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Dynamics of Railway Bridges
Provides a comprehensive survey of the dynamic stresses in railway bridges under moving vehicles and summarizes important theoretical and experimental results which has been obtained from various research programs dealing with European railway bridges.
Dynamics of Complex Intracontinental Basins : The Central European Basin System
This book documents how researchers from different geo-scientific disciplines have jointly analysed the structural, thermal, and sedimentary evolution as well as fluid dynamics of a complex sedimentary basin system which has experienced a variety of activation and reactivation impulses as well as intense salt tectonics. In this book we have summarized our geological, geophysical and geochemical understanding of some of the most important processes affecting sedimentary basins in general and our view on the evolution of one of the largest, best explored and most complex continental sedimentary basins on Earth: The Central European Basin System.
Drugs in Ophthalmology
This drug handbook is divided into two sections: Alphabetical Listing of Drugs Entries in this section are listed by generic name. Information for each drug is arranged in a consistent format for easy reference. Summary of Anti-infectives This section summarizes the common doses of antibiotics, antifungals, and antivirals. For each drug, the dose for each route of administration is included.
Drug development for rare diseases
A disease is defined as rare if the prevalence is fewer than 200,000 in the United States. It is estimated that there are more than 7,000 rare diseases, which collectively affect 30 million Americans or 10% of the US population. This diverse and complex disease area poses challenges for patients, caregivers, regulators, drug developers, and other stakeholders. This book is proposed to give an overview of the common issues facing rare disease drug developers, summarize challenges specific to clinical development in small populations, discuss drug development strategies in the evolving regulatory environment, explain generation and utilization of different data and evidence
Drug delivery via nasal route
Over the past 10 years, the interest in intranasal drug delivery has increased. The objective of this research is to summarize recent developments on intranasal administration for local and systemic delivery, as well as for CNS indications. Nasal delivery offers many advantages over standard systemic delivery systems, nevertheless, there are still formulation limitations and side effects to be optimized. Intranasal drug delivery in the field of drug development is an interesting delivery route for the treatment of neurological disorders. Systemic approaches often fail to efficiently supply the CNS with drugs. This research describes the anatomical, histological and physiological basis and summarizes currently approved drugs for administration via intranasal delivery. Further, the research focuses on advantages and disadvantages of intranasal applied compounds and discusses formulation aspects that need to be considered for drug development.
Drift-Driven Design of Buildings : Mete Sozen’s Works on Earthquake Engineering
Summarizes the most essential concepts that every engineer designing a new building or evaluating an existing structure should consider in order to control the damage caused by drift (deformation) induced by earthquakes. It presents the work on earthquake engineering done by Dr. Mete Sozen and dozens of his collaborators and students over decades of experimentation, analysis, and reconnaissance. Many of the concepts produced through this work are integral part of earthquake engineering today. Nevertheless, the connection between the concepts in use today and the original sources is not always explained.
Diverse Roles of Integrin Receptors in Articular Cartilage
Recent studies from the authors' laboratory and from other leading groups have shown that ß1-integrins are essential for cell signalling and communication in chondrocytes. Furthermore, ß1-integrins function as mechanoreceptors in the chondrocyte mechanotransduction pathway. Their expression is therefore essential for maintaining the chondrocyte phenotype, preventing chondrocyte apoptosis and regulating chondrocyte-specific gene expression. This book volume summarizes the work that the authors have done on ß1-integrins over the last 18 years and focuses on the expression and regulation of these proteins in chondrocytes and their role in the context of the unique function of chondrocytes within articular cartilage.
Discovering Biomolecular Mechanisms with Computational Biology
In this anthology, leading researchers present critical reviews of methods and high-impact applications in computational biology that lead to results that also non-bioinformaticians must know to design efficient experimental research plans. Discovering Biomolecular Mechanisms with Computational Biology also summarizes non-trivial theoretical predictions for regulatory and metabolic networks that have received experimental confirmation. Discovering Biomolecular Mechanisms with Computational Biology is essential reading for life science researchers and higher-level students that work on biomolecular mechanisms and wish to understand the impact of computational biology for their success.
Diagnosis of endometrial biopsies and curettings : A practical approach
Diagnosis of Endometrial Biopsies and Curettings, 2nd edition, revised and now with color illustrations, continues the tradition of its predecessor as being the concise and complete diagnostic guide to the endometrial biopsy. The text is structured to present a logical approach to formulating a pathologic diagnosis from the diverse array of tissue received in the surgical pathology laboratory with an emphasis on differential diagnosis. More than 220 illustrations complement the text, with 70 of them in full color throughout. Each chapter includes a section on "Clinical Queries and Reporting", which summarizes the features that must be discussed in the final pathology report. The authors are two prominent gynecologic pathologists, and this book is derived from their long-running Short Course presented at the International Academy of Pathology.
Developments in Telecommunications : With a Focus on SS7 Network Reliability
This book summarizes important developments in telecommunications, including SS7 over IP, with a focus on SS7 network reliability.
Developing Students Statistical Reasoning : Connecting Research and Teaching Practice
This book is written for mathematics and statistics educators and researchers. It summarizes the research and highlights the important concepts for teachers to emphasize, and shows the interrelationships among concepts. It makes specific suggestions regarding how to build classroom activities, integrate technological tools, and assess students’ learning.
