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Open and Toroidal Electrophoresis : Ultra-High Separation Efficiencies in Capillaries, Microchips and Slabs
Written by one of the developers of Toroidal Capillary Electrophoresis (TCE), this book is the first to present this novel analytical technique, in detail, to the field of analytical chemistry. The exact expressions of separation efficiency, resolution, peak capacity, and many other performance indicators of the open and toroidal layouts are presented and compared.
Oncogenes Meet Metabolism : From Deregulated Genes to a Broader Understanding of Tumour Physiology
In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).
Offshore Risk Assessment : Principles, Modelling and Applications of QRA Studies
This updated and expanded second edition has been informed by a major R&D programme on offshore risk assessment in Norway (2002–2006), and reflects the trend of expanded use of floating production installations. It starts with a thorough discussion of risk metrics and risk analysis methodology with subsequent chapters devoted to analytical approaches to escalation, escape, evacuation and rescue analysis of safety and emergency systems. Separate chapters analyse the main hazards of offshore structures: fire, explosion, collision and falling objects. Risk mitigation and control are discussed, as well as an illustration of how the results from quantitative risk assessment studies should be presented. The second edition has a stronger focus on the use of risk assessment techniques in the operation of offshore installations. Also decommissioning of installations is covered.
Numerical Solution of Partial Differential Equations on Parallel Computers
The scientific fields of Ma- ematics and Physics provide a powerful vehicle for such descriptions in terms of Partial Differential Equations (PDEs). Formulated as such equations, physical laws can become subject to computational and analytical studies. In the computational setting, the equations can be discreti ed for ef?cient solution on a computer, leading to valuable tools for simulation of natural and man-made processes. Numerical so- tion of PDE-based mathematical models has been an important research topic over centuries, and will remain so for centuries to come. In the context of computer-based simulations, the quality of the computed results is directly connected to the model’s complexity and the number of data points used for the computations. Therefore, computational scientists tend to ?ll even the largest and most powerful computers they can get access to, either by increasing the si e of the data sets, or by introducing new model terms that make the simulations more realistic, or a combination of both. Today, many important simulation problems can not be solved by one single computer, but calls for parallel computing.
Non-Linear Electromechanics
This is the first book in which problems of electromechanics are considered from the perspective of analytical mechanics. The book includes fundamental results in the theory of non-linear electromechanical systems and will be useful both for researchers, engineers, scholars and graduate students of electromechanical faculties of technical universities. It includes not only theoretical results but also various examples from many industrial applications. A sizeable part of the book is devoted to the general theory of synchronous machines and electro-magnetic exciters of oscillations.
Nonlinear dynamics in complex systems via fractals and fractional calculus
Current advances in the knowledge of nonlinear dynamical networks, systems and processes, as well as their unified repercussions, allow us to include some typical complex natural phenomena, from the nanoscale to an extra-galactic scale, in an unitarian comprehensive manner. In other words, the physical, biological and financial data, as well as technological ones (mechanical or electronic devices), of complex systems available today can be managed by the same unique conceptual approach, both analytically and through a computer simulation, using effective nonlinear dynamics procedures. This volume collected some important advances in the fields of fractal curves, fractal analysis and fractional calculus, as well as new solutions of fractal differential equations.
Non-Equilibrium Phase Transitions ; Vol. I : Absorbing Phase Transitions
This book describes two main classes of non-equilibrium phase-transitions: (a) static and dynamics of transitions into an absorbing state, and (b) dynamical scaling in far-from-equilibrium relaxation behaviour and ageing. The first volume begins with an introductory chapter which recalls the main concepts of phase-transitions, set for the convenience of the reader in an equilibrium context. The extension to non-equilibrium systems is made by using directed percolation as the main paradigm of absorbing phase transitions and in view of the richness of the known results an entire chapter is devoted to it, including a discussion of recent experimental results. Scaling theories and a large set of both numerical and analytical methods for the study of non-equilibrium phase transitions are thoroughly discussed.
NMR - From Spectra to Structures : An Experimental Approach
Nuclear magnetic resonance spectroscopy is one of the most powerful analytical methods. This practice-oriented textbook aims at teaching how NMR experiments should be used to make structural asssignments. The book is intended as a practical guide for students and laboratory personnel, so that the emphasis is on practical rather than on theoretical aspects, which are treated only to the extent necessary to understand the experiments and to interpret the results.The second edition has been expanded to include several other heteronuclei (15N, 19F, 29Si, 77Se, 113Cd, 117Sn/119Sn, 195Pt, 207Pb) and a new chapter on solid state NMR. The problems section has been enlarged and now includes 50 problems.
New Techniques in Solid-State NMR
After the discovery of nuclear magnetic resonance, [1, 2] the new spectroscopy was used for the study of 1 H nuclei in liquids, but then the signal from copper in the receiver coil itself, the first observation of NMR in the solid state, was found.“Wide-line NMR”, named thus because of the line-broadening effects of dipolar interaction and chemical shift anisotropy, was not far behind, and soon led to significant advances through the analysis of spectral lineshapes. Inthis way Richards and Smith [3] demonstrated the presence of H3O+ cations in solid hydrates of strong acids, while Andrew and Eades [4] investigated the details of molecular motion in three solid benzenes. Even now, 50 years later, it is difficult to think of a technique which would provide a more convincing demonstration of the reality of these effects.
New Results in Numerical and Experimental Fluid Mechanics VI ; Contributions to the 15th STAB/DGLR Symposium Darmstadt, Germany, 2006
The volume gives a broad overview over the ongoing work in this field in Germany, with the topics being high-aspect ratio wings, low aspect-ratio wings, bluff bodies, laminar flow control and transition, active flow control, hypersonic flows, aeroelasticity, aeroacoustics, mathematical fundamentals/ numerical simulation, physical fundamentals, and facilities.
