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Formulating poorly water soluble drugs
A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.
Food powders : Physical properties, processing, and functionality
Food Powders: Physical Properties, Processing, and Functionality is a comprehensive review on the characterization of ingredients, semi-processed and finished products when they are in a powdered form. It includes the description of different industrial unit operations such as drying, grinding, mixing, agglomeration, and encapsulation that supply food powders of different composition and microstructure. It also includes several analytical tools to characterize food powders by their particle size, size distribution, physical properties, and functionality.
Fluorescence of supermolecules, polymers, and nanosystems
The field of fluorescence continues to steadily grow, both in its fundamental aspects and in applications in highly interdisciplinary areas including analytical, physical and organic chemistry, molecular sciences, biology, biomedicine and medical research. The 4th volume in the Springer Series on Fluorescence focuses on the fluorescence of nanosystems, polymers and supermolecules, and the development and application of fluorescent probes. Special emphasis is placed on the fluorescence of artificial and biological nanosystems, single molecule fluorescence and the luminescence of polymers, micro- and nanoparticles and nanotubes. Fluorescence microscopy and fluorescence correlation spectroscopy are covered as well. Historical aspects of this growing field and an overview of fluorescence applications are also provided.
Fluid Mechanics : An Introduction to the Theory of Fluid Flows
Advancements of fluid flow measuring techniques and of computational methods have led to new ways to treat laminar and turbulent flows. These methods are extensively used these days in research and engineering practise. This also requires new ways to teach the subject to students at higher educational institutions in an introductory manner. The book provides the knowledge to students in engineering and natural science needed to enter fluid mechanics applications in various fields. Analytical treatments are provided, based on the Navier-Stokes equations. Introductions are also given into numerical and experimental methods applied to flows. The main benefit the reader will derive from the book is a sound introduction into all aspects of fluid mechanics covering all relevant subfields.
Flavours and Fragrances : Chemistry, Bioprocessing and Sustainability
This book is an introduction to the fascinating world of aroma chemicals, essential oils, fragrances and flavour compositions for the food, cosmetics and pharmaceutical industry. The present state-of-the-art technology, the future use of resources and biotechnological approaches for the production of the respective chemical compounds are described. A large section is devoted to the description of the renewable resources of flavours: spice plants, fruits from moderate to tropical climates, vegetables, fermented and heated plants. Analytical methods, such as gas chromatography coupled to human or electronic noses or to a mass spectrometer, are outlined and consumer trends, legal and safety aspects are described. Novel renewable resources come from biotechnology.
Financial markets and institutions
A practical introduction to the workings of today's financial markets and institutions. Moving beyond the descriptions and definitions provided by other textbooks in the field, Financial Markets and Institutions encourages students to understand the connection between the theoretical concepts and their real-world applications. By enhancing students' analytical abilities and concrete problem-solving skills, this textbook prepares students for successful careers in the financial services industry or successful interactions with financial institutions, whatever their jobs
Fibre reinforced concrete : Improvements and innovations II : X rILEM-fib international symposium on fibre reinforced concrete (BEFIB) 2021
Highlights the latest advances, innovations, and applications in the field of fibre-reinforced concrete (FRC). It discusses a diverse range of topics concerning FRC: technological aspects, nanotechnologies related with FRC, mechanical properties, long-term properties, analytical and numerical models, structural design, codes and standards, quality control, case studies, Textile-Reinforced Concrete, Geopolymers.
Fault-Diagnosis Systems : An Introduction from Fault Detection to Fault Tolerance
This book gives an introduction into the field of fault detection, fault diagnosis and fault-tolerant systems with methods which have proven their performance in practical applications. It guides the reader in a structured tutorial style: supervision methods, reliability, safety, system integrity and related terminology; fault detection with signal-based methods for periodic and stochastic signals; fault detection with process model-based methods like parameter estimation, state estimation, parity equations and principal component analysis; fault diagnosis with classification and inference methods; fault-tolerant systems with hardware and analytical redundancy; many practical simulation examples and experimental results for processes like electrical motors, pumps, actuators, sensors and automotive components; end-of-chapter exercises for self testing or for practice.
Facilities Design
Describes tools commonly used for presenting layout designs Presents traditional models for facility layout including the popular systematic layout planning (SLP) model in detail Provides a layout project involving the SLP model Covers group technology and cellular manufacturing at the elementary level Includes a project and case study on machine grouping and layout Considers next-generation factory layouts Discusses analytical queuing and queuing network models, and more Explains the ins and outs of facility planning and design. A reference for both student and professional, the book addresses facilities design and layout problems in manufacturing systems and covers layout, logistics, supply chain, warehousing, and materials handling.
Evolution of Thin Film Morphology : Modeling and Simulations
Thin film deposition is the most ubiquitous and critical of the processes used to manufacture high tech devices. Morphology and microstructure of thin films directly controls their optical, magnetic, and electrical properties. This book focuses on modeling and simulations used in research on the morphological evolution during film growth. The authors emphasize the detailed mathematical formulation of the problem both through numerical calculations based on Langevin continuum equations, and through Monte Carlo simulations based on discrete surface growth models when an analytical formulism is not convenient. Evolution of Thin-Film Morphology will be of benefit to university researchers and industrial scientists working in the areas of semiconductor processing, optical coating, plasma etching, patterning, micro-machining, polishing, tribology, and any discipline that requires an understanding of thin film growth processes.
