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Management of Acute Pulmonary Embolism
Management of Acute Pulmonary Embolism highlights traditional, novel, and evolving aspects of the diagnosis and treatment of pulmonary embolism (PE). Emphasis is placed on specific issues related to PE, including pregnancy, cancer, thrombophilia, and air travel. The authors critically review and interpret available data, and provide clear recommendations for diagnosis and therapeutic concerns in clinical management of PE patients. Management of Acute Pulmonary Embolism is organized in three precise sections - diagnosis, treatment, and special topics. Each section is up-to-date and detailed, and provides clear recommendations for diagnostic and therapeutic approaches to patients with PE in clinical practice. This practical volume is an essential starting point for future study for both medical students and established investigators.
Machine learning for neurodegenerative disorders : advancements and applications
Explores the application of machine learning to the understanding, early diagnosis, and management of neurodegenerative disorders. With a specific focus on its role in ongoing clinical trials, the book covers essential topics such as data collection, pre-processing, feature extraction, model development, and validation techniques. It delves into the applications of neuroimaging techniques like magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) in the diagnosis and understanding of neurodegenerative disorders. Additionally, the book examines various machine-learning algorithms employed for biomarker discovery in neurodegenerative disorders. It highlights the role of neuroinformatics and big data analysis in advancing the understanding and management of neurodegenerative disorders. Furthermore, the book reviews future prospects and presents the ethical considerations and regulatory challenges associated with implementing machine learning approaches in the diagnosis, treatment, and prevention of neurodegenerative disorders.
Lipids in Health and Disease
Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of the present volume and the reader is referred to volume 28 of this series which is the subject of cholesterol. The polar lipids are comprised of fatty acids attached to either glycerol or sphingosine. The fatty acids themselves constitute an important reservoir of substrates for conversion into families of signalling and modulating molecules including the eicosanoids amongst which are the prostaglandins, thromboxanes and leucotrienes. The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume. This section also deals with the modulation of protein function and inflammation by unsaturated fatty acids and their derivatives. New insights into the role of fatty acid synthesis and eicosenoid function in tumour progression and metastasis are presented.
Life as We Know It
Life As we Know It ["LAKI"] covers several aspects of Life, ranging from the prebiotic level, origin of life, evolution of prokaryotes to eukaryotes and finally to various affairs of human beings. Although it is hard to define Life, one can, however, characterize it and describe its features. Topics treated are categories of bacteria, algae and fungi, conscience, philosophy, theology, aesthetics, appearance of sport and life destiny, life after clinical death, and thoughts of the world to come ("Olam Haba"). The various chapters have been written so that they are accessible to all - from the avid lay reader to the specialist – and make available multidisciplinary sources of information about Life. This volume will interest open minded scholars, students at all levels of general sciences, natural and Life science, researchers of philosophy, theology, history of Life, astrobiology, and those who wish to widen their knowledge about "who are we in the universe".
Lemurs : Ecology and Adaptation
In this comprehensive volume, written by experts in the field, information gathered on lemur ecology and adaptation over the past 15 years is presented by both seasoned and newer lemur researchers, and provides us with further knowledge concerning both well-studied and rarely studied extant species, as well as insights into the ecology and adaptation of some of the recently extinct lemurs.
Landscapes of a New Cultural Economy of Space
Aims to tie together various perspectives, insights and constructions pertaining to landscapes and landscape representations from different theoretical and methodological positions as well as from diverse geographical and historical contexts in order to elucidate and illustrate processes of cultural transformation inscribed in space.
Complexity in landscape ecology
Interactions matter. To understand the distributions of plants and animals in a landscape you need to understand how they interact with each other, and with their environment. The resulting networks of interactions make ecosystems highly complex. Recent research on complexity and artificial life provides many new insights about patterns and processes in landscapes and ecosystems. This book provides the first overview of that work for general readers. It covers such topics as connectivity, criticality, feedback, and networks, as well as their impact on the stability and predictability of ecosystem dynamics. With over 60 years of research experience of both ecology and complexity, the authors are uniquely qualified to provide a new perspective on traditional ecology.
Competence Assessment in Dementia
The increasing proportion of demented elderly in populations, debates over patient's rights and autonomy, and the growing body of knowledge on dementia has inspired the European Dementia Consensus Network to regard competence assessment in dementia as an important topic of debate.
Clinical Neuroembryology : Development and Developmental Disorders of the Human Central Nervous System
Combines data from human embryology, animal research and developmental neuropathology. This book provides an overview of the development of the human Central Nervous System (CNS) in the context of its many developmental disorders due to genetic, environmental and hypoxic causes. It highlights numerous clinical cases and contains over 400 figures.
