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Vascular Mechanics and Pathology
Vascular Mechanics and Pathology focuses on the artery and arterial diseases. As the fundamental functions of the artery are to serve as a conduit of blood flow and as a container of blood pressure, Vascular Mechanics and Pathology describes both the general principles and the occurrence of stress concentration at the pressure vessel junctions and examines the role of beta-blockers in the reduction of atherosclerosis and related complications. This cutting-edge work presents the use of veins as arterial grafts and discusses the role of vein valves in graft stenosis. Vascular Mechanics and Pathology illustrates aneurysm formation, growth, and rupture, using pressure vessel principles. This new work details the investigation of, amongst other topics, aortic dissection, showing for the first time that the aortic root mechanics plays a vital role in the development of this pathology.
Trends in Cerebrovascular Surgery and Interventions
This book proceeding book of 9th European-Japanese Cerebrovascular Congress at Milan 2018. Since many experts from Europe and Japan had very important and fruitful discussion on the management of Cerebrovascular diseases, the proceeding book is very attractive for the physician and scientists of the area.
The Vascular Endothelium II
This wide ranging work provides a complete representation of the present state of knowledge of the vascular endothelium. The volume comprises 20 chapters by experts who have made significant contributions to research in the vascular endothelium. The text discusses the structure, development and function of the normal vascular endothelium, considers conditions that lead to the disruption of vascular physiology and provides a comprehensive description of pathologies and their treatment.
The Vascular Endothelium I
This wide ranging work provides a complete representation of the present state of knowledge of the vascular endothelium. The volume comprises 20 chapters by experts who have made significant contributions to research in the vascular endothelium. The text discusses the structure, development and function of the normal vascular endothelium, considers conditions that lead to the disruption of vascular physiology and provides a comprehensive description of pathologies and their treatment.
The Physics of Coronary Blood Flow
This book is devoted specifically to the dynamics and physics of coronary blood flow. While relevance to the clinical and pathophysiological issues is clearly maintained, the book approaches the subject from a biomedical engineering point of view. With this perspective, the Physics of Coronary Blood Flow complements other treatments of the subject that focus largely on the clinical and pathophysiological issues.
Reconstructive Neurosurgery
International experts present in this volume advances in reconstructive neurosurgery focusing on the fields of neurotrauma and neurodegenerative disorders. The highlights include building an international strategy for risk reduction, documentating an multidisciplinary approach towards restoration of function in paraplegic spinal cord-injured patients, describing a new approach for statistical analysis in traumatic brain injury trials, describing blood flow changes in diffuse brain injury, discussing rehabilitation programs in Germany following acute brain injury, describing research data form Taiwan on neurotrauma, showing the neuropsychiatric effects from deep brain stimuation fro ovement disorders, difining the role played by imanging for deep brain stimulation targeting in mental illness, using radiosurgery in decompresssion in the treatment of trigeminal neuralgia, describing the development of radiosurgery from brain to the spine, listing new transgenic animal models of Parkinson's disease, discussing gene therapy for neuropathic pain and Parkinson's disease, and finally, discussing constrained-induced movement therapy fro stroke patients, and endovascular therapy for cerebrovenous disorders.
On Bypass : Advanced Perfusion Techniques
With the introduction of cardiac surgery more than five decades ago and the use of the heart-lung machine for open heart surgical procedures granting the surgeon unlimited time in which to operate inside the heart, a complex task has been given to the Perfusionist. With a pairing of a perfusionist and a surgeon for each chapter, On Bypass: Advanced Perfusion Techniques is an essential collection of techniques and protocols to aid in the difficult and immediate decision making in the operating room. Among the topics covered in this comprehensive text are pediatric perfusion techniques for complex congenital, separation from cardiopumonary bypass, blood flow during cardiopumonary bypass, and minimally invasive perfusion techniques. Also covered is ultrafiltration in cardiac surgery, echocardiography and cardiopulmonary bypass, and advances in long-term pulmonary support.
Minimally Invasive Neurosurgery and Neurotraumatology
Neurotraumatology patients present an enormous challenge to society. Neuros- gical management of brain and spinal cord injury has been a frustrating area, as s- gical methods, especially in moderate and severe injuries, have been limited to control of brain and spinal compression, control of intracranial pressure with its expected effect on cerebral blood flow, and structural repair of the supporting structures (skull, spine, brain and spinal cord coverings). Achieving the best outcome for the neu- traumatology patient, however, requires much more than that.
Mechanisms of Angiogenesis
Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.
