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Adhesion Molecules : Function and Inhibition
Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.
Addition Reactions with Unsaturated Hydrocarbons
Addition Reactions with Unsaturated Hydrocarbons presents an up-to-date overview of modern methods that utilize reactions of unsaturated hydrocarbons as building blocks of organic synthesis, covering the conceptual and practical knowledge required for designing atom-efficient reactions to synthesize functionalized molecules. This authoritative volume discusses homo-dimerization and cross-dimerization of alkynes and/or alkenes, synthesis of carbonyl compounds from the hydration of alkynes, cycloadditions of alkynes and alkenes for the synthesis of carbocycles and heterocycles.
Adaptation to Life at High Salt Concentrations in Archaea, Bacteria, and Eukarya
This book complements “Halophilic Microorganisms”, edited by A. Ventosa and published by Springer-Verlag (2004), “Halophilic Microorganism and their Environments” by A. Oren (2002), published by Kluwer Academic Publishers as volume 5 of “Cellular Origins, Life in Extreme Habitats and Astrobiology” (COLE), and “Microbiology and Biogeochemistry of Hypersaline Environments” edited by A. Oren, and published by CRC Press, Boca Raton (1999).
Active Processes and Otoacoustic Emissions in Hearing
Sounds that are actually produced by healthy ears allow researchers and clinicians to study hearing and cochlear function noninvasively in both animals and humans. Active Processes and Otoacoustic Emissions in Hearing presents the first serious review of the biological basis of these otoacoustic emissions. Active processes, such as those in hair cells that produce emissions, represent a burgeoning and important area of sensory research. By providing a basis for understanding how and why otoacoustic emissions testing works through a basic understanding of general hearing processes, this volume will also interest clinicians, particularly otolaryngologists and audiologists.
Actin-Binding Proteins and Disease
This volume, written by experts in the field, is the first to deal with the relationship between human disease and the actin cytoskeleton. It provides overviews of actin and selected actin-binding proteins, and then focuses on diseases that involve these proteins. Specific chapters deal with actin, cofilin, profilin, gelsolin and thymosin ¾4. Other chapters discuss the roles of multiple actin-binding proteins in cancer and metastasis, leukocyte disorders, and heart failure, and there is a chapter that describes how intracellular pathogens use the host actin cytoskeleton. This seminal volume is intended for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
A Time for Metabolism and Hormones
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
A Legacy for Living Systems : Gregory Bateson as Precursor to Biosemiotics
This book represents a major attempt to revise this deficiency. Scholars from ecology, biochemistry, evolutionary biology, cognitive science, anthropology and philosophy discuss how Bateson's thinking might lead to a fruitful reframing of central problems in modern science. Most important perhaps, Bateson's bioanthropology is shown to play a key role in developing the set of ideas explored in the new field of biosemiotics. The idea that organismic life is indeed basically semiotic or communicative lies at the heart of the biosemiotic approach to the study of life.The only book of its kind, this volume provides a key resource for the quickly-growing substratum of scholars in the biosciences, philosophy and medicine who are seeking an elegant new approach to exploring highly complex systems.
2D Functional Nanomaterials : Synthesis, Characterization, and Applications
In 2D Functional Nanomaterials: Synthesis, Characterization, and Applications, Dr. Ganesh S. Kamble presents an authoritative overview of the most recent progress in the rational design and synthesis of 2D nanomaterials and their applications in semiconducting catalysts, biosensors, electrolysis, batteries, and solar cells. This interdisciplinary volume is a valuable resource for materials scientists, electrical engineers, nanoscientists, and solid-state physicists looking for up-to-date information on 2D heterojunction nanomaterials.
Legitimate expectations in the common law world
The sceptical and critical reception to Coughlan outside England is a striking contrast to the reception the case received within the UK. This book provides a detailed scholarly analysis of these issues and considers the doctrine of legitimate expectations both in England and elsewhere in the common law world. Volume 12 in the series Hart Studies in Comparative Public Law
Community-oriented policing and technological innovations
Presents new approaches and innovative challenges to address bringing technology into community-oriented policing efforts. “Community-oriented policing” is an approach that encourages police to develop and maintain personal relationships with citizens and community organizations. By developing these partnerships, the goal is to enhance trust and legitimacy of police by the community (and vice versa), and focus on engaging the community crime prevention and detection efforts for sustainable, long-term crime reduction. The contributions to this volume emphasize how technological innovations can advance community-oriented policing goals.
Common Law, Civil Law, and Colonial Law : Essays in Comparative Legal History from the Twelfth to the Twentieth Centuries
This volume is a selection of essays taken from the excellent range of papers presented at the British Legal History Conference hosted by the Institute for Legal and Constitutional Research at the University of St Andrews, 10-13 July 2019. The theme of the conference gives this book its title: 'comparative legal history'. The topic came easily to the organisers because of their association with the St Andrews-based European Research Council Advanced grant project 'Civil law, common law, customary law: consonance, divergence and transformation in Western Europe from the late eleventh to the thirteenth centuries'.
