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Formulating poorly water soluble drugs

A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.

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Formulas, ingredients and production of cosmetics technology of skin- and hair-care products in Japan

Provides the comprehensive knowledge and instruction necessary for researchers to design and create cosmetics products. The book’s chapters cover a comprehensive list of topics, which include, among others, the basics of cosmetics, such as the raw materials of cosmetics and their application; practical techniques and technologies for designing and manufacturing cosmetics, as well as theoretical knowledge; emulsification; sensory evaluations of cosmetic ingredients; and how to create products such as soap-based cleansers, shampoos, conditioners, creams, and others. The potential for innovation is great in Japan’s cosmetics industry. This book expresses the hope that the high level of dedicated research continues and proliferates, especially among those who are innovators at heart.

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Forms of List-Making : Epistemic, Literary, and Visual Enumeration

This book attempts to show that an examination of the list’s formal features has the potential to produce genuine insights into the production of knowledge, the poetics of literature and the composition of visual art. Following a conceptual introduction, the twelve single-authored chapters place the list in a variety of well-researched contexts, including ancient Roman historiography, medieval painting, Enlightenment periodicals, nineteenth-century botanical geography, American Beat poetry and contemporary photobooks.

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Formal Modelling in Electronic Commerce

Advances in automation for electronic commerce require improved understanding and formalization of the objects, processes, and policies of commerce itself. These include business objects such as bills of lading and contracts; processes such as workflows and trade procedures; and policies covering such problems as contract or procedure validation and strategic behaviour. This book is about theory, formalization, and proof-of-concept implementation of these and related matters. In addition to presenting state-of-the-art results, the book places this work in the context of nearly twenty years of developments in formal modelling for electronic commerce. A comprehensive bibliography and index are provided.

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Formal Methods for Components and Objects ; Vol. 3657 ; 3rd International Symposium, FMCO 2004, Leiden, The Netherlands, November 2-5, 2004, Revised Lectures

This book presents revised tutorial lectures given by invited speakers at the Third International Symposium on Formal Methods for Components and Objects, FMCO 2004, held in Leiden, The Netherlands, in November 2004. The 14 revised lectures by leading researchers present a comprehensive account of the potential of formal methods applied to large and complex software systems such as component-based systems and object systems. The book provides an unique combination of ideas on software engineering and formal methods that reflect the expanding body of knowledge on modern software systems.

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Formal concept analysis ; Vol. 3874 ; 4th International Conference, ICFCA 2006, Dresden, Germany, Feburary 13-17, 2006, Proceedings

This book constitutes the refereed proceedings of the 4th International Conference on Formal Concept Analysis, held in February 2006. The 17 revised full papers presented together with four invited papers were carefully reviewed and selected for inclusion in the book. The papers show advances in applied lattice and order theory and in particular scientific advances related to formal concept analysis and its practical applications: data and knowledge processing including data visualization, information retrieval, machine learning, data analysis and knowledge management.

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Formal Concept Analysis ; 6th International Conference, ICFCA 2008, Montreal, Canada, February 25-28, 2008. Proceedings

Formal Concept Analysis (FCA) is a mathematical theory of concepts and c- ceptual hierarchyleadingto methods for conceptually analyzing data and kno- edge. The theory itselfstronglyreliesonorder and lattice theory,whichhasbeen studied by mathematicians over decades. FCA proved itself highly relevant in several applications from the beginning , and, over the last years, the range of application shaskept growing. The mainreasonfor this comesfromthe fact that our modern society has turned into an “information” society. After years and years of using computers, companies realized they had stored gigantic amounts of data.

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Formal Concept Analysis ; 5th International Conference, ICFCA 2007, Clermont-Ferrand, France, February 12-16, 2007, Proceedings

This book constitutes the refereed proceedings of the 5th International Conference on Formal Concept Analysis, ICFCA 2007. The papers comprise state of the art research from foundational to applied lattice theory and related fields, all of which involve methods and techniques of formal concept analysis such as data visualization, information retrieval, machine learning, data analysis and knowledge management.

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Forging New Frontiers : Fuzzy Pioneers II

The chapters of the book are evolved from presentations made by selected participants at the meeting and organized in two books. The papers include reports from the different front of soft computing in various industries and address the problems of different fields of research in fuzzy logic, fuzzy set and soft computing.

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Forest Restoration in Landscapes

This book integrates the restoration of forest functions into landscape conservation plans. and this book represents the collective body of knowledge and experience of WWF and its many partners--which is collected here for the first time and which will be invaluable to all of those working in the field. This guide will serve as a first stop for practitioners and researchers in any organization or region and as a key reference on the subject. Along with concise, practical information for a variety of specific systems and issues, it gives many suggestions for further research.

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Forest Mensuration

Van Laar and Akça’s popular text book, Forest Mensuration, was first published in 1997. Like that first edition, this modern update is based on extensive research, teaching and practical experience in both Europe, and the tropics and subtropics. However, it has also been extensively revised, and now includes chapters on remote sensing and the application of aerial photographs and satellite imagery. As with its predecessor, this book assumes no advanced knowledge of statistical methods, and combines practical techniques with important historical and disciplinary context. The result is a strong balance between a handbook on traditional mensuration methods, and a valuable reference on the many recent research and inventory-related innovations which have emerged in recent years.

