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Atlas effectors of anti-tumor immunity
The “Atlas Effectors of Anti-Tumor Immunity” is a unique scientific publication, which includes major issues of up-to-date information about immunophenotype, morphology and function of main effectors of anti-tumor immunity presented in a reasonable format. The Atlas comprises a large number of illustrations presented by schemes and original micrographs demonstrating morphological features and ultrastructure of immunocompetent cells at various stages of differentiation. The volume includes data referring to the history of anti-tumor immunity effectors research, state of the art and perspectives for development of anti-cancer adoptive immunotherapy methods.A special section of the Atlas describes cellular tumor microenvironment and micro-anatomy of carcinomas. Several parts include data about killer cells (natural killer T-cells, lymphokine-activated killers) and T-regulatory lymphocytes. A special chapter gives a wide-range description of antigen-presenting dendritic cells, methods of dendritic cell generation and development of DC-based vaccines for anti-tumor immunotherapy.
Atherosclerosis : Diet and Drugs
Divided into four parts and intends to give an overview on the pathogenesis of atherosclerosis, established treatment and prevention regimen, and of perspectives for the development of new treatment modalities.
Asymmetric Cell Division
Cell biologists have recently become aware that the asymmetry of cell division is an important regulatory phenomenon in the fate of a cell. During development, cell diversity originates through asymmetry; in the adult organism asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to the aging of organisms with renewable cell compartments. Because of the concept of semi-conservative DNA synthesis, it was thought that the distribution of DNA between daughter cells was symmetric. The analysis of the phenomenon in cells during mitosis, however, revealed the asymmetry in the distribution of the genetic material that creates the drift contributing to aging of mammals. On the other hand, cancer cells can originate from a deregulation of asymmetry during mitosis in particular during stem cell expansion. The book describes the phenomenon in different organisms from plants to animals and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.
Associative and endophytic nitrogen-fixing bacteria and cyanobacterial associations
Associative and Endophytic Nitrogen-fixing Bacteria and Cyanobacterial Associations This book is part of the seven-volume series that was launched a few years ago with the ambitious objectives of reviewing the field of nitrogen fixation from its earliest beginnings through the millennium change and of consolidating the relevant information - from fundamental to agricultural and environmental aspects – all in one place. Volume 5 covers the biology of bacteria that associate with n- leguminous plants. The subject matter includes a wide range of associations; it covers the bacterial species that associate either with the surface or within the tissues of grasses (often referred as plant growth-promoting rhizobacteria) and also the symbiotic associations that cyanobacteria form with fungi, algae, and both lower and higher plants. This volume does not deal with the Frankia-actinorhizal plant associations, which is the topic of Volume 6
Association Mapping in Plants
For the past decade, there has been success in using conventional map-based strategies in identification and cloning of quantitative trait loci (QTL) in model plant species including tomato and Arabidopsis. These quantitative traits are generally the products of many loci with varying degrees of effect upon the observed phenotypes. Recently, a new approach to genetic mapping has emerged called association mapping. This new technique takes into account the thousands of genes to evaluate for QTL effect and is a more efficient approach that does not require generation of segregating populations/large numbers of progeny. As it can utilize all of the historic recombination events in a diverse population of individuals it can generate higher resolution genetic maps and, is needed to complement current map based cloning methods.
Assessment of cancer screening : A primer
Provides an in-depth look at the many aspects of cancer screening and its assessment, including screening phenomena, performance measures, population-level outcomes, research designs, and other important and timely topics.
Assessing Recent Soil Erosion Rates through the Use of Beryllium-7 (Be-7)
This book is the first comprehensive guideline for the beryllium-7 (Be-7) technique that can be applied to evaluate short-term patterns and budgets of soil redistribution in agricultural landscapes. While covering the fundamental and basic concepts of the approach, this book distinguishes itself from other publications by offering step-by-step instructions on how to use this isotopic technique effectively. It covers experimental design considerations and clear instruction is given on data processing. As accurate laboratory measurement is crucial to ensure successful use of Be-7 to investigate soil erosion, a full chapter is devoted to its specific determination by gamma spectrometry.
Ascochyta blights of grain legumes
Ascochyta blights consistently affect large areas of grain legume production (pea, lentil, chickpea and faba bean) in all countries where they are cultivated. These diseases are capable of causing large yield losses under conducive environmental conditions. This book considers the state of the art by taking a comparative approach of Ascochyta blight diseases of cool season food and feed legumes. Topics considered are pathogen diversity, legume genetics and breeding, and integrated disease management.
Artificial sight : Basic research, biomedical engineering, and clinical advances
Artificial sight is a frontier area of modern ophthalmology combining the multidisciplinary skills of surgical ophthalmology, biomedical engineering, biological physics, and psychophysical testing. Many scientific, engineering, and surgical challenges must be surmounted before widespread practical applications can be realized. The goal of Artificial Sight is to summarize the state-of-the-art research in this exciting area, and to describe some of the current approaches and initiatives that may help patients in a clinical setting.
