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Aging and the Heart : A Post-Genomic View
In this book, the genetic and molecular basis of cardiovascular aging will be discussed. In addition, a comprehensive assessment of the bioenergetic changes that occur in human and animal models of cardiac aging as well as current diagnostic and future therapeutic modalities will be undertaken.
African Biodiversity : molecules, organisms, ecosystems
BIOTA is an interdisciplinary research project focusing on sustainable use and conservation of biodiversity in Africa (http://www.biote-africa.de). Session titles were Biogeography and Speciation Processes, Phylogenetic Patterns and Systematics, Diversity Declines and Conservation, and Applied Biodiversity Informatics
Advancing the Science of Cancer in Latinos
This book gives an overview of the sessions, panel discussions, and outcomes of the Advancing the Science of Cancer in Latinos conference, held in February 2018 in San Antonio, Texas, USA, and hosted by the Mays Cancer Center and the Institute for Health Promotion Research at UT Health San Antonio.
Advances in multiple Sclerosis and Experimental Demyelinating Diseases
Challenging Charcot’s hypothesis that inflammatory response is the primary contributor to demyelination, Dr. Rodriguez and colleagues take a fresh, bold look at the causes and possible treatments of MS.Assuming oligodendrocyte injury as a prerequisite to MS, the authors explore viruses, toxins and genetic defects as possible culprits. They present novel methods to interrupt and reverse demyelination. This book examines the correlation between axonal loss and clinical deficits, including the implied role of the CD8+ T cell and perforin. It assesses proteases, specifically, kallikrein 6, which are strongly associated with active demyelination. By directing natural autoantibodies against oligodendrocytes that demonstrate remyelination in animal models, the authors envision clinical trials for remyelination enhancement.
Advances in Molecular Breeding Toward Drought and Salt Tolerant Crops
Advances in Molecular Breeding toward Drought and Salt Tolerant Crops seeks to integrate the most recent findings about key biological determinants of plant stress tolerance with modern crop improvement strategies. This volume is unique because is provides exceptionally wide coverage of current knowledge and expertise being applied in drought and salt tolerance research, spanning the scientific hierarchy from physiology, biochemistry, development, and genetics, to the newest technologies being used to manipulate drought and salinity associated traits for germplasm improvement. This book will be an invaluable reference for educators and researchers in agronomy and horticulture, crop breeding, molecular genetics, and biotechnology.
Advances in Breast Cancer Management, 2nd ed.
Advances in Breast Cancer Management, Second Edition will highlight many of the important advances that have transformed our understanding of the biology and therapeutics of breast cancer.
Advances in Bioactivation Research
This volume provides researchers with recent information on bioactivation reactions of drugs and toxicants. In other sections, focus is on recent applications of bioactivation research in pharmacology, toxicology, and environmental health sciences, where contributors demonstrate the integration of bioactivation research.
Advances in Alzheimer’s and Parkinson’s Disease : Insights, Progress, and Perspectives
Proceedings of the 7th International Conference on Alzheimer’s Disease and Parkinson’s Disease (ADPD), held March 9-13, 2005 in Sorrento, Italy.The subject matter of the ADPD conferences is unique in that it deals not only with issues related individually to Alzheimer’s disease and Parkinson’s disease, but also with the integration of these and other related diseases. The most up-to-date techniques and research findings are illustrated in this volume, covering topics such as immunology, neuroscience, pharmacology, genetics, molecular biology, biochemistry and the history, epidemiology, clinical phenomenology, diagnosis, imaging, treatment ,and future perspectives of Alzheimer’s and Parkinson’s Diseases.
Advanced chemical biology : chemical dissection and reprogramming of biological systems
Organized around the central dogma of life, progressing from genes to proteins and higher-order cellular structures, including core application areas such as imaging, chemical genetics, activity-based protein profiling, and natural product discovery and biosynthesis. Advanced topics and applications in, e. g., microbiology, developmental biology, and neurobiology, are covered in separate sections.
Adipose Tissue and Adipokines in Health and Disease
The aim of Adipose Tissue and Adipokines in Health and Disease is to provide comprehensive information regarding adipose tissue, its physiological functions and its role in disease. This volume contains a collection of information spanning the entire range of adipose tissue studies, from basic anatomical and physiological research to epidemiology and clinical aspects, in one place. This book is indispensable for basic researchers and clinicians interested in the fields of obesity, metabolic diseases, inflammation and immunity, and specialists in each of the pathologies associated with obesity.
Acute Promyelocytic Leukemia : Molecular Genetics, Mouse Models and Targeted Therapy
Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved, finding their molecular functions in transcriptional control, establishing mouse models and culminating in the development of targeted therapy.