New Results in Numerical and Experimental Fluid Mechanics V ; Contributions to the 14th STAB/DGLR Symposium Bremen, Germany 2004
This volume contains the contributions to the 14. Symposium of the STAB (German Aerospace Aerodynamics Association). The volume gives a broad overview over the ongoing work in this field in Germany, with the topics being high-aspect ratio wings, low aspect-ratio wings, bluff bodies, laminar flow control and transition, active flow control, hypersonic flows, aeroelasticity, aeroacoustics, mathematical fundamentals/ numerical simulation, physical fundamentals, and facilities.
New Partnerships for Innovation in Microfinance
"The book presents valuable information with a strong analytical tilt. … targets economists and managers in banking and development finance organizations, as well as policy makers, international development organizations, and development agencies. Because it covers a range of issues related to funding microfinance, and is written in relatively simple language, yet intelligently argued, it can be used as a resource book for courses on microfinance funding and development. … a useful read for practitioners in the sector."
New insights in machine learning and deep neural networks
Gatheres ten exemplary papers, each delineating advancements within the spheres of machine learning and deep neural networks. Commencing with a thorough exploration by Figueira and Vaz, readers are introduced to the nuances of synthetic data generation and evaluation, followed closely by Silva and Pedroso's systematic approach to leveraging deep reinforcement learning within the intricate realm of delivery logistics. Kamran et al. contribute an astute methodology for camouflage object segmentation, whereas Pinheiro and collaborators offer a crafted semi-supervised strategy for predicting EGFR mutations via CT images. Subsequent contributions, such as Lee and Yoo's framework for portrait emotion recognition and Balakrishnan et al.'s analytical exploration of transformer models for Twitter disaster detection, further exemplify the depth of research contained herein.
Network Performance Analysis : Using the J Programming Language
This useful volume introduces concepts and principles of network performance analysis by example, using the J programming language. J is rich in mathematical functionality, which makes it an ideal tool for analytical methods. The book favours a practical approach and develops functions in J to demonstrate mathematical concepts, thereby enabling readers to explore the underlying principles behind network performance analysis. In addition, this allows the subject to become more accessible to those who, although have a mathematical background, are not pure mathematicians.
Nearest Neighbor Search : A Database Perspective
Modern applications are both data and computationally intensive and require the storage and manipulation of voluminous traditional (alphanumeric) and nontraditional data sets (images, text, geometric objects, time-series). Examples of such emerging application domains are: Geographical Information Systems (GIS), Multimedia Information Systems, CAD/CAM, Time-Series Analysis, Medical Information Sstems, On-Line Analytical Processing (OLAP), and Data Mining. These applications pose diverse requirements with respect to the information and the operations that need to be supported. From the database perspective, new techniques and tools therefore need to be developed towards increased processing efficiency. This monograph explores the way spatial database management systems aim at supporting queries that involve the space characteristics of the underlying data, and discusses query processing techniques for nearest neighbor queries. It provides both basic concepts and state-of-the-art results in spatial databases and parallel processing research, and studies numerous applications of nearest neighbor queries.
Natural product experiments in drug discovery
Explores a wide range of evidence-based complementary medicine and various bio-analytical techniques used to define botanical products. Collecting recent work and current developments in the field of contemporary phytomedicine as well as their future possibilities in human health care, the book includes unique contributions in the form of chapters on phytomedicine and screening biological activities explained with diverse hyphenated techniques, as well as issues related to herbal medications, such as efficacy, adulteration, safety, toxicity, regulations, and drug delivery. Written for the Springer Protocols Handbooks series, chapters feature advice from experts on how to best conduct future experiments. Extensive and practical, Natural Product Experiments in Drug Discovery serves as an ideal reference for students, professors, and researchers in universities, R&D institutes, pharmaceutical and herbal enterprises, and health organizations.
Nanobiosensors : From design to applications
Nanobiosensors - From Design to Applications covers several aspects of biosensors beginning from the basic concepts to advanced level research. It will help to bridge the gap between various aspects of biosensors development technology and applications. It covers biosensors related material in broad spectrum such as basic concepts, biosensors & their classification, biomarkers & their role in biosensors, nanostructures-based biosensors, applications of biosensors in human diseases, drug detection, toxins, and smart phone based biosensors.
Mutagenic Impurities : Strategies for Identification and Control
In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective.
Multiphase Flow Dynamics 2 : Thermal and Mechanical Interactions ; 3rd ed.
Multi-phase flows are part of our natural environment such as tornadoes, typhoons, air and water pollution and volcanic activities as well as part of industrial technology such as power plants, combustion engines, propulsion systems, or chemical and biological industry. The industrial use of multi-phase systems requires analytical and numerical strategies for predicting their behavior. In its third extended edition this book contains theory, methods and practical experience for describing complex transient multi-phase processes in arbitrary geometrical configurations. This book provides a systematic presentation of the theory and practice of numerical multi-phase fluid dynamics. In the present second volume the mechanical and thermal interactions in multiphase dynamics are provided. This third edition includes various updates, extensions, improvements and corrections.
Multiphase Flow Dynamics 1 : Fundamentals ; 3rd ed.
Multi-phase flows are part of our natural environment such as tornadoes, typhoons, air and water pollution and volcanic activities as well as part of industrial technology such as power plants, combustion engines, propulsion systems, or chemical and biological industry. The industrial use of multi-phase systems requires analytical and numerical strategies for predicting their behavior. In its third extended edition this monograph contains theory, methods and practical experience for describing complex transient multi-phase processes in arbitrary geometrical configurations, providing a systematic presentation of the theory and practice of numerical multi-phase fluid dynamics. This third edition includes various updates, extensions and improvements in all book chapters.
