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Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
Online Communities and Social Computing ; 2nd International Conference, OCSC 2007, Held as Part of HCI International 2007, Beijing, China, July 22-27, 2007, Proceedings
The 12th International Conference on Human-Computer Interaction, HCI Inter- tional 2007, was held in Beijing, P.R. China, 22-27 July 2007. This volume, edited by Douglas Schuler, contains papers in the thematic area of Online Communities and Social Computing, addressing the following major topics: • Designing and Developing On-line Communities • Knowledge, Collaboration, Learning and Local On-line Communities
One-Dimensional Nanostructures
One-dimensional (1D) nanostructures, including nanowires, nanotubes and quantum wires, have been regarded as the most promising building blocks for nanoscale electronic and optoelectronic devices. Worldwide efforts in both the theory and the experimental investigation of growth, characterization and applications of 1D nanostructures have resulted in a mature, multidisciplinary field. In this book, a wealth of state-of-the-art information offers the opportunity to uncover the underlying science from diverse perspectives. Leading researchers elucidate the synthesis and properties of 1D nanostructures for various morphologies and compositions (semiconductor, metal, carbon, etc.) as well as their considerable impact on spintronics, information storage, and the design of field-effect transistors.
Once upon a time : illustrations from fairytales, fables, primers, pop-ups, and other children's books
The 1905 obituary of John McLoughlin, Jr., in Publisher's Weekly declared,?Every child in the land knows the McLoughlin books. ... In fact, the history in the last decade of colored toy books for youngsters is the history of Mr. McLoughlin and his firm.?
On the Way to the Web : The Secret History of the Internet and its Founders
On the Way to the Web: The Secret History of the Internet and Its Founders is an absorbing chronicle of the inventive, individualistic, and often cantankerous individuals who set the Internet free. Michael A. Banks describes how the online population created a new culture and turned a new frontier into their vision of the future. This book will introduce you to the innovators who laid the foundation for the Internet and the World Wide Web, the man who invented online chat, and the people who invented the products all of us use online every day. Learn where, when, how and why the Internet came into being, and exactly what hundreds of thousands of people were doing online before the Web. See who was behind it all, and what inspired them.
On the Move to Meaningful Internet Systems : OTM 2008 ; OTM 2008 Confederated International Conferences, CoopIS, DOA, GADA, IS, and ODBASE 2008, Monterrey, Mexico, November 9-14, 2008, Proceedings, Part II
This two-volume set LNCS 5331/5332 constitutes the refereed proceedings of the five confederated international conferences on Cooperative Information Systems (CoopIS 2008), Distributed Objects and Applications (DOA 2008), Grid computing, high performAnce and Distributed Applications (GADA 2008), Information Security (IS 2008), and Ontologies, Databases and Applications of Semantics (ODBASE 2008), held as OTM 2008 in Monterrey, Mexico, in November 2008.
On color
Investigates color from numerous perspectives: literary, historical, cultural, anthropological, philosophical, art historical, political, and scientific. In ten lively and wide-ranging chapters, each devoted to a different color, they examine the various ways colors have shaped and continue to shape our social and moral imaginations. Each individual color becomes the focal point for a consideration of one of the extraordinary ways in which color appears and matters in our lives. Beautifully produced in full color, this book is a remarkably smart, entertaining, and fascinating guide to this elusive topic.
olution Sets for Net Zero Energy Buildings : Feedback from 30 Buildings Worldwide
Presents a unique study of 30 NZEBs that have been constructed and have had their performance measured for at least 12 months. The study is based upon an international collaborative research initiated by the International Energy Agency. It is the first book to evaluate building strategies in houses, educational buildings and offices that have been demonstrated to work in practice. It examines how the design challenges of climate and building type have been addressed, and to what extent the various design approaches have been successful. This book presents convincing evidence that a careful re-thinking of conventional design norms can achieve a far greater performance benefit than is normally feasible. It identifies 'solution sets' that work at the whole building level and at the individual building design challenge level for each climate and building type. In doing so, the book provides guidance as to how to improve the design by learning from these cases. Unusually for a book of this type it has examples of buildings in what are conventionally labeled 'hot' and 'cold' climates.
Old Buildings New Designs
Increasingly, architects are hired to design new work for existing structures. Whether for reasons of preservation, sustainability, or cost-effectiveness, the movement to reuse buildings presents a variety of design challenges and opportunities. Old Buildings, New Designs is an Architecture Brief devoted to working within a given architectural fabric from the technical issues that arise from aging construction to the controversy generated by the various project stakeholders to the unique aesthetic possibilities created through the juxtaposition of old and new.
Odell's clinical problem solving in dentistry
Explores care planning and treatment alternatives and evaluates their advantages and disadvantages as well as medico-legal implications Integrates material from all the dental disciplines in order to cover an extensive range of clinical problems which will be encountered in daily practice A practical approach to learning - includes a large number of real-life clinical cases including those relevant to new techniques and issues such as implantology, use of CAD-CAM, CBCT (cone beam computed tomography) Designed to help the reader use the knowledge gained in a clinically useful, practically applied format Highly visual guide with more than 350 colour illustrations, artwork and tables presenting clinical, diagnostic and practical information in an easy-to-follow structure
Obstetric life support manual
A comprehensive review in normal and abnormal pregnancy physiology, the most common etiologies of maternal medical emergencies, recognition of maternal deterioration and pending cardiopulmonary arrest, modifications to cardiopulmonary resuscitation in pregnant and postpartum patients, special procedures that can assist in diagnosing and treating maternal medical emergencies tailored to the setting (e.g., point-of-care ultrasound, resuscitative cesarean delivery, extracorporeal cardiopulmonary resuscitation), treatment of trauma/stroke in pregnancy, and postpartum maternal medical emergencies. There are streamlined algorithms and cognitive aids designed to improve a team’s ability to successfully implement techniques unique to treating maternal medical emergencies and car..
