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Leading Pharmaceutical Innovation : Trends and Drivers for Growth in the Pharmaceutical Industry
Pharmaceutical giants have doubled their investments in drug development in the past decade only to see new drug approvals remain constant. This book investigates and highlights a set of proactive strategies aimed at generating sustainable competitive advantage based on value-generating business practices. We focus on three sources of pharmaceutical innovation: new management methods in the drug development pipeline, new technologies as enablers for cutting-edge R&D, and new forms of cooperation and internationalization, such as open innovation in the early phases of R&D. Our findings are illustrated by cases from Europe, the US, and Asia.
A Risk-Benefit Perspective on Early Customer Integration
Customer integration in the early innovation phase has been considered the method of choice in theory and practice. Growing experience with the concept has shown unexpected side effects that may even outweigh its recognized advantages. Therefore, management needs to be able to assess in advance whether the involvement of customers will add overall value to each particular innovation project. To support but not to replace the final managerial decision, a mathematical formula is developed. It can be applied to all kinds of process structures, takes into account the risks and benefits contingent on a company's situation as well as risk-reducing and benefit-increasing measures and translates them into numerical values. The resulting figure indicates the prospective value of customer integration in a specific project.
Architectural lighting design : A practical guide
Answers these questions and more in a comprehensive introduction to the design, application and techniques of lighting interior spaces. Using real examples of successful lighting schemes, experienced designer Admir Jukanovic explains the fundamentals of lamps and luminaires, and how to meet the requirements of a design brief. Topics include treatments and techniques for lighting designs; tips for understanding the deliverables and fulfilling brief; the five project phases, from concept to commission and the common pitfalls to avoid when using artificial lighting in architecture.
Building for well-being : Exploring health-focused rating systems for design and construction professionals
The first introduction to health-focused building standards for design and construction professionals. More than a summary of the state of the field, this practical resource guides designers, builders, developers, and owners through considerations for incorporating WELL®, Fitwel®, and other systems from the planning phase to ground-breaking and beyond.Drawing on the authors’ backgrounds in sustainable design and public health, chapters on the evolution of the green building movement and the relationship between health and the built environment provide vital context for understanding health-focused standards and certifications. The final chapter looks toward the future of health and the built environment.
Mathematical Modelling of Biosystems
This volume is an interdisciplinary book, which introduces, in a very readable way, state of the art research in the fundamental topics of mathematical modelling of Biosystems. These topics include: the study of Biological Growth and its mechanisms, the coupling of pattern to form via theorems of Differential Geometry, the human immunodeficiency virus dynamics, the inverse folding problem and the possibility of analysing true protein backbone flexibility, the Biclustering techniques for the organization of microarray data, the analytical approach to the modelling of biomolecular structure via Steiner trees, the action of biocides on resistance mechanisms of mutated and phenotypic bacteria strains, a description of the fundamental processes for the distribution and abundances of species towards a unified theory of Ecology, and a special introduction to Protein Physics aiming to explain the all-or-none first order phase transitions from native to denatured states.
Marine Geochemistry
Since 1980 a considerable amount of scientific research dealing with geochemical processes in marine sediments has been carried out. This textbook summarizes the state of the art in this field of research. The topics comprise the examination of sedimentological and physical properties of the sedimentary solid phase, of pore water and pore water constituents, organic matter as the driving force of most microbiological processes, biotic and abiotic redox reactions, carbonates and stable isotopes as proxies for paleoclimate reconstruction, metal enrichments in ferromanganese nodules and crusts as well as in hot vents and cold seeps on the seafloor. A new chapter describes properties, occurrence and formation of gas hydrates in marine sediments. The textbook ends with a chapter on model conceptions and computer models to quantify processes of early diagenesis.
Low-Power High-Speed ADCs for Nanometer CMOS Integration
Low-Power High-Speed ADCs for Nanometer CMOS Integration is about the design and implementation of ADC in nanometer CMOS processes that achieve lower power consumption for a given speed and resolution than previous designs, through architectural and circuit innovations that take advantage of unique features of nanometer CMOS processes. A phase lock loop (PLL) clock multiplier has also been designed using new circuit techniques and successfully tested.
