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Managing Failed Anti-Reflux Therapy
This multiauthored text provides information on the pathophysiology of GERD, appropriate medical management, and proper indications for and performance of surgical and endoscopic procedures for GERD. Thousands of patients will experience inadequate relief from medical therapy or will develop complications from their procedures or recurrent or new symptoms afterwards; this text describes in detail the proper evaluation and management of such patients.
Lung biology and pathophysiology
The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas exchange. In addition to lung structural cells, immune cells, including alveolar macrophages and lymphocytes play critical roles in the maintenance of lung function. This book contributes to the understanding homeostasis of lung cells in the physiological and pathological conditions critical to the development of novel therapeutics.
Les thérapies ciblées = Targeted therapies
We are at the start of the development of new therapeutic classes, directed against new molecular targets (EGFR, VEGF, IGFR, Rank, etc.) Several diseases such as kidney, colon or breast cancer, GIST, have a natural history now modified thanks to these therapies. This practical book takes stock of the current use of these molecules.
Les douleurs abdominales en questions : Rôle physiopathologique de la sensibilité viscérale = Abdominal pain in question : The pathophysiological role of visceral sensitivity
The gut-brain axis refers to the network of nerve pathways that connect the myenteric plexus, the veritable "gut brain," to the central nervous system. Nearly 80% of these neurons are sensory neurons, and the afferent pathways that transmit information from the digestive tract to the central nervous system play a crucial role in the physiological regulation of digestive functions, as well as in certain pathological conditions. A large majority of these sensations remain unconscious and give rise to reflex responses. Only those requiring a conscious response reach the level of awareness in a normal state (hunger, thirst, the urge to defecate). In pathological situations, the same is true for painful sensations of digestive origin. Functional bowel disorders are a frequent reason for consultation. Their pathophysiology is now based on a model integrating the various etiological factors around the brain-gut axis. These patients frequently present with visceral hypersensitivity, which manifests as an increased perception of digestive sensations, notably the onset of pain in response to stimuli that are not painful in normal subjects. Recognizing the role of visceral hypersensitivity has made it possible to explain the mechanism of action of medications used to treat functional bowel disorders and paves the way for the development of new molecules acting on digestive afferents. In this book, we will describe the anatomical and physiological basis for understanding the concept of visceral sensitivity and the role of digestive afferents in the pathophysiology of acute and chronic abdominal pain, particularly irritable bowel syndrome.
Le dépistage du cancer colorectal : État des lieux et perspectives = Colorectal cancer screening: Current status and perspectives
Prevention and screening are two major challenges for Public Health to reduce cancer mortality in our country. Screening for colorectal cancer is therefore quite exemplary. The number one cancer in both sexes in France, its incidence continues to increase due to the aging of the population. Its mortality remains high, in the order of fifty percent, despite the major therapeutic advances made in recent years. Preceded by a precancerous lesion - the adenomatous polyp, which can be removed by colonoscopy - colorectal cancer is also curable at the early stage. Finally, it can be the subject of a screening strategy, the impact of which has been demonstrated today on the reduction in mortality, when it is detected before any symptom by a simple test for blood in the stool followed by , in case of positivity, by a total colonoscopy. This book takes stock of the scientific rationale and the state of play of organized colorectal cancer screening in France. It is also an opportunity to discuss emerging techniques and strategies that can help improve the results of this screening if they prove their superiority over the current strategy. Intended primarily for doctors, this book is also intended for healthcare professionals and all those who, concerned about their health, have a proactive attitude in terms of screening and preventing this cancer.
Lamto : Structure, Functioning, and Dynamics of a Savanna Ecosystem
Known as "a dream place for scientists," the Lamto savannas, located on the edge of the Cote d'Ivoire rain forests, are one of the only savannas in the world where ongoing ecological research has endured for more than forty years. Drawing from and synthesizing this abundance of research, the book examines the structure, functioning, and dynamics of the Lamto humid savanna. Beginning with the history of the Lamto ecology station and an overview of the major environmental conditions of the site, this exacting work specifically examines the integrative view of energy and nutrient fluxes relative to the dynamics of the savanna's vegetation.