Clinical metabolomics applications in genetic diseases
Helps readers discover the forefront of personalized medicine on clinical metabolomics and its applications in genetic diseases. This comprehensive guide offers a functional relationship map between cell components and genetic variations in various diseases, providing insights that can be applied to personalized medicine. Covers the latest developments in metabolomics for health, with practical guidance for clinical experts looking to advance their laboratory techniques and career. The metabolomics profile is a powerful tool that has revolutionized our understanding of the relationship between genetics, clinical readouts, and disease outcomes. By integrating metabolomics with genomics and clinical phenotypes, the authors have developed diagnostic and prediction models that have vastly improved patient outcomes and deepened the understanding of disease mechanisms.
Chemokines and Viral Infection
This edition of Current Topics in Microbiology and Immunology examines the role of chemokines and chemokine receptors in host defense and disease development following viral infection. Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection. With this in mind, this book highlights the functional roles of chemokines and their receptors in participating in various aspects of the immune response against well-known viral pathogens.
Cephalopods Present and Past : New Insights and Fresh Perspectives
Cephalopods are diverse, highly developed molluscs capable of swimming and jet propulsion. These animals are an important component of present-day marine ecos- tems throughout the world and comprise approximately 900 species. They also have an extraordinary fossil record, extending back to the Cambrian Period, with as many as 10,000 extinct species. Throughout their long history, they have experienced sp- tacular radiations and near-total extinctions. Because of their superb fossil record, they also serve as ideal index fossils to subdivide geologic time. This book touches on many of these themes, and it treats both fossil and present-day cephalopods.
Cell-Cycle Mechanisms and Neuronal Cell Death
This book serves to gain new insights into the molecular determinants of neuronal death and to establish new targets for therapeutic intervention.
Cell Surface Receptors : A Short Course on Theory and Methods
Cell Surface Receptors: A Short Course on Theory and Methods, 3rd Edition, links theoretical insights into drug-receptor interactions described in mathematical models with the experimental strategies to characterize the biological receptor of interest.
Cell Motility in Cancer Invasion and Metastasis
Cancer Morbidity and mortality result from invasive and metastatic spread. Currently, no therapies are aimed at the underlying mechanisms that enable this progression due to only nascent recognition of the distinct biology which occurs only during tumor dissemination. Recent advances have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book includes state-of-the-art updates by international leaders in these studies. Chapters first present the novel model systems that enable new investigations and insights. Chapters then describe in depth the key processes and molecules that may be therapeutically targeted. Finally, the role of cell motility and its signals is explored in a number of key tumor types. This compilation should be useful to researchers in basic and translational oncology as well as those developing novel agents to prevent tumor invasion and metastasis.
Catalytic role of amino acids in organic reactions
Asymmetric organometallic and organocatalytic processes have attracted great interest. Asymmetric synthesis using both natural and unnatural amino acids has been tremendously important from synthetic as well as industrial viewpoints, and numerous new methodologies have been developed in the last decades. Herein we provide an overview of old and very recent (since 1900 till now) advances and applications in the area of heterogeneous catalysis, homogeneous catalysis, electrocatalysis, photocatalysis, organocatalysis, thermal catalysis using amino acids [proline, glycine, alanine, valine, serine, threonine, cysteine, methionine, asparagine, glutamine, lysine, arginine, histidine, aspartate, glutamate, phenylalanine, and tryptophan], (supported or unsupported), an amino acid containing materials or amino acids derivatives as an essential component of catalysts, this book highlights the most important and recent developments to immobilize or support amino acids on various support materials. This book is suitable as supplementary reading for courses targeting the design, synthesis, and application of chiral catalysts, asymmetric catalysis, and sustainable production.
Cardiovascular Disease in AIDS
In this new edition of Cardiovascular Disease in AIDS new insights coming from basic and clinical research in the field of HIV-associated cardiovascular disease and antiretroviral therapy are reported, along with the clinical guidelines for a careful stratification of the cardiovascular risk and cardiovascular monitoring of HIV-infected patients receiving HAART. The authors offer a wide overview of the topic for specialists in cardiology and infectious diseases involved in the clinical management of HIV-infected patients.
Cancer in the Arab World
Over the past few decades, the Arab world has witnessed a swift evolution in healthcare provision. Nonetheless, Arab countries have considerable variability in economic capabilities, resource allocation, and intellectual talent that inevitably reflect on access to modern cancer care and prevention. This book is authored by experts from the Arab world who provide vital information on cancer statistics and risk factors, available clinical care pathways and infrastructure, and prevention programs in their individual countries. The chapters also address specific challenges in each country and insights into future directions to achieve optimal care with conventional and novel diagnostics and therapies to keep up with the era of precision medicine.
Breast cancer ; 2nd ed.
This book highlights M. D. Anderson Cancer Center’s multidisciplinary approach and reviews the entire spectrum of patient care, from prevention and screening through diagnosis and treatment through posttreatment follow-up and survivorship issues.
Bodily Integrity and the Politics of Circumcision : Culture, Controversy, and Change
This book explores the problem of male and female circumcision in modern society from religious, anthropological, psychological, medical, legal, and ethical perspectives. Bodily Integrity and the Politics of Circumcision provides a much-needed, thoughtful, and detailed analysis of the devastating impact of circumcision on bodily integrity and human rights, and it provides hope for change.
