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Nicotinic Acetylcholine Receptor Signaling in Neuroprotection
Presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.
New Trends of Surgery for Cerebral Stroke and its Perioperative Management
In July 2004 specialists in neurosurgery, neuroradiology, neurology and neurointensive care discussed recent trends at the 2nd Swiss Japanese Joint Conference on Cerebral Stroke Surgery, held in Zurich, Switzerland. New concepts were worked out during the conference and are published in this volume. The book starts with the topic intracranial aneurysms, discussing microsurgical and endovascular treatment modalities, as well as new surgical approaches. Further chapters deal with the management of unruptured aneurysms and with subarachnoid hemorrhage. Practical guidelines for vasospasm treatment are given. Together with contributions about arteriovenous malformations and fistulas, cerebral revascularization techniques and surgery related to the intracranial venous system a comprehensive overview about stroke surgery is given with an interdisciplinary approach. The book will be of interest for all specialists involved in therapy of cerebrovascular disease.
Neuropathology Review
The scope of neuropathology continues to expand, as evidenced by increasing numbers of multivolume and specialty texts, which have been published in recent years. For those in the neuroscience disciplines, the ever increasing amount of information one needs to assimilate and master can be challenging and even at times daunting. As with the first edition, this second edition of Neuropathology Review summarizes, in outline form, the essentials of neuropathology. The objective is twofold: 1) to provide an overview of neuropathology for those initially encountering the discipline and, 2) to provide a framework for review for those preparing for in-service and board examinations in the disciplines of neurology, neurosurgery and pathology, which require some knowledge of neuropathology.
Neuromuscular Disease : Evidence and Analysis in Clinical Neurology
Through a series of questions and answers concerning specific neuromuscular disorders, each chapter critiques the best available evidence to illustrate strengths and weaknesses of the data and make the reader aware of the quality of clinical research studies in general. Introductory chapters facilitate this learning process by elucidating the epidemiological and biostatistical issues pertinent to diagnosis, treatment, and prognosis. A broad range of disorders of the anterior horn cell, nerve roots, peripheral nerves, neuromuscular junction, and muscle are critically appraised and discussed.
Neurology Study Guide : Oral Board Examination Review
The book is divided into two parts. Part 1 is devoted to practical tips on the exam’s structure, its etiquette and preparation. Particular emphasis is placed on reasons for failing the exam. Part 2 provides sample adult and pediatric vignettes, mirroring that part of the oral Board. Each vignette is presented in a format similar to the exam’s format. Each case provides a differential diagnosis, most likely diagnosis and treatment recommendations. Where relevant, potential pitfalls, do’s and don’ts, musts and shoulds and frequently asked questions, complement the case discussion.
Neurology Oral Boards Review : A Concise and Systematic Approach to Clinical Practice
Rapid recall of vast amounts of factual material is the key to success in both the Neurology Oral Board examination and in everyday patient care. In Neurology Oral Boards Review: A Concise and Systematic Approach to Clinical Practice, Eroboghene E. Ubogu offers a comprehensive review of relevant topics and examination strategies needed to pass the American Board of Psychiatry and Neurology (ABPN) Part II (Oral) exam, complete with up-to-date, evidence-based guidelines on diagnosis and management in clinical neurology. The author has written the book specifically to satisfy the requirements of the ABPN, with clinical case vignettes designed to allow the examinee to localize the plausible disease process, to indicate which investigations may help in establishing a diagnosis, to deduce treatment plans, and to make a prognosis, including patient and family counseling. The emergency cases test the ability to think critically when faced with a neurological emergency, putting a premium on resuscitation, patient safety, and rapid high-yield investigations. The general neurology cases reflect the breadth of disorders experienced in hospital and outpatient settings. The author also provides a detailed description of the oral ABPN examination and suggests a study regimen that takes into account the difficulties of allotting time to prepare while in post-residency training or practice.
Neurodevelopmental Disorders
The book comprises a number of topics related to psychosocial and motor development and is exemplary with regard to its comprehensiveness, as reviews of the topics presented are generally not available in a single publication. It starts with a timely and critical discussion of the genetics of attention deficit hyperactivity disorder by Dr. Buitelaar in which prospects and challenges of this approach are outlined. The next chapter by Drs. Nicolson and Fawcett deals with dyslexia and its relationship to cerebellar function providing a framework that can explain motor, speed, and phonological deficits in a unified approach. Diagnostic and treatment aspects of speech development disorders are the focus of Dr. Zorowka’s contribution in which, among other issues, the necessity of mul- professional cooperation is stressed. Dr. Sigmundsson then focuses on disorders of motor development. 6-10 % of children have motor competence well below the norm, which often persist.
Neuroanatomy for the Neuroscientist
Neurology, more than any other system of medicine, is rooted in the firm knowledge of basic science material (i.e., the anatomy, physiology, and pathology of the nervous system). This material enables students to readily arrive at diagnoses and to apply their knowledge at solving problems in clinical situations. Neuroanatomy for the Neuroscientist gives neuroscientists the tools to teach this material at levels appropriate for students at several levels of study, including undergraduate, graduate, dental, and medical school. The text also provides an updated approach to lesion localization in neurology, utilizing the techniques of computerized axial tomography (CT scanning), magnetic resonance imaging (MRI), and magnetic resonance angiography (MRA). Multiple illustrations demonstrating the value of these techniques in clinical neurology and neuroanatomical localization has been provided.
Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders : Novel Strategies for Research and Treatment
Over the past few decades the involvement of neurosteroids in brain function and mental health has attracted much interest, not only from a neuroscience perspective, but also from clinical and therapeutic aspects. In recent years, much of the research has focused on the multifunctional position of neurosteroids in the nervous system. The areas that have been explored, in particular, are the cellular and molecular mechanisms involved in the activity of neurosteroids in the brain, the role of neurosteroids in brain development, neurodegeneration and neuroplasticity, and their pharmacological properties. The large increase in the number of publications highlights this amplified interest in neurosteroids. Over the last 7 years at least 400 papers have been published describing the putative role of neurosteroids in the modulation of basic brain function and in the etiology and treatment of psychiatric and neurological disorders.
Neonatal Pain : Suffering, Pain and Risk of Brain Damage in the Fetus and Newborn
Until the 1980s it was denied that fetuses and neonates feel pain. With the advent of a deeper understanding of the pathophysiology and new diagnostic tools, the last 30 years have seen great developments in this field. This volume aims to give an overview of current knowledge in the field.
Molecular Pain
This book focus on molecular and synaptic mechanisms for pain transmission, modulation and plasticity. Unlike traditional textbooks about pain, this book covers recent progress in neuroscience and relates these developments to the basic mechanisms of chronic pain. The book also discusses current pain medicine and alternative pain treatments such as acupuncture.
Mitochondrial Medicine : Mitochondrial Metabolism, Diseases, Diagnosis and Therapy
Mitochondrial Medicine is a relatively new area where several disciplines from basic science to clinical medicine converge. Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation.
Micro-, Meso- and Macro-Dynamics of the Brain
This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The topics cover the most fascinating facets of neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory and mental illness, brain controlled robots, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Overall, this volume offers an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.
Micro-, Meso- and Macro-Connectomics of the Brain
Highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.
Metabolism and Functions of Bioactive Ether Lipids in the Brain
This book will be particularly useful to neuroscience graduate students, academics, and researchers. Clinicians will find this book useful for understanding molecular aspects of neurodegeneration in acute neural trauma and neurodegenerative diseases that are mediated by plamalogen-selective phospholipases A2 and PAF acetyl hydrolases. This monograph is the first to provide a comprehensive description of not only metabolism and role of plasmalogen and platelet activating factor in brain tissue but also the involvement of these lipids with abnormal signal transduction processes in neurological disorders.
Intracranial vascular malformations and aneurysms : From diagnostic work-up to endovascular therapy ; 2nd ed.
This book describes the pathoanatomical, pathophysiological, and imaging features of vascular malformations and aneurysms of the brain and the modern, minimally invasive endovascular methods and techniques employed in their treatment.
Integrative Pain Medicine : The Science and Practice of Complementary and Alternative Medicine in Pain Management
This important book fills a need in the developing area of Pain Medicine, providing physicians with an up-to-date resource that would detail the current understanding about the basic science underlying the mechanism of action of the various CAM therapies used for pain, summarizing the clinical evidence both for efficacy and safety, and then end with practical guidelines about how such treatments could be successfully and safely integrated into a Pain practice.
I disturbi della consapevolezza nelle malattie neuropsichiatriche = Disturbances of awareness in neuropsychiatric diseases
Aims to outline the set of current international knowledge on disease awareness in various neuropsychiatric conditions (hemiplegia resulting from brain damage, psychosis, dementia and mood disorders), with particular reference to anosognosia and 'insight. The comparison between different conceptualizations and the variety of clinical manifestations gives rise to a very complex picture that requires a multidimensional approach, especially as regards the diagnostic moment. To this end, the authors propose an integration of various contributions on the pathogenetic level, based on neuroanatomical evidence and supported by the most recent neuroimaging techniques. In addition, the use of a complex diagnostic battery is suggested, capable of analyzing the different aspects of the phenomenon, and distinguishing it from the psychological defensive mechanism of denial. Research in this field is also essential to promote rehabilitation and compliance with treatment, as well as the enrichment of knowledge on the processes underlying consciousness and awareness in the human being.
Hughes Syndrome : Antiphospholipid Syndrome
The second edition of Hughes Syndrome: Antiphospholipid Syndrome addresses the complete range of conditions produced by this common disorder which is also known as APS or "sticky blood" syndrome. APS is one of the main causes of strokes (40%), leg deep vein thrombosis, and recurrent miscarriages in women.
Head and Neck Cancer Imaging ; 3rd ed.
This book is a comprehensive guide to imaging as a crucial part of the multidisciplinary approach to head and neck cancer management. Readers will find a detailed overview of the findings obtained using different imaging techniques during the evaluation of head and neck neoplasms, both before and after therapy. All anatomic areas in the head and neck are covered, and the impact of imaging on patient management is discussed in detail. Full account is taken of the rapid technological developments of recent years, with explanation of the potential applications, limitations, and advantages of existing and evolving imaging technologies – vital knowledge for all members of the multidisciplinary team. The authors are recognized experts in the field, and numerous high-quality images are included. This third edition includes information on the latest imaging developments in this area as well as the most recent staging classification of head and neck cancer.
