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Molecular biology : Structure and dynamics of genomes and proteomes
Illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins. Emphasis is on the experimental basis of discovery and the most recent advances in the field while presenting a rigorous, yet still concise, summary of the structural mechanisms of molecular biology. Topics new to this edition include the CRISPR-Cas gene editing system, Coronaviruses – structure, genome, vaccine and drug development, and newly recognized mechanisms for transcription termination.
Medical genetics and law : An international perspective
Essential resource to understanding the intersection of medical genetics and law. In a unique approach, it provides an overview on the biological principles of DNA basics and genetic inheritance linking the knowledge with the ethical and legal challenges presented by modern developments in genetics.
Mechanisms of Lymphocyte Activation and Immune Regulation XI ; B Cell Biology
These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.
Introduction to blender 3.0 : Learn organic and architectural modeling, lighting, materials, painting, rendering, and compositing with blender
Explains modeling, materials, lighting, painting, and more with Blender and other external tools. You will configure a 3D architectural environment and set up the workflow of an art and design project within Blender. You will use Blender's main tools—mesh modeling and sculpting—to create virtual objects and environments. And, you will explore building materials and light scenes, followed by drawing and virtual painting. Chapters cover rendering scenes and transforming them into 2D images or videos. You will learn to use Blender 3.0 for video editing as a compositor and video sequence editor (VSE or sequencer) with a wide range of effects available through the nodal system. You Will Learn : Create objects and architectural buildings with different techniques of 3D modeling / Master creating an environment for your objects and how to light them / Determine how to create node materials and assign them to your Blender objects / Pick up UV unwrapping and texture painting / Get closer to painting and drawing in Blender / Render your scenes and create stunning videos
Immune mediators in cancer : Methods and protocols
Provides a comprehensive collection of classic and cutting-edge methodologies as well as bioinformatics and genome-editing approaches that are used to quantify immune mediators and analyze their function and biological activity in cancer cells and tissues. Beginning with a section on the detection of immune mediators in samples, the volume continues with sections covering cytokine bioassays, the expression and regulation of immune mediators in cancer cells, and methods to navigate the enormous datasets created by modern DNA and RNA sequencing and proteomic technology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Guidelines for reports by autopsy pathologists
Traditionally, pathology residents have learned how to write autopsy reports by trial-and-error, with oral feedback from local mentors. Now, pathologists and pathologists in training throughout the English-speaking world have access to a manual that describes what should be in an autopsy report, how to organize the material, and what the purposes are. Guidelines for Reports by Autopsy Pathologists lists numerous bad habits to avoid, and offers examples of effective report construction. It covers not only how to describe diseases and injuries, but also how to formulate and write opinions. As a supplement, Guidelines for Reports by Autopsy Pathologists also contains recommendations on record retention schedules for medical examiners (not everything needs to be saved in perpetuity), and how to formulate opinions for death certificates. Aimed at pathologists in training, Guidelines for Reports by Autopsy Pathologists will alos benefit the seasoned pathologists who want to improve their reports.
Genome editing in neurosciences
Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders.
Genome editing in drug discovery
In Genome Editing in Drug Discovery, a team of distinguished biologists delivers a comprehensive exploration of genome editing in the drug discovery process, with coverage of the technology’s history, current issues and techniques, and future perspectives and research directions. The book discusses techniques for disease modeling, target identification with CRISPR, safety studies, therapeutic editing, and intellectual property issues.
Genome Editing : Gene Therapy or Gene Optimization?
Genome editing technology is considered one of the most revolutionary techniques lately. The ability of modifying the human genome has been one of the biggest dreams for therapist for the reason that the genetic modification with exogenous DNA can be considered a problem solver for many diseases and disorders (genetic disorders), especially those with high risks and low survival rates, on this case, gene therapy appears as the tool to be used, with its many protocols and approaches. Gene therapy is based on delivering a therapeutic gene throw suitable vectors, which is most of the time-modified viruses to carry the therapeutic genes to the target cells and so on providing the functional copy of the defective gene.
Genetic surgery : from genes to solutions
As a tool for modifying the genome, gene editing technologies has developed rapidly in recent years, the application of these technologies in basic biomedical research has yielded significant advances in identifying and studying key molecular targets relevant to human diseases and their treatment. The clinical translation of genome editing techniques offers unprecedented biomedical engineering capabilities in the diagnosis, prevention, and treatment of disease or disability...
