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Cancer drug safety and public health policy : A changing landscape
Description and analysis of recent developments and current trends in health policy with regard to cancer drug safety. Opens with an overview of pharmacovigilance for cancer blockbuster drugs, covering both general considerations and efforts to develop a structured framework for the identification and reporting of adverse drug reactions (ADRs). A number of important examples of serious ADRs to hematology and oncology drugs are then reviewed, with evaluation of the lessons learned and the policy implications of the ensuing legal cases and their settlements. Further, the difficulty of reporting such blockbuster side effects in the medical literature is explored in an empirical study. Significant advances have been achieved in analytic methods for the identification of ADRs, and here there is a particular focus on the value of optimal discriminant analysis. Finally, the impacts on pharmacovigilance and drug safety of the huge fines paid under the U.S. False Claims Act relating to the defrauding of governmental programs also receive careful attention – these fines are playing an important role in changing the landscape for pharmaceutical safety.
Bayesian Methods in the Search for MH370
This book demonstrates how nonlinear/non-Gaussian Bayesian time series estimation methods were used to produce a probability distribution of potential MH370 flight paths. It provides details of how the probabilistic models of aircraft flight dynamics, satellite communication system measurements, environmental effects and radar data were constructed and calibrated. The probability distribution was used to define the search zone in the southern Indian Ocean. The book describes particle-filter based numerical calculation of the aircraft flight-path probability distribution and validates the method using data from several of the involved aircraft’s previous flights. Finally it is shown how the Reunion Island flaperon debris find affects the search probability distribution.
Advances in UAV detection, classification and tracking
Explores the latest techniques and advancements in unmanned aerial vehicle (UAV) detection, classification, and tracking. As UAV technology continues to evolve and become more accessible, there is a growing need for effective methods to detect, identify, and track these devices in various scenarios. This reprint provides a thorough overview of the state-of-the-art approaches for UAV detection, classification, and tracking, covering both theoretical and practical aspects.The reprint begins by introducing the basics of UAVs and their various applications, followed by a detailed overview of the challenges associated with UAV detection, classification, and tracking. The authors then present the latest techniques and algorithms used in the field, including machine-learning-based approaches, computer vision techniques, and sensor fusion techniques. The reprint also covers the challenges of real-world applications, such as dealing with occlusions, sensor noise, and environmental factors.
Advances in radar systems for target detection and tracking
Radar systems can provide the all-weather and all-time detection and tracking of targets of interest, and they have been extensively applied by the remote sensing community, in applications such as geological exploration, disaster forecasting, traffic monitoring, urban planning, environmental sciences, hydrology, littoral zones, oceans, etc. This reprint contains the several advance research studies on radar systems for target detection and tracking. It includes multipath ghost suppression, maneuvering target tracking, target detection, and other topics.
Low Power Uwb Cmos Radar Sensors
Low Power UWB CMOS Radar Sensors deals with the problem of designing low cost CMOS radar sensors. The radar sensor uses UWB signals in order to obtain a reasonable target separation capability, while maintaining a maximum signal frequency below 2 GHz. This maximum frequency value is well within the reach of current CMOS technologies. The use of UWB signals means that most of the methodologies used in the design of circuits and systems that process narrow band signals, can no longer be applied. Low Power UWB CMOS Radar Sensors provides an analysis between the interaction of UWB signals, the antennas and the processing circuits.
Lidar : Range-Resolved Optical Remote Sensing of the Atmosphere
Written by leading experts in optical radar, or lidar, this book brings all the recent practices up-to-date and covers a multitude of applications, from atmospheric sciences to environmental protection. Its broad cross-disciplinary scope should appeal to both the experienced scientist and the novice in the field. The Foreword is by one of the early pioneers in the area, Herbert Walther.
Analog Circuit Design : Sensors, Actuators and Power Drivers ; Integrated Power Amplifiers from Wireline to RF ; Very High Frequency Front Ends
This book is part of the Analog Circuit Design series and contains the revised contributions of all speakers of the 16th AACD Workshop, which was organized by Jan Sevenhans of AMI Semiconductor and held in Oostende, Belgium on March 27-29, 2007. The book comprises 17 tutorial papers, divided in three chapters, each discussing a very relevant topic in present days analog design.
Advancements in Electric Machines
Discusses the stateof-the art of electric machines, associated components and contemporary trends of their development. Novel electric machines considered in this book have been limited to rotary electric machines. Linear electric machines and linear actuators have not been included.
Advanced Microsystems for Automotive Applications 2008 ; 4th ed.
With the total number of vehicles steadily increasing and soon approaching one billion, the world is facing serious challenges in terms of both safety of road transport and sustainability. Consequently the two major persistent issues for the automotive industry are improved safety and reduced emissions. The book in hand is a showroom of activities, the International Forum on Advanced Microsystems for Automotive Applications (AMAA) has been known for during the last 12 years.
Advanced Microsystems for Automotive Applications 2007 ; 3rd ed.
There is a coincidence of the AMAA objectives and those of EPoSS, the European Technology Platform on Smart Systems Integration, contributing intensively to the development of automotive-specific smart systems. You will find a series of the EPoSS items in the programme of the 11th AMAA, which continues to be a unique exchange forum for companies in the automotive value chain. The publication in hand also reflects these issues. It is a cut-out of new technological priorities in the area of microsystems-based smart devices and opens up a mid-term perspective of future smart systems applications in automobiles
Advanced Microsystems for Automotive Applications 2005 ; 1st ed.
The book accompanying the event has demonstrated to be an efficient instrument for the diffusion of new concepts and technology results. The present volume including the papers of the AMAA 2005 gives an overview on the state-of-the-art and outlines imminent and mid-term R&D perspectives. The 2005 publication reflects – as in the past – the current state of discussions within industry. More than the previous publications, the AMAA 2005 "goes back" to the technological requirements and indispensable developments for fulfilling the market needs. The large part of contributions dealing with sensors as well as "sensor technologies and data fusion" is exemplary for this tendency.
