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Pharmaceutical cocrystals : Along the path to improved medicines
Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to differences in the intermolecular interactions, Differences in solid forms often lead to differences in thermodynamic parameters and physicochemical properties for example solubility {especially that a lot of drugs are in Class II and IV according to BCS (Biopharmaceutics Classification System) and these classes suffer from poor aqueous solubility and hence low bioavailability} ,dissolution rate, stability and mechanical properties of APIs and excipients. Hence, solid forms of APIs play a vital role in drug discovery and development.
Parametric X-Ray Radiation in Crystals : Theory, Experiment and Applications
Devoted to parametric X-ray radiation (PXR). This radiation is generated by the motion of electrons inside a crystal, whereby the emitted photons are diffracted by the crystal and the radiation intensity critically depends on the parameters of the crystal structure. Nowadays PXR is the subject of numerous theoretical and experimental studies throughout the world. The first part of the book is a theoretical treatment of PXR, which includes a new approach to describe the radiation process in crystals. The second part is a survey of PXR experimental results and the possible applications of PXR as a tool for crystal structure analysis and a source of tunable X-ray radiation.
Organic Solid State Reactions
Organic reactions in the absence of solvent, so called “Organic Solid-State Reactions”, have been well established as proceeding much more efficiently and faster than solution reactions in many cases, since solid-state reactions are infinitely high-concentration reactions. Organic solid-state reactions proceed even more selectively than solution reactions in some cases, since substrate molecules in solids or crystals are ordered regularly. Solid-state reactions are important not only for their high efficiency and selectivity but also for their simplicity and cleanness. In this volume, thermochemical and photochemical reactions in the solid state which have been studied mainly during the last five years by eight research groups are included. The editor hopes that this volume will contribute to the further development of organic solid-state reactions and solid-state chemistry.
Organic Nanostructures for Next Generation Devices
This book provides the first comprehensive overview of fabrication, fundamental properties and applications of a new class of nanoscaled organic materials which holds huge promise for future submicron-sized photonics and optoelectronics. By controlled self-assembled growth on single crystal surfaces, fiber-like structures are fabricated with macroscopic lengths up to millimeter size but mesoscopic widths of mere hundreds of nanometers and nanoscopic heights of several ten nanometers. The extraordinary beauty of these new structures is that they are quasi single crystalline, providing superior optical and electronic properties, and that their properties can be freely tailored via functionalization of their organic building blocks.
Oral cancer detection : Novel strategies and clinical impact
Equips clinicians with the knowledge required to detect oral cancer at the earliest possible stage while simultaneously inspiring researchers to work on novel methods of detection.Individual chapters focus on conventional oral screening and application of vital stains, optical methods.
Optically Anomalous Crystals
Optically Anomalous Crystals begins with an historical introduction covering the contributions of Brewster, Biot, Mallard, Brauns, Tamman, and many other distinguished crystallographers. From this follows a tutorial in crystal optics.
Optical Properties of Photonic Crystals
This is the first comprehensive textbook on the optical properties of photonic crystals. It deals not only with the properties of the radiation modes inside the crystals but also with their peculiar optical response to external fields. A general theory of linear and nonlinear optical response is developed in a clear and detailed fashion using the Green's function method. The symmetry of the eigenmodes is treated systematically using group theory to show how it affects the optical properties of photonic crystals. Important recent developments such as the enhancement of stimulated emission, second harmonic generation, quadrature-phase squeezing, and low-threshold lasing are also treated in detail and made understandable. Numerical methods are also emphasized. Thus this book provides both an introduction for graduate and undergraduate students and also key information for researchers in this field. This second edition has been updated and includes a new chapter on superfluorescence.
Optical Microresonators : Theory, Fabrication, and Applications
Explains why microresonators came to be important components in the photonic toolbox. While functionally similar to the Fabry-Perot, microring resonators offer a planar nature which is naturally compatible with monolithic microfabrication technologies. In these chapters lie the principles required to characterize, design, construct, and implement microresonators as lasers, amplifiers, sensors, filters, demultiplexers, switches, routers, and logic gates. Additionally, much like quantum dots and photonic crystals, it will be shown how microresonators offer an alternative method for creating engineerable materials with designer linear and nonlinear responses tailored for advanced functionalities operating at ultrafast speeds and compact scales.
