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The Semantic Web : Research and applications ; 4th European Semantic Web Conference, ESWC 2007, Innsbruck, Austria, June 3-7, 2007, Proceedings
Coverage includes semantic Web services, ontology learning, inference and mapping, social semantic Web, ontologies, personalization, foundations of the semantic Web, natural languages and ontologies, and querying and Web data models.
The Semantic Web - ISWC 2002 ; 1st International Semantic Web Conference, Sardinia, Italy, June 9-12, 2002, Proceedings
PrefaceThis volume contains the papers presented at the First International Seman-tic Web Conference (ISWC 2002) held in Sardinia, Italy, 9–12th June, 2002.The conference followed on from the highly successful Semantic Web WorkingSymposium held at Stanford University, USA in 2001.A total of 133 papers were submitted to ISWC 2002, comprising 95 researchpapers, 22 position papers, and 16 system description papers. Each submissionwas evaluated by at least two referees, mainly members of the Program Commit-tee. This resulted in the selection of 40 papers for presentation at the conferenceand publication in this volume. Of these, 27 are research papers, 6 are positionpapers, and 7 are system description papers.
The Scioto Hopewell and Their Neighbors : Bioarchaeological Documentation and Cultural Understanding
This book presents, for the first time, a detailed, holistic synthesis of the lifeways, culture, history, and material record of the ceremonially and socially rich Hopewell peoples who lived in the Scioto valley and neighboring areas in Ohio in the first centuries A.D. The Scioto Hopewell built monumental, 80 acre earthworks aligned precisely to astronomical events, masterfully worked glistening metals and semiprecious stones into elegant designs, and honored their dead with these vocal artifacts in community burial houses two-thirds the size of a football field. The Scioto Hopewell’s intricate social order and religious concepts of alliance afforded them three centuries of intercommunity peace.
The Science of the Individual : Leibnizs Ontology of Individual Substance
In his well-known Discourse on Metaphysics, Leibniz puts individual substance at the basis of metaphysical building. In so doing, he connects himself to a venerable tradition. His theory of individual concept, however, breaks with another idea of the same tradition, that no account of the individual as such can be given.Contrary to what has been commonly accepted, Leibniz’s intuitions are not the mere result of the transcription of subject-predicate logic, nor of the uncritical persistence of some old metaphysical assumptions.
The roles of variants in human multidrug resistance (MDR1) gene on drug response
MDR-1 belongs to a large family of ATP-binding cassette transporter proteins. These pumps bind their substrate and export it through the membrane using energy derived from ATP hydrolysis. In vivo and in vitro studies have demonstrated that MDR-1 plays a very significant role in the ADME processes (absorption, distribution, metabolism, excretion) and drug-drug interaction (DDI) of drugs in humans. Moreover, this efflux transporter is not only expressed in tumor cells, but also in normal tissues (Brain, intestine, liver and kidney) with excretory function that limits oral absorption and central nervous system entry of many drugs.
The Role of Wnt Signalling in the Development of Somites and Neural Crest
The Wnt family of secreted signalling molecules controls a wide range of developmental processes in all metazoans. In this investigation, the authors have concentrated on the role that members of this family play during the development of the somites and the neural crest. Finally they have isolated a novel component of the Wnt signalling pathway called Naked Cuticle and investigated the role that this protein may play in both the previously mentioned processes.
The role of nutrition in preventing chronic diseases
The importance of nutrition in the prevention of chronic disease has been recognized for some time in the global community. In developing countries, the problem is sometimes referred to as double burden of disease, where malnutrition exists in the company of growing rates of lifestyle related diseases such as obesity, diabetes and cardiovascular disease. The frontiers of science have brought forth new understanding of the links between early under-nutrition and the later development of chronic lifestyle related disease, challenging the nutrition scientist and practitioner to evaluate practice to better support health throughout the life course...
The Purple Phototrophic Bacteria
This book is a compilation of 48 authoritative chapters, written by leading experts who highlight the huge progress made in spectroscopic, structural and genetic studies of these bacteria since 1995, when the last book on this topic was published i.e.Anoxygenic Photosynthetic Bacteria, Volume 2 in the Series, edited by Robert E. Blankenship, Michael T. Madigan and Carl E. Bauer. This new volume is similarly intended to be the definitive text on these bacteria for many years to come, and it will be a valuable resource for experienced researchers, doctoral & masters students, as well as advanced undergraduates in the fields of ecology, microbiology, biochemistry, biophysics, integrative biology, and molecular & cell biology. Scientists interested in future applications of these bacteria which could harness their potential for nanotechnology, solar energy research, bioremediation, or as cell factories, will also find this book useful.
The Psychodynamics of Enlightened Leadership : Coping with Chaos
This book provides a comprehensive look at the pluses and minuses of leadership in times of an unparalleled crisis, such as the COVID-19 global pandemic. It examines the COVID-19 crisis in terms of psychodynamics, crisis management, and especially from the standpoint of complex, messy systems. It analyses how leaders need to think and act differently to cope better with—unfortunately not prevent—future crises.
The Pollen Tube : A Cellular and Molecular Perspective
The enormous amount of data now available about the pollen tube clearly reflects its qualities as a biological model that go much beyond that of a carrier of sperm cells essential for plant reproduction. The diversity of techniques and methodologies currently used to study pollen and pollen tube growth is reflected in this book written by biochemists, cell biologists, molecular biologists and geneticists. Their different perspectives demonstrate that pollen tubes are excellent models for plant cell research, particularly suitable for investigations on cell tip growth and polarization, signal transduction, channel and ion flux activity, gene expression, cytoskeleton and wall structure, membrane dynamics and even cell–cell communication.