Artificial neural networks : Biological Inspirations – ICANN 2005 ; 15th International Conference, Warsaw, Poland, September 11-15, 2005, Proceedings, Part I
The two volume set LNCS 3696 and LNCS 3697 constitutes the refereed proceedings of the 15th International Conference on Artificial Neural Networks, ICANN 2005, held in Warsaw, Poland in September 2005. The over 600 papers submitted to ICANN 2005 were thoroughly reviewed and carefully selected for presentation. The first volume includes 106 contributions related to Biological Inspirations; topics addressed are modeling the brain and cognitive functions, development of cognitive powers in embodied systems spiking neural networks, associative memory models, models of biological functions, projects in the area of neuroIT, evolutionary and other biological inspirations, self-organizing maps and their applications, computer vision, face recognition and detection, sound and speech recognition, bioinformatics, biomedical applications, and information- theoretic concepts in biomedical data analysis.
Artificial neural networks - ICANN 2008 ; 18th International Conference, Prague, Czech Republic, September 3-6, 2008, Proceedings, Part II
This two volume set LNCS 5163 and LNCS 5164 constitutes the refereed proceedings of the 18th International Conference on Artificial Neural Networks, ICANN 2008, held in Prague Czech Republic, in September 2008.
Artificial neural networks – ICANN 2007 ; 17th International Conference, Porto, Portugal, September 9-13, 2007, Proceedings, Part II
It features contributions related to computational neuroscience, neurocognitive studies, applications in biomedicine and bioinformatics, pattern recognition, self-organization, text mining and internet applications, signal and times series processing, vision and image processing, robotics, control, and more.
Artificial neural networks – ICANN 2007 ; 17th International Conference, Porto, Portugal, September 9-13, 2007, Proceedings, Part I
This book contains learning theory, advances in neural network learning methods, ensemble learning, spiking neural networks, advances in neural network architectures neural network technologies, neural dynamics and complex systems, data analysis, estimation, spatial and spatio-temporal learning, evolutionary computing, meta learning, agents learning, complex-valued neural networks, as well as temporal synchronization and nonlinear dynamics in neural networks.
Artificial intelligence in medicine ; 11th Conference on artificial intelligence in medicine in Europe, AIME 2007, Amsterdam, The Netherlands, July 7-11, 2007, Proceedings
This book contains development of theory, systems, and applications of AI in medicine, including the exploitationof AI approachesto molecularmedicine and biomedical informatics.
Artificial intelligence in drug design
Looks at applications of artificial intelligence (AI), machine learning (ML), and deep learning (DL) in drug design. The chapters in this book describe how AI/ML/DL approaches can be applied to accelerate and revolutionize traditional drug design approaches such as: structure- and ligand-based, augmented and multi-objective de novo drug design, SAR and big data analysis, prediction of binding/activity, ADMET, pharmacokinetics and drug-target residence time, precision medicine and selection of favorable chemical synthetic routes. How broadly are these approaches applied and where do they maximally impact productivity today and potentially in the near future.
Artificial Intelligence Applications for Health Care
Covers topics on health care and artificial intelligence. Data sets related to biomedical signals (ECG, EEG, EMG) and images (X-rays, MRI, CT) are explored, analyzed, and processed through different computation intelligence methods. Applications of computational intelligence techniques like artificial and deep neural networks, swarm optimization, expert systems, decision support systems, clustering, and classification techniques on medial datasets are explained. Survey of medical signals, medial images, and computation intelligence methods are also provided.
Arthropod Diversity and Conservation
Despite their enormous bulk and complexity of architecture, plants make up only around a quarter of a million of the 8 million or so species on Earth. The major components of biodiversity, instead, are the smaller, largely unseen, silent majority of invertebrates – most of which are arthropods. Vertebrates, a mere blip on the biotic horizon, are elevated in importance in the bigger scheme of things only by the human psyche. This collection of more than 30 peer-reviewed papers focuses on the diversity and conservation of arthropods, whose species inhabit virtually every recess and plane – and feature somewhere in virtually every food web – on the planet. Highlighting issues ranging from large-scale disturbance to local management, and from spatial heterogeneity to temporal patterns, these papers reflect some of the most exciting new research taking place today – and in some of the most biodiverse corners of the planet.
Aromatase Inhibitors
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.
Aromatase Inhibitors
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.
Arid Dune Ecosystems: The Nizzana Sands in the Negev Desert
Sand dune dynamics plays a key role in many arid deserts. This volume provides a synthesis of a specific sand dune ecosystem, the Nizzana site in the Negev Desert. Describing its climate and geophysical/geochemical properties of soils, geological history, flora and fauna, and past/present land-use patterns, it elucidates ecological and geomorphological processes and their interrelations, based on long-term monitoring, in situ experiments and satellite imagery. Particular attention is drawn to the impact of the topsoil biological crust in controlling water availability at local/regional scales. The interdisciplinary approach adopted in this case study offers a good example of a highly complex and dynamic system, which could easily be applied to other sandy ecosystems.