Optical Interconnects : The Silicon Approach
Optical Interconnects provides a fascinating picture of the state of the art in optical interconnects and a perspective on what can be expected in the near future. It is composed of selected reviews authored by world leaders in the field, and these reviews are written from either an academic or industrial viewpoint. An in-depth discussion of the path towards fully-integrated optical interconnects in microelectronics is presented. This book will be useful not only to physicists, chemists, materials scientists, and engineers but also to graduate students who are interested in the fields of microelectronics and optoelectronics.
Number Theory and the Periodicity of Matter
The book launch was held at the University of Pretoria (UP) on 26 March 2008. … It’s a fascinating and original concept and I hope you all get the opportunity to read it. It will challenge your current views of numbers. … If there is a link between numbers and the Periodic Table this will of course have major implications as to the ‘meaning’ on the Periodic Table. It’s great to have original thinkers in our midst
Novel Optical Resolution Technologies
After theend ofthe 20th century, the science ofcrystallizationreached a truly exciting stage where new opportunities emerged in both theory and expe- ment. Variousphysical methodsare capable of resolving the surface as wellas the insid estructure of crystalsat the atomiclevel while newhigh-performance computing resourcesafford thecapability of modeling the complexlarge-scale alignments necessary to simulatecrystallizationinrealsystems. Asaresult, the science of crystallization has shifted gradually fromstatic to dynamic science and considerable progress now underlies the complex but beautiful cryst- lization process.The vastpotential ofcrystallizationasan- portant feld ofscience isfar beyondthesimple technologyofpharmaceutical industries during the 20th century.
Nonlinear Optical Crystals : A Complete Survey
Nonlinear optical crystals are widely used in modern optical science and technology for frequency conversion of laser light, i.e. to generate laser radiation at any specific wavelength in visible, UV or IR spectral regions. This unrivalled reference book contains the most complete and up-to-date information on properties of nonlinear optical crystals. It includes: * Database of 63 common and novel nonlinear optical crystals * Periodically-poled and self-frequency-doubling materials * Full description of linear and nonlinear optical properties * Significant amount of crystallophysical, thermophysical, spectroscopic, electro-optic and magneto-optic information * 7 mini-reviews on novel applications, such as deep-UV light generation, terahertz-wave generation, ultrashort laser pulse compression, photonic band-gap crystals, x3 nonlinearity, etc. * More than 1500 different references with full titles It is a vital source of information for scientists and engineers dealing with modern applications of nonlinear optical crystals in quantum electronics, photonics, optoelectronics and laser physics.
Nonlinear Homogenization and its Applications to Composites, Polycrystals and Smart Materials ; Proceedings of the NATO Advanced Research Workshop, held in Warsaw, Poland, 23-26 June 2003
Although several books and conference proceedings have already appeared dealing with either the mathematical aspects or applications of homogenization theory, there seems to be no comprehensive volume dealing with both aspects. The present volume is meant to fill this gap, at least partially, and deals with recent developments in nonlinear homogenization emphasizing applications of current interest. It contains thirteen key lectures presented at the NATO Advanced Workshop on Nonlinear Homogenization and Its Applications to Composites, Polycrystals and Smart Materials. The list of thirty one contributed papers is also appended.
Nonlinear Fokker-Planck Equations : Fundamentals and Applications
Providing an introduction to the theory of nonlinear Fokker-Planck equations, this book discusses fundamental properties of transient and stationary solutions, emphasizing the stability analysis of stationary solutions by means of self-consistency equations, linear stability analysis, and Lyapunov's direct method. Also treated are Langevin equations and correlation functions. Nonlinear Fokker-Planck Equations addresses various phenomena such as phase transitions, multistability of systems, synchronization, anomalous diffusion, cut-off solutions, travelling-wave solutions and the emergence of power law solutions. A nonlinear Fokker-Planck perspective to quantum statistics, generalized thermodynamics, and linear nonequilibrium thermodynamics is given. Theoretical concepts are illustrated where possible by simple examples. The book also reviews several applications in the fields of condensed matter physics, the physics of porous media and liquid crystals, accelerator physics, neurophysics, social sciences, population dynamics, and computational physics.
