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Molecular autoimmunity
The autoimmune disease paroxysmal cold hemoglobinuria, a rare hemolytic disorder. After a century of research, the list of autoimmune diseases has become impressive. With a prevalence of approximately 5% of the world-wide population, these chronic, debilitating conditions affect almost every major organ of the body and, for reasons that remain unclear, are much more prevalent in woman than in men. Despite our rapidly expanding knowledge of the cellular and molecular pathways that govern a normal immune response, deciphering the precise etiology of autoimmune diseases remains an important challenge. Over the last few years, our understanding of the pathogenesis of autoimmune diseases has improved rapidly, leading to the emergence of elegant immunointervention strategies. Molecular Autoimmunity illustrates how cutting-edge research is continuing to advance our understanding of autoimmune disease mechanisms and identifies novel therapeutic targets that provide a hope for effective future treatments. This volume contains a selected number of exciting advances in unraveling autoimmune reactions, and the resulting new armory of experimental immunotherapies that may lead to new ways of controlling autoimmune reactions.
Molecular and Cellular Signaling
A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding.
Modern treatments for chronic blood diseases
Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells. In vertebrates, it is composed of blood cells suspended in blood plasma. Plasma, which constitutes 55% of blood fluid, is mostly water (92% by volume), and contains proteins, glucose, mineral ions, hormones, carbon dioxide (plasma being the main medium for excretory product transportation), and blood cells themselves. Albumin is the main protein in plasma, and it functions to regulate the colloida osmotic pressure of blood. The blood cells are mainly red blood cells (also called RBCs or erythrocytes), white blood cells (also called WBCs or leukocytes) and platelets (also called thrombocytes). Thalassemias are inherited blood disorders characterized by decreased hemoglobin production Symptoms depend on the type and can vary from none to severe. Often there is mild to severe anemia (low red blood cells or hemoglobin). Anemia can result in feeling tired and pale skin. There may also be bone problems, an enlarged spleen, yellowish skin, and dark urine. Slow growth may occur in children.
Modern structural analysis : Modelling process and guidance
Essential reading for 21st century practitioners and students who need to do structural analysis. It contains a great deal of information that is not available in any other book on the subject. This is because the conventional view of structural analysis is rooted in the early part of the 20th century in the pre-computer era rather than present time.
Modern Operative Dentistry : Principles for Clinical Practice
Provides the theoretical knowledge required by students when learning how to diagnose oral diseases, plan treatment, and perform various types of dental restoration. It is also useful for clinicians wishing to update their treatment skills and broaden their understanding operative dentistry. Adopting an evidence-based approach, and in accordance with the philosophy of minimally invasive dentistry, it explains in detail the use of both classic and new restorative materials in various clinical situations. It also discusses the principles of smile analysis, as well the technique for esthetic composite restorations on posterior and anterior teeth, including direct and indirect veneers.
Modern Control Systems ; 14th ed.
Written to be equally useful for all engineering disciplines, this text is organized around the concepts of control systems theory in the context of frequency and time domains. It provides coverage of both classical and modern methods of control engineering to give students a strong foundation in basic principles that they can utilize to explore advanced topics in later chapters. Emphasis is placed on real-world complex control systems and practical design applications as well as evolving design strategies like green engineering and human-centered design. Problem solving is strongly emphasized, with an abundance of problems of increasing complexity that help students learn to apply theory to computer-aided design and analysis concepts using MATLAB® and LabVIEW MathScript.
Modern Aspects of Electrochemistry ; Vol. 41
The 41st volume in this series covers a range of topics that touch on issues of potential interest to those working in electrochemistry-related fields. … Overall, this text contains a diverse collection of topics that would be of varying degrees of interest to the broader electrochemistry community. More likely, the individual chapters would be most valued by specialists working in these areas."As the most recent volume of a successful series established 1954 and carefully continued this book provides a timely collection of four review papers covering widely distributed aspects of electrochemistry in representative contributions.
Models and Algorithms for Global Optimization : Essays Dedicated to Antanas Žilinskas on the Occasion of His 60th Birthday
The research of Antanas Žilinskas has focused on developing models for global optimization, implementing and investigating the corresponding algorithms, and applying those algorithms to practical problems. This volume, dedicated to Professor Žilinskas on the occasion of his 60th birthday, contains new survey papers in which leading researchers from the field present various models and algorithms for solving global optimization problems.
