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Explainable artificial intelligence in troke from the clinical, rehabilitation and nursing perspectives
As we know, strokes are one of the world's leading causes of death, and the cruel aspect of a stroke is that it leaves people with severe functional disability and/or cognitive impairment. Strokes have a significant impact on economies worldwide, as it is estimated that about 10% of the male population and 8% of the female population are affected by them. Such people need personal help in their everyday life and must be materially supported by social services. With the advancement of medicine, artificial intelligence, and new technologies have been developing rapidly and are gradually applied in diseases of the nervous system, increasingly helping diagnosis, treatment, rehabilitation, and prognosis of disease.
Exosomes based drug delivery strategies for brain disorders
Provides a comprehensive overview of the role of exosomes in brain diseases, including stroke, multiple sclerosis, Parkinson's disease, Alzheimer's disease, epilepsy, and depression. It covers the basics of exosome biogenesis, composition, and synthesis, as well as the therapeutic potential of exosomes in brain disorders. The correlation between exosomes and neuroinflammation, the challenges of using exosomes as a novel carrier, and engineered exosomes to deliver therapeutic protein are covered well in this book. Use of radiolabelled exosomes as a diagnostic tool and the toxicity studies of exosomes with potential overcome approaches. It is an essential resource for researchers, clinicians, and healthcare professionals working in the field of exosome research, especially on its applications in brain disorders.
Existence and Regularity Properties of the Integrated Density of States of Random Schrödinger Operators
The theory of random Schrödinger operators is devoted to the mathematical analysis of quantum mechanical Hamiltonians modeling disordered solids. Apart from its importance in physics, it is a multifaceted subject in its own right, drawing on ideas and methods from various mathematical disciplines like functional analysis, selfadjoint operators, PDE, stochastic processes and multiscale methods. The present text describes in detail a quantity encoding spectral features of random operators: the integrated density of states or spectral distribution function. Various approaches to the construction of the integrated density of states and the proof of its regularity properties are presented.
Évaluation des troubles neuropsychologiques en vie quotidienne = Assessment of neuropsychological disorders in daily life
Neurological diseases such as stroke, head trauma, Alzheimer's disease pose a public health problem. They affect all ages, from children to the elderly. They affect the possibilities of autonomy in daily life, the possibilities of social or professional integration. In these pathologies, neuropsychological disorders: disorders of language, memory, attention, etc., are the source of crucial difficulties. Cognitive tests performed by psychologists are essential for their diagnosis, but do not on their own make it possible to prejudge the difficulties encountered by people in their everyday life. This book presents an original approach to neuropsychological disorders, by describing specific assessments describing difficulties in daily life, in order to better understand them and to quantify their impact. The second part of the book develops the consequences in clinical practice in particular populations - children and the elderly - or the social objective of the evaluation, in particular school integration, professional integration and driving. Finally, the relevance of these assessments in the context of recent laws on disabled people as well as the development of compensation for bodily injury after an accident are also discussed.
Ethnobotany and ethnopharmacology of medicinal and aromatic plants : steps towards drug discovery
Medicinal and aromatic plants are beneficial to human health. Plant-derived molecules possess biological activities that can be used to prevent many infectious diseases and metabolic disorders. Ethnobotany and Ethnopharmacology of Medicinal and Aromatic Plants summarizes techniques and methods used to study the biological activities of plant-derived extracts and compounds to study ethnobotanical and ethnopharmacological features of medicinal and aromatic plants.
Estrogen Effects in Psychiatric Disorders
A number of studies, mostly focusing on estrogen replacement therapy in women, have reported beneficial actions of these hormones on various neurobiological and neuropathological parameters in health and disease. Recent research has focused on gender differences and there is increasing evidence that estrogens exert protective effects in schizophrenia. Hormonal fluctuations or lack of estrogen may increase the risk of depression among vulnerable women. Treatment of depression with estrogen may stabilize and restore disrupted homeostasis – as during post-partum, premenstrual, or perimenopausal conditions – and act as a psychomodulator to offset vulnerability to dysphoric mood when estrogen levels are significantly decreased, as in the case of postmenopausal women. Studies on the effect of estrogens on Alzheimer’s Disease are still rather controversial, they do, however, facilitate the hypothesis that estrogens may have a modifying effect on the onset and course of AD, at least in subgroups of patients.
