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Industrial hygiene in the pharmaceutical and consumer healthcare industries
Use of containment in the pharmaceutical industry and consumer healthcare. It serves to highlight how industrial hygiene acts as a driving force within these industries to reduce the risk of exposure to chemical and physical agents, particularly to powders and dusts, while taking all factors into account. The author emphasizes how this book is not designed to replace other texts on containment; rather, it will serve to show a practical approach of utilizing the technologies within the high-demand industries of pharmaceuticals and consumer healthcare.
In vivo Models of HIV Disease and Control
An AIDS vaccine is still elusive and HIV treatment continues to develop multidrug resistance at alarming rates. Because of the similarities between HIV and immune deficiency infections in a variety of animals, it is only natural that scientists use these animals as models to study pathogenesis, treatment, vaccine development and many other aspects of HIV. Part of the series Infectious Agents and Pathogenesis, this volume reviews the immune deficiency virus in a variety of hosts. Pathogenesis, vaccine and drug development, epidemiology, and the natural history of the monkey, mouse, cat, cow, horse, and other animal viruses are detailed and compared to HIV. Also included are chapters on the history and future of animal models, as well as a chapter on ethical and safety considerations in using animal models for AIDS studies.
In Vivo Imaging of Cancer Therapy
In Vivo Imaging of Cancer Therapy addresses a variety of cutting-edge imaging techniques, including their use for best practice, and provides examples of results found in both pre-clinical and clinical studies. This comprehensive text covers the entire spectrum of in vivo imaging for oncology, including current approaches to detailed anatomic measurements, MR and optical spectroscopy, and molecular imaging techniques requiring exogenously administered imaging agents. The challenges and approaches to quantification are also outlined. The authors describe technologies and methods that are currently clinically available, and many that are still in a developmental stage or useful only in animal studies.
Immunogenetics: Methods and Protocols
Explores techniques for working in the field of immunogenetics, i.e. fundamental and translational research into the adaptive immune receptor repertoire. Many chapters are dedicated to lab protocols, bioinformatics, and immunoinformatics analysis of high-resolution immunome analysis, exemplified by numerous applications. Additionally, the newest technological variations on these protocols are discussed, including non-amplicon, single-cell, and cell-free strategies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Immune receptors : Methods and protocols
Explores immune cell receptors that are used in the detection of microbes, either by binding directly to non-self molecules or through indirectly sensing microbe-associated cellular disturbances. The covers methods for studying receptor-ligand interactions at both molecular and cellular levels; methods to create and characterize novel antibody reagents; and methods to characterize the molecular processes that lead to adaptive receptor maturation. This book also contains chapters that look at high-throughput strategies that describe the diversity of immune receptors and cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Immune mediators in cancer : Methods and protocols
Provides a comprehensive collection of classic and cutting-edge methodologies as well as bioinformatics and genome-editing approaches that are used to quantify immune mediators and analyze their function and biological activity in cancer cells and tissues. Beginning with a section on the detection of immune mediators in samples, the volume continues with sections covering cytokine bioassays, the expression and regulation of immune mediators in cancer cells, and methods to navigate the enormous datasets created by modern DNA and RNA sequencing and proteomic technology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
ICCS 2007 ; Proceedings of the 15th International Workshops on Conceptual Structures
The 15th International Conference on Conceptual Structures (ICCS 2007) is the latest in a series of annual conferences that have been held in Europe, Australia, and North America since 1993. Some of the world's best minds in information technology, arts, humanities and social science converged to explore novel ways that information and communications technology (ICT) can augment human intelligence.
