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Analyzing T cell responses : How to analyze cellular immune responses against tumor associated antigens
Active specific immunotherapy is a promising but investigational modality in the management of cancer patients. Currently, several different cancer vaccine formulations such as peptides, proteins, antigen-pulsed dendritic cells, whole tumor cells, etc. in combination with various adjuvants and carriers are being evaluated in clinical trials (1-3). To determine the optimal cancer
Alternative Splicing and Disease
Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.
Agrobacterium : From Biology to Biotechnology
Agrobacterium’ is a comprehensive book on Agrobacterium research, including its history, application, basic biology discoveries, and effects on human society. Although the book largely focuses on providing a detailed review of virtually all molecular events of the genetic transformation process, it also provides coverage of ethical and legal issues relevant to the use of Agrobacterium as a "genetic transformation machine". The result is an all-inclusive text which readers—including scientists and students involved in plant genetic engineering—will find useful as a reference source for all major aspects of the Agrobacterium-mediated genetic transformation of plant and non-plant organisms.
Advances in Alzheimer’s and Parkinson’s Disease : Insights, Progress, and Perspectives
Proceedings of the 7th International Conference on Alzheimer’s Disease and Parkinson’s Disease (ADPD), held March 9-13, 2005 in Sorrento, Italy.The subject matter of the ADPD conferences is unique in that it deals not only with issues related individually to Alzheimer’s disease and Parkinson’s disease, but also with the integration of these and other related diseases. The most up-to-date techniques and research findings are illustrated in this volume, covering topics such as immunology, neuroscience, pharmacology, genetics, molecular biology, biochemistry and the history, epidemiology, clinical phenomenology, diagnosis, imaging, treatment ,and future perspectives of Alzheimer’s and Parkinson’s Diseases.
Acute Myelogenous Leukemia
The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. Bringing together new concepts and findings in the basic and clinical science of AML, the book emphasizes the molecular basis for new therapies that stand to have the greatest potential impact on the clinical face of these diseases. The text provides insights into selected novel strategies currently and prospectively being developed, including interruption of specific signal transduction pathways, modulation of gene expression, attempts to reinstate differentiation, and immunomodulation.
Actin-Binding Proteins and Disease
This volume, written by experts in the field, is the first to deal with the relationship between human disease and the actin cytoskeleton. It provides overviews of actin and selected actin-binding proteins, and then focuses on diseases that involve these proteins. Specific chapters deal with actin, cofilin, profilin, gelsolin and thymosin ¾4. Other chapters discuss the roles of multiple actin-binding proteins in cancer and metastasis, leukocyte disorders, and heart failure, and there is a chapter that describes how intracellular pathogens use the host actin cytoskeleton. This seminal volume is intended for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
About Life : Concepts in Modern Biology
This book uses modern biological knowledge to tackle the question: "What distinguishes living organisms from the non-living world?" In the first few chapters, the authors draw on recent advances in cell and molecular biology to develop an account of the "living state" that applies to all organisms, but only to organisms. Subsequent chapters use this account to explore questions about evolution, the origin of life and the possibility of extraterrestrial life. Towards the end of the book the authors consider human evolution, intelligence and the extent to which our species can be regarded as biologically unique. About Life is written as far as possible in non-technical language; all scientific terms are explained straightforwardly when they are introduced. It is aimed at the general, non-specialist reader, but the novel approach that it takes to general issues in biology will also interest students of the life sciences.
Abiotic Stress Tolerance in Plants : Toward the Improvement of Global Environment and Food
Stresses in plants caused by salt, drought, temperature, oxygen, and toxic compounds are the principal reason for reduction in crop yield. For example, high salinity in soils accounts for large decline in the yield of a wide variety of crops world over; ~1000 million ha of land is affected by soil salinity. Increased sunlight leads to the generation of reactive oxygen species, which damage the plant cells. The threat of global environment change makes it increasingly demanding to generate crop plants that could withstand such harsh conditions. Much progress has been made in the identification and characterization of the mechanisms that allow plants to tolerate abiotic stresses.
Abeta Peptide and Alzheimers Disease : Celebrating a Century of Research
Abeta Peptide and Alzheimer’s Disease summarizes current knowledge of beta-amyloid peptide (Aß) and its role as the major culprit in Alzheimer’s Disease (AD), shown by recent advances in genetics and brain biochemistry.the book covers fundamental biochemical studies on the Aß peptide, the genetic impact on Aß expression and processing, and various AD therapeutic strategies that target Aß. Although specifically focusing on Aß and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases.
Linked Democracy : Foundations, Tools, and Applications
This book shows the factors linking information flow, social intelligence, rights management and modelling with epistemic democracy, offering licensed linked data along with information about the rights involved. This model of democracy for the web of data brings new challenges for the social organisation of knowledge, collective innovation, and the coordination of actions. Licensed linked data, licensed linguistic linked data, right expression languages, semantic web regulatory models, electronic institutions, artificial socio-cognitive systems are examples of regulatory and institutional design (regulations by design). The web has been massively populated with both data and services, and semantically structured data, the linked data cloud, facilitates and fosters human-machine interaction. Linked data aims to create ecosystems to make it possible to browse, discover, exploit and reuse data sets for applications. Rights Expression Languages semi-automatically regulate the use and reuse of content.
