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Cancer drug safety and public health policy : A changing landscape
Description and analysis of recent developments and current trends in health policy with regard to cancer drug safety. Opens with an overview of pharmacovigilance for cancer blockbuster drugs, covering both general considerations and efforts to develop a structured framework for the identification and reporting of adverse drug reactions (ADRs). A number of important examples of serious ADRs to hematology and oncology drugs are then reviewed, with evaluation of the lessons learned and the policy implications of the ensuing legal cases and their settlements. Further, the difficulty of reporting such blockbuster side effects in the medical literature is explored in an empirical study. Significant advances have been achieved in analytic methods for the identification of ADRs, and here there is a particular focus on the value of optimal discriminant analysis. Finally, the impacts on pharmacovigilance and drug safety of the huge fines paid under the U.S. False Claims Act relating to the defrauding of governmental programs also receive careful attention – these fines are playing an important role in changing the landscape for pharmaceutical safety.
Biodiversity Conservation and Phylogenetic Systematics : Preserving our evolutionary heritage in an extinction crisis
This book brings an updated state of the art of phylogenetic diversity in conservation biology. Nineteen chapters written by scientists from research institutions of fourteen countries demonstrate that approaches for preserving the evolutionary heritage are now very tuned into human impacts and sustainability issues. The questions, methods and applications around which it is organized show the importance of phylogenetic diversity in avoiding biodiversity losses in the present extinction crisis. They touch important points such as the way we value phylogenetic diversity, the importance of thinking at a much wider sample of the Tree of Life, the choice of adequate measures. In methods section, new solutions, such as dealing with abundances, sampling effort, or with information coming from conflicting phylogenetic trees are provided. Application section includes study cases of different groups of organi
Assessment of cancer screening : A primer
Provides an in-depth look at the many aspects of cancer screening and its assessment, including screening phenomena, performance measures, population-level outcomes, research designs, and other important and timely topics.
Building the Infrastructure for Cloud Security : A Solutions view
For cloud users and providers alike, security is an everyday concern, yet there are very few books covering cloud security as a main subject. This book will help address this information gap from an Information Technology solution and usage-centric view of cloud infrastructure security. The book highlights the fundamental technology components necessary to build and enable trusted clouds. Here also is an explanation of the security and compliance challenges organizations face as they migrate mission-critical applications to the cloud, and how trusted clouds, that have their integrity rooted in hardware, can address these challenges.
Anti-Spam Measures : Analysis and Design
The goal of this book is the methodical analysis of the potential, limitations, advantages, and drawbacks of anti-spam measures. These determine to which extent the measures can contribute to the reduction of spam in the long run. The range of considered anti-spam measures includes legislative, organizational, behavioral and technological ones. Furthermore, the conceptual development and analysis of an infrastructural email framework that features such a complementary application, is pointed out. The technological and organizational facets, the framework is analyzed twofold: its theoretical effectiveness is assessed with the aid of the formal model mentioned above, its storage and traffic requirements are analyzed quantitatively.
Anomaly Detection : Techniques and Applications
When information in the data warehouse is processed, it follows a definite pattern. An unexpected deviation in the data pattern from the usual behavior is called an anomaly. The anomaly in the data is also referred to as noise, outlier, spammer, deviations, novelties and exceptions. Identification of the rare items, events, observations, patterns which raise suspension by differing significantly from the majority of data is called anomaly detection. With progress in the technologies and the widespread use of data for the purpose for business the increase in the spams faced by the individuals and the companies are increasing day by day. This noisy data has boomed as a major problem in various areas such as Internet of Things, web service, Machine Learning, Artificial Intelligence, Deep learning, Image Processing, Cloud Computing, Audio processing, Video Processing, VoIP, Data Science, Wireless Sensor etc. Identifying the anomaly data and filtering them before processing is a major challenge for the data analyst. This anomaly is unavoidable in all areas of research. This book covers the techniques and algorithms for detecting the deviated data.
Analysis and Development of Sustainable Urban Production Systems
Manufacturing of products in urban production sites is connected to unique potentials, yet also to specific challenges. Urban factories can provide functional diversity and contribute positive impacts to a city. The concept of urban production receives rising attention in research and industry and it is recognized in its interdisciplinary nature. With a holistic approach from both the urban perspective and the factory perspective, negative impacts can be minimized, positive effects enabled and mutually beneficial, symbiotic combinations created. The presented framework and methods for the evaluation and implementation of sustainable urban production systems allow the assessment of impacts and provide the means to control and utilize the unique strengths of urban factories for cities and industry. This will allow a structured derivation of methods and measures from the concept of urban production for producing enterprises and the urban stakeholders.
An Invitation to Statistics in Wasserstein Space
This book presents the key aspects of statistics in Wasserstein spaces, i.e. statistics in the space of probability measures when endowed with the geometry of optimal transportation.
Agile software engineering
This textbook presents the crucial issues in software engineering using the agile approach to software development - one of the mainstream paradigms for the management of software projects and one that is being applied more and more extensively.
