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Chemokines and Viral Infection
This edition of Current Topics in Microbiology and Immunology examines the role of chemokines and chemokine receptors in host defense and disease development following viral infection. Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection. With this in mind, this book highlights the functional roles of chemokines and their receptors in participating in various aspects of the immune response against well-known viral pathogens.
Bioinformatics and systems biology : Collaborative research and resources
Collaborative research in bioinformatics and systems biology is a key element of modern biology and health research. This book highlights and provides access to many of the methods, environments, results and resources involved, including integral laboratory data generation and experimentation and clinical activities. Collaborative projects embody a research paradigm that connects many of the top scientists, institutions, their resources and research worldwide, resulting in first-class contributions to bioinformatics and systems biology. Central themes include describing processes and results in collaborative research projects using computational biology and providing a guide for researchers to access them. The book is also a practical guide on how science is managed. It shows how collaborative researchers are putting results together in a way accessible to the entire biomedical community.
An introduction to bioanalysis of biopharmaceuticals
Provides a comprehensive review of the fundamental and practical aspects of bioanalytical support and the integral role it plays in the development of safe and efficacious biopharmaceutical drugs with speed and cost-effectiveness. Focuses on a broad range of conventional and emerging biopharmaceutical modalities including monoclonal antibody-based therapeutics, gene therapy, cell therapy, peptides and oligonucleotides.
Common law constitutional rights
Explores both the content and role of individual common law constitutional rights alongside the constitutional significance and broader implications of these developments. It therefore contributes not only to ourunderstanding of what the common law might be capable of offering in terms of the protection of rights, but also to our understanding of the nature of the constitutional order of which such rights are an integral part.
Comprehensive mathematics for computer scientists 2 : Calculus and ODEs, splines, probability, fourier and wavelet theory, fractals and neural networks, categories and lambda calculus
This second volume of a comprehensive tour through mathematical core subjects for computer scientists completes the ?rst volume in two - gards: Part III ?rst adds topology, di?erential, and integral calculus to the t- ics of sets, graphs, algebra, formal logic, machines, and linear geometry, of volume 1. With this spectrum of fundamentals in mathematical e- cation, young professionals should be able to successfully attack more involved subjects, which may be relevant to the computational sciences. In a second regard, the end of part III and part IV add a selection of more advanced topics. In view of the overwhelming variety of mathematical approaches in the computational sciences, any selection, even the most empirical, requires a methodological justi?cation. Our primary criterion has been the search for harmonization and optimization of thematic - versity and logical coherence. This is why we have, for instance, bundled such seemingly distant subjects as recursive constructions, ordinary d- ferential equations, and fractals under the unifying perspective of c- traction theory.
Automorphic forms and even unimodular lattices : Kneser neighbors of niemeier lattices
This book includes a self-contained approach of the general theory of quadratic forms and integral Euclidean lattices.It explains how the new advances in the Langlands program mentioned above pave the way for a solution. This study proves to be very rich, leading us to classical themes such as theta series, Siegel modular forms, the triality principle, L-functions and congruences between Galois representations.
An Introduction to Quantum and Vassiliev Knot Invariants
Provides an accessible introduction to knot theory, focussing on Vassiliev invariants, quantum knot invariants constructed via representations of quantum groups, and how these two apparently distinct theories come together through the Kontsevich invariant. Consisting of four parts, the book opens with an introduction to the fundamentals of knot theory, and to knot invariants such as the Jones polynomial. The second part introduces quantum invariants of knots, working constructively from first principles towards the construction of Reshetikhin-Turaev invariants and a description of how these arise through Drinfeld and Jimbo's quantum groups. Its third part offers an introduction to Vassiliev invariants, providing a careful account of how chord diagrams and Jacobi diagrams arise in the theory, and the role that Lie algebras play. The final part of the book introduces the Konstevich invariant. This is a universal quantum invariant and a universal Vassiliev invariant, and brings together these two seemingly different families of knot invariants. The book provides a detailed account of the construction of the Jones polynomial via the quantum groups attached to sl(2), the Vassiliev weight system arising from sl(2), and how these invariants come together through the Kontsevich invariant.