Endocrinology and diabetes
Covers endocrine anatomy and physiology, scientific background, clinical presentations, diagnosis and management of various endocrine disorders. Clear and concise chapters focus on conditions commonly encountered in both clinical practice and assessments.
Endocrinology : Basic and Clinical Principles
For this new edition of Conn & Melmed's Endocrinology: Basic and Clinical Principles, a panel of distinguished scientists and clinicians has completely rewritten every chapter to reflect the latest advances in our understanding of the endocrine system. Maintaining the original goal of the first edition to integrate the basic science of endocrinology with its physiological and clinical principles, the authors have succinctly summarized in 450 pages the latest findings on hormone secretion and hormone action, as well as all of the most recent insights into the physiology and pathophysiology of hormonal disorders. Coverage extends across the entire spectrum of endocrinology-from mammalian cells, plants, and insects to animal models and human diseases-with much increased coverage of diabetes and metabolism. Highlights include cutting-edge discussions of appetite disorders, obesity, reproductive failure, control of thyroid function, hormone action in humans and the lower species, and the mechanisms subserving hormone secretion.
Encyclopedia of medicinal plants
This compilation reports different therapeutic plant species, most ordinarily utilized by native persons throughout the planet. The botanical term, family name, dialect name, partly utilized, and the use of the plants have been mentioned in this work. This encyclopedia presents a rundown of restorative plants generally used for relieving disorders, their bioactive elements, and their means of operation.
Encyclopedia of Cognitive Behavior Therapy
One of the hallmarks of cognitive behavior therapy is its diversity today. Since its inception, over twenty five years ago, this once revolutionary approach to psychotherapy has grown to encompass treatments across the full range of psychological disorders. The Encyclopedia of Cognitive Behavior Therapy brings together all of the key aspects of this field distilling decades of clinical wisdom into one authoritative volume
Emergency Vascular Surgery : A Practical Guide
The book provides detailed guidelines to any physician treating patients with emergency vascular disorders, such as ruptured abdominal aortic aneurysms, acute limb ischemia, vascular trauma, iatrogenic vascular injuries and complications to vascular surgery. It provides an introduction to vascular surgical operations and focuses on how to manage patients from the emergency ward through the urgent operation and all the way to the immediate postoperative period. Numerous figures illustrate the particular points in vascular techniques and diagnostic problems in the emergency situation.
Eating disorders
What is an Eating Disorder (ED)? Eating disorders are a type of serious mental health condition characterized by severe disturbances in eating behaviors and related to persistent eating behaviors that negatively impact your health, your emotions and your ability to function in important areas of life. Most eating disorders involve focusing too much on your weight, body shape and food, leading to dangerous eating behaviors. These behaviors can significantly impact your body's ability to get appropriate nutrition. Eating disorders can harm the heart, digestive system, bones, and teeth and mouth, and lead to other diseases. Eating disorders affect several million people at any given time, ED often develop in the teen and young adult years, although they can develop at other ages. Eating disorders can affect people of all genders, ages, races, religions, ethnicities, sexual orientations, body shapes, and weights.
Drugs, the brain, and behavior : The pharmacology of therapeutics and drug use disorders
Provides a comprehensive overview of the brain and explores the clinical and pharmacological issues surrounding drug abuse and dependence. Dr Brick provides definitions, historic discoveries about the nervous system, and original, eye-catching illustrations to discuss the brain/behavior relationship, basic neuroanatomy, neurophysiology, and the mechanistic actions of mood-altering drugs. Topics include: how psychoactive drugs affect cognition, behavior, and emotion; the brain/behavior relationship; the specific effects of major addictive and psychoactive drug groups; new definitions and thinking about abuse and dependence; and the medical uses of drugs, such as cannabinoids. A new chapter on biobehavioral markers explores how markers can guide the clinician in the diagnosis of some disorders. This book offers a quick reference guide which uses a balance of instruction, illustrations, tables, and formulas, that will give you a broad, lasting introduction to this intriguing subject.
