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Bioactive Confirmation II
Specific binding of a ligand to a receptor is a key step in a variety of biol- ical processes, such as immune reactions, enzyme cascades, or intracellular transport processes. The ligand-receptor terminology implies that the rec- tor molecule is signi?cantly larger than the ligand, and the term "bioactive conformation" usually characterizes the conformation of a ligand when it is bound to a receptor. In a more general sense, bioactive conformation applies toanymoleculeinabiologicallyrelevantboundstateregardlessofsizecons- erations. Mostofthecontributions tothisbookaddressligandsthat aremuch smaller than their receptors. X-ray crystallography and high resolution NMR spectroscopy are the two main experimental techniques used to study bioactive conformations. The- fore, the twovolumes ofthisbookcover approachesthat use either ofthetwo techniques, or a combination thereof.
Binary Rare Earth Oxides
The book begins with a brief introduction to binary rare earth oxides, their physical and chemical stabilities, polymorphism, crystal structures and phase transformation and the association with current applications. The book goes on to present the band structure of the oxides using several quantum chemical calculations, which belong to a newly developed area in the binary rare earth oxides. Central to this chapter are the characterizations of electrical, magnetic and optical properties, as well as details of single crystal growth and particle preparation methods that have progressed in recent years. Later chapters concentrate on thermo-chemical properties and trace determination techniques. The final chapter contains a variety of useful applications in various fields such as phosphors, glass abrasives, automotive catalysts, fuel cells, solid electrolytes, sunscreens, iron steels, and biological materials.
Beyond the apparent Banality of the mathematics classroom
New research in mathematics education deals with the complexity of the mathematics’ classroom. The classroom teaching situation constitutes a pertinent unit of analysis for research into the ternary didactic relationship which binds teachers, students and mathematical knowledge. The classroom is considered as a complex didactic system, which offers the researcher an opportunity to gauge the boundaries of the freedom that is left with regard to choices about the knowledge to be taught and the ways of organizing the students’ learning, while giveing rise to the study of interrelations between three main elements of the teaching process the: mathematical content to be taught and learned, management of the various time dimensions, and activity of the teacher who prepares and manages the class, to the benefit of the students' knowledge and the teachers' own experience.
Azaheterocycles Based on -, ß-Unsaturated Carbonyls
Devoted to heterocyclizations of aliphatic and aromatic, -unsaturated carbonyls with various binucleophiles leading to three-, five-, six and seven-membered partially hydrogenated nitrogen-containing heterocycles. During the last decade interest in these classes of organic c- pounds has been experiencing a scientific renaissance owing to their significant role in biological processes in living cells and diverse effects on physiological activities. In addition, such compounds are also more prevalent from the vi- point of ''classical'' problems of organic chemistry, among them reactivity, chemo- and regioselectivity, tautomerism, conformational analysis and features of their electronic structure. The character of these problems in the case of partially hydrogenated heterocycles differs sufficiently from that for hetero- omatized and perhydrogenated heterocyclic compounds and investigations in this field very often lead to interesting and unusual results. Extensively characterized cyclocondensations of, -unsaturated carbonyls, their synthetic equivalents and their precursors are the most widespread, facile and generally valid pathway to dihydroazaheterocycles.
Autistic community and the neurodiversity movement : Stories from the frontline
This book marks the first historical overview of the autism rights branch of the neurodiversity movement, describing the activities and rationales of key leaders in their own words since it organized into a unique community in 1992. Sandwiched by editorial chapters that include critical analysis, the book contains 19 chapters by 21 authors about the forming of the autistic community and neurodiversity movement, progress in their influence on the broader autism community and field, and their possible threshold of the advocacy establishment
Authoritative communities : The scientific case for nurturing the whole child
Authoritative Communities: The Scientific Case for Nurturing the Whole Child introduces innovative solutions based firmly in the children’s mental health and resilience literature and in the hypothesis that humans are "hardwired to connect." These "authoritative communities" consist of such individuals and institutions as parents, teachers, coaches, elders, and a variety of organizations that are committed to each other’s well-being over the long-term and who instill children with prosocial values such as empathy and compassion. Living within these communities enables children and youth to develop a consistent sense of purpose and meaning, so that they, in turn, are able to grow up to be responsible, productive, and nurturing adults.
