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Imaging in Drug Discovery and Early Clinical Trials
Efficient tools for the selection and validation of drug targets both at the preclinical and clinical level are required. Non-invasive imaging and in particular molecular imaging methods are becoming essential technologies to support drug discovery and dvelopment. Imaging provides structural, functional, metabolic and molecular readouts that are being applied to characterize a disease phenotype (diagnosis), to elucidate molecular mechanisms involved, to evaluate drug efficacy and safety, and to identify potential biomarkers of the drug's mechanism-of-action, efficacy and safety. Non-invasive imaging techniques constitute a bridge between preclinical and clinical drug evaluation. In this monograph the contribution of imaging modalities to the various stages of drug discovery and development, from early target validation to their use in clinical development programs, is described. Chapters are devoted to the description of the drug discovery process as such, to the various imaging modalities being used both preclinically and clinically, to applications of imaging during the optimization of a lead compound (addressing issues such as bioavailability and efficacy) and during the drug safety evaluation.
Imaging for Detection and Identification
The dynamic interaction between world-renowned scientists from the usually disparate communities of pure mathematicians and applied sci- tists which occurred at our seven previous ASI’s continued at this meeting. The fusion of basic ideas in mathematics, radar, sonar, biology, and ch- istry with ongoing improvements in hardware and computation offers the promise of much more sophisticated and accurate detection and identi?cation capabilities than currently exist. Coupled with the dramatic rise in the need for surveillance in innumerable aspects of our daily lives, brought about by hostile acts deemed unimaginable only a few short years ago, the time is ripe for image processing scientists in these usually diverse ?elds to join together in a concerted effort to combat the new brands of terrorism. This ASI was one important initial step.
Imaging del rachide : Il vecchio e il nuovo = Spine Imaging: The Old and the New
The vertebral column represents the anatomical district most subjected to diagnostic imaging investigations and, in this field, much of the "old" still retains its relevance. The volume fits into this context as a valid professional refresher tool aimed at the radiologist, but is also a useful reference work for the orthopedist, rheumatologist and physiatrist.
Imaging Cellular and Molecular Biological Functions
Imaging cellular and molecular biological function’ provides a unique selection of essays by leading experts, aiming at scientist and student alike who are interested in all aspects of modern imaging, from its application and up-scaling to its development. Indeed the philosophy of this volume is to provide student, researcher, PI, professional or provost the means to enter this applications field with confidence, and to construct the means to answer their own specific questions.
Imaging Beyond the Pinhole Camera
The world's first photograph was taken in 1826 using a pinhole camera called camera obscura. Cameras used since then are basically following the pinhole camera principle. This book looks at the development as well as the applications of alternative camera architectures.
Imaging Atlas of the Pelvic Floor and Anorectal Diseases
The goal of Imaging Atlas of the Pelvic Floor and Anorectal Diseases is to clearly and precisely present indications, techniques, limitations, sources of errors, and pitfalls of these imaging modalities.
Imagination and Rigor : Essays on Eduardo R. Caianiello's Scientific Heritage
The aim of this Volume of scientific essays is twofold. From one side, by remembering the scientific figure of Eduardo R. Caianiello, it aims at focusing his outstanding contributions - from theoretical physics to cybernetics - which after so many years still represent occasion of innovative paths to be fruitfully followed. It must be stressed the contribution that his interdisciplinary methodology can still be of great help in affording and solving present day complex problems. On the other side, it aims at pinpointing with the help of the scientists contributing to the Volume - some crucial problems in present day research in the fields of interest of Eduardo Caianiello and which are still among the main lines of investigation of some of the Istitutes founded by Eduardo (Istituto di Cibernetica del CNR, IIAS, etc).
Images, Representations and Heritage : Moving beyond Modern Approaches to Archaeology
Recent archaeological theory has show that images of the past have carried a particularly strong resonance within modern social groups. This volume explores the immeasurable impact that the phenomenon of archaeology has had on the representation of the past in the modern world. Modern society’s ‘archaeological imagination’ conceives of archaeology as a producer of images of the past which become representations of modern group identities. If archaeology is utilized by public groups to construct and represent identities, then what are archaeologists to do with that public? The very fact that the public is interested in the past and in archaeological research is an opportunity for archaeology to engage that public.
Image-Guided Interventions : Technology and Applications
Responding to the growing demand for minimally invasive procedures, Image-Guided Interventions: Technology and Applications provides a cohesive overview of the current technological advances in image-guided surgery, and their applications in the clinical environment.
Image-Guided IMRT
Intensity-modulated radiation therapy (IMRT), one of the most important developments in radiation oncology in the past 25 years, involves technology to deliver radiation to tumors in the right location, quantity and time. Unavoidable irradiation of surrounding normal tissues is distributed so as to preserve their function. The achievements and future directions in the field are grouped in the three sections of the book, each suitable for supporting a teaching course.
Image-Based Rendering
Image-based rendering (IBR) refers to a collection of techniques and representations that allows 3D scenes and objects to be visualized in a realistic way without full 3D model reconstruction. The potential for photorealistic visualization has tremendous appeal, especially for applications such as video games, virtual travel, and E-commerce, which stand to greatly benefit from this technology.