Evaluation and Decision Models with Multiple Criteria : Stepping stones for the analyst
The purpose of Evaluation and Decision Models: A Critical Perspective is to provide a critical thinking framework for all individuals utilizing decision and evaluation models, whether it be for research or applications. It is axiomatic that all evaluation and decision models suffer some limitations. There are situations where a decision model will not perform to expectations. This book argues that there is no best decision or evaluation model, but that decision-makers must understand the principles of formal evaluation and decision models and apply them critically. Hence, the book seeks to deepen our understanding of evaluation and decision models and encourage users of these models to think more analytically about them.
EU-Turkey Relations : Theories, Institutions, and Policies
This book explores the new complexities and ambiguities that epitomize EU-Turkey relations. With a strong focus on the developments in the last decade, the book provides full access to a comprehensive understanding of the multifaceted relationship through three entry points: (1) Theories and Concepts, (2) Institutions, and (3) Policies. Part I brings together complementary and competing analytical approaches to study the evolution of EU-Turkey relations, ranging from traditional integration theories to novel concepts. Part II investigates the institutional machinery of EU-Turkey relations by analyzing the roles and perspectives of the European Council, the European Commission, and the European Parliament. Part III offers analyses of the policies most relevant for the relationship: enlargement policy, trade and macroeconomic policies, foreign and security policy, migration and asylum policies, and energy policy. In Part IV, the volume closes with a systematic survey of the conditions under which cooperative trends in EU-Turkey relations could be (re)invigorated. The systematic setup and the balanced combination of distinguished experts from EU- and Turkey-based institutions make this book a fundamental reading for students, researchers, lecturers, and practitioners of EU-Turkey relations, European integration and Turkish foreign policy.
Essentials of pharmaceutical analysis
Provides detailed information on the background, basic principles, and components of techniques used for the analysis of pharmaceuticals and biopharmaceuticals. Focusing on those analytical techniques that are most frequently used for pharmaceuticals, it classifies them into three major sections and 19 chapters, each of which discusses a respective technique in detail. Chiefly intended for graduate students in the pharmaceutical sciences, the book will familiarize them with the components, working principles and practical applications of these indispensable analytical techniques.
Essentials of mechanical stress analysis
Essentials of Mechanical Stress Analysis, updated for the second edition, covers stress analysis from an interdisciplinary perspective. Discussing techniques and theories essential to analysing structures, the book covers both analytical and numerical approaches. Also covering beams, plates, columns and elastic instability, the book discusses fatigue, life cycle, energy methods and MathCAD sample code.
Essential NMR : For Scientists and Engineers
ESSENTIAL NMR is a set of lecture notes for scientists and engineers who want to brush up on their knowledge of NMR. This book is also a compendium for graduate and postgraduate students of physics and chemistry as well as for their teachers, covering all fields of NMR, i.e. NMR methodology and hardware, chemical analysis, 2D-spectroscopy, NMR imaging, flow NMR, and quality control NMR. The material, selected and organized for a one-semester course, is presented with pairs of pages addressing particular topics. One page of each pair provides a text containing the key information, the other page shows a color illustration. This is the most comprehensive textbook on NMR to date.
Essays on Transport Economics
This book covers the basic analytical methods used in transportation economics and policy analysis. Encompassing fields of economics such as Industrial Organisation, Welfare Economics, General Equilibrium Theory and Input-Output-Analysis.
Ernst Equation and Riemann Surfaces : Analytical and Numerical Methods
Exact solutions to Einstein`s equations have been useful for the understanding of general relativity in many respects. They have led to physical concepts as black holes and event horizons and helped to visualize interesting features of the theory. In addition they have been used to test the quality of various approximation methods and numerical codes. The most powerful solution generation methods are due to the theory of Integrable Systems. In the case of axisymmetric stationary spacetimes the Einstein equations are equivalent to the completely integrable Ernst equation. In this volume the solutions to the Ernst equation associated to Riemann surfaces are studied in detail and physical and mathematical aspects of this class are discussed both analytically and numerically.
Equity and efficiency considerations of public higher education
It has become part of the conventional wisdom in the economics of education that subsidies to higher education have a regressive distributional effect. Given that relatively more children from wealthier families enroll in higher education, many economist assume that these subsidies to higher education have an unwanted distributional impact. This volume presents new empirical evidence for the cross-sectional point of view and provides an analytical framework for the longitudinal perspective. The present volume also analyzes the equity and efficiency effects of widely-discussed funding reforms and proposes a voluntary graduate tax.
Environmental Policy Analyses : Learning from the Past for the Future - 25 Years of Research
The criteria used to select the fifteen contributions in this book were their impact on the scientific debate at the time of their publication, their validity for p- sent conceptualizations of policy analysis in the field of the environment, and their contribution to the development of policy analysis as a whole . Moreover, the selected contributions mainly focus on empirical appli- tions in the field of environmental policies or the interface between en- ronmental and non-environmental policies. Some have led to concrete p- icy recommendations of which most have been partly implemented since, This research also sometimes addressed regional political administrative arrangements leading to administrative reforms and new strategic directions of implementing agencies.
Environmental Chemistry : Green Chemistry and Pollutants in Ecosystems
Environmental chemistry is a new, fast developing science aimed at deciphering fundamental mechanisms ruling the behaviour of pollutants in ecosystems. Applying this knowledge to current environmental issues leads to the remediation of environmental media, and to new, low energy, low emission, sustainable processes. This book describes the state-of-the-art advances regarding the pollution of water, soils, atmosphere, food and living organisms by toxic metals, fossil fuels, pesticides and other organic pollutants. Furthermore, the eco-toxicology section presents novel bio-assays to assess the toxicity of various pollutants such as dioxins and endocrine disrupters within complex media. The green chemistry section highlights novel chemical reactions based upon environmentally friendly conditions. The analytical chemistry section describes very sensitive methods which trace the fate of pollutants in complex ecosystems.