The Plaston Concept : Plastic Deformation in Structural Materials
This book presents the novel concept of plaston, which accounts for the high ductility or large plastic deformation of emerging high-performance structural materials, including bulk nanostructured metals, hetero-nanostructured materials, metallic glasses, intermetallics, and ceramics.
The Paraoxonases : Their Role in Disease Development and Xenobiotic Metabolism
Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few “mad” scientists searching for “natural” substrates. Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity.
The Pangenome: Diversity, Dynamics and Evolution of Genomes
The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded.
The Onlife Manifesto : Being Human in a Hyperconnected Era
What is the impact of information and communication technologies (ICTs) on the human condition? In order to address this question, in 2012 the European Commission organized a research project entitled The Onlife Initiative: concept reengineering for rethinking societal concerns in the digital transition. This volume collects the work of the Onlife Initiative. It explores how the development and widespread use of ICTs have a radical impact on the human condition. ICTs are not mere tools but rather social forces that are increasingly affecting our self-conception (who we are), our mutual interactions (how we socialise); our conception of reality (our metaphysics); and our interactions with reality (our agency).
The NMR Probe of High-Tc Materials
The NMR probe has yielded a vast array of data for the high-Tc materials, corresponding to different compounds, ionic sites, and nuclear species, as well as to a wide variety of experimental conditions. Over the twenty years, since the discovery of superconducting cuprates, ongoing analysis and discussion of cuprate NMR data have resulted in a wealth of important insights into the physics of these exotic systems. The aims of this monograph are threefold. First, it reviews NMR methodology as it has been applied to the cuprate studies. This is addressed to NMR practitioners and to physics laypersons alike. Next, it presents a review of cuprate NMR measurements and the wide variety of phenomena which they represent. The third phase is to recount the theoretical model calculations and other proposals which have been put forward to account for these data.
The Next Wave in Computing, Optimization, and Decision Technologies
The first section contains two papers on network models. The second section focuses in integer and mixed integer programming. The third section contains papers in which heuristic search and metaheuristics are applied. Three papers using stochastic modeling comprise the fourth section. In the fifth section, the unifying theme is software and modeling. The sixth section contains four papers on classification, clustering, and ranking. Each article in the volume has been carefully reviewed and revised accordingly. Computer Science and Operations Research continue to have a synergistic relationship and this book represents the results of the cross-fertilization between OR/MS and CS/AI. It is this interface of OR/CS that makes possible advances that could not have been achieved in isolation. Taken collectively, these articles are indicative of the state-of-the-art in the interface between OR/MS and CS/AI and of the high-caliber research being conducted by members of the INFORMS Computing Society.
The Myc/Max/Mad Transcription Factor Network
Intense study of the enigmatic myc proto-oncogene over the last 20 years has broadened our view of its functions and led to insights into transcriptional regulation as well as cancer etiology, cell proliferation, apoptosis, and organismal development. How can one gene be involved in so many aspects of cellular behavior? Of particular interest is the fact that the Myc protein functions as part of a network (comprising Myc, Max, and Mad proteins) whose specific interactions direct transcriptional activation or repression of a large number of target genes. The chapters in this volume examine both molecular and biological aspects of the Myc/Max/Mad network. Included are contributions concerning the regulation of its expression, the mechanisms underlying its diverse transcriptional activities, the structural bases for its critical interactions, and the nature of its target genes. Other chapters explore the evolution of the network, its role in development and genomic instability, and the evidence for a parallel transcriptional network. Overall, this volume provides a broad and current overview of research on a crucial group of transcription factors.
The Metaphysics of Science : An Account of Modern Science in Terms of Principles, Laws and Theories
The roots of this work lie in my earlier book, Scientific Progress, which first appeared in 1981. One of its topics, the distinction - tween scientific laws and theories, is there treated with reference to the same distinction as drawn by N. R. Campbell in his Physics: The Elements. Shortly after completing Scientific Progress, I read Rom Harré’s The Principles of Scientific Thinking, in which the concept of theory is even more clearly delineated than in Campbell, being directly connected to the notion of a model – as it was in my book. In subsequent considerations regarding science, Harré’s work thus - came my main source of inspiration with regard to theories, while Campbell’s remained my main source with respect to empirical laws. Around the same time I also read William Whewell’s Philosophy of the Inductive Sciences.
The Metaphysics of Memory
This book investigates central issues in the philosophy of memory. Does remembering require a causal process connecting the past representation to its subsequent recall and, if so, what is the nature of the causal process? Of what kind are the primary intentional objects of memory states? How do we know that our memory experiences portray things the way they happened in the past? Given that our memory is not only a passive device for reproducing thoughts but also an active device for processing stored thoughts, when are thoughts sufficiently similar to be memory-related? The Metaphysics of Memory defends a version of the causal theory of memory, argues for direct realism about memory, proposes an externalist response to skepticism about memory knowledge, and develops a contextualist account of the factivity constraint on memory.
The Metal-Hydrogen System : Basic Bulk Properties
Metal hydrides are of inestimable importance for the future of hydrogen energy. This unique monograph presents a clear and comprehensive description of the bulk properties of the metal-hydrogen system. The statistical thermodynamics is treated over a very wide range of pressure, temperature and composition. Another prominent feature of the book is its elucidation of the quantum mechanical behavior of interstitial hydrogen atoms, including their states and motion. The important topic of hydrogen interaction with lattice defects and its materials-science implications are also discussed thoroughly. This second edition has been substantially revised and updated.