Carbon and nitrogen in the terrestrial environment
Carbon and Nitrogen in the Terrestrial Environment is a comprehensive, interdisciplinary description of C and N fluxes between the atmosphere and the terrestrial biosphere; issues related to C and N management in different ecosystems and their implications for the environment and global climate change; and the approaches to mitigate emission of greenhouse gases.Drawing upon the most up-to-date books, journals, bulletins, reports, symposia proceedings and internet sources documenting interrelationships between different aspects of C and N cycling in the terrestrial environment, Carbon and Nitrogen in the Terrestrial Environment fills the gap left by most of the currently available books on C and N cycling. They either deal with a single element of an ecosystem, or are related to one or a few selected aspects like soil organic matter (SOM) and agricultural or forest management, emission of greenhouse gases, global climate change or modeling of SOM dynamics.
Cancer du sujet âgé = Cancer in the elderly
Etablir un diagnostic précoce, définir une stratégie adaptée et offrir une meilleure qualité de vie chez le sujet âgé atteint de cancer constituent les défis de l’Oncologie de ce début de siècle. Cet ouvrage a pour objectif de proposer aux médecins et aux étudiants un condensé des différents aspects de l’oncologie sur le sujet âgé. Dans une première partie, les aspects épidémiologiques et biologiques ainsi que l’évaluation gériatrique multiparamétrique sont abordés. Les particularités de l’application de la chimiothérapie, de la radiothérapie et de la chirurgie au sujet âgé sont passées en revue. Dans une troisième partie, la stratégie thérapeutique multidisciplinaire est ensuite détaillée par site.
Biomedical applications and toxicity of nanomaterials
Covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of information for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.
Auriculothérapie : Acupuncture auriculaire = Auriculotherapy : Auricular acupuncture
The auricle is a privileged place to observe and treat patients reflexively. It is endowed with both a particularly rich innervation, and brief connections with the higher nervous centers. It constitutes both a reading pavilion, to observe information coming from the organs and nerve endings of the skin, and a control pavilion to help correct abnormal information. It is a lookout post, placed bypassing the brainstem, on the path connecting the organs and the brain. It thus allows a fair control and an effective intervention. In this medical treatise on Auriculotherapy, historical and scientific data, medical explanations and bibliographical references are presented.
Applied Bioinformatics : An Introduction
In this book, anyone who can operate a PC, standard software and the Internet will learn to understand the biological basis of bioinformatics of the existence as well as the source and availability of bioinformatics software how to apply these tools and interpret results with confidence.This is aided by introductory chapters to important aspects of bioinformatics, detailed bioinformatics exercises, including solutions and a glossary of definitions and terminology relating to bioinformatics.
Abord clinique des urgences traumatiques au cabinet du généraliste = Clinical approach to traumatic emergencies in the general practitioner's office
Cet ouvrage a été conçu comme une aide pour le médecin généraliste, confronté quotidiennement à la pathologie traumatique. Les deux auteurs, urgentistes expérimentés, apportent des réponses claires, concises et pratiques aux problèmes que posent les lésions traumatiques. Des gestes simples, un abord clinique détaillé, la nécessité de recourir ou non à des examens complémentaires ou à un avis spécialisé sont ici expliqués et justifiés. Le style est précis, concis, et un lexique complète les définitions et les matériels cités dans le texte. Les auteurs se sont entourés des avis de généralistes et de spécialistes pour définir des conduites à tenir simples et compatibles avec les nécessités du terrain.