Drugs Compromising Male Sexual Health
This concise drug guide lists approximately 500 substances, such as pharmaceutical drugs, lifestyle drugs, and environmental toxicants, that show documented untoward effects on the male sexual organs and their functions.
Drug-Induced Oral Complications
Provides detailed information on the prevalence and manifestations of the most important oral complications associated with different drug treatments, focusing especially on recently developed therapies. Among the diverse adverse drug reactions covered are gingival overgrowth, ulcerations, lichenoid reactions, pigmentation, and bullous reactions. The potential direct toxic effects on bone of drugs that prevent bone mass loss, such as bisphosphonates and denosumab, are fully examined, as is the occurrence of spontaneous oral bleeding in patients receiving antithrombotic therapies. Further chapters focus on drug-induced taste disorders and salivary gland disturbances, including xerostomia, swelling, and hypersalivation. The enhanced risk of oral infections when using chemotherapy and biotherapy is addressed, and the closing chapter examines drug-related perioral and facial complications. This book is a collaborative work that brings together clinicians, surgeons, and specialists in drug safety surveillance.
Drug discovery and GBCR – Related CNS Disorders
Neurodegenerative diseases are a large group of neurological disorders with diverse etiological and pathological phenomena. However, current therapeutics rely mostly on symptomatic relief while failing to target the underlying disease pathobiology. G-protein-coupled receptors (GPCRs) are one of the most frequently targeted receptors for developing novel therapeutics for central nervous system (CNS) disorders. Many currently available antipsychotic therapeutics also act as either antagonists or agonists of different GPCRs. Therefore, GPCR-based drug development is spreading widely to regulate neurodegeneration and associated cognitive deficits through the modulation of canonical and noncanonical signals.
Drug delivery via nasal route
Over the past 10 years, the interest in intranasal drug delivery has increased. The objective of this research is to summarize recent developments on intranasal administration for local and systemic delivery, as well as for CNS indications. Nasal delivery offers many advantages over standard systemic delivery systems, nevertheless, there are still formulation limitations and side effects to be optimized. Intranasal drug delivery in the field of drug development is an interesting delivery route for the treatment of neurological disorders. Systemic approaches often fail to efficiently supply the CNS with drugs. This research describes the anatomical, histological and physiological basis and summarizes currently approved drugs for administration via intranasal delivery. Further, the research focuses on advantages and disadvantages of intranasal applied compounds and discusses formulation aspects that need to be considered for drug development.
Drug Delivery Systems for Metabolic Disorders
Covers recent developments in advanced drug delivery systems in various metabolic disorders, including disturbances in protein, lipid, carbohydrate and hormone metabolism and lysosomal and mitochondrial disorders. It provides a brief introduction to metabolic disorders, along with a focus on the current landscape and trends in understanding disease pathology using different in vitro and in vivo models required for clinical applications and developments of new therapeutics.
Drug Addiction : From Basic Research to Therapy
Drug Addiction: From Basic Research to Therapy provides a comprehensive overview of physiological, biochemical, genetic and behavioral pathways underlying drug addiction. Focusing on fundamental neurophysiological processes that overlap between drug addiction and other CNS disorders, this volume covers the translation of basic research into novel therapies, not only of drug addiction but a spectrum of related CNS disorders, including pain. Chapters are written by leading scientists with widely ranging expertise in synthetic and computational chemistry, molecular biology, genetics, neurosciences, drug discovery and development, drug targeting, and quantitative therapeutics, providing an unprecedented overview of a complex field of high societal signficance.
Doppler Ultrasound in Obstetrics and Gynecology
Doppler Ultrasound in Obstetrics & Gynecology encompasses the full spectrum of clinical applications of Doppler ultrasound for the practicing obstetrician-gynecologist, including the latest advances in 3D and color Doppler and the newest techniques in 4D fetal echocardiography. Written by preeminent experts in the field, the book covers the basic and physical principles of Doppler ultrasound; the use of Doppler for fetal examination, including fetal cerebral circulation; Doppler echocardiography of the fetal heart; and the use of Doppler for postdated pregnancy and in cases of multiple gestation. Chapters on the use of Doppler for gynecologic investigation include ultrasound in ectopic pregnancy, for infertility, for benign disorders and for gynecologic malignancies.