Gene delivery systems development and applications
Covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases.
Gene delivery systems : nano delivery technologies
Gene therapy involves altering the genes in the body's cells in an effort to treat or stop disease, instead of using drugs or surgery. This book discusses the development of gene therapy today, from the technology involved to gene correction and the advances in genome editing.
Fine-Tuning of RNA Functions by Modification and Editing
This book provides advance information on RNA modification, including the associated editing machinery, while offering the reader some perspective on the significance of such modifications in fine-tuning the structure and functions of mature RNA molecules and hence the ability to influence the efficiency and accuracy of genetic expression.
Excel 2007 : Beyond the Manual
Excel 2007: Beyond the Manual will introduce those who are already familiar with Excel basics to more advanced features, like consolidation, what-if analysis, PivotTables, sorting and filtering, and some commonly used functions.
Epigenome editing : Methods and protocols
This second volume details new and updated methods covering applications of epigenome editing. Chapters guide readers through general and topical reviews, DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Epigenetics in oncology
Covers the most recent advances in RNA/histone/DNA epigenetics in Oncology. RNA/histone/DNA epigenetics have been shown to play pivotal roles in cancer initiation, progression, maintenance and drug response/resistance, tumor microenvironment, cancer stem cell self-renewal, cancer metabolism, and tumor immune evasion. In particular, research in RNA cancer epigenetics has made impressive progress in the last few years. Individual chapters in Part I (focusing on RNA epigenetics) are devoted to RNA modifications in Cancer Metabolism and Microenvironment, Cancer Stem Cell Biology, Immune Surveillance, Solid Tumors and Tumor Immunity, and Hematopoietic Malignancies, as well as to RNA editing in Cancer. Chapters in Part II and III of the book focus on histone epigenetics and DNA epigenetics, respectively.
E-Business@Print : Internet-based services and processes
The Internet has opened up exciting new opportunities for print media companies, enabling information to be processed for both paper and online output. It also offers new possibilities for print media companies to work increasingly closely with customers and production partners. The author provides a comprehensive overview of the new services that are now available and the new processes that the Internet enables. The reader is systematically guided through the various specialist terms, and numerous examples are used to illustrate possible applications, e.g. online editing systems, Web-based project management tools and online tracking of print jobs.
Deployment and operation of complex software in heterogeneous execution environments : The SODALITE approach
This book provides an overview of the work developed within the SODALITE project, which aims at facilitating the deployment and operation of distributed software on top of heterogeneous infrastructures, including cloud, HPC and edge resources. The experts participating in the project describe how SODALITE works and how it can be exploited by end users. While multiple languages and tools are available in the literature to support DevOps teams in the automation of deployment and operation steps, still these activities require specific know-how and skills that cannot be found in average teams. The SODALITE framework tackles this problem by offering modelling and smart editing features to allow those we call Application Ops Experts to work without knowing low level details about the adopted, potentially heterogeneous, infrastructures. The framework offers also mechanisms to verify the quality of the defined models, generate the corresponding executable infrastructural code, automatically wrap application components within proper execution containers, orchestrate all activities concerned with deployment and operation of all system components, and support on-the-fly self-adaptation and refactoring.
Data-Driven 3D Facial Animation
Data-Driven 3D Facial Animation: systematically describes the emerging data-driven techniques developed over the last ten years or so. Although data-driven 3D facial animation is used more and more in animation practice, to date there have been very few books that specifically address the techniques involved. Comprehensive in scope, the book covers not only traditional lip-sync (speech animation), but also expressive facial motion, facial gestures, facial modeling, editing and sketching, and facial animation transferring. It provides an up-to-date reference source for academic research and for professionals working in the facial animation field.
Data Quality and Record Linkage Techniques
This book helps practitioners gain a deeper understanding, at an applied level, of the issues involved in improving data quality through editing, imputation, and record linkage. The first part of the book deals with methods and models. Here, we focus on the Fellegi-Holt edit-imputation model, the Little-Rubin multiple-imputation scheme, and the Fellegi-Sunter record linkage model. Brief examples are included to show how these techniques work. In the second part of the book, the authors present real-world case studies in which one or more of these techniques are used. They cover a wide variety of application areas. These include mortgage guarantee insurance, medical, biomedical, highway safety, and social insurance as well as the construction of list frames and administrative lists.
