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Non-Vitamin K Antagonist Oral Anticoagulants : A Concise Guide
An essential guide to the medical treatment of thrombosis and presents core principles of anticoagulant therapeutics as well as drug recommendations. Written by recognized experts in the field, this concise, accessible handbook provides a unique and valuable resource in the cardiovascular field, both for those currently in training, and for those already in clinical or research practice.
New Vision of Metformin in treating cancer
The anti-diabetic drug metformin is rapidly emerging as a potential anticancer agent. Metformin is a biguanide that is effective in treating type 2 diabetes and the insulin resistance syndromes, improves insulin resistance by reducing hepatic gluconeogensis and by enhancing glucose uptake by skeletal muscle. Metformin can reduce the incidence of cancers and can reduce the mortality from cancers, increase the response to treatment cancer cells when using radiotherapy and chemotherapy, reduce the likelihood of relapse. Diabetes can be a factor in the occurrence of various types of cancer, and develop a variety of cancers such as colo-rectal, pancreas and liver cancers, compared to non-diabetic patients. Incidence of various cancers is high among patients of T2DM due to insulin resistance and mitogenic effects caused by hyperglycemia.
Neurocutaneous Disorders : Phakomatoses and Hamartoneoplastic Syndromes
Neurocutaneous diseases are a wide group of conditions that affect the nervous system but appear as lesions of the skin. Some of the more common entities have variable forms of expression that can confuse the diagnosis; for the rare conditions it is difficult to find descriptions in the literature. Recent insights into their cellular, biochemical and molecular genetic bases have shown the essential need for a new nosology and updated genotype-phenotype correlations. The book provides an authoritative source of knowledge about these difficult problems and bridges the gap between clinical recognition and the new molecular medicine. The editors, distinguished clinicians and geneticists, assembled an internationally renowned group of collaborators, many of them the experts who first described a particular disorder or established its present accepted definition.
Neurocutaneous disorders : A clinical, ciagnostic and therapeutic approach
Provides extensive data on the more common and many of the more rare congenital and hereditary syndromes that manifest in the nervous system and skin. Though often complex and multi-systemic, these disorders can frequently be diagnosed using a combination of simple visual inspection and sound clinical expertise. Drawing on fully referenced information from thousands of articles, the international editorial team has prepared a comprehensive overview that includes historical perspectives, clinical features, the pathogenesis, and diagnostic and therapeutic strategies. In addition, it addresses the biochemical, molecular, and genetic basis of the disorders.
Neuroacanthocytosis Syndromes II
Awareness of neuroacanthocytosis disorders has increased significantly in recent years. There have been a number of important developments in the field since the publication of the first volume, Neuroacanthocytosis Syndromes. This book contains the latest research in this area. Recent advances have identified the range of mutations in the causative genes, shedding light on potential phenotypegenotype correlations. Studies of the proteins affected in these disorders have resulted in increased understanding of their functions and distribution. In vitro studies have identified potential protein interactions, which have important implications for pathophysiology. Work on erythrocyte membranes suggests mechanisms for the generation of acanthocytes. Animal models are being generated which will greatly facilitate understanding the role of gene mutations in humans, and provide the foundation for possible therapeutic interventions. In addition, advances in other neurodegenerative disorders, such as Huntington’s and Parkinson’s diseases, have implications for neuroacanthocytosis.
Neuroacanthocytosis Syndromes
Neuroacanthocytosis Syndromes is the first comprehensive review of a field that has not yet received the attention it deserves. Affecting the brain as well as the circulating red cells, these multi-system disorders in the past had often been mistaken for Huntington's disease. Recent breakthroughs have now identified the molecular basis of several of these. This volume grew out of the first international scientific meeting ever devoted to neuroacanthocytosis and provides in-depth information about the state of the art. Its thirty chapters were written by the leading authorities in the field to cover the clinical as well as the basic science perspective, including not only molecular genetics but also experimental pharmacology and cell membrane biology, among others. The book vehemently poses the question of how the membrane deformation of circulating red blood cells relates to degeneration of nerve cells in the brain, the basal ganglia, in particular. It provides a wealth of data that will help to solve an intriguing puzzle and ease the suffering of those affected by one of the neuroacanthocytosis syndromes.
Myelodysplastic Syndromes
This book summarizes our current knowledge of MDS, from very basic aspects to the clinical management. It provides guidance to the diagnosis, an understanding of disease mechanisms, and a discussion of treatment strategies.
Modafinil as a drug to raise mental and cognitive abilities
Investigates the scientific foundation of Modafinil’s cognitive effects, examining its pharmacodynamics, pharmacokinetics, and clinical applications. Furthermore, it explores the drug’s comparative advantages over natural cognitive enhancers, its side effect profile, patterns of use, and broader societal impact. By offering a comprehensive overview, this study aims to contribute to a better understanding of Modafinil as a modern cognitive enhancer in both medical and non-medical contexts.
Mayo clinic infectious disease case review : With board-style questions and answers
Addresses many of the current-day illnesses seen by primary care clinicians and infectious diseases specialists. A case presentation format is used for all 54 chapters, and this framework serves as a wonderful educational tool that mirrors, in many respects, the objectives of a “case conference” format. The dozens of authors from different areas of our specialty have ensured that a robust clinical examination of specific infection syndromes has been included. In addition, the Question and Answer section solidifies the educational benefits for all levels and types of clinicians who seek an understanding of disease diagnosis, management, and prevention. A well-recognized characteristic of infectious diseases specialists is our focus on epidemiology, and this trait has served us well in developing successful clinical careers.
