physical-chemical, biochemical, structural, cellular and extracellular aspects of the mineralization process as they relate to crystal nucleation, growth and maturation. Throughout the book, defects in regulation at the genetic and transcriptional levels are linked to the numerous clinical problems associated with the mineralization of bone, cartilage, tendon, tooth, and soft tissues.
Mechanisms of Insulin Action
More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. In addition, between 17 and 40 million people have insulin resistance, impaired glucose tolerance, or the cluster of abnormalities referred to variably as the metabolic syndrome, the dysmetabolic syndrome, syndrome X, or the insulin resistance syndrome. In all of these disorders, a central component of the pathophysiology is insulin resistance, i.e., reduced responsiveness to insulin in tissues such as muscle, fat and liver. Insulin resistance is also closely linked to other common health problems, including obesity, polycystic ovarian disease, hyperlipidemia, hypertension, and atherosclerosis. In this book, we will attempt to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. We explore insulin action at the most basic levels, through complex systems. The book will be appealing to basic and clinical scientists.
Mechanisms of Angiogenesis
Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.
Mechanics of biomaterials : Fundamental principles for implant design
Teaching mechanical and structural biomaterials concepts for successful medical implant design, this self-contained text provides a complete grounding for students and newcomers to the field. Split into three sections: Materials, Mechanics and Case Studies, it begins with a review of sterilization, biocompatibility and foreign body response before presenting the fundamental structures of synthetic biomaterials and natural tissues. Mechanical behavior of materials is then discussed in depth, covering elastic deformation, viscoelasticity and time-dependent behavior, multiaxial loading and complex stress states, yielding and failure theories, and fracture mechanics. The final section on clinical aspects of medical devices provides crucial information on FDA regulatory issues.
Mechanical Ventilation
This book represents a state-of-the-art review by the leading experts in this field and covers a number of important topics including epidemiology, underlying physiological concepts, and approaches to monitoring. The pros and cons of various modes of ventilation are reviewed, as are novel forms of ventilation that may play a role in the future management of patients with respiratory failure. The importance of patient-ventilator synchrony and ventilator-induced lung injury are reviewed, with a focus on recent clinical trials and the challenges of implementing the results into clinical practice.
MDCT and 3D Workstations : A Practical How-To Guide and Teaching File
Written by Scott A. Lipson, MD, an authority in the field, this book is ideal for radiologists, radiology residents, and CT technologists who are getting started in multidetector CT or who want to improve and optimize their CT service. This concise guide and teaching file is the perfect introduction to MDCT volumetric imaging and 3D workstations. Intended to serve as a practical, easy-to-read systematic learning tool, the book begins by introducing the reader to the process of image data acquisition, CT protocols, image reconstruction and review, 3D workstations, clinical workstation use, and CT workflow efficiency. The second section of this book is a volumetric imaging teaching file.
MDCT : A Practical Approach
Computed tomography (CT) is the most rapidly evolving medical imaging technology. This book describes current examination techniques and advanced clinical applications of state-of-the-art multidetector computed tomography (MDCT) scanners in chapters contributed by several distinguished radiologists and clinicians. Each chapter is written from a practical perspective so that radiologists, residents, medical physicists, and radiology technologists can obtain relevant information about MDCT applications in neuroradiology, cardiac imaging, chest, abdominal, and musculoskeletal radiology subspecialties. Each coauthor provides pertinent illustrations and tables for better understanding of current and advanced applications of MDCT scanners. Readers will benefit from the experience these authors describe in chapters on MDCT technology, contrast administration techniques, contrast adverse effects and their management, and advanced applications of MDCT.
Mayo clinic infectious disease case review : With board-style questions and answers
Addresses many of the current-day illnesses seen by primary care clinicians and infectious diseases specialists. A case presentation format is used for all 54 chapters, and this framework serves as a wonderful educational tool that mirrors, in many respects, the objectives of a “case conference” format. The dozens of authors from different areas of our specialty have ensured that a robust clinical examination of specific infection syndromes has been included. In addition, the Question and Answer section solidifies the educational benefits for all levels and types of clinicians who seek an understanding of disease diagnosis, management, and prevention. A well-recognized characteristic of infectious diseases specialists is our focus on epidemiology, and this trait has served us well in developing successful clinical careers.
Maxillofacial prosthetics and dental oncology : Practical approach from a high volume head and neck cancer centre
An assimilation of clinical and practical work done at Tata Memorial Hospital. It reflects the evolution of Dental Oncology and Maxillofacial Prosthodontics and more than 33 years of exclusive maxillofacial prosthodontic experience of Dr. Kanchan Dholam. This book covers the clinical guidelines for treatment, based on sound scientific principles and published literature. It also provides a step-by-step approach in the fabrication of commonly-indicated maxillofacial prostheses.
