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Novel drug delivery systems : Fundamentals and applications
Serves as a unique resource on the field of novel drug delivery systems (NDDSs). The evolving nature of diseases and the emergence of new health complications have driven a significant shift in drug therapy. Coupled with changes in human lifestyles and economic conditions, these factors have compelled the pharmaceutical industry to develop novel, efficient, and affordable drug products. The rise of promising technologies aimed at enhancing therapeutic performance further underscores the importance of novel drug delivery systems (NDDSs), making this field one of the most dynamic in pharmaceutical sciences today.
Nonlinear Fokker-Planck Equations : Fundamentals and Applications
Providing an introduction to the theory of nonlinear Fokker-Planck equations, this book discusses fundamental properties of transient and stationary solutions, emphasizing the stability analysis of stationary solutions by means of self-consistency equations, linear stability analysis, and Lyapunov's direct method. Also treated are Langevin equations and correlation functions. Nonlinear Fokker-Planck Equations addresses various phenomena such as phase transitions, multistability of systems, synchronization, anomalous diffusion, cut-off solutions, travelling-wave solutions and the emergence of power law solutions. A nonlinear Fokker-Planck perspective to quantum statistics, generalized thermodynamics, and linear nonequilibrium thermodynamics is given. Theoretical concepts are illustrated where possible by simple examples. The book also reviews several applications in the fields of condensed matter physics, the physics of porous media and liquid crystals, accelerator physics, neurophysics, social sciences, population dynamics, and computational physics.
Non-Formal Education : Flexible Schooling or Participatory Education?
This is the first full study of non-formal education on an international scale since the 1980s. The book describes the emergence of the concept in the context of development and educational reform. It traces the debate about non-formal education from its origins in 1968 to the mid 1980s, and looks at the issues that this debate raised. It then describes a number of programmes in different parts of the world which call themselves ‘non-formal’, pointing out the wide range of different views about what is and what is not non-formal. Rogers asks whether we should drop the term altogether or try to reconceptualise it in terms of flexible schooling or participatory education.
Natural Products : Drug Discovery and Therapeutic Medicine
Although the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to overcome such problems as antibiotic resistance, the emergence of new diseases, the failure to conquer old diseases, and the toxicity of some contemporary medical products. In Natural Products: Drug Discovery and Therapeutic Medicine, a panel of recognized experts and leaders in the field discuss the past successes of natural products as medicines and review future possibilities arising from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discovery, to accessing microbial diversity, to investigating specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to exploiting specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Multi-Agent-Based Simulation VI ; International Workshop, MABS 2005, Utrecht, The Netherlands, July 25, 2005, Revised and Invited Papers
This book constitutes the thoroughly refereed post-proceedings of the 6th International Workshop on Multi-Agent-Based Simulation, MABS 2005, held in Utrecht, The Netherlands in July 2005 as an associated event of AAMAS 2005, the main international conference on autonomous agents and multi-agent systems. The 12 revised full papers presented together with 1 invited talk were carefully reviewed. The papers are organized in topical sections on coalition emergence, theories and models, applications, and environments.
Molecular Biology in Plant Pathogenesis and Disease Management : Disease Management ; Vol.3
Exclusion and eradication of plant pathogens by rapid and precise detection and identification of microbial pathogens in symptomatic and asymptomatic plants and planting materials by employing molecular methods has been practiced extensively by quarantines and certification programs with a decisive advantage. Identification of sources of resistance genes, cloning and characterization of desired resistance genes and incorporation of resistance gene(s) into cultivars and transformation of plants with selected gene(s) have been successfully performed by applying appropriate molecular techniques. Induction of resistance in susceptible cultivars by using biotic and abiotic inducers of resistance is a practical proposition for several crops whose resistance levels could not be improved by breeding or transformation procedures. The risks of emergence of pathogen strains less sensitive or resistant to chemicals have been reduced appreciably by rapid identification of resistant strains and monitoring the occurrence of such strains in different geographical locations.