Law, surveillance and the humanities
Explores key issues such as the use and legitimacy of surveillance to address a global health crisis, the role of surveillance in the experience of indigenous peoples in post-colonial societies, how surveillance interacts with gender, race, ethnicity, and social class, and the interaction between technology, surveillance, and changing attitudes to expression. how philosophy and sociology can help to correct biases and law and politics can offer new approaches to the legitimacy, use and implications of surveillance.
Machine Learning in Computer Vision
The goal of this book is to address the use of several important machine learning techniques into computer vision applications. An innovative combination of computer vision and machine learning techniques has the promise of advancing the field of computer vision, which contributes to better understanding of complex real-world applications. The effective usage of machine learning technology in real-world computer vision problems requires understanding the domain of application, abstraction of a learning problem from a given computer vision task, and the selection of appropriate representations for the learnable (input) and learned (internal) entities of the system. In this book, we address all these important aspects from a new perspective: that the key element in the current computer revolution is the use of machine learning to capture the variations in visual appearance, rather than having the designer of the model accomplish this. As a bonus, models learned from large datasets are likely to be more robust and more realistic than the brittle all-design models.
Linear Genetic Programming
Linear Genetic Programming examines the evolution of imperative computer programs written as linear sequences of instructions. In contrast to functional expressions or syntax trees used in traditional Genetic Programming (GP), Linear Genetic Programming (LGP) employs a linear program structure as genetic material whose primary characteristics are exploited to achieve acceleration of both execution time and evolutionary progress.
Knowledge Representation and the Semantics of Natural Language
This book presents a method for the semantic representation of natural l- guage expressions (texts, sentences, phrases, etc. ) which can be used as a u- versal knowledge representation paradigm in the human sciences, like lingu- tics, cognitive psychology, or philosophy of language, as well as in com- tational linguistics and in arti?cial intelligence. It is also an attempt to close the gap between these disciplines, which to a large extent are still working separately.
Computation Engineering : Applied Automata Theory and Logic
This book covers automata in depth, providing good intuitions along the way, and culminating with applications that are used every day in the field. In this respect, it is a departure from the conventional textbooks on complexity and computability, although these 'tradtional' aspects remain well represented.
Blog Design Solutions
In this book, a team of renowned web designers take you through the ins and outs of putting together great blogs. They waste no time harking on about the philosophy of blogs, or the community behind them. Instead, they get straight to the practical details, showing how to set up a basic blog in some of the world's most popular blogging engines Movable Type, ExpressionEngine, WordPress, and Textpattern. With your blog set up, they then show you how to build great looking, usable layouts for your blog. The last chapter even shows you how to build your very own PHP/MySQL-based blog engine!
Bioinformatics research and development ; 2nd International Conference, BIRD 2008 Vienna, Austria, July 7-9, 2008 Proceedings
This book constitutes the refereed proceedings of the Second International Bioinformatics Research and Development Conference, BIRD 2008, held in Vienna, Austria in July 2008.
Beginning Java 17 Fundamentals : Object-Oriented Programming in Java 17
Learn the fundamentals of the Java 17 LTS or Java Standard Edition version 17 Long Term Support release, including basic programming concepts and the object-oriented fundamentals necessary at all levels of Java development. You will: Write your first Java programs with emphasis on learning object-oriented programming / How to work with switch expressions, value types (records), local variable type inference, pattern matching switch and more from Java 17 / Handle exceptions, assertions, strings and dates, and object formatting / Learn about how to define and use modules / Dive in depth into classes, interfaces, and inheritance in Java / Use regular expressions / Take advantage of the JShell REPL tool
Analysis and Modelling of Faces and Gestures ; 2nd International workshop, AMFG 2005, Beijing, China, October 16, 2005, Proceedings
During the last 30 years, face recognition and related problems such as face detection/tracking and facial expression recognition have attracted researchers from both the engineering and psychology communities. In addition, extensive research has been carried out to study hand and body gestures. The understanding of how humans perceive these important cues has significant scientific value and extensive applications. this one-day workshop (AMFG 2005) provided a focused international forum to bring together well-known researchers and research groups to review the status of recognition, analysis and modeling of faces and gestures, to discuss the challenges that we are facing, and to explore future directions. Overall, 30 papers were selected from 90 submitted manuscripts. The topics of these papers range from feature representation, robust recognition, learning, and 3D modeling to psychology.
Advertising culture and translation : From colonial to global
A first comprehensive study combining and integrating advertising, culture and translation within the framework of colonial, Commonwealth, and postcolonial studies, and globalization. It addresses a number of controversial issues evident in two relatively young disciplines, as a result of decades of research and teaching in university courses. A cross-cultural approach to translational issues and the translatability of advertising cohesively is adopted here, exploring the dynamics of the conflict between the 'centre' and the 'periphery'. It introduces the concept of advertising English as lingua franca (AELF), marking new trends in the domain of varieties of English around the world (VEAW). The data examined here show the ambivalent polarity conditioning advertising and translation: both have been mutually exclusive, and both have been subject to bans, censorship and ideological control, racism, propaganda, and stereotyping. In their fundamental principles and concepts of theories and applications, however, neither discipline cannot exist outside a free market and total freedom of expression and trust