Auralization : Fundamentals of acoustics, modelling, simulation, algorithms and acoustic virtual reality
"Auralization" is the technique of creation and reproduction of sound on the basis of computer data. With this tool is it possible to predict the character of sound signals which are generated at the source and modified by reinforcement, propagation and transmission in systems such as rooms, buildings, vehicles or other technical devices. This book is organized as a comprehensive collection of the basics of sound and vibration, acoustic modelling, simulation, signal processing and audio reproduction. Implementations of the auralization technique are described using examples drawn from various fields in acoustic’s research and engineering, architecture, sound design and virtual reality.
Augmented Humanity : Being and Remaining Agentic in a Digitalized World
This book will examine the implications of digitalization for the understanding of humanity, conceived as a community of intelligent agency. It addresses important topics across a range of social and behavioral theories and identifies a range of novel mechanisms and their social behavioral effects. Across the book, the author highlights the expansion of intelligent processing capability brought about by digitalization and the challenges this exposes for integrating artificial and human capabilities
Audacious Education Purposes : How Governments Transform the Goals of Education Systems
This book offers a comparative study of eight ambitious national reforms that sought to create opportunities for students to gain the necessary breath of skills to thrive in a rapidly changing world.
At the crossroads : The world trading system and the Doha Round
Since its foundation in 1995 the legitimacy of the WTO – and herewith the notion of organising global trade on the basis of herewith the notion of organising global trade on the basis of concepts like trade-liberalisation, treaty-based rule of law and concepts like trade-liberalisation, treaty-based rule of law and enforceability – is challenged for very different reasons this volume not only documents the proceedings of this conference but, against the backdrop of the ongoing efforts to revive the Doha Round wants to be understood as some sort of stocktaking: What did really go wrong in Cancún? Where does the WTO stand today? Has there been any progress made since? And, finally: Is there any chance left to reach the ambitions goals postulated by the Doha Development Agenda? These and other, related questions are being discussed in the volume at hand.
Astrobiology : Future perspectives
Astrobiology, a new exciting interdisciplinary research field, seeks to unravel the origin and evolution of life wherever it might exist in the Universe. The current view of the origin of life on Earth is that it is strongly connected to the origin and evolution of our planet and, indeed, of the Universe as a whole. We are fortunate to be living in an era where centuries of speculation about the two ancient and fundamental problems: the origin of life and its prevalence in the Universe are being replaced by experimental science. The subject of Astrobiology can be approached from many different perspectives. This book is focused on abiogenic organic matter from the viewpoint of astronomy and planetary science and considers its potential relevance to the origins of life on Earth and elsewhere. Guided by the review papers in this book, the concluding chapter aims to identify key questions to motivate future research and stimulate astrobiological applications of current and future research facilities and space missions. Today’s rich array of new spacecraft, telescopes and dedicated scientists promises a steady flow of discoveries and insights that will ultimately lead us to the answers we seek.
Arctic Alpine ecosystems and people in a changing environment
This book addresses the significant environmental changes experienced by high latitude and high altitude ecosystems at the beginning of the 21st c- tury. Increased temperatures and precipitation, reduction in sea ice and glacier ice, the increased levels of UV-radiation and the long-range tra- ported contaminants in arctic and alpine regions are stress factors that challenge terrestrial and aquatic ecosystems. The large natural variation in the physical parameters of these extreme environments is a key factor in structuring the biodiversity and biotic productivity, and the effect of the new stress factors can be critical for the population structures and the - teraction between species. These changes may also have socio-economic effects if the changes affect the bio-production, which form the basis for the marine and terrestrial food chains. The book is uniquely multidisciplinary and provides examples of va- ous aspects of contemporary environmental change in arctic and alpine - gions. The 21 chapters of the book are organised under the fields of •Climate change and ecosystem response, •Long range transport of poll- ants and ecological impacts, and •UV radiation and biological effects, each also including aspects of the •Socio-economic effects of environmental change. The introductory chapter presents and explains the internal c- nection and integration of all chapters.