Abord clinique des malades de lalcool : En médecine générale = Clinical approach to patients with alcoholism : In general medicine
Les médecins généralistes sont destinataires d’un grand nombre d’informations sur l’alcool, son usage et ses conséquences pathologiques immédiates ou potentielles. Ces connaissances, émanant de médecins le plus souvent hospitaliers et spécialisés, ont conduit à des recommandations destinées à guider les médecins généralistes dans le repérage des malades de l’alcool et leur prise en charge thérapeutique. Cependant, la pertinence et l’applicabilité de la plupart de ces recommandations sont peu ou mal évaluées dans la pratique de la médecine générale. De ce fait, les médecins généralistes, parfois à l’encontre des recommandations, sont amenés à élaborer des concepts et des pratiques propres à leur clientèle et à leurs conditions de travail. L’originalité de ce livre vient de la confrontation des connaissances et des pratiques de deux médecins, soignant des malades de l’alcool dans des structures différentes.
AI and law : How automation is changing the law
Provides insights into how AI is changing legal practice, government processes, and individuals’ access to those processes, encouraging each of us to consider how technological advances are changing the legal system. Particularly, and distinct from current debates on how to regulate AI, this books focuses on how the progressive merger between computational methods and legal rules changes the very structure and application of the law itself.
Logical Aspects of Computational Linguistics ; 5th International Conference, LACL 2005, Bordeaux, France, April 28-30, 2005, Proceedings
Inaugurates the new FoLLI LNAI subline. It constitutes the refereed proceedings of the 5th International Conference on Logical Aspects of Computational Linguistics, LACL 2005, held in Bordeaux, France in April 2005. The 25 revised full papers presented were carefully reviewed and selected from over 40 submissions. The papers address a wide range of logical and formal methods in computational linguistics with studies of particular grammar formalisms and their computational properties, language engineering, and traditional topics about the syntax/semantics interface.
LNA-ESD Co-Design for Fully Integrated CMOS Wireless Receivers
LNA-ESD Co-Design for Fully Integrated CMOS Wireless Receivers fits in the quest for complete CMOS integration of wireless receiver front-ends. With a combined discussion of both RF and ESD performance, it tackles one of the final obstacles on the road to CMOS integration.
Learning network programming with Java
Learn to deliver superior server-to-server communication through the networking channels / Gain expertise of the networking features of your own applications to support various network architectures such as client/server and peer-to-peer Explore the issues that impact scalability, affect security, and allow applications to work in a heterogeneous environment
Knowledge graphs and big data processing
This book is part of the LAMBDA Project (Learning, Applying, Multiplying Big Data Analytics), funded by the European Union, GA No. 809965. Data Analytics involves applying algorithmic processes to derive insights.
Journal on Data Semantics VI
Data warehousing and semantic data mining • Spatial, temporal, multimedia and multimodal semantics • Semantics in data visualization • Semantic services for mobile users • Supporting tools • Applications of semantic-driven approaches These topics are to be understood as speci?cally related to semantic issues. Contributions submitted to the journal and dealing with semantics of data will be considered even if they are not within the topics in the list. While the physical appearanceof the journal issues looks like the books from the well-known Springer LNCS series, the mode of operation is that of a jo- nal. Contributions can be freely submitted by authors and are reviewed by the Editorial Board. Contributions may also be invited, and nevertheless carefully reviewed, as in the case for issues that contain extended versions of best papers from major conferences addressing data semantics issues. Special issues, foc- ing on a speci?c topic, are coordinated by guest editors once the proposal for a special issue is accepted by the Editorial Board.
Beginning Ubuntu Server Administration : From novice to professional
You love it as the world's most popular desktop Linux distribution, and now Ubuntu is available at a server near you. Embracing the very same features desktop users have grown to love, system administrators are rapidly adopting Ubuntu due to their ability to configure, deploy, and manage network services more effectively than ever. Beginning Ubuntu Server Administration guides you through all of the key configuration and administration tasks you'll need to know. Whether you're interested in adopting Ubuntu within a Fortune 500 environment or just want to use Ubuntu to manage your home network, this book is your go–to guide to using the distribution securely for a wide variety of network services. Topics include file, print, web, and FTP management, command–line tips and tricks, automated installation, configuration and deployment processes, and kernel management.