Nonlinear Dielectric Phenomena in Complex Liquids
Complex liquids constitute a basic element in modern materials science; their significant features include self-assembly, mesoscale structures, complex dynamics, unusual phases and enormous sensitivity to perturbations. Understanding their nature and properties are a great challenge to modern materials science that demands novel approaches. This book focuses on nonlinear dielectric phenomena, particularly on nonlinear dielectric spectroscopy (NDS), which may be considered a possible successor to broadband dielectric spectroscopy (BDS). NDS phenomena directly coupled to mesoscale heterogeneity fluctuations, so information obtained in this way is basically complementary to BDS tests. The book also discusses the application of NDS in a set of complex liquid systems: glassy liquids, liquid crystals, liquids with critical point phenomena, and bio-relevant liquids. The complementary application of NDS and BDS may allow the discovery of universal patterns for the whole category of complex liquids. Written by specialists in the field of nonlinear dielectric studies, theoreticians and experimentalists, ranging from solid state physics to biophysics, the book is organized so that it can serve as a basic textbook for a non-experienced reader.
Neutron Scattering in Biology : Techniques and Applications
The advent of new neutron facilities and the improvement of existing sources and instruments world wide supply the biological community with many new opportunities in the areas of structural biology and biological physics. The present volume offers a clear description of the various neutron-scattering techniques currently being used to answer biologically relevant questions. Their utility is illustrated through examples by some of the leading researchers in the field of neutron scattering. This volume will be a reference for researchers and a step-by-step guide for young scientists entering the field and the advanced graduate student.
Narrow Gap Semiconductors 2007 ; Proceedings of the 13th International Conference, 8-12 July, 2007, Guildford, UK
Narrow gap semiconductors have provided an exciting field of research and show a number of extreme physical and material characteristics. They are the established material systems for infrared detectors and emitters, and with new developments in the technology these materials are emerging as a viable route to high speed, low power electronics. New kinds of narrow gap semiconductor, such as graphene and other composite nanocrystals, are also providing renewed interest in the underlying physics.
Nanostructured and advanced materials for applications in sensor, optoelectronic and photovoltaic technology ; Proceedings of the NATO Advanced Study Institute on nanostructured and advanced materials for applications in sensors, optoelectronic and photovoltaic technology ; Sozopol, Bulgaria, 6-17 September 2004
Nanotechnology is an emerging scientific field receiving significant worldwide attention. On a nanometer scale, materials or structures may possess new and unique physical properties. Some of these are now known to the scientific community, but there may well be many properties not yet known to us, rendering it as a fascinating area of research and a suitable subject for a NATO ASI. Yet another aspect of the field is the possibility for creating meta-stable phases with unconventional properties and the ultra-miniaturization of current devices, sensors, and machines. Such nanotechnological and related advanced materials have an extremely wide range of potential applications, viz. nanoscale electronics, sensors, optoelectronics, photonics, nano-biological systems, na- medicine, energy storage systems, etc. This is a wide-ranging subject area and therefore requires the formation of multi-disciplinary teams of physicists, chemists, materials scientists, engineers, molecular biologists, pharmacologists, and others to work together on the synthesis and processing of materials and structures, the understanding of their physical properties, the design and fabrication of devices.
Nanoscale Phenomena : Basic Science to Device Applications
Nanotechnology is the result of the continuing technological trend toward device miniaturization and the characterization, manipulation, and fine control of structure and function at diminishing length scales. A large class of nanoscale materials can be stable even though they are far from the lowest-energy thermodynamic state, and many possess novel properties unattainable in bulk. These trends are supported by the increasing sophistication of characterization and fabrication tools such as the scanning tunneling microscope and the transmission electron microscope, which allow the resolution and manipulation of single atoms and molecules.
Nanoformulations in Human Health: Challenges and Approaches
This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers, etc. The most important aspect of the book covers various types of nanoformulations and their applications in the treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, cancer, arthritis and tuberculosis.