Low Power VCO Design in CMOS
The performance of voltage controlled oscillators (VCO) is of extreme importance for any telecommunication or data communication system. This practical guide develops a systematic, fully-integrated LC-VCO design for low power and low phase noise, especially useful to meet the demands on mobile devices such as cell phones. The proposed VCO design approaches are experimentally verified with several fully integrated CMOS VCOs. The concise presentation is offered in three parts (VCO design; CMOS devices for VCO design; and fully-integrated CMOS DESIGNS) and supplemented by an appendix summarizing the state of the art.
Logos of Phenomenology and Phenomenology of the Logos. Book One : Phenomenology as the Critique of Reason in Contemporary Criticism and Interpretation
During its century-long unfolding, spreading in numerous directions, Husserlian phenomenology while loosening inner articulations, has nevertheless maintained a somewhat consistent profile. As we see in this collection, the numerous conceptions and theories advanced in the various phases of reinterpretations have remained identifiable with phenomenology.
Light Scattering Reviews 3 : Light Scattering and Reflection
Ddevoted to modern knowledge and milestones in both experimental and theoretical techniques related to light scattering and radiative transport problems. It will consist of 3 parts comprising 11 contributions written by world leading experts in their respective fields. The general focus of the book will be on remote sensing of geophysical media. The first part will be devoted exclusively to studies of single light scattering by particles of different shapes and chemical compositions. The first chapter will review in situ measurements of cloud optical characteristics like cloud extinction and phase function, with the emphasis on ice clouds. Chapter 2 will cover opitcally soft particles common in marine environments and bio-suspensions while Chapter 3 will describe numerical techniques applicable not only to isotropic but also to chiral and anisotropic mdia. The final chapter in this part will deal with spatial symmetries in light scattering problems.
Lattice Boltzmann Modeling : An Introduction for Geoscientists and Engineers
Lattice Boltzmann models have a remarkable ability to simulate single- and multi-phase fluids and transport processes within them. A rich variety of behaviors, including higher Reynolds numbers flows, phase separation, evaporation, condensation, cavitation, buoyancy, and interactions with surfaces can readily be simulated. This book provides a basic introduction that emphasizes intuition and simplistic conceptualization of processes. It avoids the more difficult mathematics that underlies LB models. The model is viewed from a particle perspective where collisions, streaming, and particle-particle/particle-surface interactions constitute the entire conceptual framework. Beginners and those with more interest in model application than detailed mathematical foundations will find this a powerful "quick start" guide. Example simulations, exercises, and computer codes are included. Working code is provided on the Internet.
Lateral Alignment of Epitaxial Quantum Dots
Accurate positioning of self-organized nanostructures on a substrate surface can be regarded as the Achilles’ heel of nanotechnology. This perception also applies to self-assembled semiconductor quantum dots. This book describes the full range of possible strategies to laterally align self-assembled quantum dots on a substrate surface, starting from pure self-ordering mechanisms and culminating with forced alignment by lithographic positioning. The text addresses both short- and long-range ordering phenomena and paves the way for the future high integration of single quantum dot devices on a single chip. Contributions by the best-known experts in this field ensure that all relevant quantum-dot heterostructures are elucidated from diverse relevant perspectives.
Laser Resonators and Beam Propagation : Fundamentals, Advanced Concepts, Applications
Optical Resonators provides a detailed discussion of the properties of optical resonators for lasers from basic theory to recent research. In addition to describing the fundamental theories of resonators such as geometrical optics, diffraction, and polarisation the characteristics of all important resonator schemes and their calculation are presented. Experimental examples, practical problems and a collection of measurement techniques support the comprehensive treatment of the subject. Optical Resonators is the only book currently available that provides a comprehensive overview of the the subject. Combined with the structure of the text and the autonomous nature of the chapters this work will be as suitable for those new to the field as it will be invaluable to specialists conducting research. This second edition has been enlarged by new sections on Q-switching and resonators with internal phase/amplitude control. In addition, the whole book has been brought up-to-date.
Knowledge Discovery from Legal Databases
Describes data mining , techniques as they apply to law. Law students, legal academics and applied information technology specialists are guided thorough all phases of the knowledge discovery from databases process with clear explanations of numerous data mining algorithms including rule induction, neural networks and association rules. Throughout the text, assumptions that make data mining in law quite different to mining other data are made explicit. Issues such as the selection of commonplace cases, the use of discretion as a form of open texture, transformation using argumentation concepts and evaluation and deployment approaches are discussed at length.