Applied Hydrogeophysics
This book focuses on how hydrogeophysical methods can be applied to solve problems facing environmental engineers, geophysicists, agronomists, hydrologists, soil scientists and hydrogeologists. We present applications of hydrogeophysical methods to the understanding of hydrological processes and environmental problems dealing with the flow of water and the transport of solutes and contaminants. The majority of the book is organized as a series of process-driven chapters, each authored by leading experts. Areas covered include: infiltration and solute transport processes, biogeochemical functioning of soil-water systems, coastal groundwater interactions, cold region hydrology, engineered barriers and landfill processes. In addition, the book offers insight into the development of new data fusion methodologies, of value to many hydrogeophysical investigations, and provides an account how the rapidly developing self-potential technique can give valuable information about water fluxes and hydrochemical states within the subsurface.
Applied Fuzzy Arithmetic : An Introduction with Engineering Applications
Applied Fuzzy Arithmetic provides a well-structured compendium that offers both a deeper knowledge about the theory of fuzzy arithmetic and an extensive view on its applications in the engineering sciences, making it a resource for students, researchers, and practical engineers. The first part of the book gives an introduction to the theory of fuzzy arithmetic, which aims to present the subject in a well-organized and comprehensible form. The derivation of fuzzy arithmetic from the original fuzzy set theory and its evolution towards a successful implementation is presented with existing formulations of fuzzy arithmetic included and integrated in the overall context. The second part of the book presents a diversified exposition of the application of fuzzy arithmetic, addressing different areas of the engineering sciences, such as mechanical, geotechnical, biomedical, and control engineering.
Anti-vivisection and the profession of medicine in Britain : A social history
This book explores the social history of the anti-vivisection movement in Britain from its nineteenth-century beginnings until the 1960s. It discusses the ethical principles that inspired the movement and the socio-political background that explains its rise and fall. Opposition to vivisection began when medical practitioners complained it was contrary to the compassionate ethos of their profession. Christian anti-cruelty organizations took up the cause out of concern that callousness among the professional classes would have a demoralizing effect on the rest of society. As the nineteenth century drew to a close, the influence of transcendentalism, Eastern religions and the spiritual revival led new age social reformers to champion a more holistic approach to science, and dismiss reliance on vivisection as a materialistic oversimplification.
Antifouling Paint Biocides
This volume describes the state-of-the-art advances regarding antifouling paint biocides and provides thorough evaluation of research and information on major topics such as occurrence and levels, environmental fate, analytical techniques and methods for the monitoring and control, environmental modeling, ecotoxicological effects and risk assessment placing emphasis on the knowledge acquired over the last 10 years. The contamination of the aquatic environment by antifouling compounds has been a topic of increasing importance during the last few years. The major classes of antifouling active biocides are discussed including the old-fashioned organotin compounds, the modern organic booster biocides and the promising naturally occurring antifoulant products. Therefore, the reader will get a balanced view of this developing field. Chapters were written by leading experts in their field who critically surveyed all the major areas of progress. This volume is an important resource and can constitute a good grounding in the field of antifouling paint biocides.
Anthropological Perspectives on Environmental Communication
Through anthropological and ethnographic analyses, this collection addresses how interests, values, and ideologies affect dialogue and sustainability work. Drawing on studies from three continents – Europe, North America, and South America – the paradoxes and the plurality of meanings associated with the creation of sustainable futures are explored. The book focuses on how communication practices collide with organizational frameworks, customary practices, livelihoods, and landscape.
Anthracycline Chemistry and Biology II : Mode of Action, Clinical Aspects and New Drugs
This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. The series is still valid and useful after five or ten years. More information as well as the electronic version of the whole content is available at: springerlink.com.
Anion Sensing
This treatise on anion sensing and recognition represents a new addition to a very small number of books in this area, Although this Topics volume does not cover all the different classes fo receptors, it does provide new and timely perspectives to anion chemistry by highlighting several areas that have been generally overlooked in other reviews. The individual chapters are well-written and include references from earlier works up to the present. As such, this volume will be of interest to the community of researchers interested in anions as well as to those who wish to learn about the host-guest chemistry of anion recognition and its applications.
Andean Archaeology III : North and South
In this volume, the strong cultural differences between northern and southern regions of the Central Andes are examined and the conditions under which these differences evolved are explored.