Acute Myelogenous Leukemia
The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. Bringing together new concepts and findings in the basic and clinical science of AML, the book emphasizes the molecular basis for new therapies that stand to have the greatest potential impact on the clinical face of these diseases. The text provides insights into selected novel strategies currently and prospectively being developed, including interruption of specific signal transduction pathways, modulation of gene expression, attempts to reinstate differentiation, and immunomodulation.
Actin-Binding Proteins and Disease
This volume, written by experts in the field, is the first to deal with the relationship between human disease and the actin cytoskeleton. It provides overviews of actin and selected actin-binding proteins, and then focuses on diseases that involve these proteins. Specific chapters deal with actin, cofilin, profilin, gelsolin and thymosin ¾4. Other chapters discuss the roles of multiple actin-binding proteins in cancer and metastasis, leukocyte disorders, and heart failure, and there is a chapter that describes how intracellular pathogens use the host actin cytoskeleton. This seminal volume is intended for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
Abnormal Skeletal Phenotypes : From Simple Signs to Complex Diagnoses
This book focuses on the radiographic changes of malformation syndromes and skeletal dysplasias. It is structured such that the reader can identify the radiographic changes and relate them to specific disease entities. The aim is to provide an essential, practical guideline to the recognition of the key radiographic signs for diagnosing malformation syndromes and skeletal dysplasias.
Abl Family Kinases in Development and Disease
Abl Family Kinases in Development and Disease provides an overview of the functions of Abl family kinases in Development and Disease. This new title discusses the biochemical, genetic, and cell biological data that elucidate the cellular roles for these kinases in these processes.
Abiotic Stress Tolerance in Plants : Toward the Improvement of Global Environment and Food
Stresses in plants caused by salt, drought, temperature, oxygen, and toxic compounds are the principal reason for reduction in crop yield. For example, high salinity in soils accounts for large decline in the yield of a wide variety of crops world over; ~1000 million ha of land is affected by soil salinity. Increased sunlight leads to the generation of reactive oxygen species, which damage the plant cells. The threat of global environment change makes it increasingly demanding to generate crop plants that could withstand such harsh conditions. Much progress has been made in the identification and characterization of the mechanisms that allow plants to tolerate abiotic stresses.
Abeta Peptide and Alzheimers Disease : Celebrating a Century of Research
Abeta Peptide and Alzheimer’s Disease summarizes current knowledge of beta-amyloid peptide (Aß) and its role as the major culprit in Alzheimer’s Disease (AD), shown by recent advances in genetics and brain biochemistry.the book covers fundamental biochemical studies on the Aß peptide, the genetic impact on Aß expression and processing, and various AD therapeutic strategies that target Aß. Although specifically focusing on Aß and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases.
A Changing World : Challenges for Landscape Research
Written primarily for researchers and advanced students in environmental and social sciences, this latest book in Springer’s Landscape Series looks at some of the emerging fields and new challenges in landscape research. These include: the role of value systems in perceiving, appreciating, and managing landscapes the ‘space’ and ‘place’ concept in landscape research GIS and remote sensing techniques for gathering and processing spatially and temporally explicit land cover, vegetation, and land use data methods of landscape history landscape genetics and genetic methods to test landscape connectivity and dispersal of plant and animal species
Machine learning for brain disorders
Organized into five parts. Part One presents the fundamentals of ML. Part Two looks at the main types of data used to characterize brain disorders, including clinical assessments, neuroimaging, electro- and magnetoencephalography, genetics and omics data, electronic health records, mobile devices, connected objects and sensors. Part Three covers the core methodologies of ML in brain disorders and the latest techniques used to study them. Part Four is dedicated to validation and datasets, and Part Five discusses applications of ML to various neurological and psychiatric disorders.
Machine learning for biomedical application
Biomedicine is a multidisciplinary branch of medical science that consists of many scientific disciplines, e.g., biology, biotechnology, bioinformatics, and genetics; moreover, it covers various medical specialties. In recent years, this field of science has developed rapidly. This means that a large amount of data has been generated, due to (among other reasons) the processing, analysis, and recognition of a wide range of biomedical signals and images obtained through increasingly advanced medical imaging devices. The analysis of these data requires the use of advanced IT methods, which include those related to the use of artificial intelligence, and in particular machine learning. It is a summary of the Special Issue “Machine Learning for Biomedical Application”, briefly outlining selected applications of machine learning in the processing, analysis, and recognition of biomedical data, mostly regarding biosignals and medical images.