Kinetics of Water-Rock Interaction
Systems at the surface of the Earth are continually responding to energy inputs derived from solar radiation or from the radiogenic heat in the interior. These energy inputs drive plate movements and erosion, exposing metastable mineral phases at the Earth’s surface. In addition, these energy fluxes are harvested and transformed by living organisms. As long as these processes persist, chemical disequilibrium at the Earth’s surface will be perpetuated. Chemical disequilibrium is also driven by human activities related to production of food, extraction of water and energy resources, and burial of wastes. To understand how the surface of the Earth will change over time, we must understand the rates at which reactions occur and the chemical feedbacks that relate these reactions across extreme temporal and spatial scales. This book addresses fundamental and applied questions concerning the rates of water-rock interactions driven by tectonic, climatic, and anthropogenic forcings.
Kinetics of Catalytic Reactions--Solutions Manual
This textbook contains all the information needed for graduate students or industrial researchers to design kinetic experiments involving heterogeneous catalysts, to characterize these catalysts, to acquire valid rate data, to verify the absence of mass (and heat) transfer limitations, to propose reaction models, to derive rate expressions based on these models and, finally, to assess the consistency of these rate equations.The most recent technique to calculate heats of adsorption and activation barriers on metal surfaces, the BOC-MP approach, is discussed in detail. Methods to measure metal surface areas and crystallite sizes using x-ray diffraction, transmission electron microscopy and various chemisorption techniques are discussed. Different experimental techniques to determine the influence of mass transfer limitations, especially within the pores of a catalyst, are reviewed in detail, with a particular emphasis on liquid-phase reactions.
Composite Materials : Properties as Influenced by Phase Geometry
This book deals with the mechanical and physical behavior of composites as influenced by composite geometry. This monograph provides a comprehensive introduction for researchers and students to modern composite materials research with a special emphasis on the influence of geometry to materials properties. Composite Materials enables the reader to a better understanding of the behavior of natural composites, improvement of such materials, and design of new materials with prescribed properties.
Complex Nonlinearity : Chaos, Phase Transitions, Topology Change and Path Integrals
The book starts with a textbook-like expose on nonlinear dynamics, attractors and chaos, both temporal and spatio-temporal, including modern techniques of chaos–control. Chapter 2 turns to the edge of chaos, in the form of phase transitions (equilibrium and non-equilibrium, oscillatory, fractal and noise-induced), as well as the related field of synergetics. While the natural stage for linear dynamics comprises of flat, Euclidean geometry (with the corresponding calculation tools from linear algebra and analysis), the natural stage for nonlinear dynamics is curved, Riemannian geometry (with the corresponding tools from nonlinear, tensor algebra and analysis). The extreme nonlinearity – chaos – corresponds to the topology change of this curved geometrical stage, usually called configuration manifold. Chapter 3 elaborates on geometry and topology change in relation with complex nonlinearity and chaos. Chapter 4 develops general nonlinear dynamics, continuous and discrete, deterministic and stochastic, in the unique form of path integrals and their action-amplitude formalism.
Complex Effects in Large Eddy Simulations
This volume contains a collection of expert views on the state of the art in Large Eddy Simulation (LES) and its application to complex ?ows. Much of the material in this volume was inspired by contributions that were originally presented at the symposium on Complex E?ects in Large Eddy Simulation held in Lemesos (Limassol), Cyprus, between September 21st and 24th, 2005.
Classical Nucleation Theory in Multicomponent Systems
Nucleation is the initial step of every first-order phase transition, and most phase transitions encountered both in everyday life and industrial processes are of the first-order. Using an elegant classical theory based on thermodynamics and kinetics, this book provides a fully detailed picture of multi-component nucleation. As many of the issues concerning multi-component nucleation theory have been solved during the last 10-15 years, it also thoroughly integrates both fundamental theory with recent advances presented in the literature. It covered are: the basic relevant thermodynamics and statistical physics; modelling a molecular cluster as a spherical liquid droplet; predicting the size and composition of the nucleating critical clusters; kinetic models for cluster growth and decay; calculating nucleation rates; and a full derivation and application of nucleation theorems that can be used to extract microscopic cluster properties from nucleation rate measurements.