An Integrated Approach to Software Engineering
An Integrated Approach to Software Engineering introduces software engineering to advanced-level undergraduate and graduate students of computer science. It emphasizes a case-study approach whereby a project is developed through the course of the book, illustrating the different activities of software development. The sequence of chapters is essentially the same as the sequence of activities performed during a typical software project. All activities, including quality assurance and control activities, are described in each chapter as integral activities for that phase of development. Similarly, the author carefully introduces appropriate metrics for controlling and assessing the software process. Chapters in this revised edition, updated for today’s standards, include these new features: Software Process, Requirements Analysis and Specification, Software Architecture, Project Planning, Object Oriented Design, Coding,Testing,
Advancing Computational Intelligence Techniques for Security Systems Design
Security systems have become an integral part of the building and large complex setups, and intervention of the computational intelligence (CI) paradigm plays an important role in security system architecture. This book covers both theoretical contributions and practical applications in security system design by applying the Internet of Things (IoT) and CI. It further explains the application of IoT in the design of modern security systems and how IoT blended with computational intel- ligence can make any security system improved and realizable. Focuses on the computational intelligence techniques of security system design / Covers applications and algorithms of discussed computational intelligence techniques / Includes convergence-based and enterprise integrated security systems with their applications / Explains emerging laws, policies, and tools affecting the landscape of cyber security / Discusses application of sensors toward the design of security systems
Behavior and design of high-strength constructional steel
Presents readers with extensive information on the behavior of high-strength constructional steels, providing them with the confidence they need to use them in a safe and economic manner to design and construct steel structures. The book includes detailed discussions on the mechanical properties of HHS while explaining the latest progress in research and design guidelines, including material properties at ambient and elevated temperatures. In addition, the book explains the behavior of elementary members subject to different types of loads and load combinations, and those that are integral to the design of bolted and welded connections.
Application of numerical methods in engineering problems using MATLAB
Presents an analysis of structures using numerical methods and mathematical modeling. This structural analysis also includes beam, plate, and pipe elements, and examines deflection and frequency or buckling loads. The various engineering theories of beams/plates/shells are comprehensively presented, and the relationships between stress and strain, and the governing equations of the structure are extracted. To solve governing equations with numerical methods, there are two general types, including methods based on derivatives or integrals. Derivative-based methods have the advantage of flexibility in modeling boundary conditions, low analysis time, and a very high degree of accuracy.
Mathematical Formulas for Economists
This collection of formulas constitutes a compendium of mathematics for eco nomics and business. It contains the most important formulas, statements and algorithms in this significant subfield of modern mathematics and addresses primarily students of economics or business at universities, colleges and trade schools. But people dealing with practical or applied problems will also find this collection to be an efiicient and easy-to-use work of reference. First the book treats mathematical symbols and constants, sets and state ments, number systems and their arithmetic as well as fundamentals of com binatorics. The chapter on sequences and series is followed by mathematics of finance, the representation of functions of one and several independent vari ables, their differential and integral calculus and by differential and difference equations. In each case special emphasis is placed on applications and models in economics. The chapter on linear algebra deals with matrices, vectors, determinants and systems of linear equations. This is followed by the representation of struc tures and algorithms of linear programming. Finally, the reader finds formu las on descriptive statistics (data analysis, ratios, inventory and time series analysis), on probability theory (events, probabilities, random variables and distributions) and on inductive statistics (point and interval estimates, tests). Some important tables complete the work.
Manual of multi-storey timber construction
Wood is suitable for use in multi-storey building construction with barely any restrictions. This is new and requires creative rethinking of tried and tested practices in wood construction: classical categories can be replaced by mixed construction methods as necessary within a project, which yields completely new possibilities in designing wood structures. The Manual provides architects, engineers and wood specialists with the essential expertise on the new systematic and construction methodology, from the design to prefabrication to the implementation on site. It lays the grounds for mutual understanding among everyone involved in the project, to facilitate the necessary cooperation in the integral planning and construction process
Affordable housing for smart villages
Initiates a fresh discussion of affordability in rural housing set in the context of the rapidly shifting balance between rural and urban populations. It conceptualises affordability in rural housing along a spectrum that is interlaced with cultural and social values integral to rural livelihoods at both personal and community level. Developed around four intersecting themes: explaining houses and housing in rural settings; exploring affordability in the context of aspirations and vulnerability; rural development agendas involving housing and communities; and construction for resilience in rural communities, the book provides an overview of some of the little understood and sometimes counter-intuitive best practices on rural affordability and affordable housing that have emerged in developing economies over the last thirty years.
