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Drug Absorption Studies : In Situ, In Vitro and In Silico Models
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening. Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.
Drinking in Victorian and Edwardian Britain : Beyond the Spectre of the Drunkard
Investigates the reasons why Victorians and Edwardians consumed alcohol in the ways that they did and explores the ideas about alcohol that circulated in the period. This book shows that they had many reasons for purchasing and consuming alcoholic substances and these were driven by broader social, cultural, medical and commercial factors. Although drunkenness may have been the most visible consequence of alcohol consumption, it was not the only type of drinking behaviour. Alcohol played an important social role in the everyday lives of Victorians and Edwardians where its consumption held many different meanings.
DNA Methylation, Epigenetics and Metastasis
Provides an outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. This book describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour
Disturbed soil properties and geotechnical design
Describes the developments leading to the Original Cam Clay model, focusing on fundamentals of the shearing of soil. The aim is to lay the groundwork of understanding that should form the basis of geotechnical design, guiding engineers towards the class of behaviour to be expected under different combinations of effective stress and water content.
Dissecting Discrimination : Identifying Its Various Faces and Their Sources
This book examines the phenomenon of discrimination using a descriptive approach. Discrimination is omnipresent, whether it is people who discriminate against other people or, more recently, also machines that discriminate against people. The first part of the analysis employs decision theory on discrimination, leading to two fundamental subtypes: taste-based discrimination and statistical discrimination. The second part links taste-based discrimination to social identity theory, demonstrates that not all taste-based discrimination is ultimately statistical discrimination, and reveals the evolutionary origins of our tastes.
Digital Marketing Outreach : The Future of Marketing Practices
Looks at diverse areas of business and non-business activities involving the use of digital platforms to augment marketing initiatives and improve reach, sales, and social media engagement. The volume analyses various themes including viral marketing, influencer marketing, webrooming behaviour, online impulse buying, telemedicine, social media advertising, and app-based cab services. It examines the role of digital marketing in creating a positive and favourable brand image for organizations by advertising their social responsiveness on social media and studies the influence of political brand value on social media activities.
Developments in Fish Telemetry ; Proceedings of the Sixt Conference on Fish Telemetry held in Europe
This volume includes 33 peer-reviewed papers presented at the Sixth Conference on Fish Telemetry held in Europe (Sesimbra, Portugal, 5-11 June 2005). The papers focus on the application of aquatic telemetry techniques by scientists to investigate fundamental aspects of animal biology in order to conserve and manage natural resources. The topics addressed in this issue are human impacts and fisheries, migration and behaviour, species conservation and habitat rehabilitation, and methodology and new technology. This book is aimed at scientists and engineers actively involved in aquatic telemetry projects, aquatic biologists (marine and freshwater), fisheries biologist and managers.
Dental fear and anxiety in pediatric patients: Practical strategies to help children cope
A comprehensive guide to pediatric dental fear/anxiety (DFA) and phobia that will provide practitioners with a full understanding of the etiology, prevalence, assessment, and management of these conditions. The coping styles of children when under stress are explored, with discussion of their relevance to the assessment visit and treatment allocation. Practical treatment techniques are comprehensively covered, from non-pharmacological behavioral strategies relevant for children with no or mild DFA to those approaches more appropriate for children with severe DFA/phobia. The importance of the use of language and communication skills to build rapport and allay anxiety is explored. Relaxation and hypnosis techniques are described, with guidance on how to introduce these to patients and their parents/carers. Techniques that help children cope when receiving injections are detailed, including systematic needle desensitization
Dental Care for Children with Special Needs : A Clinical Guide
This concise manual offers best practice guidance on dental treatment of pediatric patients with special health care needs (CSHCN). Readers will find up-to-date information on case-based treatment planning, alternative caries management strategies, the use of behavioral and pharmacological interventions to facilitate delivery of quality treatment, and a team approach to care.
Death in a consumer culture
Organised into five sections covering: The death industry; death rituals; death and consumption; death and the body; and alternate endings, The book explores topics from celebrity death tourism, pet and online memorialization; family history research, to alternatives to traditional corpse disposal methods and patient-assisted suicide. Work from scholars in history, religious studies, sociology, psychology, anthropology, and cultural studies sits alongside research in marketing and consumer culture.
Data-driven BIM for Energy Efficient Building Design
Conceptualises the scale and spectrum of Building Information Modelling (BIM) and Artificial Intelligence (AI) approaches in energy efficient building design and to develop its functional solutions with a focus on four crucial aspects of building envelop, building layout, occupant behaviour and heating, ventilation and air-conditioning (HVAC) systems. Drawn from theoretical development on the sustainability, informatics and optimisation paradigms in built environment, the energy efficient building design will be marked through the power of data and BIM-intelligent agents during the design phase.
Cyclotomic Fields and Zeta Values
Cyclotomic fields have always occupied a central place in number theory, and the so called "main conjecture" on cyclotomic fields is arguably the deepest and most beautiful theorem known about them. It is also the simplest example of a vast array of subsequent, unproven "main conjectures'' in modern arithmetic geometry involving the arithmetic behaviour of motives over p-adic Lie extensions of number fields. These main conjectures are concerned with what one might loosely call the exact formulae of number theory which conjecturally link the special values of zeta and L-functions to purely arithmetic expressions.