Hypersensitivity = فرط الحساسية
فرط التحسس هو عبارة عن ردود فعل لجهاز المناعة تسبب ظواهر غير مرغوب بها تشمل تضرر الأنسجة و الإمراض المتعددة هذه الظواهر المرضية الناجمة عن نشاط جهاز المناعة تسمى ظواهر فرط التحسس حيث إن جهاز المناعة يحمي الجسم من الأجسام الضارة الخارجية وخاصة الملوثات و السبب الأكثر شيوعا لحدوث ظواهر فرط التحسس هي عدم تمييز جهاز المناعة أحيانا بين الأجسام الذاتية وبين الأجسام الدخيلة هذا التمييز يشكل صفه ضرورية لجهاز المناعة لضمان أداء وضيفي سليم وحتى ليقوم جهاز المناعة بمهاجمة الأنسجة الذاتية أمراض فرط التحسس من الممكن ان تحدث بسبب رد فعل مناعي مفرط ضد مسببات خارجية مثلما هو الحال مع إمراض الحساسية .
Hydroboration and Organic Synthesis : 9-Borabicyclo [3.3.1] nonane (9-BBN)
Borabicyclo [3.3.1]nonane, a commercially available reagent, is the most versatile hydroborating reagent to synthesize organoboranes (B-R-9-BBN). The reagent exhibits remarkable regio-, chemo-, and stereoselectivity during hydroboration reactions. The organoboranes can be converted to C-H, C-O, C-N, C-S, C-halogen, C-metal and above all C-C bonds. In addition, the suitable substituted / unsaturated R of B-R-9-BBN can be utilized to produce dienes, enynes, allenes etc. with defined stereochemistry. 9-BBN’s derivatives have been elegantly used for the asymmetric reduction of ketone moiety. Diels-Alder and Suzuki reactions have expanded the utility of 9-BBN for the synthesis of a variety of organic compounds required for industry. Consequently, this vast field in the form of a book will be helpful to synthetic organic chemists for easy access to literature, required for chemical transformations.
Hybrid Systems : Computation and Control ; 11th International Workshop, HSCC 2008, St. Louis, MO, USA, April 22-24, 2008. Proceedings
Contains the proceedings ofthe 11th Workshop on Hybrid Systems: Computation and Control (HSCC 2008) held in St. Louis, Missouriduring April 22–24,2008.The annual workshop on hybrid systems focuses on research inbedded ,reactive systems in volving theinterplay between symbolic/switchingand continuous dynamical behaviors. HSCC attracts academic as well as industrial researchers to exchange information on the latest developments of applications and theoretical advancements in the design, analysis, control, optimization, and implementation of hybrid systems, with particular attention to embedded and networked control systems. We would like to thank the Program Committee members and the reviewers for an excellent job of evaluating the submissions and participating in the online Program Committee discussions.
Humanizing modern medicine : An introductory philosophy of medicine
In this book the author explores the shifting philosophical boundaries of modern medical knowledge and practice occasioned by the crisis of quality-of-care, especially in terms of the various humanistic adjustments to the biomedical model. To that end he examines the metaphysical, epistemological, and ethical boundaries of these medical models. He begins with their metaphysics, analyzing the metaphysical positions and presuppositions and ontological commitments upon which medical knowledge and practice is founded. Next, he considers the epistemological issues that face these medical models, particularly those driven by methodological procedures undertaken by epistemic agents to constitute medical knowledge and practice.
Human-Computer Interaction : Interaction design and usability ; 12th International Conference, HCI International 2007, Beijing, China, July 22-27, 2007, Proceedings, Part I
The 12th International Conference on Human-Computer Interaction, HCI Inter- tional 2007, was held in Beijing, P.R. This volume, edited by Julie A. Jacko, contains papers in the thematic area of Human-Computer Interaction, addressing the following major topics: • Interaction Design: Theoretical Issues, Methods, Techniques and Practice • Usability and Evaluation Methods and Tools • Understanding Users and Contexts of Use • Models and Patterns in HCI
Hugo and Russell's pharmaceutical microbiology
Microbiology is one of the essential pharmaceutical sciences upon which the study and practice of pharmacy is built. It has a bearing on all aspects of the manufacture of medicines and sterile products, from their design and development to their delivery as quality products. Few interventions are more central to modern medicine than the treatment of infection, where antibiosis, vaccination and hygienic practices have essential roles to play. The COVID-19 pandemic, the appearance of new pathogens and the rise of antibiotic resistance have demonstrated most completely the need for pharmaceutical practitioners, researchers and industrial scientists to be fully conversant with this field. The 9th edition of Hugo and Russell’s Pharmaceutical Microbiology has been updated to meet this need. Having long served as the sole comprehensive textbook covering this subject, it has now been adapted to a critical new period in the advancement of medical and pharmaceutical research and development. Its experienced editors have incorporated contributions from subject experts and created a text which will serve the next generation of pharmacy students, pharmaceutical industry scientists and researchers.