Deoxynucleoside Analogs in Cancer Therapy
Emerging as an important new volume in the renowned Cancer Drug Discovery and Development™ series, Deoxynucleoside Analogs in Cancer Therapy expertly summarizes the current status of development and application of deoxynucleoside analogs. Authoritative up-to-date reviews are presented by scientists well known in their specific areas and all contributions include valuable sound advice on structure and topics. Organized into several sections, the first part covers general aspects of drug uptake and metabolism and explains how novel technology has enabled a rapid expansion of this field. The second part is concerned with a number of specific drugs including cytarabine, gemcitabine, troxacitabine, clofarabine and Ara-G. The final section covers pharmacokinetics, prodrugs, and specific applications such as radiosensitization, gene therapy, and the use of deoxynucleoside analogs as tracers
Dental materials : Properties and manipulation ; 11th ed.
Comprehensive and cutting-edge content describes the latest materials commonly used in dental practice, including those in esthetics, ceramics, dental implants, and impressions. Approximately 500 illustrations and photographs make it easier to understand properties and differences in both materials and specific types of products. Review questions provide an excellent study tool with 20 to 30 self-test questions in each chapter. Quick Review boxes summarize the material in each chapter. Note boxes highlight key points and important terminology throughout the text. Key terms are bolded at their initial mention in the text and defined in the glossary. A logical and consistent format sets up a solid foundation before progressing into discussions of specific materials, moving from the more common and simple applications such as composites to more specialized areas such as polymers and dental implants. Learning objectives in each chapter focus readers’ attention on essential information. Supplemental readings in each chapter cite texts and journal articles for further research and study.
Data Warehousing and Data Mining Techniques for Cyber Security
It provide techniques for collecting information from distributed databases and for performing data analysis. The ever expanding, tremendous amount of data collected and stored in large databases has far exceeded our human ability to comprehend--without the proper tools. There is a critical need for data analysis that can automatically analyze data, summarize it and predict future trends. In the modern age of Internet connectivity, concerns about denial of service attacks, computer viruses and worms are extremely important. Data Warehousing and Data Mining Techniques for Cyber Security contributes to the discipline of security informatics. The author discusses topics that intersect cyber security and data mining, while providing techniques for improving cyber security. Since the cost of information processing and internet accessibility is dropping, an increasing number of organizations are becoming vulnerable to cyber attacks. This volume introduces techniques for applications in the area of retail, finance, and bioinformatics, to name a few.
Data center networking : Network topologies and traffic management in large-scale data centers
Provides a comprehensive reference in large data center networking. It first summarizes the developing trend of DCNs, and reports four novel DCNs, including a switch-centric DCN, a modular DCN, a wireless DCN, and a hybrid DCN. Furthermore another important factor in DCN targets at managing and optimizing the network activity at the level of transfers to aggregate correlated data flows and thus directly to lower down the network traffic resulting from such data transfers. In particular, the book reports the in-network aggregation of incast transfer, shuffle transfer, uncertain incast transfer, and the cooperative scheduling of uncertain multicast transfer.
Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases
Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases.This book summarizes the findings of the 56th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".
Cytogenetics and molecular cytogenetics
Genomic technologies provide the means of diagnosis and management of many human diseases. Without insights from cytogenetics, correct interpretation of modern high-throughput results is difficult, if not impossible. This book summarizes applications of cytogenetics and molecular cytogenetics for students, clinicians and researchers in genetics, genomics and diagnostics. The book combines the state-of-the-art knowledge and practical expertise from leading researchers and clinicians and provides a comprehensive overview of current medical and research applications of many of these technologies.
Cytochrome P450 : Structure, Mechanism, and Biochemistry
In this newest edition, we find that the newest discussion of P450 structure includes information of bacterial (soluble) P450s interwoven with that of eukaryotic (membrane bound) of this superfamily, highlighting the newest developments in this area. The complete battery of human P450s is now known and summarized in the new edition. In addition, general overviews of plant P450s and those from microbes contained within this newest edition provide a broader view of P450 diversity than seen in earlier editions. Each of these three editions should be on bookshelves of laboratories studying P450s. The third edition of Cytochrome P450: Structure, Mechanism, and Biochemistry provides an opportunity to judge progress in many key areas of P450 research while at the same time learn of new directions in the field. It is an excellent and most useful volume.
Cyclized Helical Peptides : Synthesis, Properties and Therapeutic Applications
Constraint helical peptides have emerged as a solution to target previously undruggable protein-protein interactions, which feature large and complex surfaces. Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications offers a review of the most current methodologies of constructing constrained helices. The authors noted experts on the topic include the information on the fundamental features of cyclized helical peptides and discuss their limitations. The book summarizes and explores the effects of chemical methods constructing helical peptides on helicity, binding affinity, cell penetration, and nonspecific toxicity
Critical Points for the Organisation of Test Performance Studies in Microbiology : Plant Pathogens as a Case Study
This book in the field of plant pest detection shows a constant demand in development and improvement of fast and reliable detection tools, especially for high-priority pests. This open access book describes and summarizes the whole process of the organization of test performance study (TPS) for these tools. The outcome of TPS, obtained through the evaluation of the performance of one or more diagnostic tests by several laboratories on defined samples, is the finding of the best performing test/s for particular pest and for specific uses.