Image recognition : progress, trends and challenges
Focuses on research trends in image processing and recognition and corresponding developments. Among them, the book focuses on recent research, especially in the field of advanced human-computer interaction and intelligent computing. Given the existing interaction and recognition of the station, some novel topics are proposed, including how to establish a cognitive model in human-computer interaction and how to express and transfer human knowledge into human-machine image recognition. In an interactive implementation, how to implement user experience through image recognition during machine interaction
Image Processing Using Pulse-Coupled Neural Networks
This is the first book to explain and demonstrate the tremendous ability of Pulse-Coupled Neural Networks (PCNNs) when applied to the field of image processing. PCNNs and their derivatives are biologically inspired models that are powerful tools for extracting texture, segments, and edges from images.
Image Processing in Radiology : Current Applications
Few fields have witnessed such impressive advances as image processing in radiology. The progress achieved has revolutionized diagnosis and greatly facilitated treatment selection and accurate planning of procedures. This book provides a comprehensive and up-to-date description of how to use 2D and 3D processing tools in clinical radiology.
Image processing based on partial differential equations ; Proceedings of the International Conference on PDE-Based Image Processing and Related Inverse Problems, CMA, Oslo, August 8-12, 2005
The book contains twenty-two original scienti?c research articles that address the state-of-the-art in using partial di?erential equations for image and signal processing. The articles arose from presentations given at the inter- tional conference on PDE-Based Image Processing and Related Inverse Pr- lems, held at the Centre of Mathematics for Applications, University of Oslo, Norway, August 8-12, 2005.
Image and video retrieval ; Vol. 3568 ; 4th International conference, CIVR 2005, Singapore, July 20-22, 2005, Proceedings
It was our great pleasure to host the 4th International Conference on Image and Video Retrieval (CIVR) at the National University of Singapore on 20–22 July 2005. CIVR aims to provide an international forum for the discussion of research challenges and exchange of ideas among researchers and practitioners in image/video retrieval technologies. It addresses innovative research in the broad ?eld of image and video retrieval. A unique feature of this conference is the high level of participation by researchers from both academia and industry. Another unique feature of CIVR this year was in its format – it o?ered both the traditional oral presentation sessions, as well as the short presentation cum poster sessions. The latter provided an informal alternative forum for animated discussions and exchanges of ideas among the participants.After a rigorous review process, 20 papers were accepted for oral presentations, and 42 papers were accepted for poster presentations. In addition to the accepted submitted papers, the program also included 4 invited papers, 1 keynote industrial paper, and 4 invited industrial papers. Altogether, we o?ered a diverse and interesting program, addressing the current interests and future trends in this area.
Image and video retrieval ; Vol. 4071 ; 5th Internatinoal Conference, CIVR 2006, Tempe, AZ, USA, July 13-15, 2006, Proceedings
This volume contains the proceeding of the 5th International Conference on - age and Video Retrieval (CIVR), July 13–15, 2006, Arizona State University, Tempe, AZ, USA: http://www. civr2006. org. Image and video retrieval cont- ues to be one of the most exciting and fast-growing research areas in the ?eld of multimedia technology. However, opportunities for exchanging ideas between researchers and users of image and video retrieval systems are still limited.
Image and video encryption : From digital rights management to secured personal communication
Image and Video Encryption provides a unified overview of techniques for encryption of images and video data. This ranges from commercial applications like DVD or DVB to more research oriented topics and recently published material. This volume introduces different techniques from unified viewpoint, then evaluates these techniques with respect to their respective properties (e.g., security, speed.....). Encryption of visual data is an important topic in the area of mutimedia security, applications range from digital rights management (DVD, DVB) ) to secure personal communications. Within this topic area, we face several aims which contradict each other. What we thrive on is good compression, fast compression, high security, fast encryption, bitstream compliance, little power consumption and little memory requirements. The authors experimentally compare different approaches proposed in the literature and include an extensive bibliography of corresponding published material. Image and Video Encryption is designed for a professional audience composed of researchers and practitioners in industry. The book is also suitable for graduate-level students in computer science and electrical engineering.
Image and Signal Processing ; 3rd International Conference, ICISP 2008. Cherbourg-Octeville, France, July 1 - 3, 2008. Proceedings
This book constitutes the refereed proceedings of the Third International Conference on Image and Signal Processing, ICISP 2008, held in Cherbourg-Octeville, France, in July 2008.The 48 revised full papers and 22 revised poster papers presented were carefully reviewed and selected from 193 submissions. The papers are organized in topical sections on image filtering, image segmentation, computer vision, feature extraction, pattern recognition, graph-based representations, motion detection and estimation, new interfaces, document processing, and signal processing.
Image Analysis, Sediments and Paleoenvironments
This seventh volume of the DPER series examines imaging techniques for sedimentologists, paleolimnologists, paleoceanographers and microscopists working on issues related to paleoenvironmental reconstruction. It will help the researcher or graduate student to understand every step involved in the imaging process, from image acquisition to measurements.nbsp; Procedures are described to ensure that the right protocols and methodology are selected to solve a particular issue, and to evaluate the validity of scientific results. Case studies illustrate the wide range of information that can be obtained from many kinds of sediments (marine, lacustrine and aeolian) and different types of samples (cores, embedded blocks, microscopic slides) using different regions of the electromagnetic spectrum (visible, UV, IR, X-ray). The volume provides comprehensive protocols, guidelines, and recommendations for the use of low cost image analysis techniques, to facilitate intercomparisons of measurements.