IAEA Atlas of Cardiac PET/CT : A Case-Study Approach
This book presents a wide portfolio of examples of positron emission tomography coupled with computer tomography (PET/CT) studies in various cardiac conditions in order to provide a rationale for the implementation of this technology in an array of clinical conditions. Cardiovascular diseases are a major contributor to premature morbidity and mortality worldwide. Low- and middle-income countries (LMICs) are particularly affected by cardiovascular diseases (CVDs), with more than 75% of all CVDs deaths occurring in these countries. For this reason, target 3.4 of the United Nations (UN) Sustainable Development Goals (SDGs) agenda aims at a 30% reduction in premature mortality due to non-communicable diseases (NCDs), which include CVDs, by 2030.
Homocysteine
Homocysteine is a non-proteinogenic α-amino acid. It is a homologue of the amino acid cysteine, differing by an additional methylene bridge (-CH2-). It is biosynthesized from methionine by the removal of its terminal methyl group. In the body, Homocysteine (HCY) can be recycled into methionine or converted into cysteine with the aid of certain B-vitamins. A high level of Homocysteine in the blood (hyperhomocysteinemia) makes a person more prone to endothelial cell injury, which leads to inflammation in the blood vessels, which in turn may lead to atherogenesis, which can result in ischemic injury. Therefore, hyperhomocysteinemia is a possible risk factor for coronary artery disease (CAD). Coronary artery disease occurs when an atherosclerotic plaque blocks blood flow to the coronary arteries, which supply the heart with oxygenated blood.
High performance computing for drug discovery and biomedicine
Explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. Collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. And delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects.
Fluid-structure interaction : Modelling, simulation, optimisation
Fluid-structure interactions (FSI), that is interactions of some movable or deformable structure with an internal or surrounding fluid flow, are among the most important and, with respect to both modelling and computational issues, the most challenging multi-physics problems. The variety of FSI occurrences is abundant and ranges from tent-roofs to micropumps, from parachutes via airbags to blood flow in arteries.
Biology and mechanics of blood flows ; Part II : Mechanics and medical aspects
Biology and Mechanics of Blood Flows presents the basic knowledge and state-of-the-art techniques necessary to carry out investigations of the cardiovascular system using modeling and simulation. Part II of this two-volume sequence, Mechanics and Medical Aspects, refers to the extraction of input data at the macroscopic scale for modeling the cardiovascular system, and complements Part I, which focuses on nanoscopic and microscopic components and processes. This volume contains chapters on anatomy, physiology, continuum mechanics, as well as pathological changes in the vasculature walls including the heart and their treatments. Methods of numerical simulations are given and illustrated in particular by application to wall diseases. This authoritative book will appeal to any biologist, chemist, physicist, or applied mathematician interested in the functioning of the cardiovascular system.
Biology and mechanics of blood flows ; Part I : Biology
Biology and Mechanics of Blood Flows presents the basic knowledge and state-of-the-art techniques necessary to carry out investigations of the cardiovascular system using modeling and simulation. Part I of this two-volume sequence, Biology, addresses the nanoscopic and microscopic scales. The nanoscale corresponds to the scale of biochemical reaction cascades involved in cell adaptation to mechanical stresses among other stimuli. The microscale is the scale of stress-induced tissue remodeling associated with acute or chronic loadings. The cardiovascular system, like any physiological system, has a complicated three-dimensional structure and composition. Its time dependent behavior is regulated, and this complex system has many components.
Aortic valve disease
Your heart has four valves to keep blood flowing in the direction. These valves include the mitral valve, tricuspid valve, pulmonary valve and aortic valve. Each valve has flaps (epiphysis or leaflets) that opens and close once during each heartbeat sometimes the valve do not open or close completely; this interferes with the flow of blood inside the heart, and may lead to impaired ability to pump blood to your body. In aortic valve disease, the aortic valve between the lower left chamber (left ventricle) and the primary artery that delivers blood from the heart to the body (the aorta) does not work completely. It may not close completely; This causes blood to leak back into the left ventricle (regurgitation), or possibly narrowing of the valve (stenosis).
Anticoagulants and coronary artery disease
Blood thinners are medicines that help blood flow smoothly through your veins and arteries. There are two. The first is called anticoagulants (Warfarin, Heparin, Enoxaparin) and The second class of blood thinners is called antiplatelet (Aspirin, Ticagrelor , Clopidogrel). . Coronary arteries supply blood to the heart muscle. Coronary artery disorder or disease can have serious implications by reducing the flow of oxygen and nutrients to the heart muscle. This can lead to a heart attack and possibly death. Atherosclerosis. Medications to reduce the risk of blood clots, such as anticoagulants (including aspirin) and antiplatelet. , in particular aspirin, are effective in preventing platelet activation and thus thrombus formation and Clopidogrel is an inhibitor of platelet activation.