Host-pathogen interactions : Methods and protocols
Serves as multidisciplinary compendium of approaches and techniques employed to analyze the role of different molecules, processes, or strategies used by different guests to survive and proliferate in their associations with eukaryotic hosts. Beginning with animal-pathogen interactions, the book then continues with chapters exploring virus-host interactions, plant-microbe interactions, as well as different molecular techniques that were initially applied to non-pathogenic interactions but can be adapted to study other host-pathogen associations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips for troubleshooting and avoiding known pitfalls.
Hormones, metabolism and the benefits of exercise
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
Homing Endonucleases and Inteins
This book provides detailed summary of the genetics, structure, function, mechanisms of action, evolution and engineering of homing endonucleases and inteins. These two unique protein superfamilies have generated considerable excitement for their fundamental, structural, and functional properties, their evolution as parasitic elements, and their widespread applications as gene targeting agents and as instruments for the generation of modified proteins and novel protein combinations.
Holonic Execution: A BDI Approach
Holonic manufacturing has been an active area of research for the past decade. However, this work has been predominately in the areas of planning and scheduling on the one hand and control on the other. In this book we propose these two areas can be integrated through adopting a focus on execution.
Holonic and multi-agent systems for manufacturing ; 3rd International Conference on industrial applications of holonic and multi-agent systems, HoloMAS 2007, Regensburg, Germany, September 3-5, 2007, Proceedings
The research of holonic and agent-based systems is developing rapidly, as is the community around this R&D topic. Despite the fact that real-life practical implementations of such systems remain surprisingly rare, the leaders in different branches of industry feel that the holonic and agent-based systems represent the only way to manage and control very complex, highly distributed systems in the future.
Holonic and multi-agent systems for manufacturing ; 2nd International conference on industrial applications of holonic and multi-agent systems, HoloMAS 2005, Copenhagen, Denmark, August 22-24, 2005, Proceedings
The challenge faced in today’s manufacturing and business environments is the question of how to satisfy increasingly stringent customer requirements while managing growing system complexity. For example, customers expect high-quality, customizable, low-cost products that can be delivered quickly. The systems that deliver these expectations are by nature distributed, concurrent, and stochastic, and, as a result, increasingly difficult to manage. Unfortunately, the traditional hierarchical, strictly centralized approach to control used in these domains is characteristically inflexible, fragile, and difficult to maintain. These shortcomings have led to the development of a new class of manufacturing and supply-chain decision-making approaches in recent years. Solutions based on these approaches usually explore a set of highly distributed decision-making units that are capable of autonomous operations while cooperating interactively to resolve larger problems. The units, referred to as agents in classical computer science and software engineering, or holons if physically integrated with the manufacturing hardware, interact by exchanging information. These units are motivated by arriving at local solutions as well as collaborating and sharing resources and goals in solving the overall problem in question collectively.
Histones : Methods and protocols
Provides new and updated chapters on histones for molecular biologists, biochemists and geneticists. Chapters cover protein complexes that modify chromatin either by adding or removing post-translational modifications, or by exchanging histone variants within the nucleosome. Written in the highly successful Methods in Molecular Biology series format, the chapters include brief introductions to the material, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and a Notes section which highlights tips on troubleshooting and avoiding known pitfalls.