Molecular autoimmunity
The autoimmune disease paroxysmal cold hemoglobinuria, a rare hemolytic disorder. After a century of research, the list of autoimmune diseases has become impressive. With a prevalence of approximately 5% of the world-wide population, these chronic, debilitating conditions affect almost every major organ of the body and, for reasons that remain unclear, are much more prevalent in woman than in men. Despite our rapidly expanding knowledge of the cellular and molecular pathways that govern a normal immune response, deciphering the precise etiology of autoimmune diseases remains an important challenge. Over the last few years, our understanding of the pathogenesis of autoimmune diseases has improved rapidly, leading to the emergence of elegant immunointervention strategies. Molecular Autoimmunity illustrates how cutting-edge research is continuing to advance our understanding of autoimmune disease mechanisms and identifies novel therapeutic targets that provide a hope for effective future treatments. This volume contains a selected number of exciting advances in unraveling autoimmune reactions, and the resulting new armory of experimental immunotherapies that may lead to new ways of controlling autoimmune reactions.
Modern Aryne Chemistry
The book reveiws the recent use of aryne chemistry for the development of new multicomponent reactions. New advances in this area has shown rapid emergence of a new class of reactions classified under rearrangement reactions. The author also includes information on aryne methods that have been employed for the synthesis of several natural products. The simplicity and sophistication of the synthetic strategy using arynes can serve as a springboard for organic chemists to explore new possibilities and imagine applications of the concept of arynes.
Migration, Agriculture and Rural Development : IMISCOE Short Reader
This short reader looks into the dynamics which have reshaped rural development and human landscapes in European agriculture and the role of immigrant people. Within this framework it analyses contemporary rural migrations and the emergence of immigrants in relation to the incorporation of agrarian systems into global markets, the European agricultural governance (CAP), and the struggle of local territories as differentiated practices in constant stress between innovation and resilience
Methods and Models in Transport and Telecommunications : Cross Atlantic Perspectives
One aspect of the new economy is a transition to a networked society, and the emergence of a highly interconnected, interdependent and complex system of networks to move people, goods and information. An example of this is the in creasing reliance of networked systems (e. g. , air transportation networks, electric power grid, maritime transport, etc. ) on telecommunications and information in frastructure. Many of the networks that evolved today have an added complexity in that they have both a spatial structure , they are located in physical space but also an a spatial dimension brought on largely by their dependence on infor mation technology. They are also often just one component of a larger system of geographically integrated and overlapping networks operating at different spatial levels. An understanding of these complexities is imperative for the design of plans and policies that can be used to optimize the efficiency, performance and safety of transportation, telecommunications and other networked systems. In one sense, technological advances along with economic forces that encourage the clustering of activities in space to reduce transaction costs have led to more efficient network structures.
Messenger RNA therapeutics
Focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine.
Medical centers management system
The medical clinics management system (MCMS) is a system that manages a group of clinics distributed within different governorates and regions in Syria, as it manages data entry processes for each patient such as personal information, disease and accompanying symptoms in addition to doctors' information, and clinics through a web application. The system also performs mining algorithms on the current data for discovering new symptoms and diseases by analyzing patient, diseases and symptoms data available within the database, to subsequently notify the admins of the emergence of a new symptom or an increase in a disease in a given area. In addition to generating daily or weekly reports containing the number of visits and cases of recovery and other information.
Mechanics and natural philosophy before the scientific revolution
This volume deals with a variety of moments in the history of mechanics when conflicts arose within one textual tradition, between different traditions, or between textual traditions and the wider world of practice. Its purpose is to show how the accommodations sometimes made in the course of these conflicts ultimately contributed to the emergence of modern mechanics.