Ion channels as targets in drug discovery
Built around ion channel research and, more specifically, ion channels as important therapeutic drug targets. Under the editorial leadership of Gary Stephens in academic research and Edward Stevens from industry, the aim is to bring these strands together to provide a cutting-edge translational reference on ion channel drug discovery. Exploiting our knowledge of ion channel structure and function has clear current and future potential to intervene and correct the pathophysiology associated with debilitating conditions, including cardiovascular disease, diabetes, cystic fibrosis, pain, epilepsy, and neurodegenerative disorders. Individual chapters have a disease focus, also providing a “case study story” that will also appeal to a clinical audience
Investing in e-Health : What it Takes to Sustain Consumer Health Informatics
Investing in eHealth: What it Takes to Sustain Consumer Health Informatics examines the evolution of the IHCS and the significant changes in organizational culture and operational systems that may be required for successful and sustained implementation. This book culminates a set of general guidelines for any health care provider striving to successfully employ the model, and suggests directions for future research on the diffusion of IHCSs and related technologies. Investing in eHealth provides a principled approach to support health care managers, clinicians, and educators interested in complementing clinical services with interactive health communication systems (IHCSs).
Investigative Electrocardiography in Epidemiological Studies and Clinical Trials
It reviews the prevalence and incidence and emphasizes the prognostic implications of common ECG abnormalities in contrasting populations. It provides a comprehensive, penetrating and critical analysis of topics such as QT prolongation in clinical drug trials, left ventricular hypertrophy, myocardial ischemia/infarction and epidemiological consideration of relative risks associated with ECG abnormalities. As such it is an essential tool in epidemiological or clinical research using ECGs and in investigations of possible adverse responses of new pharmacological agents.
Investigating the Body in the Victorian Asylum : Doctors, Patients, and Practices
This book explores how the body was investigated in the late nineteenth-century asylum in Britain. As more and more Victorian asylum doctors looked to the bodily fabric to reveal the ‘truth’ of mental disease, a whole host of techniques and technologies were brought to bear upon the patient's body. These practices encompassed the clinical and the pathological, from testing the patient's reflexes to dissecting the brain.
Invasive Bladder Cancer
It offers an updated, simple overview bridging the information coming from basic research to clinical practice, facilitated by most chapters having both a basic researcher and a clinician writing together.
Introduction to basics of pharmacology and toxicology ; Vol.2 : Essentials of systemic pharmacology : From principles to practice
Describes the pharmacology of drugs acting on different systems in the human body Analyses various human diseases and the pharmacological agents governing them Provides a valuable reference resource for academicians, researchers, and clinical practitioners Offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics.
Intraperitoneal Cancer Therapy
The volume details major clinical trails to date, including immunotherapy, hyperthermic treatment of colo-rectal and ovarian cancers. Authors also examine regional approaches to therapy, systemic therapy, and the use of carboplatin and paclitaxel as the standard treatment for women with stages III and IV ovarian cancer. Other chapters also investigate techniques and procedures in treatment, as well as the future direction of both normothermic and hyperthermic intraperitoneal chemotherapy.
Intracranial vascular malformations and aneurysms : From diagnostic work-up to endovascular therapy ; 1st ed.
This book describes the pathoanatomical, pathophysiological, and imaging features of vascular malformations and aneurysms of the brain and the modern, minimally invasive endovascular methods or techniques employed in their treatment. Individual chapters are devoted to venous malformations, capillary telangiectasias and cavernomas, pial arteriovenous malformations, dural arteriovenous malformations, and intracranial aneurysms. Each chapter is subdivided into four principal sections on pathology, clinical presentation, diagnostic imaging, and therapy, ensuring a standardized approach throughout. The book is richly illustrated with numerous informative CT, MR and DSA images.
Intracranial Pressure and Brain Monitoring XII
88 short papers originating from the 12th International Symposium on Intracranial Pressure and Brain Monitoring held in August 2004 in Hong Kong present experimental as well as clinical research data on invasive and non-invasive intracranial pressure and brain biochemistry monitoring. The papers have undergone a peer-reviewing and are organized in nine sections: ICP management in head injury, neurochemical monitoring, intracranial hypertension, neuroimaging, hydrocephalus, clinical trails, experimental studies, brain compliance and biophysics.
Interventional Management of Urological Diseases
This eighth volume in the series Recent Advances in Endourology brings together the latest clinical findings regarding various endourological treatment modalities and innovative materials. In this book, world-recognized experts outline their techniques clearly and concisely to provide an updated review of state-of-the-art endourological techniques.
Intervening in the Brain : Changing Psyche and Society
The present book subjects the whole range of questions associated with these problems to a thorough exploration. Extensive state-of-the-art accounts of the relevant clinical and theoretical neurosciences are followed by an in-depth philosophical analysis of the problems of personal identity and a comprehensive disquisition on legal and ethical questions posed by present and foreseeable future practices of neuroenhancement. A concluding chapter presents the study’s main results as recommendations, addressing clinical practitioners and researchers in the field as well as to politicians, legislators, law courts, philosophers, lawyers, and anybody fascinated by or concerned about the dawning era of intervening in the brain.