Modelling water and nutrient dynamics in soil-crop systems : Applications of different models to common data sets - Proceedings of a workshop held 2004 in Müncheberg, Germany
This book contains articles from a workshop on "Modelling water and nutrient dynamics in crop-soil systems". Data sets from lysimeters and experimental fields of multiyear crop rotations were provided for modellers. A unique data set is provided of a 100 year long term field experiment regarding crop yield and organic carbon development under different management systems. The book includes a detailed description of data sets which can be used by modellers and the papers describe the applications of 18 different modelling approaches describing soil-crop-atmosphere interactions for water, nitrogen and carbon dynamics.
Modelling in Mechanical Engineering and Mechatronics : Towards Autonomous Intelligent Software Models
Modelling in Mechanical Engineering and Mechatronics presents a model-centred approach focusing on distributed development and use of autonomous intelligent software models, particularly the efficiency of the models, and their interaction and integration into distributed autonomous intelligent systems. In order to systematise the available knowledge, a domain ontology is presented; a subset of which is used to create a modelling theory based on knowledge and experience in the areas of software engineering, mechanical engineering and mechatronics. This holistic view of modelling explains the purpose and the essence of modelling, as well as the benefits that are to be expected. It discusses the relations to other branches of engineering and science and as a result, it demonstrates strategies, methods and tools for unleashing the full power of modelling.
Modelli Dinamici Discreti = Discrete Dynamic Models
Discrete mathematical modeling is one of the driving factors in modern mathematics research, and has played a role of synthesis between different disciplines, becoming a tool for qualitative and quantitative analysis in applied sciences. This volume provides an introduction to the analysis of discrete dynamic systems, following a modeling approach. An examination of a wide range of examples, models, and motivations drawn from Biology, Demography, Engineering and Economics, is followed by the presentation of the tools for the study of linear and non-linear scalar dynamical systems, with particular attention to stability analysis. The linear difference equations are studied in detail and an elementary introduction to the Z and DFT transforms is provided. One chapter is devoted to the study of bifurcations and chaotic dynamics. One-step vector dynamical systems and the applications of Markov chains are the subject of three chapters.
Modeling, Simulation and Optimization of Complex Processes ; Proceedings of the Third International Conference on High Performance Scientific Computing, March 6–10, 2006, Hanoi, Vietnam
This proceedings volume contains a selection of papers presented at the Third International Conference on High Performance Scientific Computing held at the Hanoi Institute of Mathematics, Vietnamese Academy of Science and Technology (VAST), March 6-10, 2006. The conference has been organized by the Hanoi Institute of Mathematics, Interdisciplinary Center for Scientific Computing (IWR), Heidelberg, and its International PhD Program ``Complex Processes: Modeling, Simulation and Optimization'', and Ho Chi Minh City University of Technology. The contributions cover the broad interdisciplinary spectrum of scientific computing and present recent advances in theory, development of methods, and applications in practice. Subjects covered are mathematical modelling, numerical simulation, methods for optimization and control, parallel computing, software development, applications of scientific computing in physics, chemistry, biology and mechanics, environmental and hydrology problems, transport, logistics and site location, communication networks, production scheduling, industrial and commercial problems.
Modeling, Simulation and Optimization of Complex Processes ; Proceedings of the International Conference on High Performance Scientific Computing, March 10-14, 2003, Hanoi, Vietnam
This proceedings volume contains a selection of papers presented at the symposium "International Conference on High Performance Scientific Computing'' held at the Hanoi Institute of Mathematics of the Vietnam National Center for Natural Science and Technology (NCST). The contributions cover the broad interdisciplinary spectrum of scientific computing and present recent advances in theory, development of methods, and applications in practice. Subjects covered are mathematical modelling, numerical simulation, methods for optimization and optimal control, parallel computing, symbolic computing, software development, applications of scientific computing in physics, chemistry, biology and mechanics, environmental and hydrology problems, transport, logistics and site location, communication networks, production scheduling, industrial and commercial problems.