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Forest Landscape Ecology : Transferring Knowledge to Practice

Forest Landscape Ecology: Transferring Knowledge to Practice is the first book to introduce landscape ecologists to the discipline of knowledge transfer. The book considers knowledge transfer in general, critically examines aspects of transfer that are unique to forest landscape ecology, and reviews several case studies of successful applications for policy developers and forest managers in North America. Readers are encouraged to recognize the value of sharing their knowledge, and to understand their role in active knowledge transfer. The intent is to connect, as seamlessly and effectively as possible, ecological principles to policy and practice.

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Forest Environments in the Mekong River Basin

Deforestation and forest degradation have continued over a long period of time, and the deterioration of forest environment management services is becoming one of the biggest concerns in the world. Especially in large continental river basins, sel? sh political attitudes and individual interests in some regions predispose other regions to problems downstream and bring about international issues. The Mekong is just such a river basin and its water is the most important resource, interdependent with the forest conditions in the region. The lives of millions of people are sustained by the water of the Mekong River, and mutual understanding on water resource mana- ment is essential in this region. Consequently, appropriate environment management to control water resources is required of each country along with scienti? c knowledge of forest management, including forest hydrology.

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Forensic pathology of trauma

The practice of forensic pathology includes the collection and analysis of evidence in relation to a corpse in order to establish the cause of death. Knowledge of the cause of death contributes to the determination of the manner of death by medical examiners and coroners, who are occasionally assisted by law enforcement officers. In the process of establishing the cause and manner of death, representatives of various investigative bodies have several responsibilities, including explaining the death to family members, attempting to reduce the risk of similar deaths in the future, and, if applicable, apprehending the individuals who are responsible for the death. The most well-known and popular role of a forensic pathologist is in the inves- gation of cases of suspicious death; however, most medicolegal autopsies involve unexpected deaths that are above suspicion, many of which are caused by trauma (trauma being defined as any physical force or agent that causes bodily harm). The purpose of Forensic Pathology of Trauma: Common Problems for the Pathologist is to provide practical advice and information about the conduct of the forensic autopsy in cases of trauma, and to offer guidance about the analysis of the autopsy findings in these cases.

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Forensic Genetics in the Governance of Crime

This book uses a critical sociological perspective to explore contemporary ways of reformulating the governance of crime through genetics. Through the lens of scientific knowledge and genetic technology, Machado and Granja offer a unique perspective on current trends in crime governance. They explore the place and role of genetics in criminal justice systems, and show how classical and contemporary social theory can help address challenges posed by social processes and interactions generated by the uses, meanings, and expectations attributed to genetics in the governance of crime

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Football Traumatology : Current Concepts : From Prevention to Treatment

Lesions associated with football are on the increase and their typology has also changed over the years. Football, like many other sports, has undergone major changes: the increase in the intensity and speed of the game, the modern training methodologies, the technical and tactical innovations are all factors contributing to increased risks of traumatic injury. The footballers, the trainers, the sport's medical staff are asking for greater information and knowledge on the traumatic lesions associated with this sport. The primary role of those who are concerned with the health of footballers is to enforce preventive measures to reduce wherever possible the risks of trauma.

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Foot-and-Mouth Disease Virus

The chapters in this volume provide an account of the present knowledge and understanding of Foot and Mouth disease virus pathogenesis and global epidemiology, the detailed structure of the virus itself and the properties of its RNA genome. Also considered are the immune response of the host and the state of the art in vaccine production, and the nature of virus evolution.

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Food-Borne Parasitic Zoonoses : Fish and Plant-Borne Parasites

The focus of this book is on those zoonoses that are transmitted by fish, plant and invertebrate foods. While people, especially those living in developed countries, are commonly aware of meat-borne zoonoses such as trichinellosis and cysticercosis, fewer are acquainted with parasitic diseases caused by liver, lung and intestinal flukes, fish-borne tapeworms, and tissue roundworms. This book reviews not only the prevalence and distribution of these zoonoses, including available health and economic impact data, but also highlights gaps in our knowledge base that must be filled in order to gain insights on approaches to prevention. The topics on epidemiology, diagnosis, and clinical aspects emphasize knowledge gaps that limit a full understanding of these zoonoses, and target where greater research investments on these parasitic diseases should be focused.

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Food Safety : A Practical and Case Study Approach

The ISEKI-Food book series is a collection where various aspects of food safety and environmental issues are introduced and reviewed by scientists specializing in the field. In all of the books special emphasis is placed on including case studies applicable to each specific topic. The books are intended for graduate students and senior level undergraduate students as well as professionals and researchers interested in food safety and environmental issues applicable to food safety."ISEKI-Food" is an acronym for "Integrating Safety and Environmental Knowledge Into Food Studies".

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Food Materials Science : Principles and Practice

Food manufacture is about producing billions of units of standardized products which must be cheap, nutritious, safe and appealing to the consumer’s taste. Food products are complex multicomponent and structured edible materials that nevertheless must comply with the laws of physics and fundamentals of engineering sciences. In the last 20 years the design of food products with specific functionalities has advanced significantly by the application of scientific knowledge from disciplines such as polymer physics, colloidal and mesoscopic physics, materials science and new imaging and probing techniques borrowed from chemistry, biology and medicine. Our knowledge of the relationship between microstructure, processing, and macroscopic properties continues to increase as the science of food materials advances at a fast pace.

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