Mathematical Analysis I
The purpose of the volume is to provide a support for a first course in Mathematical Analysis, along the lines of the recent Programme Specifications for mathematical teaching in European universities. The contents are organised to appeal especially to Engineering, Physics and Computer Science students, all areas in which mathematical tools play a crucial role. Basic notions and methods of differential and integral calculus for functions of one real variable are presented in a manner that elicits critical reading and prompts a hands-on approach to concrete applications. The layout has a specifically-designed modular nature, allowing the instructor to make flexible didactical choices when planning an introductory lecture course. The book may in fact be employed at three levels of depth. At the elementary level the student is supposed to grasp the very essential ideas and familiarise with the corresponding key techniques.
Linear Functional Analysis
This introduction to the ideas and methods of linear functional analysis shows how familiar and useful concepts from finite-dimensional linear algebra can be extended or generalized to infinite-dimensional spaces. Aimed at advanced undergraduates in mathematics and physics, the book assumes a standard background of linear algebra, real analysis (including the theory of metric spaces), and Lebesgue integration, although an introductory chapter summarizes the requisite material. The initial chapters develop the theory of infinite-dimensional normed spaces, in particular Hilbert spaces, after which the emphasis shifts to studying operators between such spaces. Functional analysis has applications to a vast range of areas of mathematics; the final chapters discuss the particularly important areas of integral and differential equations.
Limit Cycles of Differential Equations
Contains the lecture series originally delivered at the "Advanced Course on Limit Cycles of Differential Equations" in the Centre de Recerca Matemàtica Barcelona in 2006.The topics covered are the center-focus problem for polynomial vector fields, and the application of abelian integrals to limit cycle bifurcations. Both topics are related to Hilbert's sixteenth problem. In particular, the book will be of interest to students and researchers working in the qualitative theory of dynamical systems.
Lie theory ; Vol.230 : Harmonic analysis on symmetric spaces, general Plancherel theorems
Van den Ban’s introductory chapter explains the basic setup of a reductive symmetric space along with a careful study of the structure theory, particularly for the ring of invariant differential operators for the relevant class of parabolic subgroups. Advanced topics for the formulation and understanding of the proof are covered, including Eisenstein integrals, regularity theorems, Maass–Selberg relations, and residue calculus for root systems. Schlichtkrull provides a cogent account of the basic ingredients in the harmonic analysis on a symmetric space through the explanation and definition of the Paley–Wiener theorem. Approaching the Plancherel theorem through an alternative viewpoint, the Schwartz space, Delorme bases his discussion and proof on asymptotic expansions of eigenfunctions and the theory of intertwining integrals.
Lacroix and the Calculus
Lacroix and the Calculus is the first major study of Lacroix’s large Traité. It uses the unique and massive bibliography given by Lacroix to explore late 18th-century calculus, and the way it is reflected in Lacroix’s account. Several particular aspects are addressed in detail, including: the foundations of differential calculus, analytic and differential geometry, conceptions of the integral, and types of solutions of differential equations (singular/complete/general integrals, geometrical interpretations, and generality of arbitrary functions).
Israel Gohberg and Friends : On the Occasion of his 80th Birthday
It is an expression of esteem and friendship for a great mathematician, a remarkable person and an inspiring colleague. The book contains reflections by Gohberg himself on his own mathematical activities and those of others. It also includes contributions of colleagues and co-workers, both from his time in the Soviet Union and from when he lived and worked in the West. The contributions in question are not mathematical research papers but focus on the man Israel Gohberg and are intended for a wide audience.