Modeling Uncertainty : An Examination of Stochastic Theory, Methods, and Applications
Modeling Uncertainty: An Examination of Stochastic Theory, Methods, and Applications, is a volume undertaken by the friends and colleagues of Sid Yakowitz in his honor. Fifty internationally known scholars have collectively contributed 30 papers on modeling uncertainty to this volume. Each of these papers was carefully reviewed and in the majority of cases the original submission was revised before being accepted for publication in the book. The papers cover a great variety of topics in probability, statistics, economics, stochastic optimization, control theory, regression analysis, simulation, stochastic programming, Markov decision process, application in the HIV context, and others. There are papers with a theoretical emphasis and others that focus on applications. A number of papers survey the work in a particular area and in a few papers the authors present their personal view of a topic. It is a book with a considerable number of expository articles, which are accessible to a nonexpert - a graduate student in mathematics, statistics, engineering, and economics departments, or just anyone with some mathematical background who is interested in a preliminary exposition of a particular topic. Many of the papers present the state of the art of a specific area or represent original contributions which advance the present state of knowledge. In sum.
Modeling Longitudinal Data
This book teaches the art and statistical science of modern longitudinal data analysis. The author emphasizes specifying, understanding, and interpreting longitudinal data models. He inspects the longitudinal data graphically, analyzes the time trend and covariates, models the covariance matrix, and then draws conclusions. The book has many figures and tables illustrating longitudinal data and numerous homework problems. The associated web site contains many longitudinal data sets, examples of computer code, and labs to re-enforce the material.
Modeling biological systems : Principles and applications
This extensively revised second edition of Modeling Biological Systems: Principles and Applications describes the essentials of creating and analyzing mathematical and computer simulation models for advanced undergraduates and graduate students. It offers a comprehensive understanding of the underlying principle, as well as details and equations applicable to a wide variety of biological systems and disciplines. Students will acquire from this text the tools necessary to produce their own models. The text contains two major sections: Principles and Applications. The first section discusses the principles of biological systems with a thorough description of the essential modeling activities of formulation, implementation, validation, and analysis. These activities are illustrated by a set of example models taken from recent and classical literature, chosen for their breadth of coverage and current timeliness. The new edition updates extensively many of these topics, especially quantitative model formulation, validation and model discrimination using information theory measures and Bayesian probability, and stability analysis and non-dimensionalization.
Modeling and using context ; 6th International and interdisciplinary Conference, CONTEXT 2007, Roskilde, Denmark, August 20-24, 2007, Proceedings
This volume contains the papers presented at CONTEXT 2007, the Sixth International and Interdisciplinary Conference on Modeling and Using Context. We believe that the papers of this volume represent a snapshot of current work and contribute to both theoretical and applied aspects of research.
Modeling and simulation tools for emerging telecommunication networks : Needs, trends, challenges and solutions
This book contains a selection of papers presented at a symposium organized under the aegis of COST Telecommunications Action 285. The main objective of the Action is to enhance existing tools and develop new modeling and simulation tools for research in emerging multi-service telecommunication networks in the areas of model performance improvements, multilayer traffic modeling, and the important issue of evaluation and validation of the new modeling tools.
Modeling and Simulation in Scilab
Scilab is a free open-source software package for scientific computation. It includes hundreds of general purpose and specialized functions for numerical computation, organized in libraries called toolboxes, which cover such areas as simulation, optimization, systems and control, and signal processing. One important Scilab toolbox is Scicos. Scicos provides a block diagram graphical editor for the construction and simulation of dynamical systems. The objective of this book is to provide a tutorial for the use of Scilab/Scicos with a special emphasis on modeling and simulation tools. The book is divided into two parts. The first part concerns Scilab and includes a tutorial covering the language features, the data structures and specialized functions for doing graphics, importing, exporting data and interfacing external routines. It also covers in detail Scilab numerical solvers for ordinary differential equations and differential-algebraic equations. Even though the emphasis is placed on modeling and simulation applications, this part provides a global view of Scilab. The second part is dedicated to modeling and simulation of dynamical systems in Scicos. This type of modeling tool is widely used in industry because it provides a means for constructing modular and reusable models. This part contains a detailed description of the editor and its usage, which is illustrated through numerous examples.
Modeling and Simulation for RF System Design
The focus of Modeling and Simulation for RF System Design lies on RF specific modeling and simulation methods and the consideration of system and circuit level descriptions. It contains application-oriented training material for RF designers which combines the presentation of a mixed-signal design flow.