Crypto Wars : Faked Deaths, Missing Billions and Industry Disruption
Unveils the biggest scams and frauds that have shocked the world of cryptocurrency, from the disappearing Crypto Queen with OneCoin, to Bitconnect, the initial coin offering crash and Quadriga where the founder seems to have faked his own death to escape prosecution Contains exclusive interviews and commentaries from many of the key people who have been actively investigating the biggest crypto-scams, from the Metropolitan police, to insolvency practitioners, researchers, BBC journalists and tech geeks Goes beyond the sensationalist and concludes on the real potential for change and good that cryptocurrencies bring; from challenging the greedy practices of the banking and remittance industries, to reaching over 2.5 billion unbanked users, allowing for greater transparency and ethical behaviours
Crowd Simulation
Focuses on methods and techniques for crowd simulation, filling the gap in the professional literature. This survey covers topics that include Modelling of Populations; Virtual Human Animation; Behavioural Animation of Crowds; and, Crowd Rendering and Populated Environments.
Criminal Dilemmas : Understanding and Preventing Crime
Fighting crime breeds emotional responses which often lead to counter-productive government policy. To allow a rational analysis of these important concerns, this book employs the thinking of economics, political science, and game theory to develop new perspectives on crime and its causes. A basic assumption is that the criminal is a rational actor who makes decisions based on his or her personal expected gains and costs. By using this assumption, predictions about behaviour as well as emotional concerns such as prostitution and gun control are given a theoretical perspective. By understanding the strategic variables which cause, for example, gang wars and drug sales, we are better equipped to design effective public policy.
Corporate and Investment Banking : Preparing for a Career in Sales, Trading, and Research in Global Markets
Provides unique information to prepare graduates and newly hired corporate and investment banking professionals for a career in the global markets environment of large universal and international investment banks. It shows the interrelationship between the three specific business functions of sales, trading, and research, as well as the interaction with corporate and institutional clients. The book fills a gap in the available literature by linking financial market theory to the practical aspects of day-to-day operations on a trading floor and offers a taxonomy of the current banking business, providing an in-depth analysis of the main market participants in the global markets ecosystem. Engaging the reader with case studies, anecdotes, and industry color, the book addresses the risks and opportunities of the global markets business in today’s global financial markets both from a theoretical and from a practitioner’s perspective and focuses on the most important fixed-income financial instruments from a pricing, risk-management, and client-marketing perspective.
Control of cracking in reinforced concrete structures
Provides guidelines which can extend the existing standards and codes to cover these types of special works, especially those which are massive in nature, taking account of their specific behaviour in terms of cracking and shrinkage together with other important properties such as water/air leak tightness
Consumer Happiness : Multiple Perspectives
Helps quench the quest of knowledge of academicians, researchers, and others interested in developing a complete and critical understanding of consumer happiness. The relentless search of happiness by humans is sought in different ways. Scientific discussion on happiness for long was considered a forte of Philosophers. Other disciplines seldom delved into this. But today not only science but neuroscience, marketing, and other varied fields have started delving into it and have developed a keen interest. The book has been conceptualized on this line of thinking and thus divided into two parts. The first part is customized towards understanding various perspectives of happiness and the relative importance of knowing the same. The first chapter of this section is on the biological perspective of happiness. The second is titled ‘Behavioural perspective’. The third chapter is an attempt to elucidate the cultural perspective of the concept of happiness. The fourth is on the role of technology in inducing happiness. Fifth and sixth are on theories of happiness and measuring happiness, respectively.
Consumer Behaviour and Analytics
Consumer Behaviour and Analytics provides a consumer behaviour textbook for the new marketing reality. In a world of Big Data, machine learning and AI, this key text reviews the issues, research and concepts essential for navigating this new terrain. It demonstrates how we can use data-driven insight and merge this with insight from extant research to inform knowledge-driven decision making.
Construction of Mappings for Hamiltonian Systems and Their Applications
Based on the method of canonical transformation of variables and the classical perturbation theory, this innovative book treats the systematic theory of symplectic mappings for Hamiltonian systems and its application to the study of the dynamics and chaos of various physical problems described by Hamiltonian systems. It develops a new, mathematically-rigorous method to construct symplectic mappings which replaces the dynamics of continuous Hamiltonian systems by the discrete ones. Applications of the mapping methods encompass the chaos theory in non-twist and non-smooth dynamical systems, the structure and chaotic transport in the stochastic layer, the magnetic field lines in magnetically confinement devices of plasmas, ray dynamics in waveguides, etc. The book is intended for postgraduate students and researches, physicists and astronomers working in the areas of plasma physics, hydrodynamics, celestial mechanics, dynamical astronomy, and accelerator physics. It should also be useful for applied mathematicians involved in analytical and numerical studies of dynamical systems.