Advancing Computational Intelligence Techniques for Security Systems Design
Security systems have become an integral part of the building and large complex setups, and intervention of the computational intelligence (CI) paradigm plays an important role in security system architecture. This book covers both theoretical contributions and practical applications in security system design by applying the Internet of Things (IoT) and CI. It further explains the application of IoT in the design of modern security systems and how IoT blended with computational intel- ligence can make any security system improved and realizable. Focuses on the computational intelligence techniques of security system design / Covers applications and algorithms of discussed computational intelligence techniques / Includes convergence-based and enterprise integrated security systems with their applications / Explains emerging laws, policies, and tools affecting the landscape of cyber security / Discusses application of sensors toward the design of security systems
An effective strategy for safe design in engineering and construction
Achieves three primary goals: To improve the understanding and implementation of the Construction (Design and Management) Regulations 2015 To reduce errors during the design process via the effective implementation of design management strategy To embed the concept of safety in design
Aging, shaking, and cracking of infrastructures : From mechanics to concrete dams and nuclear structures
Focuses on the safety assessment of existing structures subjected to multi-hazard scenarios through advanced numerical methods. Whereas the focus is on concrete dams and nuclear containment structures, the presented methodologies can also be applied to other large-scale ones. This book is composed of seven sections: Fundamentals: theoretical coverage of solid mechnics, plasticity, fracture mechanics, creep, / seismology, dynamic analysis, probability and statistics / Damage: that can affect concrete structures, such as cracking of concrete, AAR, chloride ingress, and rebar corrosion, / Finite Element: formulation for both linear and nonlinear analysis including stress, heat and fracture mechanics, / Engineering Models: for soil/fluid-structure interaction, uncertainty quantification, probablilistic and random finite element analysis, machine learning, performance based earthquake engineering, ground motion intensity measures, seismic hazard analysis, capacity/fragility functions and damage indeces, / Applications to dams through potential failure mode analyses, risk-informed decision making, deterministic and probabilistic examples, / Applications to nuclear structures through modeling issues, aging management programs, critical review of some analyses, / Other applications and case studies: massive RC structures and bridges, detailed assessment of a nuclear containment structure evaluation for license renewal.
Market-Conform Valuation of Options
we will investigate the 'market-conform' pricing of newly issued contingent claims. A contingent claim is a derivative whose value at any settlement date is determined by the value of one or more other underlying assets, e. g. , forwards, futures, plain-vanilla or exotic options with European or American-style exercise features. Market-conform pricing means that prices of existing actively traded securities are taken as given, and then the set of equivalent martingale measures that are consistent with the initial prices of the traded securities is derived using no-arbitrage arguments.
Managing Elevated Risk : Global Liquidity, Capital Flows, and Macroprudential Policy—An Asian Perspective
Discusses the risks and opportunities that arise in Emerging Asia given the context of a new environment in global liquidity and capital flows. It elaborates on the need to ensure financial and overall economic stability in the region through improved financial regulation and other policy measures to minimize the emergent risks. "Managing Elevated Risk: Global Liquidity, Capital Flows, and Macroprudential Policy—An Asian Perspective" also explores the range of policy options that may be deployed to address the impact of global liquidity on domestic financial and socio-economic conditions including income inequality. The book is primarily aimed at policy makers, financial market regulators and supervisory agencies to help them improve national regulatory systems and to promote harmonization of national regulations and practices in line with global standards.
Carbon Pricing in Japan
This book evaluates, from an economic perspective, various measures introduced in Japan to prevent climate change. Although various countries have implemented such policies in response to the pressing issue of climate change, the effectiveness of those programs has not been sufficiently compared.
Brand metrics : Measuring brand efficacy along the customer journey
The metrics covered in the book correspond with the customer journey, moving through measuring brand awareness, consideration and purchase, to customer loyalty and brand advocacy, and finally an overall analysis of the brand's strength. The book not only shows the formula for a metric and explains how it should be interpreted, but also considers what each metric really measures, how it impacts the brand's equity and how is it related to other metrics.
Bond Portfolio Optimization
1 The tools of modern portfolio theory are in general use in the equity markets, either in the form of portfolio optimization software or as an accepted frame- 2 work in which the asset managers think about stock selection. In the ?xed income market on the other hand, these tools seem irrelevant or inapplicable. Bond portfolios are nowadays mainly managed by a comparison of portfolio 3 4 risk measures vis ¶a vis a benchmark. The portfolio manager’s views about the future evolution of the term structure of interest rates translate th- selves directly into a positioning relative to his benchmark, taking the risks of these deviations from the benchmark into account only in a very crude 5 fashion, i.e. without really quantifying them probabilistically. This is quite surprising since sophisticated models for the evolution of interest rates are commonly used for interest rate derivatives pricing and the derivation of ?xed 6 income risk measures.
Active labor market policies in Europe : performance and perspectives
Measures of Active Labor Market Policy - such as training, wage subsidies, public employment measures, and job search assistance - are widely used in European countries to combat unemployment.
Accounting, Cash Flow and Value Relevance
Investigates the value relevance of the operating cash flow as reported under the International Financial Reporting Standards (IAS/IFRS) for the largest European listed companies and US listed companies in the past recent years. Using the model based on the valuation theory developed by Ohlson, which measures the market value of equity as a function of accounting variables, the author concludes that operating cash flow represents a significant variable in determining the value relevance of the largest European and US listed companies. These findings provide siginificant implications for standard setters and support the continued requirements for disclosure of cash flow information under IAS 7.
A Risk-Benefit Perspective on Early Customer Integration
Customer integration in the early innovation phase has been considered the method of choice in theory and practice. Growing experience with the concept has shown unexpected side effects that may even outweigh its recognized advantages. Therefore, management needs to be able to assess in advance whether the involvement of customers will add overall value to each particular innovation project. To support but not to replace the final managerial decision, a mathematical formula is developed. It can be applied to all kinds of process structures, takes into account the risks and benefits contingent on a company's situation as well as risk-reducing and benefit-increasing measures and translates them into numerical values. The resulting figure indicates the prospective value of customer integration in a specific project.