Meaning-Making for Living : The Emergence of the Presentational Self in Children’s Everyday Dialogues
This Brief analyzes the dynamics in which children’s selves emerge through their everyday activities of meaning construction, both in their relationships with family and within school education. It begins with a discussion of new psychological inquiries into children's selves and builds upon the innovative theoretical notion of the Presentational Self, developed by the author over the last decade. The book illustrates how the observation of children’s meaning construction in their everyday lives becomes a starting point for theoretical and empirical inquiries into child development and gives a framework that promotes new inquiries in this area. The book describes the Presentational Self Theory as a sense of how the notion of the Self is being worked upon in everyday life encounters. Chapters feature in-depth analyses of exchanges between adults and children in the Japanese cultural context.
Intersecting colors : Josef Albers and his contemporaries
Offers a timely reappraisal of the immense impact of Albers's thinking, writing, teaching, and art on generations of students. It shows the formative influence on his work of non-scientific approaches to color (notably the work of Johann Wolfgang von Goethe) and the emergence of Gestalt psychology in the first decades of the twentieth century. The work also shows how much of Albers's approach to color-dismissed in its day by a scientific approach to the study and taxonomy of color driven chiefly by industrial and commercial interests-ultimately anticipated what neuroscience now reveals about how we perceive this most fundamental element of our visual experience.
International Handbook of the Religious, Spiritual and Moral Dimensions in Education
This International Handbook presents the research and professional practice of scholars who are daily engaged in the consideration of these dimensions in education. The result is a collection of essays which reflects the discipline, in all of its internationality, as it is today. Embedded within the chapters is also an agenda for the future, where the religious, moral and spiritual dimensions in education are proposed as an exciting and challenging way forward for educators at all levels in society. As well, it offers a vision for the emergence of a peaceful and just world.
International business
Provides thorough coverage, delving into fundamental concepts and theory; the cultural, political, and economic environment; international business strategies; and even functional management areas. More comprehensive than competing books, this new edition of International Business includes: New chapter on the digitalization of the global economy and its implications for firm strategy and organizations New examinations of the forces of de-globalization, implications of rising trade protectionism, challenges of geopolitical conflicts, and a friction framework for understanding the effects of cultural differences Enriched and expanded discussions about potential reconfigurations of global value chains following the Covid-19 pandemic, changing perspectives on the role of the government with renewed attention to industrial policy, shifts in regional integration with the emergence of such new trade blocks as CPTPP and RCEP, and fresh insights on factors influencing a country's balance of payments Strengthened, expanded global cases, examples, and "industry" and "country" mini-cases that give students practical insight into the ways companies actually behave within a competitive, global environment.
Intelligent Life in the Universe : Principles and Requirements Behind Its Emergence
This book addresses the possible origins, development and fate of intelligent life in the universe. The author presents a wide-ranging analysis of the type of knowldege that can be inferred about extraterrestial intelligent societies from our own biological, cultural and scientific evolution, and from the likely future of mankind. Providing extensive background information from astronomy, geology, chemistry and biology, the book will appeal to both the scientist and the general reader.
Intelligent drugs : How AI is transforming healthcare
The progress of biotechnologies and artificial intelligence allowed the development of vaccines in less than a year, thus saving millions of human lives and preserving the global economy. The emergence of intelligent drugs is highlighted, with the promise of ultra-targeted, more effective, and safer treatments against a wide range of diseases. Personalized medicine then becomes realistic, with computer-designed drugs, perfectly adapted to each individual, tested on virtual patients before their real use. In the near future, thanks to AI, new drugs will improve physical performance, stimulate cognitive abilities, prevent diseases, and slow down aging.
Innovative Internet Community Systems ; Vol. 3908 ; 5th International Workshop, IICS 2005, Paris, France, June 20-22, 2005. Revised Papers
Traditionally, there are topics discussed in three main aspects. All of them must be considered in a united manner in order to investigate and understand the emergence and evolution of communities in the Internet: knowledge about networking, content and text processing as well as theory. The goal of the I2CS workshop is to bring researchers from both industry and academic fields together to discuss current progress and future developments in these areas and to eliminate the gap between theory and application. At this point, we want to express immense gratitude to all the authors of the submitted papers and to the members of the international Program Committee for their contribution to the success of the event and a program of high quality. In a peer-to-peer review process, 17 papers were selected out of 27 submissions.