Bordieuan Field Theory as an Instrument for Military Operational Analysis
This book uses Pierre Bourdieu’s field theory as a lens through which to examine military operations. Novel in its approach, this innovative text provides a better, more nuanced understanding of the modern ‘battlespace’, particularly in instances of prolonged low-intensity conflict. Formed in two parts, this book primarily explores the scope of Bourdien theory before secondly providing a detailed case study of the Yugoslavian succession war of 1990-1992. Gunneriusson suggests that although theories do not necessarily provide answers, they do help us ask better questions. This volume suggests news lines of interdisciplinary investigation that will be of interest to members of armed forces, practitioners from NGOs, and policymakers.
Mathematical Methods in Computer Science : Essays in Memory of Thomas Beth
This Festschrift volume contains the proceedings of the conference Mathematical Methods in Computer Science, MMICS 2008, which was held during December 17-19, 2008, in Karlsruhe, Germany, in memory of Thomas Beth.The themes of the conference reflected the many interests of Thomas Beth. Although, these interests might seem diverse, mathematical methods and especially algebra as a language constituted the common denominator of all of his scientific achievements.
Mathematical Linguistics
Mathematical Linguistics introduces the mathematical foundations of linguistics to computer scientists, engineers, and mathematicians interested in natural language processing. The book presents linguistics as a cumulative body of knowledge from the ground up, with no prior knowledge of linguistics being assumed, covering more than the average two-semester introductory course in linguistics.This comprehensive, reader-friendly volume offers readers a high-level orientation, discussing the foundations of the field and presenting both the classical work and the most recent results. It covers an extremely rich array of topics including not only syntax and semantics but also phonology and morphology, probabilistic approaches, complexity, learnability, and the analysis of speech and handwriting.
Machine learning and big data : Concepts, algorithms, tools and applications
Showcase novel use-cases and applications, present empirical research results from user-centered qualitative and quantitative experiments of these new applications, and facilitate a discussion forum to explore the latest trends in big data and machine learning by providing algorithms which can be trained to perform interdisciplinary techniques such as statistics, linear algebra, and optimization and also create automated systems that can sift through large volumes of data at high speed to make predictions or decisions without human intervention
Literature-based Discovery
When Don Swanson hypothesized a connection between Raynaud’s phenomenon and dietary fish oil, the field of literature-based discovery (LBD) was born. During the subsequent two decades a steady stream of researchers have published articles about LBD and the field has made steady progress in laying foundations and creating an identity. LBD is an inherently multi-disciplinary enterprise where collaborations between the information and biomedical sciences are readily encountered. It is the hope and intention that this volume will plant a flag in the ground and inspire new researchers to the LBD challenge.
Knowledge and Information Visualization : Searching for Synergies
The basic ideas underlying knowledge visualization and information vi- alization are outlined. In a short preview of the contributions of this volume, the idea behind each approach and its contribution to the goals of the book are outlined. 2 The Basic Concepts of the Book Three basic concepts are the focus of this book: "data", "information", and "kno- edge". There have been numerous attempts to define the terms "data", "information", and "knowledge", among them, the OTEC Homepage "Data, Information, Kno- edge, and Wisdom" (Bellinger, Castro, & Mills, see http://www.syste- thinking.org/dikw/dikw.htm): Data are raw. They are symbols or isolated and non-interpreted facts. Data rep- sent a fact or statement of event without any relation to other data. Data simply exists and has no significance beyond its existence (in and of itself). It can exist in any form, usable or not. It does not have meaning of itself.
Knowledge and Data Management in GRIDs
Knowledge and Data Management in GRIDs is the third volume of the CoreGRID series and brings together scientific contributions by researchers and scientists working on storage, data, and knowledge management in GRID and Peer-to-Peer systems. This volume presents the latest GRID solutions and research results in key areas of knowledge and data management such as distributed storage management, GRID databases, Semantic GRID and GRID-aware data mining.
Comprehensive mathematics for computer scientists 2 : Calculus and ODEs, splines, probability, fourier and wavelet theory, fractals and neural networks, categories and lambda calculus
This second volume of a comprehensive tour through mathematical core subjects for computer scientists completes the ?rst volume in two - gards: Part III ?rst adds topology, di?erential, and integral calculus to the t- ics of sets, graphs, algebra, formal logic, machines, and linear geometry, of volume 1. With this spectrum of fundamentals in mathematical e- cation, young professionals should be able to successfully attack more involved subjects, which may be relevant to the computational sciences. In a second regard, the end of part III and part IV add a selection of more advanced topics. In view of the overwhelming variety of mathematical approaches in the computational sciences, any selection, even the most empirical, requires a methodological justi?cation. Our primary criterion has been the search for harmonization and optimization of thematic - versity and logical coherence. This is why we have, for instance, bundled such seemingly distant subjects as recursive constructions, ordinary d- ferential equations, and fractals under the unifying perspective of c- traction theory.
C# 10 in a Nutshell : The Definitive Reference
When you have questions about C# 10.0 or .NET 6, this guide has the answers you need. C# is a language of unusual flexibility and breadth, but with its continual growth, there's so much more to learn. In the tradition of O'Reilly's Nutshell guides, this thoroughly updated edition is simply the best one-volume reference to the C# language available today. Organized around concepts and use cases, this comprehensive and complete reference provides intermediate and advanced programmers with a concise map of C# and .NET that also plumbs significant depths