Imaging of the Sternocostoclavicular Region
Review of the normal histopathological anatomy, imaging techniques and diagnostic findings for a broad spectrum of clinical problems, including a classification of inflammatory syndromes previously described under several different terms.
Headache and Chronic Pain Syndromes
Headache and Chronic Pain Syndromes provides a case-based approach to state-of-the-art evaluation and treatment of patients with common chronically painful conditions. Offering strategies for rapidly evaluating and treating pain complaints by body region, this innovative title also provides patient educational handouts that explain the diagnosis and treatment in easy-to-understand language for each condition. Tools for implementing both medication and non-medication therapies, such as exercises and relaxation techniques, are also included. Each chapter opens with typical presentations of three to five common patient scenarios, including pediatric, adult, and geriatric patients. A targeted approach for patient assessment is provided and applied to each scenario, showing how to rapidly identify important clues to distinguish among common diagnoses, including both benign and malignant causes of pain. Standard treatment regimens are then provided for each patient, along with patient-friendly educational flyers for each common pain condition. Figures and drawings help provide ready identification of these common chronic pain syndromes.
Fundamentals of craniofacial malformations ; Vol.2 : Treatment principles
Readers will find detailed discussion of the treatment principles for craniosynostoses, orofacial clefts, branchio-oculo-facial syndromes, soft tissue malformations, dysgnathia and rare syndromes. In addition to description of important facets of treatment and the treatment planning process, guidance is offered on diagnosis and disease classification.
Fundamentals of craniofacial malformations ; Vol.1 : Disease and diagnostics
Opens by considering general topics such as developmental biology and disease classification and then examines in depth the biological basis of the various malformations, including craniosynostoses, cleft-lip and palate with complex orofacial clefts, branchio-oculo-facial syndromes, rare syndromes, soft tissue malformations, and dysgnathia. Psychological aspects, including psychological evaluation methods and therapies and quality of life issues, are then addressed. Finally, all relevant clinical, radiological, and genetic investigations are described and important diagnostic issues are explored.
Frailty and Kidney Disease : A Practical Guide to Clinical Management
This book is of importance in nephrology, specifically nephrogeriatrics, since frailty is a condition affecting many elderly patients and which is becoming increasingly common in medical practice. As such, there is a considerable need for information to assist professionals treating these patients. The book includes chapters on the frailty syndrome (definition, evaluation and treatment), the main geriatric syndromes (gait disorder, falls, incontinence, and delirium), the main renal syndromes (acute renal injury, chronic kidney disease) as well as dialysis and kidney transplant, and the relationship between geriatrics and renal syndromes.
Ethnocultural Perspectives on Disaster and Trauma : Foundations, Issues, and Applications
In this pioneering volume, experts on individual and collective trauma experience, posttraumatic stress and related syndromes, and emergency and crisis intervention – share knowledge and insights on the cultural context of working with ethnic and racial minority communities during disasters. In each chapter, emotional, psychological, and social needs as well as communal strengths and coping skills that arise in disasters are documented for major minority groups in the United States including specific chapters on African Americans, Native Americans, Arab Americans, Asian Indians, Chinese Americans, Caribbean Americans, Latin Americans, Native Hawaiians, and Vietnamese Americans
Epiduroscopy : Spinal Endoscopy
Endoscopy of the spinal canal – epiduroscopy (EDS) – has proven to be a safe, efficient and future-oriented interventional endoscopic procedure for everyday clinical use in diagnosing and managing pain syndromes.
Emerging Pathologies in Cardiology ; Proceedings of the Mediterranean Cardiology Meeting 2005
The book aims to give the most up-to-date information about the epidemiology, the pathophysiology, the diagnosis and the new treatments of the Emerging Pathologies in Cardiology. It presents the state of the art on Acute Coronary Syndromes, Sudden Cardiac Death, Heart Failure, Atrial Fibrillation, Syncope and Prevention of Global Cardiovascular Risk which are some of the emerging pathologies urging investigators to develop many and more sophisticated pharmacological, electrical or mechanical therapies. The volume chapters are written by world-renowned leading experts in these fields, and present a detailed analysis of the most recent developments in the treatment of the above mentioned cardiac pathologi
Emerging Infections in Asia
Emerging Infections in Asia offers a comprehensive overview of well studied and lesser-known infectious syndromes affecting local, regional, and international health, concentrating on their greatest areas of transmission.
Dental management of sleep disorders ; 2nd ed.
A clinically focused, updated, and expanded edition of the leading resource on the dental management of sleep disorders. Ddelivers a focused and authoritative exploration of the dentist’s role in managing patients with sleep problems, especially sleep-related breathing disorders and bruxism. Includes a variety of revealing case studies that examine the treatment of different sleep disorders, as well as: Thorough introductions to the societal impact of sleep disorders and human sleep architecture and functional anatomy of the airway Comprehensive explorations of the pathophysiology and classification of sleep disorders and sleep disorders in the pediatric population Practical discussions of medical disorders related to obstructive sleep apnea and the dental and orofacial consequences of sleep-related breathing disorders In-depth examinations of the role and interaction of the dentist with the sleep physician and sleep study center
Current News in Cardiology ; Proceedings of the Mediterranean Cardiology Meeting 2007 (Taormina May 20-22, 2007)
Aim of the volume is to give an overview of the state of the art on the emerging cardiac pathologies such as acute coronary syndromes, atrial fibrillation, sudden death, heart failure, global cardiovascular prevention and syncope. The volume chapters offer the latest information about epidemiology, pathophysiology, diagnosis and novel treatments of these pathologies.