Objects, Components, Models and Patterns ; 46th International Conference, TOOLS EUROPE 2008, Zurich, Switzerland, June 30 - July 4, 2008. Proceedings
This book constitutes the thoroughly refereed proceedings of the 46th International Conference on Objects, Components, Models and Patterns, TOOLS EUROPE 2008, held in Zurich, Switzerland, in June/July 2008.TOOLS played a major role in the spread of object-oriented and component technologies. It has now broadened its scope beyond the original topics of object technology and component-based development to encompass all modern, practical approaches to software development.
Object-oriented metrics in practice : Using software metrics to characterize, Evaluate, and Improve the design of object-oriented systems
The combination of theoretically sound results and practically tested procedures and solution paths makes this book an ideal companion for professional software architects, developers and quality engineers. The pattern-oriented description of disharmonies offers easy access to detecting shortcomings and applying solution strategies. "This well-written book is an important piece of work that takes the seemingly forgotten art of object-oriented metrics to the next level in terms of relevance and usefulness."
Object-Oriented Data Structures Using Java ; 4th ed.
an essential resource for students learning data structures using the Java programming language. It presents both the traditional and modern data structure topics with an emphasis on problem-solving and object-oriented software design. Beginning early and continuing throughout the text, it introduces and expands upon the use of many Java features such as classes, objects, generics, polymorphism, packages, interfaces, library classes, inheritance, exceptions, and threads.
Object-Oriented ActionScript for Flash 8
Object-Oriented ActionScript For Flash 8 teaches the theory and practice of OOP with ActionScript. You do not need any extensive prior programming experience, you just need to want to go beyond the usual Flash interfaces. Authors and working Flash developers Peter Elst and Todd Yard take you through the complete development cycle of a series of related applications, using numerous step-by-step instructions. You'll be able to develop highly reusable applications and services that leverage the dynamic features in Flash. This book demonstrates professional OOP skills and techniques that are completely transferable to other programming languages and technologies, including Inheritance, Polymorphism, managing classes, component development, consuming web services, and much more. It also includes some cutting edge ActionScript programming techniques, and animation and effects classes.
Objective information theory
Objective Information Theory (OIT) is proposed to represent and compute the information in a large-scale complex information system with big data in this monograph. To formally analyze, design, develop, and evaluate the information, OIT interprets the information from essential nature, measures the information from mathematical properties, and models the information from concept, logic, and physic. As the exemplified applications, Air Traffic Control System (ATCS) and Smart Court SoSs (System of Systems) are introduced for practical OITs.
Nutrient Acquisition by Plants : An Ecological Perspective
Adaptation and evolution of terrestrial plants depend, to a large extent, on their ability to acquire nutrients. This is a modern and integrative treatment of the mechanisms controlling plant nutrient uptake and how plants respond to changes in the environment. The following key topics are covered: soil nutrient bioavailability; root responses to variations in nutrient supply; nitrogen fixation; regulation of nutrient uptake by internal plant demand; root characteristics; kinetics of nutrient uptake; root architecture; life span; mycorrhizae; responses to climate change. This integrated view helps us to understand the mechanisms that govern present-day plant communities and is indispensable in models designed to predict the response of plants to a changing climate.
Nurturing Science-based Ventures : An International Case Perspective
The challenge is to nurture entrepreneurial skills and ambitions in science and engineering academic students in the hope that they will consider the starting of a new business based on their research as a compelling alternative to more traditional employment opportunities. The book by Seifert, Leleux and Tucci addresses this challenge. … designed as a teaching support for courses on science-based entrepreneurship and it primarily targets engineering and science students. The book focuses on science based ventures that originate in technological break throughs, but entrepreneurs from all backgrounds can learn from it. Nurturing Science-Based Ventures charts the development of a new venture through five chapters.
Numerical Techniques for Chemical and Biological Engineers Using MATLAB® : A Simple Bifurcation Approach
This book addresses the bifurcation characteristics of chemical and biological processes as the general case and treats systems with a unique steady state as special cases. It uses a system approach which is the most efficient for knowledge organization and transfer. The book develops mathematical models for many commercial processes utilizing the mass-, momentum-, and heat-balance equations coupled to the rates of the processes that take place within the boundaries of the system. The models are solved numerically through MATLAB codes with emphasis on the design and optimization of the chemical and biological industrial equipment and plants.
Numerical solution of Variational Inequalities by Adaptive Finite Elements
Franz-Theo Suttmeier describes a general approach to a posteriori error estimation and adaptive mesh design for finite element models where the solution is subjected to inequality constraints. This is an extension to variational inequalities of the so-called Dual-Weighted-Residual method (DWR method) which is based on a variational formulation of the problem and uses global duality arguments for deriving weighted a posteriori error estimates with respect to arbitrary functionals of the error. In these estimates local residuals of the computed solution are multiplied by sensitivity factors which are obtained from a numerically computed dual solution. The resulting local error indicators are used in a feed-back process for generating economical meshes which are tailored according to the particular goal of the computation.
