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Mammalian and Avian Transgenesis : New Approaches
Mammalian and Avian Transgenesis presents a collection of novel methods for the production of a wide range of transgenic animals. The manual focuses largely on mice, but also contains protocols for successful transgenesis in rats, cows, pigs and birds. The manual provides detailed, step-by-step protocols covering all aspects of the production of transgenic animals, including the use of lentiviral vectors in gene transfer, intracytoplasmic sperm injection, nuclear transfer, large insert transgenesis, conditional gene expression systems, the use of reporter genes in transgenesis and transgenesis in large animals and birds. The text is supplemented by superb color photos. While the focus is on newly established techniques, the fundamental methods of transgenesis are also covered for those new to the field. Thus this manual is perfectly suited for those wishing to adopt new technologies in transgenesis.
Lymphocyte Trafficking in Health and Disease
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Lentil : An ancient crop for modern times
Presents the most comprehensive and up to date review of research on lentil production systems, biotic and abiotic stresses management, quality seed production, storage techniques and lentil growing around the world. This book will be of great value to legume breeders, scientists, nutritionists, academic
La genetica nell’infertilità maschile = Genetics in male infertility
The notable recent cognitive advances in the field of cytogenetics and molecular genetics have made it possible to identify chromosomal anomalies and gene mutations responsible for numerous male infertility, which were completely ignored until recently. The fact is not without relevance, if the principle is valid that the recognition of the causes of a disease is also the first and necessary approach towards its correct therapy. With this publication, the authors wanted to offer specialists working in the field of assisted reproduction an update on this complex subject, dealing with both genetic causes in male infertility and infertility in genetic diseases.
L’esprit de l’aiguille : L’apport du Yi Jing à la pratique de l’acupuncture = The Spirit of the Needle: The contribution of the Yi Jing to the practice of acupuncture
Acupuncture deciphers and heals human beings in all their mutations. The symbolism of Yi Jing joins the humanism of this Traditional Medicine for a dynamic reading of the changes and transformations at work in human beings. The double reflection generates a global vision of the human being and the approach to patients is changed. After an approach to the state of mind, encountered in these two fields, the author sets out to find the oldest roots of the notions of Yin and Yang. This allows him to identify the main strengths of the constitution of a human being and to deepen its symbolic construction. Three fields of application of this approach are then studied. The Extraordinary Meridians are viewed from a descriptive and behavioral perspective, which makes them extremely lively and familiar. Luo points, human being's relationship points with Reality, are also considered on a practical level using a symbolic reading of the links of Heaven, Earth and Man. Many examples shed light on these aspects. The last application is a detailed and comprehensive presentation of the fundamental and symbolic functions of the twelve main meridians through the hexagrams which correspond to their ancient Shu points. This original book is intended for any practitioner of traditional Chinese medicine curious to broaden their field of investigation. Dr M. Vinogradoff has been practicing acupuncture for 25 years. He is a member of the French Acupuncture Association, the French Acupuncture College and the Ricci Institute. After having published the complete translation of Yi Jing, in 2006 he published a novel, the action of which is set in Ancient China.
Kinase Drug Discovery : Modern Approaches
Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years and builds on the first volume. This includes topics such as screening approaches to target kinases along with different modes of inhibition such as allosteric and covalent. Novel approaches such as macrocyclisation are considered along with how the properties of kinase inhibitors have evolved, including the potential for brain penetration. Recent areas of great importance also covered include cutting edge molecular modelling approaches and the importance of kinase mutations.
Complement and Kidney Disease
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
Biotechnologies for plant mutation breeding : Protocols
This book offers 19 detailed protocols on the use of induced mutations in crop breeding and functional genomics studies, which cover topics including chemical and physical mutagenesis, phenotypic screening methods, traditional TILLING and TILLING by sequencing, doubled haploidy, targeted genome editing, and low-cost methods for the molecular characterization of mutant plants that are suitable for laboratories in developing countries. The collection of protocols equips users with the techniques they need in order to start a program on mutation breeding or functional genomics using both forward and reverse-genetic approaches. Methods are provided for seed and vegetatively propagated crops (e.g. banana, barley, cassava, jatropha, rice) and can be adapted for use in other species.
Bacterial and Bacteriophage Genetics
Genetic investigations and manipulations of bacteria and bacteriophage have made vital contributions to our basic understanding of living cells and to the development of molecular biology and biotechnology. This volume is a survey of the genetics of bacteria and their viruses, and it provides students with a comprehensive introduction to this rapidly changing subject. The book is written for upper level undergraduates and beginning graduate students, particularly those who have had an introductory genetics course.
Alternative Splicing and Disease
Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.
Advances in Molecular Breeding Toward Drought and Salt Tolerant Crops
Advances in Molecular Breeding toward Drought and Salt Tolerant Crops seeks to integrate the most recent findings about key biological determinants of plant stress tolerance with modern crop improvement strategies. This volume is unique because is provides exceptionally wide coverage of current knowledge and expertise being applied in drought and salt tolerance research, spanning the scientific hierarchy from physiology, biochemistry, development, and genetics, to the newest technologies being used to manipulate drought and salinity associated traits for germplasm improvement. This book will be an invaluable reference for educators and researchers in agronomy and horticulture, crop breeding, molecular genetics, and biotechnology.
Agent-based modeling : The Santa Fe Institute artificial stock market model revisited
An excellent reference to both the learning, and empirical literature in finance." (Krzysztof Piasecki, Zentralblatt MATH, Vol. 1141, 2008) "Norman Ehrentreich was one of the daring few to take on the model, and he has summarized his work and findings in this excellent book. … It is useful primer for anyone interested in getting started in the area of agent-based finance. … It is essential reading for anyone interested in the dynamics of the SFI market in particular, but I also recommend it for others as a useful resource on agent-based financial market design as well." (Blake LeBaron, Journal of Artificial Societies and Social Simulation, Vol. 12 (2), March, 2009)
Braid Groups
Braids and braid groups have been at the heart of mathematical development over the last two decades. Braids play an important role in diverse areas of mathematics and theoretical physics. The special beauty of the theory of braids stems from their attractive geometric nature and their close relations to other fundamental geometric objects, such as knots, links, mapping class groups of surfaces, and configuration spaces. In this presentation the authors thoroughly examine various aspects of the theory of braids, starting from basic definitions and then moving to more recent results. The advanced topics cover the Burau and the Lawrence--Krammer--Bigelow representations of the braid groups, the Alexander--Conway and Jones link polynomials, connections with the representation theory of the Iwahori--Hecke algebras, and the Garside structure and orderability of the braid groups.
Algèbre, Chapitres 1 à 3 = Algebra, Chapters 1 to 3
To do algebra is essentially to calculate, that is to say to perform, on elements of a set, (<algebraic operations n, the best-known example of which is provided by the (<four rules)) of elementary arithmetic. This is not the place to retrace the slow process of progressive abstraction by which the notion of algebraic operation, initially restricted to natural integers and to measurable quantities, gradually widened its field, as it grew. at the same time generalized the notion of ((number O, until, going beyond the latter, it came to apply to elements which no longer had any character ((numeric)>, for example to permutations of a - seems (see Historical Note in chap. 1).
Accelerator-Driven System at Kyoto University Critical Assembly
This book is a unique compilation of experimental benchmark analyses of the accelerator-driven system (ADS) at the Kyoto University Critical Assembly (KUCA) on the most recent advances in the development of computational methods.
